8086 results
Cited 11 times since 2017 (1.4 per year)
source: EuropePMC
American journal of primatology,
Volume 79, Issue 10, 1 1 2017
Resilience of experimentally seeded dietary traditions in wild vervets: Evidence from group fissions.
van de Waal E, van Schaik CP, Whiten A
Controlled laboratory experiments have delivered extensive and compelling evidence for the diffusion and maintenance of socially learned behavior in primates and other animals. Such evidence is rarer in the wild, but we show that a behavior seeded in a majority of individuals within vervet monkey (Chlorocebus pygerythus) groups may be sustained across several years. Here, we report results of two natural fission events in such groups that offer novel evidence of the resilience of socially transm...
Abstract
Cited 3 times since 2017 (0.4 per year)
source: EuropePMC
Journal of graduate medical education,
Volume 9, Issue 4, 1 1 2017, Pages 523-526
Doing More With Less: A Centralized Model for Fellowship Program Coordination.
Patel T, Schwan K, Hoover S, O'Hollaren A, Sadat S, Siu A, Bains T, van Schaik S
Background: Pediatrics fellowship programs typically are small, embedded in divisions, and vary in their approach to education. Program coordination usually falls to division administrators who operate in silos despite common requirements across programs, creating redundancy and inefficiency. Objective: We examined the feasibility, acceptability, and impact of a centralized administrative model for pediatrics fellowship support at a large university-based institution. Methods: In 2014, administr...
Abstract
Cited 1 times since 2017 (0.1 per year)
source: EuropePMC
Pain,
Volume 158, Issue 8, 1 1 2017, Pages 1623
Reply.
Matic M, van den Bosch GE, de Wildt SN, Tibboel D, van Schaik RHN
Abstract
Cited 34 times since 2017 (4.3 per year)
source: EuropePMC
Circulation. Cardiovascular genetics,
Volume 10, Issue 4, 1 1 2017, Pages e001631
<i>Lamin A/C</i>-Related Cardiac Disease: Late Onset With a Variable and Mild Phenotype in a Large Cohort of Patients With the Lamin A/C p.(Arg331Gln) Founder Mutation.
Hoorntje ET, Bollen IA, Barge-Schaapveld DQ, van Tienen FH, Te Meerman GJ, Jansweijer JA, van Essen AJ, Volders PG, Constantinescu AA, van den Akker PC, van Spaendonck-Zwarts KY, Oldenburg RA, Marcelis CL, van der Smagt JJ, Hennekam EA, Vink A, Bootsma M, Aten E, Wilde AA, van den Wijngaard A, Broers JL, Jongbloed JD, van der Velden J, van den Berg MP, van Tintelen JP
Background: Interpretation of missense variants can be especially difficult when the variant is also found in control populations. This is what we encountered for the LMNA c.992G>A (p.(Arg331Gln)) variant. Therefore, to evaluate the effect of this variant, we combined an evaluation of clinical data with functional experiments and morphological studies. Methods and results: Clinical data of 23 probands and 35 family members carrying this variant were retrospectively collected. A time-to-event...
Abstract
Cited 58 times since 2017 (7.4 per year)
source: EuropePMC
Clinical pharmacokinetics,
Volume 56, Issue 8, 1 1 2017, Pages 963-975
A New CYP3A5*3 and CYP3A4*22 Cluster Influencing Tacrolimus Target Concentrations: A Population Approach.
Andreu F, Colom H, Elens L, van Gelder T, van Schaik RHN, Hesselink DA, Bestard O, Torras J, Cruzado JM, Grinyó JM, Lloberas N
Background: Single nucleotide polymorphisms (SNPs) in the CYP3A5 and CYP3A4 genes have been reported to be an important cause of variability in the pharmacokinetics of tacrolimus in renal transplant patients. The aim of this study was to merge all of the new genetic information available with tacrolimus pharmacokinetics to generate a more robust population model with data from renal transplant recipients. Methods: Tacrolimus exposure data from 304 renal transplant recipients were collected throu...
Abstract
Cited 47 times since 2017 (6 per year)
source: EuropePMC
Circulation. Cardiovascular genetics,
Volume 10, Issue 4, 1 1 2017, Pages e001632
<i>PCSK9</i> Loss-of-Function Variants, Low-Density Lipoprotein Cholesterol, and Risk of Coronary Heart Disease and Stroke: Data From 9 Studies of Blacks and Whites.
Kent ST, Rosenson RS, Avery CL, Chen YI, Correa A, Cummings SR, Cupples LA, Cushman M, Evans DS, Gudnason V, Harris TB, Howard G, Irvin MR, Judd SE, Jukema JW, Lange L, Levitan EB, Li X, Liu Y, Post WS, Postmus I, Psaty BM, Rotter JI, Safford MM, Sitlani CM, Smith AV, Stewart JD, Trompet S, Sun F, Vasan RS, Woolley JM, Whitsel EA, Wiggins KL, Wilson JG, Muntner P
Background: PCSK9 loss-of-function (LOF) variants allow for the examination of the effects of lifetime reduced low-density lipoprotein cholesterol (LDL-C) on cardiovascular events. We examined the association of PCSK9 LOF variants with LDL-C and incident coronary heart disease and stroke through a meta-analysis of data from 8 observational cohorts and 1 randomized trial of statin therapy. Methods and results: These 9 studies together included 17 459 blacks with 403 (2.3%) having at least 1 Y142X...
Abstract
Cited 153 times since 2017 (19.4 per year)
source: EuropePMC
Journal of the American College of Cardiology,
Volume 70, Issue 5, 1 1 2017, Pages 558-568
High-Sensitivity Cardiac Troponin Concentration and Risk of First-Ever Cardiovascular Outcomes in 154,052 Participants.
Willeit P, Welsh P, Evans JDW, Tschiderer L, Boachie C, Jukema JW, Ford I, Trompet S, Stott DJ, Kearney PM, Mooijaart SP, Kiechl S, Di Angelantonio E, Sattar N
Background: High-sensitivity assays can quantify cardiac troponins I and T (hs-cTnI, hs-cTnT) in individuals with no clinically manifest myocardial injury. Objectives: The goal of this study was to assess associations of cardiac troponin concentration with cardiovascular disease (CVD) outcomes in primary prevention studies. Methods: A search was conducted of PubMed, Web of Science, and EMBASE for prospective studies published up to September 2016, reporting on associations of cardiac troponin co...
Abstract
Cited 127 times since 2017 (16.1 per year)
source: EuropePMC
European heart journal,
Volume 38, Issue 32, 1 1 2017, Pages 2499-2507
The AT04A vaccine against proprotein convertase subtilisin/kexin type 9 reduces total cholesterol, vascular inflammation, and atherosclerosis in APOE*3Leiden.CETP mice.
Landlinger C, Pouwer MG, Juno C, van der Hoorn JWA, Pieterman EJ, Jukema JW, Staffler G, Princen HMG, Galabova G
Aims: Proprotein convertase subtilisin/kexin type 9 (PCSK9) has emerged as a promising therapeutic target for the treatment of hypercholesterolaemia and atherosclerosis. PCSK9 binds to the low density lipoprotein receptor and enhances its degradation, which leads to the reduced clearance of low density lipoprotein cholesterol (LDLc) and a higher risk of atherosclerosis. In this study, the AT04A anti-PCSK9 vaccine was evaluated for its therapeutic potential in ameliorating or even preventing coro...
Abstract
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine,
Volume 130, 29 5 2017, Pages 60-65
L-shell differential cross-section and alignment of uranium at 59.54-keV photon energy.
Akkuş T, Alım B, Yılmaz D, Şahin Y
L X-ray differential cross-sections of uranium were calculated at several polar scattering angles (85°, 95°, 105°, 115°, 125°, and 135°) at 59.54-keV photon energy by using a Si(Li) detector. We observed that Ll and Lα X-rays were dependent on the polar scattering angle, whereas Lβ and Lγ X-rays were independent of the polar scattering angle. Therefore, the anisotropy parameters for Ll and Lα X-rays were obtained using the intensity ratios of Ll to Lγ X-rays and of Lα to Lγ X-rays to reduce some...
Abstract
Cited 37 times since 2017 (4.7 per year)
source: EuropePMC
RMD open,
Volume 3, Issue 2, 28 4 2017, Pages e000384
Rituximab in early systemic sclerosis.
Boonstra M, Meijs J, Dorjée AL, Marsan NA, Schouffoer A, Ninaber MK, Quint KD, Bonte-Mineur F, Huizinga TWJ, Scherer HU, de Vries-Bouwstra JK
Objectives: (1) Hypothesis testing of the potency of rituximab (RTX) in preventing fibrotic complications and (2) assessing acceptability and feasibility of RTX in early systemic sclerosis (SSc). Methods: A small, 24-month, randomised, double-blind, placebo-controlled, single-centre trial in patients with SSc diagnosed
Abstract
Cited 4 times since 2017 (0.5 per year)
source: EuropePMC
Journal of interventional cardiology,
Volume 30, Issue 5, 28 4 2017, Pages 440-447
Safety and efficacy of percutaneous intramyocardial bone marrow cell injection for chronic myocardial ischemia: Long-term results.
Rodrigo SF, Mann I, van Ramshorst J, Beeres SL, Zwaginga JJ, Fibbe WE, Bax JJ, Schalij MJ, Atsma DE
Background: Intramyocardial injection of bone marrow cells (BMC) in refractory angina patients with chronic myocardial ischemia has shown to be safe and improve clinical status during short-term follow-up. However, scarce data are available on long-term (>12 months) safety and efficacy. Therefore, the occurrence of clinical events and the long-term clinical effects of intramyocardial BMC injection were evaluated in patients with chronic myocardial ischemia up to 10 years after treatment. Meth...
Abstract
Cited 9 times since 2017 (1.1 per year)
source: EuropePMC
The Journal of general virology,
Volume 98, Issue 8, 28 4 2017, Pages 2128-2142
Antibodies against the mono-methylated arginine-glycine repeat (MMA-RG) of the Epstein-Barr virus nuclear antigen 2 (EBNA2) identify potential cellular proteins targeted in viral transformation.
Ayoubian H, Fröhlich T, Pogodski D, Flatley A, Kremmer E, Schepers A, Feederle R, Arnold GJ, Grässer FA
The Epstein-Barr virus is a human herpes virus with oncogenic potential. The virus-encoded nuclear antigen 2 (EBNA2) is a key mediator of viral tumorigenesis. EBNA2 features an arginine-glycine (RG) repeat at amino acids (aa)339-354 that is essential for the transformation of lymphocytes and contains symmetrically (SDMA) and asymmetrically (ADMA) di-methylated arginine residues. The SDMA-modified EBNA2 binds the survival motor neuron protein (SMN), thus mimicking SMD3, a cellular SDMA-containing...
Abstract
Cited 6 times since 2017 (0.8 per year)
source: EuropePMC
Heart (British Cardiac Society),
Volume 104, Issue 5, 27 4 2017, Pages 385-393
Coronary anatomy in children with bicuspid aortic valves and associated congenital heart disease.
Koenraadt WMC, Bartelings MM, Bökenkamp R, Gittenberger-de Groot AC, DeRuiter MC, Schalij MJ, Jongbloed MR
Objective: In patients with bicuspid aortic valve (BAV), coronary anatomy is variable. High take-off coronary arteries have been described, but data are scarce, especially when associated with complex congenital heart disease (CHD). The purpose of this study was to describe coronary patterns in these patients. Methods: In 84 postmortem heart specimens with BAV and associated CHD, position and height of the coronary ostia were studied and related to BAV morphology. Results: High take-off right (R...
Abstract
Cited 10 times since 2017 (1.3 per year)
source: EuropePMC
Canadian journal of physiology and pharmacology,
Volume 95, Issue 10, 26 4 2017, Pages 1230-1235
Beat-to-beat variability of cardiac action potential duration: underlying mechanism and clinical implications.
Nánási PP, Magyar J, Varró A, Ördög B
Beat-to-beat variability of cardiac action potential duration (short-term variability, SV) is a common feature of various cardiac preparations, including the human heart. Although it is believed to be one of the best arrhythmia predictors, the underlying mechanisms are not fully understood at present. The magnitude of SV is basically determined by the intensity of cell-to-cell coupling in multicellular preparations and by the duration of the action potential (APD). To compensate for the APD-depe...
Abstract
Cited 23 times since 2017 (2.9 per year)
source: EuropePMC
Plant physiology,
Volume 175, Issue 1, 26 4 2017, Pages 498-510
Sequence Exchange between Homologous NB-LRR Genes Converts Virus Resistance into Nematode Resistance, and Vice Versa.
Slootweg E, Koropacka K, Roosien J, Dees R, Overmars H, Lankhorst RK, van Schaik C, Pomp R, Bouwman L, Helder J, Schots A, Bakker J, Smant G, Goverse A
Plants have evolved a limited repertoire of NB-LRR disease resistance (R) genes to protect themselves against myriad pathogens. This limitation is thought to be counterbalanced by the rapid evolution of NB-LRR proteins, as only a few sequence changes have been shown to be sufficient to alter resistance specificities toward novel strains of a pathogen. However, little is known about the flexibility of NB-LRR R genes to switch resistance specificities between phylogenetically unrelated pathogens....
Abstract
Cited 14 times since 2017 (1.8 per year)
source: EuropePMC
Pharmacogenomics,
Volume 18, Issue 12, 26 4 2017, Pages 1133-1142
Advanced cancer pain: the search for genetic factors correlated with interindividual variability in opioid requirement.
Matic M, Jongen JL, Elens L, de Wildt SN, Tibboel D, Sillevis Smitt PA, van Schaik RH
Aim: To assess association between genetic variants and opioid requirement in cancer patients. Materials & methods: A prospective observational trial of 243 advanced cancer patients with inadequate analgesia treated by the palliative care team was analyzed for ABCB1, ARRB2, COMT, GCH1, IL1RN, KCNJ6, OPRM1, RHBDF2, SCN9A and Stat6 polymorphisms. Results: For patients carrying OPRM1 118AG/GG and COMT 472GG (Val158Val) or these genotypes alone, a significant higher median percentage dose increa...
Abstract
Cited 108 times since 2017 (13.7 per year)
source: EuropePMC
Hypertension (Dallas, Tex. : 1979),
Volume 70, Issue 3, 24 4 2017, Pages e4-e19
Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney.
Wain LV, Vaez A, Jansen R, Joehanes R, van der Most PJ, Erzurumluoglu AM, O'Reilly PF, Cabrera CP, Warren HR, Rose LM, Verwoert GC, Hottenga JJ, Strawbridge RJ, Esko T, Arking DE, Hwang SJ, Guo X, Kutalik Z, Trompet S, Shrine N, Teumer A, Ried JS, Bis JC, Smith AV, Amin N, Nolte IM, Lyytikäinen LP, Mahajan A, Wareham NJ, Hofer E, Joshi PK, Kristiansson K, Traglia M, Havulinna AS, Goel A, Nalls MA, Sõber S, Vuckovic D, Luan J, Del Greco M F, Ayers KL, Marrugat J, Ruggiero D, Lopez LM, Niiranen T, Enroth S, Jackson AU, Nelson CP, Huffman JE, Zhang W, Marten J, Gandin I, Harris SE, Zemunik T, Lu Y, Evangelou E, Shah N, de Borst MH, Mangino M, Prins BP, Campbell A, Li-Gao R, Chauhan G, Oldmeadow C, Abecasis G, Abedi M, Barbieri CM, Barnes MR, Batini C, Beilby J, BIOS Consortium, Blake T, Boehnke M, Bottinger EP, Braund PS, Brown M, Brumat M, Campbell H, Chambers JC, Cocca M, Collins F, Connell J, Cordell HJ, Damman JJ, Davies G, de Geus EJ, de Mutsert R, Deelen J, Demirkale Y, Doney ASF, Doney ASF, Dörr M, Farral
Elevated blood pressure is a major risk factor for cardiovascular disease and has a substantial genetic contribution. Genetic variation influencing blood pressure has the potential to identify new pharmacological targets for the treatment of hypertension. To discover additional novel blood pressure loci, we used 1000 Genomes Project-based imputation in 150 134 European ancestry individuals and sought significant evidence for independent replication in a further 228 245 individuals. We report 6 n...
Abstract
Cited 9 times since 2017 (1.1 per year)
source: EuropePMC
The pharmacogenomics journal,
Volume 18, Issue 2, 18 3 2017, Pages 215-226
Pharmacogenomics study of thiazide diuretics and QT interval in multi-ethnic populations: the cohorts for heart and aging research in genomic epidemiology.
Seyerle AA, Sitlani CM, Noordam R, Gogarten SM, Li J, Li X, Evans DS, Sun F, Laaksonen MA, Isaacs A, Kristiansson K, Highland HM, Stewart JD, Harris TB, Trompet S, Bis JC, Peloso GM, Brody JA, Broer L, Busch EL, Duan Q, Stilp AM, O'Donnell CJ, Macfarlane PW, Floyd JS, Kors JA, Lin HJ, Li-Gao R, Sofer T, Méndez-Giráldez R, Cummings SR, Heckbert SR, Hofman A, Ford I, Li Y, Launer LJ, Porthan K, Newton-Cheh C, Napier MD, Kerr KF, Reiner AP, Rice KM, Roach J, Buckley BM, Soliman EZ, de Mutsert R, Sotoodehnia N, Uitterlinden AG, North KE, Lee CR, Gudnason V, Stürmer T, Rosendaal FR, Taylor KD, Wiggins KL, Wilson JG, Chen YD, Kaplan RC, Wilhelmsen K, Cupples LA, Salomaa V, van Duijn C, Jukema JW, Liu Y, Mook-Kanamori DO, Lange LA, Vasan RS, Smith AV, Stricker BH, Laurie CC, Rotter JI, Whitsel EA, Psaty BM, Avery CL
Thiazide diuretics, commonly used antihypertensives, may cause QT interval (QT) prolongation, a risk factor for highly fatal and difficult to predict ventricular arrhythmias. We examined whether common single-nucleotide polymorphisms (SNPs) modified the association between thiazide use and QT or its component parts (QRS interval, JT interval) by performing ancestry-specific, trans-ethnic and cross-phenotype genome-wide analyses of European (66%), African American (15%) and Hispanic (19%) populat...
Abstract
Cited 14 times since 2017 (1.8 per year)
source: EuropePMC
Statistics in medicine,
Volume 36, Issue 23, 17 3 2017, Pages 3746-3759
Extension of the association structure in joint models to include weighted cumulative effects.
Mauff K, Steyerberg EW, Nijpels G, van der Heijden AAWA, Rizopoulos D
Motivated by a study measuring diabetes-related risk factors and complications, we postulate an extension to the standard formulation of joint models for longitudinal and survival outcomes, wherein the longitudinal outcome has a cumulative effect on the hazard of the event, weighted by recency. We focus on the relationship between the biomarker HbA1c and the development of sight threatening retinopathy, since the impact of the HbA1c marker on the risk of sight threatening retinopathy is expected...
Abstract
Cited 17 times since 2017 (2.1 per year)
source: EuropePMC
Journal of surgical education,
Volume 75, Issue 1, 15 3 2017, Pages 33-42
Toward Best Practices for Surgical Morbidity and Mortality Conferences: A Mixed Methods Study.
de Vos MS, Marang-van de Mheen PJ, Smith AD, Mou D, Whang EE, Hamming JF
Objective: To assess formats for surgical morbidity and mortality conferences (M&M) for strengths and challenges. Design: A mixed methods approach with local observations to assess key domains of M&M practice (i.e., goals, structure, and process/content) and surveys to assess participants' expectations and experiences. Setting: Surgical departments of two teaching hospitals (Boston, USA and Leiden, Netherlands). Participants: Participants of surgical M&M, including attending sur...
Abstract
