8892 results
Cited 6 times since 2017 (0.7 per year)
source: EuropePMC
Heart (British Cardiac Society),
Volume 104, Issue 5, 27 4 2017, Pages 385-393
Coronary anatomy in children with bicuspid aortic valves and associated congenital heart disease.
Koenraadt WMC, Bartelings MM, Bökenkamp R, Gittenberger-de Groot AC, DeRuiter MC, Schalij MJ, Jongbloed MR
Objective: In patients with bicuspid aortic valve (BAV), coronary anatomy is variable. High take-off coronary arteries have been described, but data are scarce, especially when associated with complex congenital heart disease (CHD). The purpose of this study was to describe coronary patterns in these patients. Methods: In 84 postmortem heart specimens with BAV and associated CHD, position and height of the coronary ostia were studied and related to BAV morphology. Results: High take-off right (R...
Abstract
Cited 10 times since 2017 (1.2 per year)
source: EuropePMC
Canadian journal of physiology and pharmacology,
Volume 95, Issue 10, 26 4 2017, Pages 1230-1235
Beat-to-beat variability of cardiac action potential duration: underlying mechanism and clinical implications.
Nánási PP, Magyar J, Varró A, Ördög B
Beat-to-beat variability of cardiac action potential duration (short-term variability, SV) is a common feature of various cardiac preparations, including the human heart. Although it is believed to be one of the best arrhythmia predictors, the underlying mechanisms are not fully understood at present. The magnitude of SV is basically determined by the intensity of cell-to-cell coupling in multicellular preparations and by the duration of the action potential (APD). To compensate for the APD-depe...
Abstract
Cited 25 times since 2017 (3 per year)
source: EuropePMC
Plant physiology,
Volume 175, Issue 1, 26 4 2017, Pages 498-510
Sequence Exchange between Homologous NB-LRR Genes Converts Virus Resistance into Nematode Resistance, and Vice Versa.
Slootweg E, Koropacka K, Roosien J, Dees R, Overmars H, Lankhorst RK, van Schaik C, Pomp R, Bouwman L, Helder J, Schots A, Bakker J, Smant G, Goverse A
Plants have evolved a limited repertoire of NB-LRR disease resistance (R) genes to protect themselves against myriad pathogens. This limitation is thought to be counterbalanced by the rapid evolution of NB-LRR proteins, as only a few sequence changes have been shown to be sufficient to alter resistance specificities toward novel strains of a pathogen. However, little is known about the flexibility of NB-LRR R genes to switch resistance specificities between phylogenetically unrelated pathogens....
Abstract
Cited 16 times since 2017 (1.9 per year)
source: EuropePMC
Pharmacogenomics,
Volume 18, Issue 12, 26 4 2017, Pages 1133-1142
Advanced cancer pain: the search for genetic factors correlated with interindividual variability in opioid requirement.
Matic M, Jongen JL, Elens L, de Wildt SN, Tibboel D, Sillevis Smitt PA, van Schaik RH
Aim: To assess association between genetic variants and opioid requirement in cancer patients. Materials & methods: A prospective observational trial of 243 advanced cancer patients with inadequate analgesia treated by the palliative care team was analyzed for ABCB1, ARRB2, COMT, GCH1, IL1RN, KCNJ6, OPRM1, RHBDF2, SCN9A and Stat6 polymorphisms. Results: For patients carrying OPRM1 118AG/GG and COMT 472GG (Val158Val) or these genotypes alone, a significant higher median percentage dose increa...
Abstract
Cited 113 times since 2017 (13.7 per year)
source: EuropePMC
Hypertension (Dallas, Tex. : 1979),
Volume 70, Issue 3, 24 4 2017, Pages e4-e19
Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney.
Wain LV, Vaez A, Jansen R, Joehanes R, van der Most PJ, Erzurumluoglu AM, O'Reilly PF, Cabrera CP, Warren HR, Rose LM, Verwoert GC, Hottenga JJ, Strawbridge RJ, Esko T, Arking DE, Hwang SJ, Guo X, Kutalik Z, Trompet S, Shrine N, Teumer A, Ried JS, Bis JC, Smith AV, Amin N, Nolte IM, Lyytikäinen LP, Mahajan A, Wareham NJ, Hofer E, Joshi PK, Kristiansson K, Traglia M, Havulinna AS, Goel A, Nalls MA, Sõber S, Vuckovic D, Luan J, Del Greco M F, Ayers KL, Marrugat J, Ruggiero D, Lopez LM, Niiranen T, Enroth S, Jackson AU, Nelson CP, Huffman JE, Zhang W, Marten J, Gandin I, Harris SE, Zemunik T, Lu Y, Evangelou E, Shah N, de Borst MH, Mangino M, Prins BP, Campbell A, Li-Gao R, Chauhan G, Oldmeadow C, Abecasis G, Abedi M, Barbieri CM, Barnes MR, Batini C, Beilby J, BIOS Consortium, Blake T, Boehnke M, Bottinger EP, Braund PS, Brown M, Brumat M, Campbell H, Chambers JC, Cocca M, Collins F, Connell J, Cordell HJ, Damman JJ, Davies G, de Geus EJ, de Mutsert R, Deelen J, Demirkale Y, Doney ASF, Doney ASF, Dörr M, Farral
Elevated blood pressure is a major risk factor for cardiovascular disease and has a substantial genetic contribution. Genetic variation influencing blood pressure has the potential to identify new pharmacological targets for the treatment of hypertension. To discover additional novel blood pressure loci, we used 1000 Genomes Project-based imputation in 150 134 European ancestry individuals and sought significant evidence for independent replication in a further 228 245 individuals. We report 6 n...
Abstract
Cited 10 times since 2017 (1.2 per year)
source: EuropePMC
The pharmacogenomics journal,
Volume 18, Issue 2, 18 3 2017, Pages 215-226
Pharmacogenomics study of thiazide diuretics and QT interval in multi-ethnic populations: the cohorts for heart and aging research in genomic epidemiology.
Seyerle AA, Sitlani CM, Noordam R, Gogarten SM, Li J, Li X, Evans DS, Sun F, Laaksonen MA, Isaacs A, Kristiansson K, Highland HM, Stewart JD, Harris TB, Trompet S, Bis JC, Peloso GM, Brody JA, Broer L, Busch EL, Duan Q, Stilp AM, O'Donnell CJ, Macfarlane PW, Floyd JS, Kors JA, Lin HJ, Li-Gao R, Sofer T, Méndez-Giráldez R, Cummings SR, Heckbert SR, Hofman A, Ford I, Li Y, Launer LJ, Porthan K, Newton-Cheh C, Napier MD, Kerr KF, Reiner AP, Rice KM, Roach J, Buckley BM, Soliman EZ, de Mutsert R, Sotoodehnia N, Uitterlinden AG, North KE, Lee CR, Gudnason V, Stürmer T, Rosendaal FR, Taylor KD, Wiggins KL, Wilson JG, Chen YD, Kaplan RC, Wilhelmsen K, Cupples LA, Salomaa V, van Duijn C, Jukema JW, Liu Y, Mook-Kanamori DO, Lange LA, Vasan RS, Smith AV, Stricker BH, Laurie CC, Rotter JI, Whitsel EA, Psaty BM, Avery CL
Thiazide diuretics, commonly used antihypertensives, may cause QT interval (QT) prolongation, a risk factor for highly fatal and difficult to predict ventricular arrhythmias. We examined whether common single-nucleotide polymorphisms (SNPs) modified the association between thiazide use and QT or its component parts (QRS interval, JT interval) by performing ancestry-specific, trans-ethnic and cross-phenotype genome-wide analyses of European (66%), African American (15%) and Hispanic (19%) populat...
Abstract
Cited 17 times since 2017 (2.1 per year)
source: EuropePMC
Statistics in medicine,
Volume 36, Issue 23, 17 3 2017, Pages 3746-3759
Extension of the association structure in joint models to include weighted cumulative effects.
Mauff K, Steyerberg EW, Nijpels G, van der Heijden AAWA, Rizopoulos D
Motivated by a study measuring diabetes-related risk factors and complications, we postulate an extension to the standard formulation of joint models for longitudinal and survival outcomes, wherein the longitudinal outcome has a cumulative effect on the hazard of the event, weighted by recency. We focus on the relationship between the biomarker HbA1c and the development of sight threatening retinopathy, since the impact of the HbA1c marker on the risk of sight threatening retinopathy is expected...
Abstract
Cited 21 times since 2017 (2.5 per year)
source: EuropePMC
Journal of surgical education,
Volume 75, Issue 1, 15 3 2017, Pages 33-42
Toward Best Practices for Surgical Morbidity and Mortality Conferences: A Mixed Methods Study.
de Vos MS, Marang-van de Mheen PJ, Smith AD, Mou D, Whang EE, Hamming JF
Objective: To assess formats for surgical morbidity and mortality conferences (M&M) for strengths and challenges. Design: A mixed methods approach with local observations to assess key domains of M&M practice (i.e., goals, structure, and process/content) and surveys to assess participants' expectations and experiences. Setting: Surgical departments of two teaching hospitals (Boston, USA and Leiden, Netherlands). Participants: Participants of surgical M&M, including attending sur...
Abstract
Cited 142 times since 2017 (17.2 per year)
source: EuropePMC
Nature communications,
Volume 8, 12 2 2017, Pages 16015
Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness.
Willems SM, Wright DJ, Day FR, Trajanoska K, Joshi PK, Morris JA, Matteini AM, Garton FC, Grarup N, Oskolkov N, Thalamuthu A, Mangino M, Liu J, Demirkan A, Lek M, Xu L, Wang G, Oldmeadow C, Gaulton KJ, Lotta LA, Miyamoto-Mikami E, Rivas MA, White T, Loh PR, Aadahl M, Amin N, Attia JR, Austin K, Benyamin B, Brage S, Cheng YC, Cięszczyk P, Derave W, Eriksson KF, Eynon N, Linneberg A, Lucia A, Massidda M, Mitchell BD, Miyachi M, Murakami H, Padmanabhan S, Pandey A, Papadimitriou I, Rajpal DK, Sale C, Schnurr TM, Sessa F, Shrine N, Tobin MD, Varley I, Wain LV, Wray NR, Lindgren CM, MacArthur DG, Waterworth DM, McCarthy MI, Pedersen O, Khaw KT, Kiel DP, GEFOS Any-Type of Fracture Consortium, Pitsiladis Y, Fuku N, Franks PW, North KN, van Duijn CM, Mather KA, Hansen T, Hansson O, Spector T, Murabito JM, Richards JB, Rivadeneira F, Langenberg C, Perry JRB, Wareham NJ, Scott RA
Hand grip strength is a widely used proxy of muscular fitness, a marker of frailty, and predictor of a range of morbidities and all-cause mortality. To investigate the genetic determinants of variation in grip strength, we perform a large-scale genetic discovery analysis in a combined sample of 195,180 individuals and identify 16 loci associated with grip strength (P
Abstract
Cited 1 times since 2017 (0.1 per year)
source: EuropePMC
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology,
Volume 24, Issue 5, 11 2 2017, Pages 1594-1597
Clinical utility of cardiac innervation imaging in patients with heart failure.
Bax JJ
Abstract
Cited 17 times since 2017 (2.1 per year)
source: EuropePMC
Scientific reports,
Volume 7, Issue 1, 7 1 2017, Pages 4839
First integrative trend analysis for a great ape species in Borneo.
Santika T, Ancrenaz M, Wilson KA, Spehar S, Abram N, Banes GL, Campbell-Smith G, Curran L, d'Arcy L, Delgado RA, Erman A, Goossens B, Hartanto H, Houghton M, Husson SJ, Kühl HS, Lackman I, Leiman A, Llano Sanchez K, Makinuddin N, Marshall AJ, Meididit A, Mengersen K, Musnanda, Nardiyono, Nurcahyo A, Odom K, Panda A, Prasetyo D, Purnomo, Rafiastanto A, Raharjo S, Ratnasari D, Russon AE, Santana AH, Santoso E, Sapari I, Sihite J, Suyoko A, Tjiu A, Utami-Atmoko SS, van Schaik CP, Voigt M, Wells J, Wich SA, Willems EP, Meijaard E
For many threatened species the rate and drivers of population decline are difficult to assess accurately: species' surveys are typically restricted to small geographic areas, are conducted over short time periods, and employ a wide range of survey protocols. We addressed methodological challenges for assessing change in the abundance of an endangered species. We applied novel methods for integrating field and interview survey data for the critically endangered Bornean orangutan (Pongo pygm...
Abstract
BMJ simulation & technology enhanced learning,
Volume 3, Issue 3, 6 1 2017, Pages 88-93
The use of multiple-criteria decision-making theory to measure students' perceptions of high-fidelity simulation.
Jersby MA, Van-Schaik P, Green S, Nacheva-Skopalik L
Background: High-Fidelity Simulation (HFS) has great potential to improve decision-making in clinical practice. Previous studies have found HFS promotes self-confidence, but its effectiveness in clinical practice has not been established. The aim of this research is to establish if HFS facilitates learning that informs decision-making skills in clinical practice using MultipleCriteria DecisionMaking Theory (MCDMT). Methods: The sample was 2nd year undergraduate pre-registration adult nursing stu...
Abstract
Cited 2 times since 2017 (0.2 per year)
source: EuropePMC
The European journal of neuroscience,
Volume 46, Issue 2, 6 1 2017, Pages 1828-1836
Measuring mimicry: general corticospinal facilitation during observation of naturalistic behaviour.
van Schaik JE, Sacheli LM, Bekkering H, Toni I, Aglioti SM
Mimicry of others' postures and behaviours forms an implicit yet indispensable component of social interactions. However, whereas numerous behavioural studies have investigated the occurrence of mimicry and its social sensitivity, the underlying neurocognitive mechanisms remain elusive. In this study, single-pulse transcranial magnetic stimulation was used to measure corticospinal facilitation during a naturalistic behaviour observation task adapted from the behavioural mimicry literature....
Abstract
Cited 18 times since 2017 (2.2 per year)
source: EuropePMC
European journal of nuclear medicine and molecular imaging,
Volume 44, Issue 11, 6 1 2017, Pages 1888-1896
Relationship Between Coronary Contrast-Flow Quantitative Flow Ratio and Myocardial Ischemia Assessed by SPECT MPI.
Smit JM, Koning G, van Rosendael AR, Dibbets-Schneider P, Mertens BJ, Jukema JW, Delgado V, Reiber JHC, Bax JJ, Scholte AJ
Purpose: A new method has been developed to calculate fractional flow reserve (FFR) from invasive coronary angiography, the so-called "contrast-flow quantitative flow ratio (cQFR)". Recently, cQFR was compared to invasive FFR in intermediate coronary lesions showing an overall diagnostic accuracy of 85%. The purpose of this study was to investigate the relationship between cQFR and myocardial ischemia assessed by single-photon emission computed tomography myocardial perfusion imaging (...
Abstract
Cited 36 times since 2017 (4.3 per year)
source: EuropePMC
Journal of the American Heart Association,
Volume 6, Issue 7, 5 1 2017, Pages e005156
Prognostic Impact of Diabetes and Prediabetes on Survival Outcomes in Patients With Chronic Heart Failure: A Post-Hoc Analysis of the GISSI-HF (Gruppo Italiano per lo Studio della Sopravvivenza nella Insufficienza Cardiaca-Heart Failure) Trial.
Dauriz M, Targher G, Temporelli PL, Lucci D, Gonzini L, Nicolosi GL, Marchioli R, Tognoni G, Latini R, Cosmi F, Tavazzi L, Maggioni AP, GISSI‐HF Investigators
Background: The independent prognostic impact of diabetes mellitus (DM) and prediabetes mellitus (pre-DM) on survival outcomes in patients with chronic heart failure has been investigated in observational registries and randomized, clinical trials, but the results have been often inconclusive or conflicting. We examined the independent prognostic impact of DM and pre-DM on survival outcomes in the GISSI-HF (Gruppo Italiano per lo Studio della Sopravvivenza nella Insufficienza Cardiaca-Heart Fail...
Abstract
Cited 2 times since 2017 (0.2 per year)
source: EuropePMC
PloS one,
Volume 12, Issue 7, 5 1 2017, Pages e0179878
Herd-level animal management factors associated with the occurrence of bovine neonatal pancytopenia in calves in a multi-country study.
Sauter-Louis C, Jones BA, Henning J, Stoll A, Nielen M, Van Schaik G, Smolenaars A, Schouten M, den Uijl I, Fourichon C, Guatteo R, Madouasse A, Nusinovici S, Deprez P, De Vliegher S, Laureyns J, Booth R, Cardwell JM, Pfeiffer DU
Since 2007, mortality associated with a previously unreported haemorrhagic disease has been observed in young calves in several European countries. The syndrome, which has been named 'bovine neonatal pancytopenia' (BNP), is characterised by thrombocytopenia, leukocytopenia and a panmyelophthisis. A herd-level case-control study was conducted in four BNP affected countries (Belgium, France, Germany and the Netherlands) to identify herd management risk factors for BNP occurrence. Data we...
Abstract
Cited 10 times since 2017 (1.2 per year)
source: EuropePMC
Tuberculosis (Edinburgh, Scotland),
Volume 106, 4 1 2017, Pages 62-72
Immunological characterization of latent tuberculosis infection in a low endemic country.
de Paus RA, van Meijgaarden KE, Prins C, Kamphorst MH, Arend SM, Ottenhoff THM, Joosten SA
The diagnosis of a latent tuberculosis infection (LTBI) is based on detection of immunity against Mycobacterium tuberculosis (Mtb). The tuberculin skin test (TST), the Quantiferon (QFT) and a prolonged lymphocyte stimulation test using either ESAT-6/CFP-10 (LST-EC) or PPD (LST-PPD) were evaluated in a cohort of 495 individuals, suspected to have LTBI, in a low endemic country. While the TST and LST-PPD were both positive in the majority (75%) of individuals, only one third responded in the LST-E...
Abstract
Cited 57 times since 2017 (6.9 per year)
source: EuropePMC
Circulation. Cardiovascular imaging,
Volume 10, Issue 7, 1 1 2017, Pages e005706
Global Longitudinal Strain and Left Atrial Volume Index Provide Incremental Prognostic Value in Patients With Hypertrophic Cardiomyopathy.
Hiemstra YL, Debonnaire P, Bootsma M, van Zwet EW, Delgado V, Schalij MJ, Atsma DE, Bax JJ, Marsan NA
Background: Current methods for predicting adverse events in patients with hypertrophic cardiomyopathy are still limited. Left ventricular global longitudinal strain (GLS) and left atrial volume index (LAVI) have been recently proposed as novel prognostic factors in several cardiovascular diseases. The objective of this study was to evaluate the prognostic value of GLS and LAVI in patients with hypertrophic cardiomyopathy. Methods and results: Two-dimensional echocardiography was performed in 42...
Abstract
Cited 24 times since 2017 (2.9 per year)
source: EuropePMC
European heart journal,
Volume 38, Issue 28, 1 1 2017, Pages 2221-2226
Integrated imaging of echocardiography and computed tomography to grade mitral regurgitation severity in patients undergoing transcatheter aortic valve implantation.
van Rosendael PJ, van Wijngaarden SE, Kamperidis V, Kong WKF, Leung M, Ajmone Marsan N, Delgado V, Bax JJ
Aims: Quantitative mitral regurgitation (MR) grading remains challenging. This study evaluated the concept of integrating echocardiography and computed tomography for grading MR severity. Specifically, an integrated parameter was developed that combines the true cross-sectional mitral regurgitant orifice area (ROA) assessed with multi-detector row computed tomography (MDCT) with flow data from echocardiography. Methods and results: Systolic MDCT data of 73 patients, referred for transcatheter ao...
Abstract
Cited 76 times since 2017 (9.2 per year)
source: EuropePMC
European heart journal,
Volume 38, Issue 27, 1 1 2017, Pages 2132-2136
Optogenetic termination of ventricular arrhythmias in the whole heart: towards biological cardiac rhythm management.
Nyns ECA, Kip A, Bart CI, Plomp JJ, Zeppenfeld K, Schalij MJ, de Vries AAF, Pijnappels DA
Aims: Current treatments of ventricular arrhythmias rely on modulation of cardiac electrical function through drugs, ablation or electroshocks, which are all non-biological and rather unspecific, irreversible or traumatizing interventions. Optogenetics, however, is a novel, biological technique allowing electrical modulation in a specific, reversible and trauma-free manner using light-gated ion channels. The aim of our study was to investigate optogenetic termination of ventricular arrhythmias i...
Abstract
