Research

Publications

Below you can find a list of our published research.

8892 results

Cited 79 times since 2017 (9.4 per year) source: EuropePMC

The lancet. Diabetes & endocrinology, Volume 5, Issue 7, 26 4 2017, Pages 534-543 Relations between lipoprotein(a) concentrations, LPA genetic variants, and the risk of mortality in patients with established coronary heart disease: a molecular and genetic association study. Zewinger S, Kleber ME, Tragante V, McCubrey RO, Schmidt AF, Direk K, Laufs U, Werner C, Koenig W, Rothenbacher D, Mons U, Breitling LP, Brenner H, Jennings RT, Petrakis I, Triem S, Klug M, Filips A, Blankenberg S, Waldeyer C, Sinning C, Schnabel RB, Lackner KJ, Vlachopoulou E, Nygård O, Svingen GFT, Pedersen ER, Tell GS, Sinisalo J, Nieminen MS, Laaksonen R, Trompet S, Smit RAJ, Sattar N, Jukema JW, Groesdonk HV, Delgado G, Stojakovic T, Pilbrow AP, Cameron VA, Richards AM, Doughty RN, Gong Y, Cooper-DeHoff R, Johnson J, Scholz M, Beutner F, Thiery J, Smith JG, Vilmundarson RO, McPherson R, Stewart AFR, Cresci S, Lenzini PA, Spertus JA, Olivieri O, Girelli D, Martinelli NI, Leiherer A, Saely CH, Drexel H, Mündlein A, Braund PS, Nelson CP, Samani NJ, Kofink D, Hoefer IE, Pasterkamp G, Quyyumi AA, Ko YA, Hartiala JA, Allayee H, Tang WHW, Hazen SL, Eriksson N, Held C, Hagström E, Wallentin L, Åkerblom A, Siegbahn A, Karp I, Labos C, Pilote L, Engert JC, Brophy JM, Thanassoulis G, Bogaty P, Szczeklik W, Kaczor M,

Background: Lipoprotein(a) concentrations in plasma are associated with cardiovascular risk in the general population. Whether lipoprotein(a) concentrations or LPA genetic variants predict long-term mortality in patients with established coronary heart disease remains less clear. Methods: We obtained data from 3313 patients with established coronary heart disease in the Ludwigshafen Risk and Cardiovascular Health (LURIC) study. We tested associations of tertiles of lipoprotein(a) concentration i... Abstract

Cited 3 times since 2017 (0.4 per year) source: EuropePMC

Trials, Volume 18, Issue 1, 26 4 2017, Pages 243 The effects of a psychological intervention directed at optimizing immune function: study protocol for a randomized controlled trial. Schakel L, Veldhuijzen DS, van Middendorp H, Prins C, Joosten SA, Ottenhoff THM, Visser LG, Evers AWM

Background: Previous research has provided evidence for the link between psychological processes and psychophysiological health outcomes. Psychological interventions, such as face-to-face or online cognitive behavioral therapy (CBT) and serious games aimed at improving health, have shown promising results in promoting health outcomes. Few studies so far, however, have examined whether Internet-based CBT combined with serious gaming elements is effective in modulating health outcomes. Moreover, s... Abstract

Cited 11 times since 2017 (1.3 per year) source: EuropePMC

European journal of preventive cardiology, Volume 24, Issue 12, 25 4 2017, Pages 1319-1327 Chance of surgery in adult congenital heart disease. Verheugt CL, Uiterwaal CS, Vaartjes I, van der Velde ET, Zomer AC, Meijboom FJ, Pieper PG, Post MC, Vliegen HW, Hazekamp MG, Grobbee DE, Mulder BJ

Background Young patients with congenital heart disease reaching adulthood face mandatory transition to adult cardiology. Their new cardiologist needs to assess the chances of major future events such as surgery. Using a large national registry, we assessed if patient characteristics at the age of 18 years could predict the chance of congenital heart surgery in adulthood. Design and methods Of 10,300 patients from the CONCOR national registry, we used general patient characteristics at age 18 ye... Abstract

Cited 20 times since 2017 (2.4 per year) source: EuropePMC

The international journal of cardiovascular imaging, Volume 33, Issue 11, 25 4 2017, Pages 1753-1759 Effects of caffeine intake prior to stress cardiac magnetic resonance perfusion imaging on regadenoson- versus adenosine-induced hyperemia as measured by T1 mapping. van Dijk R, Kuijpers D, Kaandorp TAM, van Dijkman PRM, Vliegenthart R, van der Harst P, Oudkerk M

The antagonistic effects of caffeine on adenosine receptors are a possible cause of false-negative stress perfusion imaging. The purpose of this study was to determine the effects of coffee intake Abstract

Cited 9 times since 2017 (1.1 per year) source: EuropePMC

Frontiers in psychology, Volume 8, 24 4 2017, Pages 808 Commentary: The Social Dilemma of Autonomous Vehicles. Martin R, Kusev I, Cooke AJ, Baranova V, Van Schaik P, Kusev P

Abstract

Cited 10 times since 2017 (1.2 per year) source: EuropePMC

Diabetology & metabolic syndrome, Volume 9, 22 4 2017, Pages 40 Association of metabolic syndrome and electrocardiographic markers of subclinical cardiovascular disease. Elffers TW, de Mutsert R, Lamb HJ, Maan AC, Macfarlane PW, Willems van Dijk K, Rosendaal FR, Jukema JW, Trompet S

Background: The metabolic syndrome (MetS) and its components are well-established risk factors for cardiovascular diseases (CVD). It is inconclusive whether MetS and MetS score are associated with electrocardiographic markers of subclinical CVD, therefore we investigated this in a population without pre-existing CVD. Methods: We performed a cross-sectional analysis in the Netherlands Epidemiology of Obesity study, a population-based cohort including 6671 participants aged 45-65. We excluded part... Abstract

Cited 16 times since 2017 (1.9 per year) source: EuropePMC

Clinical and experimental dermatology, Volume 42, Issue 5, 22 4 2017, Pages 536-538 Guttate psoriasis triggered by perianal streptococcal infection. Garritsen FM, Kraag DE, de Graaf M

The association of guttate psoriasis (GP) with streptococcal pharyngitis is well accepted. However, less is known about the association with perianal streptococcal infection. We report a case of a 19-month-old boy with GP after a preceding perianal streptococcal dermatitis, with no clinical signs of a streptococcal pharyngitis. Treatment with phenethicillin was given together with mometasone ointment. After 4 weeks, the perianal redness was reduced and the psoriasis had improved significantly. A... Abstract

Cited 4 times since 2017 (0.5 per year) source: EuropePMC

Child development, Volume 89, Issue 3, 19 3 2017, Pages 897-913 Using a Group-Centered Approach to Observe Interactions in Early Childhood Education. van Schaik SDM, Leseman PPM, de Haan M

This study examined the value of using a group-centered approach to evaluate process quality of early childhood education and care (ECEC). Is observed support of group processes a different aspect of classroom quality, and does it predict children's collaborative play in ECEC in the Netherlands? In two play situations, 37 teachers and 120 two- to four-year-old children were observed with the Classroom Assessment Scoring System (CLASS) Toddler and two new measures. In a two-level structural... Abstract

Cited 10 times since 2017 (1.2 per year) source: EuropePMC

IEEE transactions on biomedical circuits and systems, Volume 11, Issue 3, 19 3 2017, Pages 574-584 Neuromorphic Hardware Architecture Using the Neural Engineering Framework for Pattern Recognition. Wang R, Thakur CS, Cohen G, Hamilton TJ, Tapson J, van Schaik A

We present a hardware architecture that uses the neural engineering framework (NEF) to implement large-scale neural networks on field programmable gate arrays (FPGAs) for performing massively parallel real-time pattern recognition. NEF is a framework that is capable of synthesising large-scale cognitive systems from subnetworks and we have previously presented an FPGA implementation of the NEF that successfully performs nonlinear mathematical computations. That work was developed based on a comp... Abstract

Cited 52 times since 2017 (6.2 per year) source: EuropePMC

JACC. Cardiovascular imaging, Volume 10, Issue 11, 17 3 2017, Pages 1361-1370 Prognostic Value of Coronary CT Angiography With Selective PET Perfusion Imaging in Coronary Artery Disease. Maaniitty T, Stenström I, Bax JJ, Uusitalo V, Ukkonen H, Kajander S, Mäki M, Saraste A, Knuuti J

Objectives: The purpose of this study was to evaluate the prognostic value of sequential hybrid imaging strategy in which positron emission tomography (PET) perfusion imaging is performed selectively in patients with suspected obstructive coronary artery disease (CAD) on coronary computed tomography angiography (CTA). Background: Coronary CTA is an accurate diagnostic test for excluding obstructive CAD. However, the positive predictive value is suboptimal. Methods: We investigated 864 consecutiv... Abstract

Cited 10 times since 2017 (1.2 per year) source: EuropePMC

JACC. Cardiovascular imaging, Volume 10, Issue 12, 17 3 2017, Pages 1451-1458 Long-Term Prognosis of Patients With Intramural Course of Coronary Arteries Assessed With CT Angiography. Dimitriu-Leen AC, van Rosendael AR, Smit JM, van Elst T, van Geloven N, Maaniitty T, Jukema JW, Delgado V, Scholte AJHA, Saraste A, Knuuti J, Bax JJ

Objectives: The aim of the present study was to evaluate, in low-to-intermediate pre-test probability patients who were referred for coronary computed tomography angiography (CTA) and did not show obstructive coronary artery disease (CAD), whether an intramural course of a coronary artery is associated with worse outcome compared with patients without an intramural course of the coronary arteries. Background: The prognostic value of an intramural course of the coronary arteries on coronary CTA i... Abstract

Cited 7 times since 2017 (0.8 per year) source: EuropePMC

Oncotarget, Volume 8, Issue 31, 16 3 2017, Pages 51522-51529 Prognostic microRNAs in upper tract urothelial carcinoma: multicenter and international validation study. Izquierdo L, Montalbo R, Ingelmo-Torres M, Mallofré C, Ramírez-Backhaus M, Rubio J, Van der Heijden AG, Schaafsma E, Lopez-Beltran A, Blanca A, Lawrentschuk N, Alcaraz A, Mengual L

Objective: To validate previously discovered miRNAs (miR-31-5p and miR-149-5p) as prognostic factors for UTUC in an independent cohort of UTUC patients. Patients and methods: Multicenter, international and retrospective study of formalin-fixed paraffin-embedded tissue samples from 103 UTUC patients (45 progressing and 58 non-progressing) who underwent radical nephroureterectomy. Total RNA was isolated and reverse transcribed. The expression of target miRNAs (miR-31-5p and miR-149-5p) and the end... Abstract

Cited 63 times since 2017 (7.5 per year) source: EuropePMC

Advanced healthcare materials, Volume 6, Issue 11, 12 2 2017 Engineered 3D Cardiac Fibrotic Tissue to Study Fibrotic Remodeling. Sadeghi AH, Shin SR, Deddens JC, Fratta G, Mandla S, Yazdi IK, Prakash G, Antona S, Demarchi D, Buijsrogge MP, Sluijter JPG, Hjortnaes J, Khademhosseini A, Khademhosseini A

Activation of cardiac fibroblasts into myofibroblasts is considered to play an essential role in cardiac remodeling and fibrosis. A limiting factor in studying this process is the spontaneous activation of cardiac fibroblasts when cultured on two-dimensional (2D) culture plates. In this study, a simplified three-dimensional (3D) hydrogel platform of contractile cardiac tissue, stimulated by transforming growth factor-β1 (TGF-β1), is presented to recapitulate a fibrogenic microenvironment. It is... Abstract

Cited 7 times since 2017 (0.8 per year) source: EuropePMC

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, Volume 54, Issue 1, 12 2 2017, Pages 28-33 The Consequences of Real Life Practice of Early Abdominal Aortic Aneurysm Repair: A Cost-Benefit Analysis. Tomee SM, Bastiaannet E, Schermerhorn ML, Golledge J, Hamming JF, Lindeman JH

Background: The reported 54 mm median intervention diameter for endovascular aneurysm repair (EVAR) in the Vascular Quality Initiative and European data from the Pharmaceutical Aneurysm Stabilisation Trial (PHAST) implies that in real life the majority of abdominal aortic aneurysm (AAA) repairs occur at diameters smaller than the consensus intervention threshold of 55 mm. This study explores the potential consequences of this practice. Methods: The differences between real life AAA repair and co... Abstract

Cited 269 times since 2017 (31.9 per year) source: EuropePMC

Circulation, Volume 135, Issue 24, 12 2 2017, Pages 2373-2388 Causal Associations of Adiposity and Body Fat Distribution With Coronary Heart Disease, Stroke Subtypes, and Type 2 Diabetes Mellitus: A Mendelian Randomization Analysis. Dale CE, Fatemifar G, Palmer TM, White J, Prieto-Merino D, Zabaneh D, Engmann JEL, Shah T, Wong A, Warren HR, McLachlan S, Trompet S, Moldovan M, Morris RW, Sofat R, Kumari M, Hyppönen E, Jefferis BJ, Gaunt TR, Ben-Shlomo Y, Zhou A, Gentry-Maharaj A, Ryan A, UCLEB Consortium; METASTROKE Consortium, Mutsert R, Noordam R, Caulfield MJ, Jukema JW, Worrall BB, Munroe PB, Menon U, Power C, Kuh D, Lawlor DA, Humphries SE, Mook-Kanamori DO, Sattar N, Kivimaki M, Price JF, Davey Smith G, Dudbridge F, Hingorani AD, Holmes MV, Casas JP

Background: The implications of different adiposity measures on cardiovascular disease etiology remain unclear. In this article, we quantify and contrast causal associations of central adiposity (waist-to-hip ratio adjusted for body mass index [WHRadjBMI]) and general adiposity (body mass index [BMI]) with cardiometabolic disease. Methods: Ninety-seven independent single-nucleotide polymorphisms for BMI and 49 single-nucleotide polymorphisms for WHRadjBMI were used to conduct Mendelian randomiza... Abstract

Cited 26 times since 2017 (3.1 per year) source: EuropePMC

The American journal of cardiology, Volume 120, Issue 3, 11 2 2017, Pages 500-504 Prognostic Implications of Left Ventricular Global Longitudinal Strain in Predialysis and Dialysis Patients. Hensen LCR, Goossens K, Delgado V, Rotmans JI, Jukema JW, Bax JJ

Chronic kidney disease (CKD) is a worldwide growing epidemic associated with an increased risk of cardiovascular morbidity and mortality. Left ventricular (LV) global longitudinal strain (GLS) is a measure of LV systolic function associated with prognosis in the general population. However, little is known about the association between LV GLS and survival in patients with CKD. The aim of the present study was to investigate the prognostic implications of LV GLS in predialysis and dialysis patien... Abstract

Cited 31 times since 2017 (3.7 per year) source: EuropePMC

Urologic oncology, Volume 35, Issue 9, 8 2 2017, Pages 539.e17-539.e29 Oncological and functional outcomes of sexual function-preserving cystectomy compared with standard radical cystectomy in men: A systematic review. Hernández V, Espinos EL, Dunn J, MacLennan S, Lam T, Yuan Y, Compérat E, Cowan NC, Gakis G, Lebrét T, van der Heijden AG, Witjes JA, Ribal MJ

Introduction: Different sexual function-preserving surgical techniques aimed at improving voiding and sexual function in patients undergoing radical cystectomy for bladder cancer have been described. The objective of this systematic review is to determine the effect of sexual function-preserving cystectomy (SPC) on functional and oncological outcomes. Materials and methods: Relevant databases were searched covering the time frame 2000 to 2015. All publications presenting data on any type of SPC... Abstract

Cited 51 times since 2017 (6 per year) source: EuropePMC

Journal of magnetic resonance imaging : JMRI, Volume 47, Issue 1, 4 1 2017, Pages 272-281 Comparison of fast acquisition strategies in whole-heart four-dimensional flow cardiac MR: Two-center, 1.5 Tesla, phantom and in vivo validation study. Garg P, Westenberg JJM, van den Boogaard PJ, Swoboda PP, Aziz R, Foley JRJ, Fent GJ, Tyl FGJ, Coratella L, ElBaz MSM, van der Geest RJ, Higgins DM, Greenwood JP, Plein S

Purpose: To validate three widely-used acceleration methods in four-dimensional (4D) flow cardiac MR; segmented 4D-spoiled-gradient-echo (4D-SPGR), 4D-echo-planar-imaging (4D-EPI), and 4D-k-t Broad-use Linear Acquisition Speed-up Technique (4D-k-t BLAST). Materials and methods: Acceleration methods were investigated in static/pulsatile phantoms and 25 volunteers on 1.5 Tesla MR systems. In phantoms, flow was quantified by 2D phase-contrast (PC), the three 4D flow methods and the time-beaker flow... Abstract

Cited 1 times since 2017 (0.1 per year) source: EuropePMC

Cardiovascular and interventional radiology, Volume 40, Issue 10, 3 1 2017, Pages 1641-1644 Aortic Aneurysm Rupture After Urokinase Treatment for Acute Limb Ischemia in Two Patients After EVAR. Sudiono DR, Hoencamp R, Ottevanger J, Eefting D, van der Linden E

Endovascular aneurysm repair (EVAR) is first-choice treatment for many patients with abdominal aortic aneurysms. Complications unique to endovascular treatment include endoleak and endotension, which can eventually lead to rupture. We present two cases of late aortic rupture after EVAR, where both patients had recent preceding catheter-directed thrombolysis with urokinase for acute limb ischemia. These cases suggest a relation between thrombolytic therapy and aortic rupture after EVAR, and we sh... Abstract

Cited 514 times since 2017 (60.7 per year) source: EuropePMC

The New England journal of medicine, Volume 376, Issue 20, 1 1 2017, Pages 1933-1942 Evacetrapib and Cardiovascular Outcomes in High-Risk Vascular Disease. Lincoff AM, Nicholls SJ, Riesmeyer JS, Barter PJ, Brewer HB, Fox KAA, Gibson CM, Granger C, Menon V, Montalescot G, Rader D, Tall AR, McErlean E, Wolski K, Ruotolo G, Vangerow B, Weerakkody G, Goodman SG, Conde D, McGuire DK, Nicolau JC, Leiva-Pons JL, Pesant Y, Li W, Kandath D, Kouz S, Tahirkheli N, Mason D, Nissen SE, ACCELERATE Investigators

Background: The cholesteryl ester transfer protein inhibitor evacetrapib substantially raises the high-density lipoprotein (HDL) cholesterol level, reduces the low-density lipoprotein (LDL) cholesterol level, and enhances cellular cholesterol efflux capacity. We sought to determine the effect of evacetrapib on major adverse cardiovascular outcomes in patients with high-risk vascular disease. Methods: In a multicenter, randomized, double-blind, placebo-controlled phase 3 trial, we enrolled 12,092... Abstract