8892 results
Cited 15 times since 2017 (1.8 per year)
source: EuropePMC
Journal of wound care,
Volume 26, Issue 5, 1 1 2017, Pages 218-227
Outcomes after foot surgery in people with a diabetic foot ulcer and a 12-month follow-up.
Lenselink E, Holloway S, Eefting D
Objective: The aim of this study was to retrospectively measure the outcomes of foot-sparing surgery at one year follow-up for patients with diabetic foot ulcers (DFUs). We assessed wound healing and the need for further surgery in relation to the variables that influence healing. Method: Data were retrospectively collected by reviewing the electronic files of patients attending the Wound Expert Clinic (WEC). Outcomes of surgical debridement, toe, ray and transmetatarsal amputations were assesse...
Abstract
Cited 53 times since 2017 (6.3 per year)
source: EuropePMC
The European respiratory journal,
Volume 49, Issue 5, 1 1 2017, Pages 1602008
Defining asthma-COPD overlap syndrome: a population-based study.
Bonten TN, Kasteleyn MJ, de Mutsert R, Hiemstra PS, Rosendaal FR, Chavannes NH, Slats AM, Taube C
Asthma-chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS) seems an important clinical phenotype, but multiple definitions have been proposed. This study's objectives were to assess the effect of different ACOS definitions on prevalence, patient characteristics and exacerbations.5675 individuals aged 45-65 years, with 846 asthma/COPD patients, were included in the Netherlands Epidemiology of Obesity study between 2008 and 2012, and followed-up for a median of 1.8 years. ACO...
Abstract
Cited 15 times since 2017 (1.8 per year)
source: EuropePMC
ASAIO journal (American Society for Artificial Internal Organs : 1992),
Volume 63, Issue 3, 1 1 2017, Pages 266-272
Pump Speed Optimization in Stable Patients with a Left Ventricular Assist Device.
Couperus LE, Delgado V, Khidir MJH, Vester MPM, Palmen M, Fiocco M, Holman ER, Tops LF, Klautz RJM, Verwey HF, Schalij MJ, Beeres SLMA
Optimal left ventricular assist device (LVAD) functioning and preservation of right ventricular (RV) function are major survival determinants in destination therapy (DT)-LVAD recipients. Currently, the indication for routine pump speed optimization in stable patients and its effect on RV function at follow-up remain underexplored. Hemodynamically stable patients (N = 17, age 61 [interquartile range {IQR} 51-66] years; 13 [77%] male) underwent a routine speed ramp test. Echocardiographic images w...
Abstract
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology,
Volume 19, Issue 5, 1 1 2017, Pages 703-704
Death after ablation of atrial flutter: are we doing the right thing?
Trines SA
Abstract
Cited 33 times since 2017 (3.9 per year)
source: EuropePMC
Cell host & microbe,
Volume 21, Issue 5, 1 1 2017, Pages 637-649.e6
Global Reprogramming of Host Kinase Signaling in Response to Fungal Infection.
Pandey A, Ding SL, Qin QM, Gupta R, Gomez G, Lin F, Feng X, Fachini da Costa L, Chaki SP, Katepalli M, Case ED, van Schaik EJ, Sidiq T, Khalaf O, Arenas A, Kobayashi KS, Samuel JE, Rivera GM, Alaniz RC, Sze SH, Qian X, Brown WJ, Rice-Ficht A, Russell WK, Ficht TA, de Figueiredo P
Cryptococcus neoformans (Cn) is a deadly fungal pathogen whose intracellular lifestyle is important for virulence. Host mechanisms controlling fungal phagocytosis and replication remain obscure. Here, we perform a global phosphoproteomic analysis of the host response to Cryptococcus infection. Our analysis reveals numerous and diverse host proteins that are differentially phosphorylated following fungal ingestion by macrophages, thereby indicating global reprogramming of host kinase signaling. N...
Abstract
Cited 3 times since 2017 (0.4 per year)
source: EuropePMC
Drug metabolism and personalized therapy,
Volume 32, Issue 2, 1 1 2017, Pages 119-127
8th Santorini Conference: Systems medicine and personalized health and therapy, Santorini, Greece, 3-5 October 2016.
Visvikis-Siest S, Aldasoro Arguinano AA, Stathopoulou M, Xie T, Petrelis A, Weryha G, Froguel P, Meier-Abt P, Meyer UA, Mlakar V, Ansari M, Papassotiropoulos A, Dedoussis G, Pan B, Bühlmann RP, Noyer-Weidner M, Dietrich PY, Van Schaik R, Innocenti F, März W, Bekris LM, Deloukas P
Abstract
Cited 70 times since 2017 (8.3 per year)
source: EuropePMC
Science (New York, N.Y.),
Volume 356, Issue 6337, 1 1 2017, Pages 539-542
Negative selection in humans and fruit flies involves synergistic epistasis.
Sohail M, Vakhrusheva OA, Sul JH, Pulit SL, Francioli LC, Genome of the Netherlands Consortium, Alzheimer’s Disease Neuroimaging Initiative, van den Berg LH, Veldink JH, de Bakker PIW, Bazykin GA, Kondrashov AS, Sunyaev SR
Negative selection against deleterious alleles produced by mutation influences within-population variation as the most pervasive form of natural selection. However, it is not known whether deleterious alleles affect fitness independently, so that cumulative fitness loss depends exponentially on the number of deleterious alleles, or synergistically, so that each additional deleterious allele results in a larger decrease in relative fitness. Negative selection with synergistic epistasis should pro...
Abstract
Cited 39 times since 2017 (4.6 per year)
source: EuropePMC
Nucleic acids research,
Volume 45, Issue 8, 1 1 2017, Pages e61
Rapid resistome mapping using nanopore sequencing.
van der Helm E, Imamovic L, Hashim Ellabaan MM, van Schaik W, Koza A, Sommer MOA
The emergence of antibiotic resistance in human pathogens has become a major threat to modern medicine. The outcome of antibiotic treatment can be affected by the composition of the gut. Accordingly, knowledge of the gut resistome composition could enable more effective and individualized treatment of bacterial infections. Yet, rapid workflows for resistome characterization are lacking. To address this challenge we developed the poreFUME workflow that deploys functional metagenomic selections an...
Abstract
Cited 1 times since 2017 (0.1 per year)
source: EuropePMC
PloS one,
Volume 12, Issue 5, 1 1 2017, Pages e0177040
Correction: Mortality and Length of Stay of Very Low Birth Weight and Very Preterm Infants: A EuroHOPE Study.
Numerato D, Fattore G, Tediosi F, Zanini R, Peltola M, Banks H, Mihalicza P, Lehtonen L, Sveréus S, Heijink R, Klitkou ST, Fletcher E, van der Heijden AA, Lundberg F, Over E, Häkkinen U, Seppälä TT
[This corrects the article DOI: 10.1371/journal.pone.0131685.].
Abstract
Cited 38 times since 2017 (4.5 per year)
source: EuropePMC
Circulation,
Volume 135, Issue 20, 1 1 2017, Pages 1956-1976
Stress Testing in Asymptomatic Aortic Stenosis.
Redfors B, Pibarot P, Gillam LD, Burkhoff D, Bax JJ, Lindman BR, Bonow RO, O'Gara PT, Leon MB, Généreux P
Aortic stenosis is 1 of the most common heart valve diseases among adults. When symptoms develop, prognosis is poor, and current guidelines recommend prompt aortic valve replacement. Depending of the severity of the aortic stenosis and the presence of concomitant heart disease and medical comorbidities, stress testing represents a reasonable strategy to help better risk stratify asymptomatic patients. The present report provides a comprehensive review of the current available data on stress test...
Abstract
Cited 4 times since 2017 (0.5 per year)
source: EuropePMC
European heart journal. Cardiovascular Imaging,
Volume 18, Issue 8, 1 1 2017, Pages 849-850
Improved risk stratification with computed tomographic coronary angiography in patients with suspected coronary artery disease.
van Rosendael AR, Bax JJ
Abstract
Cited 8 times since 2017 (0.9 per year)
source: EuropePMC
Journal of the American College of Cardiology,
Volume 69, Issue 19, 1 1 2017, Pages 2465-2466
Role of Acquired Cardiovascular Disease in Tetralogy of Fallot Patients >50 Years of Age.
Bokma JP, Winter MM, Kuijpers JM, Jongbloed MR, Duijnhouwer AL, Hoendermis ES, Sieswerda GT, Post MC, Mulder BJM, Bouma BJ
Abstract
Cited 95 times since 2017 (11.2 per year)
source: EuropePMC
Journal of the American College of Cardiology,
Volume 69, Issue 19, 1 1 2017, Pages 2383-2392
Prognostic Implications of Moderate Aortic Stenosis in Patients With Left Ventricular Systolic Dysfunction.
van Gils L, Clavel MA, Vollema EM, Hahn RT, Spitzer E, Delgado V, Nazif T, De Jaegere PP, Geleijnse ML, Ben-Yehuda O, Bax JJ, Leon MB, Pibarot P, Van Mieghem NM
Background: Left ventricular (LV) systolic dysfunction and moderate aortic stenosis (AS) are more frequent with advancing age and often coexist. Afterload reduction is the mainstay of pharmacological treatment of heart failure (HF). Aortic valve replacement (AVR) is only formally indicated for symptomatic severe AS. Objectives: This study sought to determine the clinical outcome of patients with concomitant moderate AS and LV systolic dysfunction. Methods: Echocardiographic and clinical data of...
Abstract
Cited 136 times since 2017 (16.1 per year)
source: EuropePMC
Journal of the American College of Cardiology,
Volume 69, Issue 17, 1 1 2017, Pages 2119-2129
Cardiac Resynchronization Therapy With Wireless Left Ventricular Endocardial Pacing: The SELECT-LV Study.
Reddy VY, Miller MA, Neuzil P, Søgaard P, Butter C, Seifert M, Delnoy PP, van Erven L, Schalji M, Boersma LVA, Riahi S
Background: A total of 30% to 40% of patients with congestive heart failure eligible for cardiac resynchronization therapy (CRT) either do not respond to conventional CRT or remain untreated due to an inability or impediment to coronary sinus (CS) lead implantation. The WiSE-CRT system (EBR Systems, Sunnyvale, California) was developed to address this at-risk patient population by performing biventricular pacing via a wireless left ventricular (LV) endocardial pacing electrode. Objectives: The S...
Abstract
Cited 4 times since 2017 (0.5 per year)
source: EuropePMC
Journal of telemedicine and telecare,
Volume 24, Issue 6, 29 5 2017, Pages 404-409
Comparison of the diagnostic accuracy of four smartphone-compatible blood pressure monitors in post-myocardial infarction patients.
Treskes RW, Wolterbeek R, van der Velde ET, Eindhoven DC, Schalij MJ
Introduction Smartphone-compatible blood pressure devices may be a good alternative to enable self-measurement of blood pressure by patients. Furthermore, automatic transferral of data to the hospital allows for remote monitoring. To our knowledge, no study has compared four of these smartphone-compatible blood pressure devices. Methods Patients who were followed up for acute myocardial infarction were asked to participate during their outpatient clinic visit. After five minutes of rest, six blo...
Abstract
Cited 6 times since 2017 (0.7 per year)
source: EuropePMC
Journal of cardiovascular computed tomography,
Volume 11, Issue 4, 27 4 2017, Pages 274-280
Coronary computed tomography angiography derived risk score in predicting cardiac events.
Uusitalo V, Kamperidis V, de Graaf MA, Maaniitty T, Stenström I, Broersen A, Dijkstra J, Scholte AJ, Saraste A, Bax JJ, Knuuti J
Background: We evaluated the prognostic value of an integrated atherosclerosis risk score combining the markers of coronary plaque burden, location and composition as assessed by computed tomography angiography (CTA). Methods: 922 consecutive patients underwent CTA for suspected coronary artery disease (CAD). Patients without atherosclerosis (n = 261) and in whom quantitative CTA analysis was not feasible due to image quality, step-artefacts or technical factors related to image acquisition or d...
Abstract
Cited 10 times since 2017 (1.2 per year)
source: EuropePMC
European journal of radiology,
Volume 93, 26 4 2017, Pages 1-8
Quantification of aortic annulus in computed tomography angiography: Validation of a fully automatic methodology.
Gao X, Boccalini S, Kitslaar PH, Budde RPJ, Attrach M, Tu S, de Graaf MA, Ondrus T, Penicka M, Scholte AJHA, Lelieveldt BPF, Dijkstra J, Reiber JHC
Background: Automatic accurate measuring of the aortic annulus and determination of the optimal angulation of X-ray projection are important for the trans-catheter aortic valve replacement (TAVR) procedure. The objective of this study was to present a novel fully automatic methodology for the quantification of the aortic annulus in computed tomography angiography (CTA) images. Methods: CTA datasets of 26 patients were analyzed retrospectively with the proposed methodology, which consists of a kn...
Abstract
Cited 12 times since 2017 (1.4 per year)
source: EuropePMC
International journal of cardiology,
Volume 240, 25 4 2017, Pages 20-24
Long-term mortality in patients with ST-segment elevation myocardial infarction is associated with anti-citrullinated protein antibodies.
Hermans MPJ, van der Velden D, Montero Cabezas JM, Putter H, Huizinga TWJ, Kuiper J, Toes REM, Schalij MJ, Wouter Jukema J, van der Woude D
Background: Cardiovascular (CV) mortality is higher in patients with rheumatoid arthritis (RA), in particular when anti-citrullinated protein antibodies (ACPA) are present. Recently, ACPA have also been described in a cohort of patients without RA, but with coronary artery disease (CAD). It is however unknown if ACPA can consistently be found in patients with CAD, and if ACPA are associated with mortality in these patients. The purpose of this study was to assess the relationship between ACPA an...
Abstract
Cited 31 times since 2017 (3.7 per year)
source: EuropePMC
Antimicrobial agents and chemotherapy,
Volume 61, Issue 5, 24 4 2017, Pages e02122-16
The Two-Component System ChtRS Contributes to Chlorhexidine Tolerance in Enterococcus faecium.
Guzmán Prieto AM, Wijngaarden J, Braat JC, Rogers MRC, Majoor E, Brouwer EC, Zhang X, Bayjanov JR, Bonten MJM, Willems RJL, van Schaik W
Enterococcus faecium is one of the primary causes of nosocomial infections. Disinfectants are commonly used to prevent infections with multidrug-resistant E. faecium in hospitals. Worryingly, E. faecium strains that exhibit tolerance to disinfectants have already been described. We aimed to identify and characterize E. faecium genes that contribute to tolerance to the disinfectant chlorhexidine (CHX). We used a transposon mutant library, constructed in a multidrug-resistant E. faecium bloodstrea...
Abstract
Cited 118 times since 2017 (13.9 per year)
source: EuropePMC
European journal of pharmacology,
Volume 816, 21 3 2017, Pages 107-115
Plaque angiogenesis and intraplaque hemorrhage in atherosclerosis.
Parma L, Baganha F, Quax PHA, de Vries MR
Acute cardiovascular events, due to rupture or erosion of an atherosclerotic plaque, represent the major cause of morbidity and mortality in patients. Growing evidence suggests that plaque neovascularization is an important contributor to plaque growth and instability. The vessels' immaturity, with profound structural and functional abnormalities, leads to recurrent intraplaque hemorrhage. This review discusses new insights of atherosclerotic neovascularization, including the effects of lea...
Abstract
