Research

Publications

Below you can find a list of our published research.

9618 results

Cited 9 times since 2017 (1.1 per year) source: EuropePMC

Nature reviews. Cardiology, Volume 14, Issue 4, 27 4 2017, Pages 209-223 Advanced imaging in valvular heart disease. Bax JJ, Delgado V

Although echocardiography remains the mainstay imaging technique for the evaluation of patients with valvular heart disease (VHD), innovations in noninvasive imaging in the past few years have provided new insights into the pathophysiology and quantification of VHD, early detection of left ventricular (LV) dysfunction, and advanced prognostic assessment. The severity grading of valve dysfunction has been refined with the use of Doppler echocardiography, cardiac magnetic resonance (CMR), and CT i... Abstract

Cited 1 times since 2017 (0.1 per year) source: EuropePMC

The Eurasian journal of medicine, Volume 49, Issue 1, 25 4 2017, Pages 69-71 A Systemic-Onset Juvenile Idiopathic Arthritis Patient with Reduced Anakinra Treatment Admitted with an Attack. Yilmaz D, Akcan M, Terlemez S, Sonmez F, Akcan AB

Interleukin-1 plays an important role in the pathogenesis of systemic-onset juvenile idiopathic arthritis (SoJIA), and the use of anti-interleukin-1 therapy has been increasing. We report a case of a 14-year-old male patient with SoJIA. He was in remission with anakinra treatment for almost 2 years. When we extended the therapeutic range and decreased the dose (1 mg/kg twice a week), he developed symptoms mimicking pulmonary embolism and cardiac ischemia. Increased cardiac enzyme levels and echo... Abstract

Cited 40 times since 2017 (4.7 per year) source: EuropePMC

European journal of clinical nutrition, Volume 71, Issue 4, 25 4 2017, Pages 512-518 No association of alcohol use and the risk of ulcerative colitis or Crohn's disease: data from a European Prospective cohort study (EPIC). Bergmann MM, Hernandez V, Bernigau W, Boeing H, Chan SS, Chan SS, Luben R, Khaw KT, van Schaik F, Oldenburg B, Bueno-de-Mesquita B, Overvad K, Palli D, Masala G, Carbonnel F, Boutron-Ruault MC, Olsen A, Tjonneland A, Kaaks R, Katzke V, Riboli E, Hart AR

Background/objectives: The role of long-term alcohol consumption for the risk of developing ulcerative colitis (UC) and Crohn's disease (CD) is unclear. For the first time, to prospectively assess the role of pre-disease alcohol consumption on the risk of developing UC or CD. Subjects/methods: Nested within the European Prospective Investigation into Cancer and Nutrition (EPIC-IBD), incident UC and CD cases and matched controls where included. At recruitment, participants completed validate... Abstract

Cited 3 times since 2017 (0.4 per year) source: EuropePMC

Omics : a journal of integrative biology, Volume 21, Issue 2, 24 4 2017, Pages 67-73 Performance Ratio Based Resource Allocation Decision-Making in Genomic Medicine. Fragoulakis V, Mitropoulou C, Katelidou D, van Schaik RH, Maniadakis N, Patrinos GP

In modern healthcare systems, the available resources may influence the morbidity, mortality, and-consequently-the level of healthcare provided in every country. This is of particular interest in developing countries where the resources are limited and must be spent wisely to address social justice and the right for equal access in healthcare services by all the citizens in economically viable terms. In this light, the current allocation is, in practice, inefficient and rests mostly on each coun... Abstract

Vascular and endovascular surgery, Volume 51, Issue 3, 23 4 2017, Pages 139-140 Endovascular Repair of Contained Abdominal Aortic Aneurysm Rupture Using a Bilateral D-Shaped Stent System. van der Sluis N, Tielliu IF, Zeebregts CJ, Krievins D, van Schaik PM

To report the first case of the treatment of a contained aortic aneurysm rupture using a bilateral D-shaped endovascular stent graft system. Abstract

Cited 1 times since 2017 (0.1 per year) source: EuropePMC

Journal of clinical lipidology, Volume 11, Issue 2, 23 4 2017, Pages 377-385.e1 Association of fasting triglyceride concentration and postprandial triglyceride response with the carotid intima-media thickness in the middle aged: The Netherlands Epidemiology of Obesity study. Christen T, de Mutsert R, Gast KB, Rensen PCN, de Koning E, Rosendaal FR, Trompet S, Jukema JW

Background: People are in a postprandial state for the majority of the day, postprandial triglyceride (TG) response may be more important in the etiology of atherosclerosis than fasting TGs. Objective: The objective of the study was to investigate the associations of fasting TG concentration (TGc) and postprandial TG response after a meal challenge with subclinical atherosclerosis, measured by intima-media thickness (IMT) in a middle-aged population. Methods: A total of 5574 participants (57% wo... Abstract

Cited 8 times since 2017 (0.9 per year) source: EuropePMC

BioMed research international, Volume 2017, 23 4 2017, Pages 5134602 The Use of Antidepressants, Anxiolytics, and Hypnotics in People with Type 2 Diabetes and Patterns Associated with Use: The Hoorn Diabetes Care System Cohort. Mast R, Rauh SP, Groeneveld L, Koopman AD, Beulens JW, Jansen AP, Bremmer M, van der Heijden AA, Elders PJ, Dekker JM, Nijpels G, Hugtenburg JG, Rutters F

Objective. With depression being present in approximately 20% of people with type 2 diabetes mellitus (T2DM), we expect equally frequent prescription of antidepressants, anxiolytics, and hypnotics. Nevertheless, prescription data in people with T2DM is missing and the effect of depression on glycaemic control is contradictory. The aim of this study was to assess the prevalence of antidepressants, anxiolytics, and/or hypnotics use in a large, managed, primary care system cohort of people with T2D... Abstract

Cited 27 times since 2017 (3.1 per year) source: EuropePMC

PloS one, Volume 12, Issue 1, 20 3 2017, Pages e0167742 Comparison of HapMap and 1000 Genomes Reference Panels in a Large-Scale Genome-Wide Association Study. de Vries PS, Sabater-Lleal M, Chasman DI, Trompet S, Ahluwalia TS, Teumer A, Kleber ME, Chen MH, Wang JJ, Attia JR, Marioni RE, Steri M, Weng LC, Pool R, Grossmann V, Brody JA, Venturini C, Tanaka T, Rose LM, Oldmeadow C, Mazur J, Basu S, Frånberg M, Yang Q, Ligthart S, Hottenga JJ, Rumley A, Mulas A, de Craen AJ, Grotevendt A, Taylor KD, Delgado GE, Kifley A, Lopez LM, Berentzen TL, Mangino M, Bandinelli S, Morrison AC, Hamsten A, Tofler G, de Maat MP, Draisma HH, Lowe GD, Zoledziewska M, Sattar N, Lackner KJ, Völker U, McKnight B, Huang J, Holliday EG, McEvoy MA, Starr JM, Hysi PG, Hernandez DG, Guan W, Rivadeneira F, McArdle WL, Slagboom PE, Zeller T, Psaty BM, Uitterlinden AG, de Geus EJ, Stott DJ, Binder H, Hofman A, Franco OH, Rotter JI, Ferrucci L, Spector TD, Deary IJ, März W, Greinacher A, Wild PS, Cucca F, Boomsma DI, Watkins H, Tang W, Ridker PM, Jukema JW, Scott RJ, Mitchell P, Hansen T, O'Donnell CJ, Smith NL, Strachan DP, Dehghan A

An increasing number of genome-wide association (GWA) studies are now using the higher resolution 1000 Genomes Project reference panel (1000G) for imputation, with the expectation that 1000G imputation will lead to the discovery of additional associated loci when compared to HapMap imputation. In order to assess the improvement of 1000G over HapMap imputation in identifying associated loci, we compared the results of GWA studies of circulating fibrinogen based on the two reference panels. Using... Abstract

Cited 19 times since 2017 (2.2 per year) source: EuropePMC

Transplantation direct, Volume 3, Issue 2, 19 3 2017, Pages e129 Overweight Kidney Transplant Recipients Are at Risk of Being Overdosed Following Standard Bodyweight-Based Tacrolimus Starting Dose. Andrews LM, de Winter BC, Tang JT, Shuker N, Bouamar R, van Schaik RH, Koch BC, van Gelder T, Hesselink DA

Background: Bodyweight-based dosing of tacrolimus (Tac) is considered standard care, even though the available evidence is thin. An increasing proportion of transplant recipients is overweight, prompting the question if the starting dose should always be based on bodyweight. Methods: For this analysis, data were used from a randomized-controlled trial in which patients received either a standard Tac starting dose or a dose that was based on CYP3A5 genotype. The hypothesis was that overweight pat... Abstract

Cited 210 times since 2017 (24.5 per year) source: EuropePMC

Nature communications, Volume 8, 18 3 2017, Pages 13624 Novel genetic loci associated with hippocampal volume. Hibar DP, Adams HHH, Jahanshad N, Chauhan G, Stein JL, Hofer E, Renteria ME, Bis JC, Arias-Vasquez A, Ikram MK, Desrivières S, Vernooij MW, Abramovic L, Alhusaini S, Amin N, Andersson M, Arfanakis K, Aribisala BS, Armstrong NJ, Athanasiu L, Axelsson T, Beecham AH, Beiser A, Bernard M, Blanton SH, Bohlken MM, Boks MP, Bralten J, Brickman AM, Carmichael O, Chakravarty MM, Chen Q, Ching CRK, Chouraki V, Cuellar-Partida G, Crivello F, Den Braber A, Doan NT, Ehrlich S, Giddaluru S, Goldman AL, Gottesman RF, Grimm O, Griswold ME, Guadalupe T, Gutman BA, Hass J, Haukvik UK, Hoehn D, Holmes AJ, Hoogman M, Janowitz D, Jia T, Jørgensen KN, Karbalai N, Kasperaviciute D, Kim S, Klein M, Kraemer B, Lee PH, Liewald DCM, Lopez LM, Luciano M, Macare C, Marquand AF, Matarin M, Mather KA, Mattheisen M, McKay DR, Milaneschi Y, Muñoz Maniega S, Nho K, Nugent AC, Nyquist P, Loohuis LMO, Oosterlaan J, Papmeyer M, Pirpamer L, Pütz B, Ramasamy A, Richards JS, Risacher SL, Roiz-Santiañez R, Rommelse N, Ropele S, Rose EJ, Royle NA, Ru

The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel.... Abstract

Cited 7 times since 2017 (0.8 per year) source: EuropePMC

Preventive veterinary medicine, Volume 139, Issue Pt B, 18 3 2017, Pages 105-114 Epidemiological performance and subsequent costs of different surveillance strategies to control bovine herpesvirus type 1 in dairy farms. Veldhuis A, Santman-Berends I, Schauer B, Mars J, Waldeck F, Staubach C, van Schaik G

This study aimed at comparing the surveillance program of bovine herpesvirus type 1 (BHV1) as laid down by EU Decision 2004/558/EC and 2007/584/EC ('conventional design') with an alternative design. The alternative design was based on monthly bulk-milk testing, clinical surveillance and a risk-based component that involves testing of animals that are purchased from non-free cattle herds. Scenario-tree analyses were carried out to determine sensitivities of the surveillance system (and... Abstract

Cited 3 times since 2017 (0.3 per year) source: EuropePMC

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, Volume 122, 17 3 2017, Pages 68-71 Albedo factors of some elements in the atomic number range 26≤Z≤79 for 59.54keV. Yılmaz D, Uzunoğlu Z, Demir C

In this study, we aimed to determine the albedo factors for Fe, Co, Ni, Cu, Zr, Mo, Ag, Dy, Yb, and Au. Albedo factors were investigated experimentally for 59.54keV photon energy by using an HPGe detector with a resolution of 182eV at 5.9keV. Albedo number (AN), albedo energy (AE), and albedo dose (AD) were plotted as a function of atomic number of the target. It was observed that albedo factors decreased with increasing atomic number. In addition, there was a good third-order polynomial relatio... Abstract

Cited 11 times since 2017 (1.3 per year) source: EuropePMC

Atherosclerosis, Volume 257, 16 3 2017, Pages 186-194 Anacetrapib, but not evacetrapib, impairs endothelial function in CETP-transgenic mice in spite of marked HDL-C increase. Simic B, Mocharla P, Crucet M, Osto E, Kratzer A, Stivala S, Kühnast S, Speer T, Doycheva P, Princen HM, van der Hoorn JW, Jukema JW, Giral H, Tailleux A, Landmesser U, Staels B, Lüscher TF

Background and aims: High-density lipoprotein cholesterol (HDL-C) is inversely related to cardiovascular risk. HDL-C raising ester transfer protein (CETP) inhibitors, are novel therapeutics. We studied the effects of CETP inhibitors anacetrapib and evacetrapib on triglycerides, cholesterol and lipoproteins, cholesterol efflux, paraoxonase activity (PON-1), reactive oxygen species (ROS), and endothelial function in E3L and E3L.CETP mice. Methods: Triglycerides and cholesterol were measured at wee... Abstract

Cited 92 times since 2017 (10.7 per year) source: EuropePMC

The Cochrane database of systematic reviews, Volume 1, 13 2 2017, Pages CD010369 Treatments for chronic inflammatory demyelinating polyradiculoneuropathy (CIDP): an overview of systematic reviews. Oaklander AL, Lunn MP, Hughes RA, van Schaik IN, Frost C, Chalk CH

Background: Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a chronic progressive or relapsing and remitting disease that usually causes weakness and sensory loss. The symptoms are due to autoimmune inflammation of peripheral nerves. CIPD affects about 2 to 3 per 100,000 of the population. More than half of affected people cannot walk unaided when symptoms are at their worst. CIDP usually responds to treatments that reduce inflammation, but there is disagreement about which t... Abstract

Cited 12 times since 2017 (1.4 per year) source: EuropePMC

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, Volume 26, Issue 5, 12 2 2017, Pages 1114-1120 Cardiorespiratory Fitness after Transient Ischemic Attack and Minor Ischemic Stroke: Baseline Data of the MoveIT Study. Boss HM, Deijle IA, Van Schaik SM, de Melker EC, van den Berg BTJ, Weinstein HC, Geerlings MI, Kappelle LJ, Van den Berg-Vos RM

Background: Cardiorespiratory fitness (CRF) is reduced in patients with stroke. It is unclear whether it is also reduced in patients with a transient ischemic attack (TIA) or minor stroke. We investigated the CRF in patients with a recent TIA or minor stroke and explored which determinants are associated with a lower fitness. Methods: In 113 patients with a recent TIA or minor ischemic stroke (64 (SD = 10) years of age; 49 (IQR 27-86) days post TIA or stroke), the peak oxygen consumption (VO2pea... Abstract

Cited 31 times since 2017 (3.6 per year) source: EuropePMC

Scientific reports, Volume 7, 9 2 2017, Pages 40052 Orientation toward humans predicts cognitive performance in orang-utans. Damerius LA, Forss SI, Kosonen ZK, Willems EP, Burkart JM, Call J, Galdikas BM, Liebal K, Haun DB, van Schaik CP

Non-human animals sometimes show marked intraspecific variation in their cognitive abilities that may reflect variation in external inputs and experience during the developmental period. We examined variation in exploration and cognitive performance on a problem-solving task in a large sample of captive orang-utans (Pongo abelii &P. pygmaeus, N = 103) that had experienced different rearing and housing conditions during ontogeny, including human exposure. In addition to measuring exploration... Abstract

Cited 5 times since 2017 (0.6 per year) source: EuropePMC

The Spanish journal of psychology, Volume 19, 9 2 2017, Pages E99 The Ecology of Social Learning in Animals and its Link with Intelligence. van Schaik C, Graber S, Schuppli C, Burkart J

Classical ethology and behavioral ecology did not pay much attention to learning. However, studies of social learning in nature reviewed here reveal the near-ubiquity of reliance on social information for skill acquisition by developing birds and mammals. This conclusion strengthens the plausibility of the cultural intelligence hypothesis for the evolution of intelligence, which assumes that selection on social learning abilities automatically improves individual learning ability. Thus, intellig... Abstract

Cited 2 times since 2017 (0.2 per year) source: EuropePMC

American heart journal, Volume 186, 2 1 2017, Pages 83-90 Right vEntricular Dysfunction in tEtralogy of Fallot: INhibition of the rEnin-angiotensin-aldosterone system (REDEFINE) trial: Rationale and design of a randomized, double-blind, placebo-controlled clinical trial. Bokma JP, Winter MM, Kornaat EM, Vliegen HW, van Dijk AP, van Melle JP, Meijboom FJ, Post MC, Berbee JK, Zwinderman AH, Mulder BJM, Bouma BJ

Renin-angiotensin-aldosterone system (RAAS) inhibition with angiotensin II receptor blockers or angiotensin-converting enzyme inhibitors is beneficial in patients with acquired left ventricular dysfunction. Adult patients with tetralogy of Fallot (TOF) with right ventricular (RV) dysfunction are at high risk for heart failure, arrhythmias, and sudden cardiac death. However, the efficacy of RAAS inhibition has not been established in these patients. Methods: The REDEFINE is an investigator-initia... Abstract

Cited 32 times since 2017 (3.7 per year) source: EuropePMC

Current opinion in virology, Volume 22, 2 1 2017, Pages 64-70 Capturing norovirus transmission. de Graaf M, Villabruna N, Koopmans MP

Human norovirus is a leading cause of gastroenteritis and is efficiently transmitted between humans and around the globe. The burden of norovirus infections in the global community and in health-care settings warrant the availability of outbreak prevention strategies and control measures that are tailored to the pathogen, outbreak setting and population at risk. A better understanding of viral and host determinants of transmission would aid in developing and fine-tuning such efforts. Here, we de... Abstract

Cited 20 times since 2017 (2.3 per year) source: EuropePMC

Journal of Alzheimer's disease : JAD, Volume 58, Issue 1, 1 1 2017, Pages 275-283 Left Ventricular Hypertrophy and Cognitive Decline in Old Age. Mahinrad S, Vriend AE, Jukema JW, van Heemst D, Sattar N, Blauw GJ, Macfarlane PW, Clark EN, de Craen AJM, Sabayan B

Background: Patients with advanced heart failure run a greater risk of dementia. Whether early cardiac structural changes also associate with cognitive decline is yet to be determined. Objective: We tested whether left ventricular hypertrophy (LVH) derived from electrocardiogram associates with cognitive decline in older subjects at risk of cardiovascular disease. Methods: We included 4,233 participants (mean age 75.2 years, 47.8% male) from PROSPER (PROspective Study of Pravastatin in the Elder... Abstract