Research

Publications

Below you can find a list of our published research.

9618 results

Cited 11 times since 2016 (1.3 per year) source: EuropePMC

Case reports in surgery, Volume 2016, 9 2 2016, Pages 9306262 Xiphoidectomy: A Surgical Intervention for an Underdocumented Disorder. Hogerzeil DP, Hartholt KA, de Vries MR

Two patients who presented with nonspecific thoracic and upper abdominal symptoms and tenderness of the xiphoid process are discussed. Both patients had undergone extensive examinations, but no source for their symptoms could be found. Plain chest radiographs revealed an anterior displacement of the xiphoid process in both patients. Physical examination confirmed this to be the primary source of discomfort. Anterior displacement of the xiphoid process may be the result of significant weight gain... Abstract

Cited 24 times since 2016 (2.7 per year) source: EuropePMC

Journal of clinical pharmacology, Volume 57, Issue 4, 9 2 2016, Pages 440-451 Safety and Tolerability of Neladenoson Bialanate, a Novel Oral Partial Adenosine A1 Receptor Agonist, in Patients With Chronic Heart Failure. Voors AA, Düngen HD, Senni M, Nodari S, Agostoni P, Ponikowski P, Bax JJ, Butler J, Kim RJ, Dorhout B, Dinh W, Gheorghiade M

We studied safety and tolerability of neladenoson bialanate, a novel oral selective partial adenosine A1 receptor agonist that maintains the cardioprotective effects of adenosine without the undesired side effects of a full agonist, in 2 pilot studies in patients with heart failure with reduced ejection fraction (HFrEF). The β-blocker interaction study was a single-blind, placebo-controlled study on the effects of a 30-mg single dose of neladenoson bialanate on atrioventricular (AV) conduction i... Abstract

Cited 13 times since 2016 (1.5 per year) source: EuropePMC

Scientific reports, Volume 6, 8 2 2016, Pages 35371 Gene-gene Interaction Analyses for Atrial Fibrillation. Lin H, Mueller-Nurasyid M, Smith AV, Arking DE, Barnard J, Bartz TM, Lunetta KL, Lohman K, Kleber ME, Lubitz SA, Geelhoed B, Trompet S, Niemeijer MN, Kacprowski T, Chasman DI, Klarin D, Sinner MF, Waldenberger M, Meitinger T, Harris TB, Launer LJ, Soliman EZ, Chen LY, Smith JD, Van Wagoner DR, Rotter JI, Psaty BM, Xie Z, Hendricks AE, Ding J, Delgado GE, Verweij N, van der Harst P, Macfarlane PW, Ford I, Hofman A, Uitterlinden A, Heeringa J, Franco OH, Kors JA, Weiss S, Völzke H, Rose LM, Natarajan P, Kathiresan S, Kääb S, Gudnason V, Alonso A, Chung MK, Heckbert SR, Benjamin EJ, Liu Y, März W, Rienstra M, Jukema JW, Stricker BH, Dörr M, Albert CM, Ellinor PT

Atrial fibrillation (AF) is a heritable disease that affects more than thirty million individuals worldwide. Extensive efforts have been devoted to the study of genetic determinants of AF. The objective of our study is to examine the effect of gene-gene interaction on AF susceptibility. We performed a large-scale association analysis of gene-gene interactions with AF in 8,173 AF cases, and 65,237 AF-free referents collected from 15 studies for discovery. We examined putative interactions between... Abstract

Cited 16 times since 2016 (1.8 per year) source: EuropePMC

BMC geriatrics, Volume 16, Issue 1, 4 1 2016, Pages 179 Cost-utility of medication withdrawal in older fallers: results from the improving medication prescribing to reduce risk of FALLs (IMPROveFALL) trial. Polinder S, Boyé ND, Mattace-Raso FU, Van der Velde N, Hartholt KA, De Vries OJ, Lips P, Van der Cammen TJ, Patka P, Van Beeck EF, Van Lieshout EM, IMPROveFALL trial collaborators

Background: The use of Fall-Risk-Increasing-Drugs (FRIDs) has been associated with increased risk of falls and associated injuries. This study investigates the effect of withdrawal of FRIDs versus 'care as usual' on health-related quality of life (HRQoL), costs, and cost-utility in community-dwelling older fallers. Methods: In a prospective multicenter randomized controlled trial FRIDs assessment combined with FRIDs-withdrawal or modification was compared with 'care as usual'... Abstract

Cited 59 times since 2016 (6.7 per year) source: EuropePMC

Circulation, Volume 135, Issue 3, 3 1 2016, Pages 264-279 Prognostic Value of N-Terminal Pro-B-Type Natriuretic Peptide, Troponin-T, and Growth-Differentiation Factor 15 in Adult Congenital Heart Disease. Baggen VJ, van den Bosch AE, Eindhoven JA, Schut AW, Cuypers JA, Witsenburg M, de Waart M, van Schaik RH, Zijlstra F, Boersma E, Roos-Hesselink JW

Background: The number of patients with adult congenital heart disease (ACHD) is rapidly increasing. To optimize patient management, there is a great need to accurately identify high-risk patients. Still, no biomarker has been firmly established as a clinically useful prognostic tool in this group. We studied the association of N-terminal pro-B-type natriuretic peptide (NT-proBNP), high-sensitive troponin-T, and growth-differentiation factor 15 with cardiovascular events in ACHD. Methods: Clinic... Abstract

Cited 5 times since 2016 (0.6 per year) source: EuropePMC

Anesthesia and analgesia, Volume 123, Issue 5, 1 1 2016, Pages 1109-1115 Implication of UGT2B15 Genotype Polymorphism on Postoperative Anxiety Levels in Patients Receiving Lorazepam Premedication. Mijderwijk H, Klimek M, van Beek S, van Schaik RH, Duivenvoorden HJ, Stolker RJ

Background: Lorazepam is used as premedication for its anxiolytic properties. The UGT2B15 genotype is of importance for the metabolism of lorazepam. The clinical effect of genetic polymorphisms in UGT2B15 genotype on the treatment of anxiety levels in same-day surgery patients receiving lorazepam, however, is unknown. Methods: Three hundred ninety-eight same-day surgery patients of mixed sex (from a previous double-blinded randomized controlled trial who were assigned to either lorazepam [n = 19... Abstract

Cited 12 times since 2016 (1.4 per year) source: EuropePMC

Pain, Volume 157, Issue 11, 1 1 2016, Pages 2476-2482 Genetic variants associated with thermal pain sensitivity in a paediatric population. Matic M, van den Bosch GE, de Wildt SN, Tibboel D, van Schaik RHN

Pain sensitivity is an inherited factor that varies strongly between individuals. We investigated whether genetic polymorphisms in the candidate genes COMT, OPRM1, OPRD1, TAOK3, TRPA1, TRPV1, and SCN9A are contributing to experimental pain variability between children. Our study included 136 children and adolescents (8-18 years). Cold and heat pain thresholds were determined with a Thermal Sensory Analyzer. Women and young children were significantly more sensitive to pain (P < 0.05). After c... Abstract

Cited 42 times since 2016 (4.8 per year) source: EuropePMC

Proceedings. Biological sciences, Volume 283, Issue 1843, 1 1 2016, Pages 20161817 Female monkeys use both the carrot and the stick to promote male participation in intergroup fights. Arseneau-Robar TJ, Taucher AL, Müller E, van Schaik C, Bshary R, Willems EP

Group-level cooperation often poses a social dilemma in which joint action may be difficult to achieve. Theoretical models and experimental work on humans show that social incentives, such as punishment of defectors and rewarding of cooperators, can promote cooperation in groups of unrelated individuals. Here, we demonstrate that these processes can operate in a non-human animal species, and be used to effectively promote the production of a public good. We took advantage of the fact that interg... Abstract

Cited 11 times since 2016 (1.3 per year) source: EuropePMC

Physiology (Bethesda, Md.), Volume 31, Issue 6, 1 1 2016, Pages 392-397 Evolutionary Medicine: The Ongoing Evolution of Human Physiology and Metabolism. Rühli F, van Schaik K, Henneberg M

The field of evolutionary medicine uses evolutionary principles to understand changes in human anatomy and physiology that have occurred over time in response to environmental changes. Through this evolutionary-based approach, we can understand disease as a consequence of anatomical and physiological "trade-offs" that develop to facilitate survival and reproduction. We demonstrate how diachronic study of human anatomy and physiology is fundamental for an increased understanding of huma... Abstract

Cited 172 times since 2016 (19.6 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 68, Issue 21, 1 1 2016, Pages 2299-2307 Long-Term Arrhythmic and Nonarrhythmic Outcomes of Lamin A/C Mutation Carriers. Kumar S, Baldinger SH, Gandjbakhch E, Maury P, Sellal JM, Androulakis AF, Waintraub X, Charron P, Rollin A, Richard P, Stevenson WG, Macintyre CJ, Ho CY, Thompson T, Vohra JK, Kalman JM, Zeppenfeld K, Sacher F, Tedrow UB, Lakdawala NK

Background: Mutations in LMNA are variably expressed and may cause cardiomyopathy, atrioventricular block (AVB), or atrial arrhythmias (AAs) and ventricular arrhythmias (VA). Detailed natural history studies of LMNA-associated arrhythmic and nonarrhythmic outcomes are limited, and the prognostic significance of the index cardiac phenotype remains uncertain. Objectives: This study sought to describe the arrhythmic and nonarrhythmic outcomes of LMNA mutation carriers and to assess the prognostic s... Abstract

Cited 6 times since 2016 (0.7 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 24, Issue 11, 1 1 2016, Pages 675-681 The effect of losartan therapy on ventricular function in Marfan patients with haploinsufficient or dominant negative FBN1 mutations. den Hartog AW, Franken R, van den Berg MP, Zwinderman AH, Timmermans J, Scholte AJ, de Waard V, Spijkerboer AM, Pals G, Mulder BJ, Groenink M

Background: Mild biventricular dysfunction is often present in patients with Marfan syndrome. Losartan has been shown to reduce aortic dilatation in patients with Marfan syndrome. This study assesses the effect of losartan on ventricular volume and function in genetically classified subgroups of asymptomatic Marfan patients without significant valvular regurgitation. Methods: In this predefined substudy of the COMPARE study, Marfan patients were classified based on the effect of their FBN1 mutat... Abstract

Cited 107 times since 2016 (12.2 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 68, Issue 19, 1 1 2016, Pages 2047-2055 Long-Term Clinical Outcomes of Subcutaneous Versus Transvenous Implantable Defibrillator Therapy. Brouwer TF, Yilmaz D, Lindeboom R, Buiten MS, Olde Nordkamp LR, Schalij MJ, Wilde AA, van Erven L, Knops RE

Background: Transvenous implantable cardioverter-defibrillators (TV-ICDs) improve survival in patients at risk for sudden cardiac death, but complications remain an important drawback. The subcutaneous ICD (S-ICD) was developed to overcome lead-related complications. Comparison of clinical outcomes of both device types in previous studies was hampered by dissimilar patient characteristics. Objectives: This retrospective study compares long-term clinical outcomes of S-ICD and TV-ICD therapy in a... Abstract

Cited 50 times since 2016 (5.7 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 103, Issue 9, 1 1 2016, Pages 666-671 QRS fragmentation is superior to QRS duration in predicting mortality in adults with tetralogy of Fallot. Bokma JP, Winter MM, Vehmeijer JT, Vliegen HW, van Dijk AP, van Melle JP, Meijboom FJ, Post MC, Zwinderman AH, Mulder BJ, Bouma BJ

Background: Although QRS duration >180 ms has prognostic value in adults with tetralogy of Fallot (TOF), its sensitivity to predict mortality is low. Fragmented QRS complexes, a simple measurement on ECG, are related to myocardial fibrosis and dysfunction in patients with TOF. Our objective was to determine whether QRS fragmentation predicts major outcomes in TOF. Methods: This multicentre study included adult patients with TOF from a prospective registry. Notches in the QRS complex in ≥2 con... Abstract

Cited 11 times since 2016 (1.3 per year) source: EuropePMC

Clinical nurse specialist CNS, Volume 30, Issue 6, 1 1 2016, Pages E7-E12 The Effect of the Z-Track Technique on Pain and Drug Leakage in Intramuscular Injections. Yilmaz D, Khorshid L, Dedeoğlu Y

Purpose/aims: The aim of this study was to investigate the effects of the Z-track technique in the administration of intramuscular diclofenac, a nonsteroidal anti-inflammatory drug, on pain and drug leakage. Design: This is a semiexperimental and randomized controlled study. Methods: It was felt necessary to conduct this study to compare the effects on pain and drug leakage of the standard intramuscular injection method and the "Z-track technique," which is claimed to be helpful in thi... Abstract

Cited 1 times since 2016 (0.1 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 24, Issue 11, 1 1 2016, Pages 653-665 NT-proBNP and exercise capacity in adult patients with congenital heart disease and a prosthetic valve: a multicentre PROSTAVA study. Schoonbeek RC, Pieper PG, van Slooten YJ, Freling HG, Sieswerda GT, van Dijk AP, Jongbloed MR, Post MC, Bouma BJ, Berger RM, Ebels T, van Melle JP

Objectives: N-terminal B‑type natriuretic peptide (NT-proBNP) is an important biomarker for the detection of heart failure. Adults with congenital heart disease (ACHD) and a prosthetic heart valve are at risk for heart failure. This study aimed to determine the value of NT-proBNP in ACHD patients with a prosthetic valve and investigate its relationship with cardiac function and exercise capacity. Methods: In this multi-centre cross-sectional observational study, data regarding medical history, e... Abstract

Nuclear medicine communications, Volume 37, Issue 11, 1 1 2016, Pages 1125-1135 Comparison between a count-based and geometrical approach for the assessment of left ventricular dyssynchrony using myocardial perfusion scintigraphy. Nguyên UC, Al Younis I, Ajmone-Marsan N, Dibbets-Schneider P, Blokland JA, de Wit-van der Veen BJ

Objective: There are two distinct approaches for the assessment of left ventricular (LV) dyssynchrony by myocardial perfusion scintigraphy (MPS). The aim of this study was to compare the performance of the count-based and geometrical approach in clinical data using gated single photon emission computed tomography MPS. Material and methods: Group 1 consisted of 113 patients (49 men, 64 women) with normal perfusion [summed rest score (SRS)≤3], normal LV ejection fraction (≥55%), and normal QRS dur... Abstract

Cited 23 times since 2016 (2.6 per year) source: EuropePMC

Journal of human evolution, Volume 100, 1 1 2016, Pages 25-34 Being fat and smart: A comparative analysis of the fat-brain trade-off in mammals. Heldstab SA, van Schaik CP, Isler K

Humans stand out among non-aquatic mammals by having both an extremely large brain and a relatively large amount of body fat. To understand the evolution of this human peculiarity we report a phylogenetic comparative study of 120 mammalian species, including 30 primates, using seasonal variation in adult body mass as a proxy of the tendency to store fat. Species that rely on storing fat to survive lean periods are expected to be less active because of higher costs of locomotion and have increase... Abstract

European journal of cancer (Oxford, England : 1990), Volume 68, 30 5 2016, Pages 198 Reply to letter commenting on: A five-gene expression signature to predict progression in T1G3 bladder cancer. van der Heijden AG, Mengual L

Abstract

Cited 78 times since 2016 (8.9 per year) source: EuropePMC

Circulation, Volume 135, Issue 14, 28 4 2016, Pages 1311-1320 Genetic Risk Prediction of Atrial Fibrillation. Lubitz SA, Yin X, Lin HJ, Kolek M, Smith JG, Trompet S, Rienstra M, Rost NS, Teixeira PL, Almgren P, Anderson CD, Chen LY, Engström G, Ford I, Furie KL, Guo X, Larson MG, Lunetta KL, Macfarlane PW, Psaty BM, Soliman EZ, Sotoodehnia N, Stott DJ, Taylor KD, Weng LC, Yao J, Geelhoed B, Verweij N, Siland JE, Kathiresan S, Roselli C, Roden DM, van der Harst P, Darbar D, Jukema JW, Melander O, Rosand J, Rotter JI, Heckbert SR, Ellinor PT, Alonso A, Benjamin EJ, AFGen Consortium

Background: Atrial fibrillation (AF) has a substantial genetic basis. Identification of individuals at greatest AF risk could minimize the incidence of cardioembolic stroke. Methods: To determine whether genetic data can stratify risk for development of AF, we examined associations between AF genetic risk scores and incident AF in 5 prospective studies comprising 18 919 individuals of European ancestry. We examined associations between AF genetic risk scores and ischemic stroke in a separate stu... Abstract

Cited 1 times since 2016 (0.1 per year) source: EuropePMC

Journal of electrocardiology, Volume 50, Issue 1, 28 4 2016, Pages 82-89 Position of ST-deviation measurements relative to the J-point: Impact for ischemia detection. Man S, Ter Haar CC, de Jongh MC, Maan AC, Schalij MJ, Swenne CA

Background: There is no consensus about the time instant relative to the J point where ST deviation has to be measured for detection of acute ischemia in the ECG. Methods: We analyzed 53 ECGs, recorded preceding emergency catheterization of acute coronary syndrome patients with a completely occluded culprit artery (cases), and 88 control ECGs recorded in the cardiology outpatient clinic. ECG-amplitude measurements were made every 10 ms, between 20 ms before till 80 ms after the J point. STEMI-de... Abstract