Research

Publications

Below you can find a list of our published research.

8892 results

Cited 109 times since 2016 (11.9 per year) source: EuropePMC

Nature chemistry, Volume 8, Issue 12, 15 3 2016, Pages 1099-1104 Mechanically controlled quantum interference in individual π-stacked dimers. Frisenda R, Janssen VA, Grozema FC, van der Zant HS, Renaud N

Recent observations of destructive quantum interference in single-molecule junctions confirm the role of quantum effects in the electronic conductance properties of molecular systems. These effects are central to a broad range of chemical and biological processes and may be beneficial for the design of single-molecule electronic components to exploit the intrinsic quantum effects that occur at the molecular scale. Here we show that destructive interference can be turned on or off within the same... Abstract

Cited 4 times since 2016 (0.4 per year) source: EuropePMC

Cardiovascular revascularization medicine : including molecular interventions, Volume 18, Issue 1, 8 2 2016, Pages 66-69 Guide extension catheter stepwise advancement facilitated by repeated distal balloon anchoring. Andreou C, Karalis I, Maniotis C, Jukema JW, Koutouzis M

Coronary stent delivery can be extremely challenging in tortuous and calcified lesions especially when radial approach is chosen. Guide extension catheter is a useful tool for overcoming the inherent difficulties arising by the use of radial access in complex percutaneous interventions. We describe a technique for guide extension catheter system advancement by presenting two cases. This was performed stepwise by repeated distal balloon anchoring in the coronary artery of interest. Abstract

Cited 10 times since 2016 (1.1 per year) source: EuropePMC

Journal of dairy science, Volume 99, Issue 10, 8 2 2016, Pages 8282-8296 Improving the time efficiency of identifying dairy herds with poorer welfare in a population. de Vries M, Bokkers EAM, van Schaik G, Engel B, Dijkstra T, de Boer IJM

Animal-based welfare assessment is time consuming and expensive. A promising strategy for improving the efficiency of identifying dairy herds with poorer welfare is to first estimate levels of welfare in herds based on data that are more easily obtained. Our aims were to evaluate the potential of herd housing and management data for estimating the level of welfare in dairy herds, and to estimate the associated reduction in the number of farm visits required for identification of herds with poore... Abstract

Cited 151 times since 2016 (16.4 per year) source: EuropePMC

Nature genetics, Volume 48, Issue 9, 8 2 2016, Pages 1055-1059 Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin. Zhou K, Yee SW, Seiser EL, van Leeuwen N, Tavendale R, Bennett AJ, Groves CJ, Coleman RL, van der Heijden AA, Beulens JW, de Keyser CE, Zaharenko L, Rotroff DM, Out M, Jablonski KA, Chen L, Javorský M, Židzik J, Levin AM, Williams LK, Dujic T, Semiz S, Kubo M, Chien HC, Maeda S, Witte JS, Wu L, Tkáč I, Kooy A, van Schaik RHN, Stehouwer CDA, Logie L, Logie L, MetGen Investigators, DPP Investigators, ACCORD Investigators, Sutherland C, Klovins J, Pirags V, Hofman A, Stricker BH, Motsinger-Reif AA, Wagner MJ, Innocenti F, 't Hart LM, Holman RR, McCarthy MI, Hedderson MM, Palmer CNA, Florez JC, Giacomini KM, Pearson ER

Metformin is the first-line antidiabetic drug with over 100 million users worldwide, yet its mechanism of action remains unclear. Here the Metformin Genetics (MetGen) Consortium reports a three-stage genome-wide association study (GWAS), consisting of 13,123 participants of different ancestries. The C allele of rs8192675 in the intron of SLC2A2, which encodes the facilitated glucose transporter GLUT2, was associated with a 0.17% (P = 6.6 × 10(-14)) greater metformin-induced reduction in hemoglob... Abstract

Cited 19 times since 2016 (2.1 per year) source: EuropePMC

Expert review of medical devices, Volume 13, Issue 9, 8 2 2016, Pages 823-830 Mobile health in cardiology: a review of currently available medical apps and equipment for remote monitoring. Treskes RW, van der Velde ET, Barendse R, Bruining N

Introduction: Recent developments in implantable cardioverter-defibrillators (ICDs) and smartphone technology have increased the possibilities for remote monitoring. It is the purpose of this review to give an overview of these new possibilities. Areas covered: Remote monitoring in ICD allows for early detection of lead fractures and remote follow-up of patients. Possible limitations are the lack of standardization and the possible unsafety of the data stored on the ICD. Secondly, remote monitor... Abstract

Cited 88 times since 2016 (9.6 per year) source: EuropePMC

Trials, Volume 17, Issue 1, 3 1 2016, Pages 387 European COMPARative Effectiveness research on blended Depression treatment versus treatment-as-usual (E-COMPARED): study protocol for a randomized controlled, non-inferiority trial in eight European countries. Kleiboer A, Smit J, Bosmans J, Ruwaard J, Andersson G, Topooco N, Berger T, Krieger T, Botella C, Baños R, Chevreul K, Araya R, Cerga-Pashoja A, Cieślak R, Rogala A, Vis C, Draisma S, van Schaik A, Kemmeren L, Ebert D, Berking M, Funk B, Cuijpers P, Riper H

Background: Effective, accessible, and affordable depression treatment is of high importance considering the large personal and economic burden of depression. Internet-based treatment is considered a promising clinical and cost-effective alternative to current routine depression treatment strategies such as face-to-face psychotherapy. However, it is not clear whether research findings translate to routine clinical practice such as primary or specialized mental health care. The E-COMPARED project... Abstract

Cited 94 times since 2016 (10.2 per year) source: EuropePMC

Biological reviews of the Cambridge Philosophical Society, Volume 92, Issue 3, 2 1 2016, Pages 1427-1433 Exorcising Grice's ghost: an empirical approach to studying intentional communication in animals. Townsend SW, Koski SE, Byrne RW, Slocombe KE, Bickel B, Boeckle M, Braga Goncalves I, Burkart JM, Flower T, Gaunet F, Glock HJ, Gruber T, Jansen DAWAM, Liebal K, Linke A, Miklósi Á, Moore R, van Schaik CP, Stoll S, Vail A, Waller BM, Wild M, Zuberbühler K, Manser MB

Language's intentional nature has been highlighted as a crucial feature distinguishing it from other communication systems. Specifically, language is often thought to depend on highly structured intentional action and mutual mindreading by a communicator and recipient. Whilst similar abilities in animals can shed light on the evolution of intentionality, they remain challenging to detect unambiguously. We revisit animal intentional communication and suggest that progress in identifying anal... Abstract

Cited 10 times since 2016 (1.1 per year) source: EuropePMC

Arrhythmia & electrophysiology review, Volume 5, Issue 2, 1 1 2016, Pages 150-160 Anatomical Substrates and Ablation of Reentrant Atrial and Ventricular Tachycardias in Repaired Congenital Heart Disease. Brouwer C, Hazekamp MG, Zeppenfeld K

Advances in surgical repair techniques for various types of congenital heart disease have improved survival into adulthood over the past decades, thus exposing these patients to a high risk of atrial and ventricular arrhythmias later in life. These arrhythmias arise from complex arrhythmogenic substrates. Substrate formation may depend on both pathological myocardial remodelling and variable anatomical boundaries, determined by the type and timing of prior corrective surgery. Accordingly, arrhyt... Abstract

Cited 18 times since 2016 (2 per year) source: EuropePMC

Therapeutic drug monitoring, Volume 38, Issue 4, 1 1 2016, Pages 487-492 SLC22A1/OCT1 Genotype Affects O-desmethyltramadol Exposure in Newborn Infants. Matic M, de Wildt SN, Elens L, de Hoon JN, Annaert P, Tibboel D, van Schaik RH, Allegaert K

Background: This study determined whether the SLC22A1 [encoding the organic cation transporter 1 (OCT1)] genotype could explain, in addition to the postmenstrual age (referring to gestational plus postnatal age) and CYP2D6 genotype, the tramadol (M) pharmacokinetic variability in early infancy. Methods: Fifty infants, median postmenstrual age 39.5 (interquartile range: 36.8-41.3) weeks, received an i.v. M loading dose (2 mg/kg) followed by a continuous infusion (5-8 mg·kg·24 h). Blood was sample... Abstract

Cited 21 times since 2016 (2.3 per year) source: EuropePMC

Therapeutic drug monitoring, Volume 38, Issue 4, 1 1 2016, Pages 525-533 Genetic Predisposition to Poor Opioid Response in Preterm Infants: Impact of KCNJ6 and COMT Polymorphisms on Pain Relief After Endotracheal Intubation. Elens L, Norman E, Matic M, Rane A, Fellman V, van Schaik RH

Background: Single-nucleotide polymorphisms in genes involved in pain control might predispose to exaggerated sensitivity or difference in opioid analgesic effect. The relevance of the KCNJ6 -1250G>A (rs6517442, c.-1787G>A) and the catecholamine-O-methyltransferase (COMT) c.472G>A (rs4680, ValMet) single-nucleotide polymorphisms were studied in preterm infants needing intubation and randomized to a premedication strategy including remifentanil (n = 17) or morphine (n = 17). Methods: Pai... Abstract

Cited 15 times since 2016 (1.6 per year) source: EuropePMC

Therapeutic drug monitoring, Volume 38, Issue 4, 1 1 2016, Pages 534-545 Population Pharmacokinetics of Prednisolone in Relation to Clinical Outcome in Children With Nephrotic Syndrome. Teeninga N, Guan Z, Stevens J, Kist-van Holthe JE, Ackermans MT, van der Heijden AJ, van Schaik RH, van Gelder T, Nauta J

Background: The relapse frequency in children with nephrotic syndrome (NS) is highly variable despite standardized prednisolone treatment regimens. Existing evidence on the relationship between prednisolone pharmacokinetics (PK) and clinical response in children with NS is scarce and limited. The aim of this study was to develop a pediatric popPK model for prednisolone based on our previous model based on healthy adults using salivary measurements in children with NS and to correlate clinical ou... Abstract

Cited 6 times since 2016 (0.7 per year) source: EuropePMC

Interactive cardiovascular and thoracic surgery, Volume 23, Issue 6, 1 1 2016, Pages 979-981 Left ventricular assist device implantation in patients after left ventricular reconstruction. Palmen M, Braun J, Beeres SL, Klautz RJ

Left ventricular assist device (LVAD) implantation can be challenging in patients with a prior surgical ventricular restoration (SVR). In this case series of heart failure patients with a history of SVR, we describe the surgical technique and outcome of a customized approach for inflow cannula orientation. Seven patients with a history of SVR with end-stage chronic heart failure were accepted for long-term LVAD support. In all patients, the Dacron patch was removed through left ventriculotomy an... Abstract

Cited 68 times since 2016 (7.4 per year) source: EuropePMC

Circulation. Arrhythmia and electrophysiology, Volume 9, Issue 8, 1 1 2016, Pages e004357 Multicenter Experience With Catheter Ablation for Ventricular Tachycardia in Lamin A/C Cardiomyopathy. Kumar S, Androulakis AF, Sellal JM, Maury P, Gandjbakhch E, Waintraub X, Rollin A, Richard P, Charron P, Baldinger SH, Macintyre CJ, Koplan BA, John RM, Michaud GF, Zeppenfeld K, Sacher F, Lakdawala NK, Stevenson WG, Tedrow UB

Background: Lamin A/C (LMNA) cardiomyopathy is a genetic disease with a proclivity for ventricular arrhythmias. We describe the multicenter experience with percutaneous catheter ablation of sustained monomorphic ventricular tachycardia (VT) in LMNA cardiomyopathy. Methods and results: Twenty-five consecutive LMNA mutation patients from 4 centers were included (mean age, 55±9 years; ejection fraction, 34±12%; VT storm in 36%). Complete atrioventricular block was present in 11 patients; 3 patients... Abstract

Cited 16 times since 2016 (1.7 per year) source: EuropePMC

Journal of hypertension, Volume 34, Issue 8, 1 1 2016, Pages 1544-1550 Visit-to-visit blood pressure variability and future functional decline in old age. Ogliari G, Smit RA, Westendorp RG, Jukema JW, de Craen AJ, Sabayan B

Objective: Higher blood pressure variability (BPV), independent of mean blood pressure (BP), has been associated with adverse health outcomes. We investigated the association between visit-to-visit BPV and functional decline in older adults at high cardiovascular risk. Methods: In PROspective Study of Pravastatin in the Elderly at Risk, 4745 participants with mean age of 75.2 years and high cardiovascular risk were followed for a mean of 3.2 years. BP was measured in every 3 months during the fi... Abstract

Cited 111 times since 2016 (12 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 68, Issue 9, 1 1 2016, Pages 934-945 Cystatin C and Cardiovascular Disease: A Mendelian Randomization Study. van der Laan SW, Fall T, Soumaré A, Teumer A, Sedaghat S, Baumert J, Zabaneh D, van Setten J, Isgum I, Galesloot TE, Arpegård J, Amouyel P, Trompet S, Waldenberger M, Dörr M, Magnusson PK, Giedraitis V, Larsson A, Morris AP, Felix JF, Morrison AC, Franceschini N, Bis JC, Kavousi M, O'Donnell C, Drenos F, Tragante V, Munroe PB, Malik R, Dichgans M, Worrall BB, Erdmann J, Nelson CP, Samani NJ, Schunkert H, Marchini J, Patel RS, Hingorani AD, Lind L, Pedersen NL, de Graaf J, Kiemeney LA, Baumeister SE, Franco OH, Hofman A, Uitterlinden AG, Koenig W, Meisinger C, Peters A, Thorand B, Jukema JW, Eriksen BO, Toft I, Wilsgaard T, Onland-Moret NC, van der Schouw YT, Debette S, Kumari M, Svensson P, van der Harst P, Kivimaki M, Keating BJ, Sattar N, Dehghan A, Reiner AP, Ingelsson E, den Ruijter HM, de Bakker PI, Pasterkamp G, Ärnlöv J, Holmes MV, Asselbergs FW

Background: Epidemiological studies show that high circulating cystatin C is associated with risk of cardiovascular disease (CVD), independent of creatinine-based renal function measurements. It is unclear whether this relationship is causal, arises from residual confounding, and/or is a consequence of reverse causation. Objectives: The aim of this study was to use Mendelian randomization to investigate whether cystatin C is causally related to CVD in the general population. Methods: We incorpor... Abstract

Cited 8 times since 2016 (0.9 per year) source: EuropePMC

The American journal of cardiology, Volume 118, Issue 8, 29 5 2016, Pages 1217-1224 Long-Term Echocardiographic Outcome in Super-Responders to Cardiac Resynchronization Therapy and the Association With Mortality and Defibrillator Therapy. van der Heijden AC, Höke U, Thijssen J, Willem Borleffs CJ, Wolterbeek R, Schalij MJ, van Erven L

Super-response to cardiac resynchronization therapy (CRT) is associated with significant left ventricular (LV) reverse remodeling and improved clinical outcome. The study aimed to: (1) evaluate whether LV reverse remodeling remains sustained during long-term follow-up in super-responders and (2) analyze the association between the course of LV reverse remodeling and ventricular arrhythmias. Of all, primary prevention super-responders to CRT were selected. Super-response was defined as LV end-sys... Abstract

Cited 10 times since 2016 (1.1 per year) source: EuropePMC

Pharmacogenomics, Volume 17, Issue 13, 29 5 2016, Pages 1391-1403 Opioid treatment failure in cancer patients: the role of clinical and genetic factors. Oosten AW, Matic M, van Schaik RH, Look MP, Jongen JL, Mathijssen RH, van der Rijt CC

Aim: To identify clinical and genetic factors associated with outcome of opioid treatment. Patients & methods: We performed an exploratory analysis in a cohort of 353 patients treated with fentanyl, morphine, oxycodone and/or hydromorphone for cancer-related pain, exploring selected clinical and pharmacogenetic factors for a correlation with treatment failure for all and per type of opioid. Results: Use of adjuvant pain medication, intensity of pain at rest and age were associated with treat... Abstract

Cited 4 times since 2016 (0.4 per year) source: EuropePMC

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, Volume 23, Issue 6, 29 5 2016, Pages 1399-1410 Diagnostic and prognostic roles of echocardiography and cardiac magnetic resonance. Delgado V, Bucciarelli-Ducci C, Bax JJ

Accurate prediction of sudden cardiac death due to ventricular arrhythmia remains challenging. Left ventricular ejection fraction has shown an association with increased risk of ventricular arrhythmias and is included in the recommendations for implantable cardioverter defibrillator as primary prevention. However, left ventricular ejection fraction may be normal in a large number of patients who are at risk of ventricular arrhythmias. Echocardiography remains the imaging technique of first choic... Abstract

Cited 92 times since 2016 (10 per year) source: EuropePMC

The Behavioral and brain sciences, Volume 40, 28 4 2016, Pages e195 The evolution of general intelligence. Burkart JM, Schubiger MN, van Schaik CP

The presence of general intelligence poses a major evolutionary puzzle, which has led to increased interest in its presence in nonhuman animals. The aim of this review is to critically evaluate this question and to explore the implications for current theories about the evolution of cognition. We first review domain-general and domain-specific accounts of human cognition in order to situate attempts to identify general intelligence in nonhuman animals. Recent studies are consistent with the pres... Abstract

Cited 26 times since 2016 (2.8 per year) source: EuropePMC

Scientific reports, Volume 6, 28 4 2016, Pages 30516 Cognitive differences between orang-utan species: a test of the cultural intelligence hypothesis. Forss SI, Willems E, Call J, van Schaik CP

Cultural species can - or even prefer to - learn their skills from conspecifics. According to the cultural intelligence hypothesis, selection on underlying mechanisms not only improves this social learning ability but also the asocial (individual) learning ability. Thus, species with systematically richer opportunities to socially acquire knowledge and skills should over time evolve to become more intelligent. We experimentally compared the problem-solving ability of Sumatran orang-utans (Pongo... Abstract