Research

Publications

Below you can find a list of our published research.

6555 results

Cited 172 times since 2011 (12.7 per year) source: Scopus

The American journal of cardiology, Volume 108, Issue 10, 17 3 2011, Pages 1470-1477 Location and severity of aortic valve calcium and implications for aortic regurgitation after transcatheter aortic valve implantation. Ewe SH, Ng AC, Schuijf JD, van der Kley F, Colli A, Palmen M, de Weger A, Marsan NA, Holman ER, de Roos A, Schalij MJ, Bax JJ, Delgado V

Location of aortic valve calcium (AVC) can be better visualized on contrast-enhanced multidetector row computed tomography. The present evaluation examined whether AVC severity and its location could influence paravalvular aortic regurgitation (AR) after transcatheter aortic valve implantation. A total of 79 patients (age 80 ± 7 years, 49% men) with preprocedural multidetector row computed tomography were included. Volumetric AVC quantification and its location were assessed. Transesophageal ech... Abstract

Cited 5 times since 2011 (0.4 per year) source: EuropePMC

European journal of heart failure, Volume 13, Issue 11, 16 3 2011, Pages 1202-1210 Myocardial collagen turnover after surgical ventricular restoration in heart failure patients. ten Brinke EA, Witkowski TG, Delgado V, Klein P, Klok M, Marsan NA, Klautz RJ, van der Wall EE, Bax JJ, van der Laarse A, Steendijk P

Aims: Surgical ventricular restoration (SVR) aims to normalize left ventricular (LV) volume and shape in patients with ischaemic cardiomyopathy and anterior wall scar. The chronic effects on LV function may depend on alterations in myocardial collagen metabolism. The present study evaluated myocardial collagen synthesis and degradation rates at baseline and at 6 months follow-up after SVR. We hypothesize that the chronic effects of SVR on LV function and clinical outcome depend on alterations in... Abstract

Cited 128 times since 2011 (9.4 per year) source: EuropePMC

Circulation. Arrhythmia and electrophysiology, Volume 4, Issue 5, 13 2 2011, Pages 653-659 Epicardial ablation for ventricular tachycardia: a European multicenter study. Della Bella P, Brugada J, Zeppenfeld K, Merino J, Neuzil P, Maury P, Maccabelli G, Vergara P, Baratto F, Berruezo A, Wijnmaalen AP

Background: The purpose of this study was to describe the epicardial percutaneous ablation experience of 6 European high-volume ventricular tachycardia (VT) ablation centers. Methods and results: Data from 218 patients with coronary artery disease (CAD, n=85 [39.0%]), idiopathic dilated of patients with idiopathic VT cardiomyopathy (IDCM, n=67 [30.7%]), arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARCD/C, n=13 [6%]), hypertrophic cardiomyopathy (HCM, n=5 [2.3%]), and absence of str... Abstract

Cited 21 times since 2011 (1.5 per year) source: EuropePMC

Inflammatory bowel diseases, Volume 18, Issue 6, 11 2 2011, Pages 1026-1033 Strategies in maintenance for patients receiving long-term therapy (SIMPLE): a study of MMX mesalamine for the long-term maintenance of quiescent ulcerative colitis. Kane S, Katz S, Jamal MM, Safdi M, Dolin B, Solomon D, Palmen M, Barrett K

Background: This was a phase IV, multicenter, open-label, 12-14-month study to assess clinical recurrence in patients with ulcerative colitis (UC) who received maintenance treatment with MMX Multi Matrix System (MMX) mesalamine. A secondary outcome was the relationship between long-term efficacy and adherence. Methods: Patients with quiescent UC (no rectal bleeding; 0-1 bowel movements more than normal per day) were enrolled directly into a 12-month maintenance phase of the study during which th... Abstract

Cited 27 times since 2011 (2 per year) source: EuropePMC

BMC geriatrics, Volume 11, 11 2 2011, Pages 39 Delirium risk screening and haloperidol prophylaxis program in hip fracture patients is a helpful tool in identifying high-risk patients, but does not reduce the incidence of delirium. Vochteloo AJ, Moerman S, van der Burg BL, de Boo M, de Vries MR, Niesten DD, Tuinebreijer WE, Nelissen RG, Pilot P

Background: Delirium in patients with hip fractures lead to higher morbidity and mortality. Prevention in high-risk patients by prescribing low dose haloperidol is currently under investigation. Methods: This prospective cohort surveillance assessed hip fracture patients for risk of developing a delirium with the Risk Model for Delirium (RD) score. High-risk patients (score ≥ 5 points) were treated with a prophylactic low-dose of haloperidol according to hospital protocol. Primary outcome was de... Abstract

Cited 34 times since 2011 (2.5 per year) source: EuropePMC

European heart journal, Volume 33, Issue 9, 10 2 2011, Pages 1076-1084 Galectin-2 expression is dependent on the rs7291467 polymorphism and acts as an inhibitor of arteriogenesis. van der Laan AM, Schirmer SH, de Vries MR, Koning JJ, Volger OL, Fledderus JO, Bastiaansen AJ, Hollander MR, Baggen JM, Koch KT, Baan J, Henriques JP, van der Schaaf RJ, Vis MM, Mebius RE, van der Pouw Kraan TC, Quax PH, Piek JJ, Horrevoets AJ, van Royen N

Aims: In patients with obstructive coronary artery disease (CAD), the growth of collateral arteries, i.e. arteriogenesis, can preserve myocardial tissue perfusion and function. Monocytes modulate this process, supplying locally the necessary growth factors and degrading enzymes. Knowledge on factors involved in human arteriogenesis is scarce. Thus, the aim of the present study is to identify targets in monocytes that are critical for arteriogenesis in patients with CAD. Methods and results: A to... Abstract

Cited 26 times since 2011 (1.9 per year) source: EuropePMC

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, Volume 24, Issue 10, 6 1 2011, Pages 1126-1133 Comprehensive assessment of changes in left atrial volumes and function after ST-segment elevation acute myocardial infarction: role of two-dimensional speckle-tracking strain imaging. Antoni ML, Ten Brinke EA, Marsan NA, Atary JZ, Holman ER, van der Wall EE, Schalij MJ, Bax JJ, Delgado V

Background: Left atrial (LA) size has been associated with adverse outcome in patients after acute myocardial infarction. However, data about the occurrence of late LA enlargement and changes in LA function during follow-up are scarce. The purpose of the current study was to evaluate changes in LA size and function during 1-year follow-up. Methods: The study population comprised 407 patients with acute myocardial infarction who were treated with primary percutaneous coronary intervention. At bas... Abstract

Cited 8 times since 2011 (0.6 per year) source: EuropePMC

Heart rhythm, Volume 9, Issue 1, 5 1 2011, Pages 10-17 Catheter ablation of ventricular tachycardia after left ventricular reconstructive surgery for ischemic cardiomyopathy. Wijnmaalen AP, Roberts-Thomson KC, Steven D, Klautz RJ, Willems S, Schalij MJ, Stevenson WG, Zeppenfeld K

Background: After surgical ventricular restoration (SVR) for ischemic cardiomyopathy, ventricular tachycardias (VTs) are an important reason for postoperative morbidity and mortality. Objective: The purpose of this study was to elucidate the VT substrate, VT characteristics, and outcome of radiofrequency catheter ablation (RFCA) in patients with VT after SVR. Methods: Twelve (3%) of 416 patients referred for RFCA for VT after myocardial infarction in three centers had undergone SVR. After induct... Abstract

Cited 94 times since 2011 (6.9 per year) source: EuropePMC

European heart journal, Volume 33, Issue 16, 4 1 2011, Pages 2098-2108 Aldosterone promotes atrial fibrillation. Reil JC, Hohl M, Selejan S, Lipp P, Drautz F, Kazakow A, Münz BM, Müller P, Steendijk P, Reil GH, Allessie MA, Böhm M, Neuberger HR

Aims: Hyperaldosteronism is associated with an increased prevalence of atrial fibrillation (AF). However, it is unclear whether this is the consequence of altered haemodynamics or a direct aldosterone effect. It was the aim of the study to demonstrate load-independent effects of aldosterone on atrial structure and electrophysiology. Methods: Osmotic mini-pumps delivering 1.5 µg/h aldosterone were implanted subcutaneously in rats (Aldo). Rats without aldosterone treatment served as controls. Afte... Abstract

Cited 93 times since 2011 (6.8 per year) source: EuropePMC

Circulation, Volume 124, Issue 8, 1 1 2011, Pages 912-919 Cardiac resynchronization therapy as a therapeutic option in patients with moderate-severe functional mitral regurgitation and high operative risk. van Bommel RJ, Marsan NA, Delgado V, Borleffs CJ, van Rijnsoever EP, Schalij MJ, Bax JJ

Background: Functional mitral regurgitation (MR) is a common finding in heart failure patients with dilated cardiomyopathy and has important prognostic implications. However, the increased operative risk of these patients may result in low referral or high denial rate for mitral valve surgery. Cardiac resynchronization therapy (CRT) has been shown to have a favorable effect on MR. Aims of this study were to (1) evaluate CRT as a therapeutic option in heart failure patients with functional MR and... Abstract

Cited 4 times since 2011 (0.3 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 97, Issue 15, 1 1 2011, Pages 1268-1276 Pharmacogenetics of antiplatelet therapy: ready for clinical application? Verschuren JJ, Jukema JW

Abstract

Cited 35 times since 2011 (2.6 per year) source: EuropePMC

Journal of the American Academy of Dermatology, Volume 65, Issue 2, 1 1 2011, Pages 420-421 Atenolol: a promising alternative to propranolol for the treatment of hemangiomas. Raphaël MF, de Graaf M, Breugem CC, Pasmans SGMA, Breur JMPJ

Abstract

Cited 17 times since 2011 (1.2 per year) source: EuropePMC

EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, Volume 7, Issue 4, 1 1 2011, Pages 505-516 Clinical performance of drug-eluting stents with biodegradable polymeric coating: a meta-analysis and systematic review. Ahmed TA, Bergheanu SC, Stijnen T, Plevier JW, Quax PH, Jukema JW

Aims: Different biodegradable-polymer drug-eluting stents have not yet been systematically analysed. We sought to; 1) evaluate the risk of target lesion revascularisation (TLR) and definite stent thrombosis (DST) among different groups of biodegradable-polymer (BioPol) DES, and 2) to compare them with permanent polymer (PermPol) DES. Methods and results: We searched PubMed and relevant sources from January 2005 until October 2010. Inclusion criteria were (a) Implantation of a drug-eluting stent... Abstract

Cited 2 times since 2011 (0.1 per year) source: EuropePMC

Journal of magnetic resonance imaging : JMRI, Volume 34, Issue 2, 1 1 2011, Pages 270-278 Automated regional wall motion abnormality detection by combining rest and stress cardiac MRI: correlation with contrast-enhanced MRI. Suinesiaputra A, Frangi AF, Kaandorp TA, Lamb HJ, Bax JJ, Reiber JH, Lelieveldt BP

Purpose: To correlate an automated regional wall motion abnormality (RWMA) detection method based on combined rest and dobutamine-stress cardiac MRI with the assessment of myocardial infarction from contrast-enhanced MRI (CE-MRI), and to demonstrate that adding stress data improves the detection of scar segments compared with rest data alone. Materials and methods: An automated RWMA detection method was built based on a statistical model of normokinetic myocardium from 41 healthy volunteers. The... Abstract

Cited 72 times since 2011 (5.3 per year) source: EuropePMC

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, Volume 18, Issue 4, 1 1 2011, Pages 685-694 SPECT myocardial perfusion imaging for the assessment of left ventricular mechanical dyssynchrony. Chen J, Garcia EV, Bax JJ, Iskandrian AE, Borges-Neto S, Soman P

Phase analysis of gated single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) is an evolving technique for measuring LV mechanical dyssynchrony. Since its inception in 2005, it has undergone considerable technical development and clinical evaluation. This article reviews the background, the technical and clinical characteristics, and evolving clinical applications of phase analysis of gated SPECT MPI in patients requiring cardiac resynchronization therapy or impla... Abstract

Cited 138 times since 2011 (10.1 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 58, Issue 10, 1 1 2011, Pages 995-1000 Implantation-related complications of implantable cardioverter-defibrillators and cardiac resynchronization therapy devices: a systematic review of randomized clinical trials. van Rees JB, de Bie MK, Thijssen J, Borleffs CJ, Schalij MJ, van Erven L

The number of implantable cardioverter-defibrillator (ICD) and cardiac resynchronization therapy (CRT) implantations is increasing drastically worldwide, and hence, the number of implanting centers is also increasing. Despite abundant data on the beneficial effect of these devices, little is known regarding safety and complication rates. Eleven ICD and 7 CRT trials were systematically reviewed to provide data on the frequency of in-hospital mortality and complications related to the implantation... Abstract

Cited 47 times since 2011 (3.5 per year) source: EuropePMC

European heart journal, Volume 33, Issue 2, 30 5 2011, Pages 165-175 A systematic review on pharmacogenetics in cardiovascular disease: is it ready for clinical application? Verschuren JJ, Trompet S, Wessels JA, Guchelaar HJ, de Maat MP, Simoons ML, Jukema JW

Pharmacogenetics is the search for heritable genetic polymorphisms that influence responses to drug therapy. The most important application of pharmacogenetics is to guide choosing agents with the greatest potential of efficacy and smallest risk of adverse drug reactions. Many studies focusing on drug-gene interactions have been published in recent years, some of which led to adaptation of FDA recommendations, indicating that we are on the verge of the clinical application of genetic information... Abstract

Cited 44 times since 2011 (3.2 per year) source: EuropePMC

American journal of obstetrics and gynecology, Volume 206, Issue 1, 30 5 2011, Pages 89.e1-5 Optimization of near-infrared fluorescent sentinel lymph node mapping for vulvar cancer. Hutteman M, van der Vorst JR, Gaarenstroom KN, Peters AA, Mieog JS, Schaafsma BE, Löwik CW, Frangioni JV, van de Velde CJ, Vahrmeijer AL

Objectives: Near-infrared fluorescence imaging has the potential to improve sentinel lymph node mapping in vulvar cancer, which was assessed in the current study. Furthermore, dose optimization of indocyanine green adsorbed to human serum albumin was performed. Study design: Nine vulvar cancer patients underwent the standard sentinel lymph node procedure using (99m)technetium-nancolloid and patent blue. In addition, intraoperative imaging was performed after peritumoral injection of 1.6 mL of 50... Abstract

Brain & development, Volume 34, Issue 4, 23 4 2011, Pages 298-301 Cerebrospinal fluid apolipoprotein E levels in subacute sclerosing panencephalitis. Yüksel D, Ichiyama T, Yilmaz D, Anlar B

Neurofibrillary tangles (NFTs) have been shown in 20% of subacute sclerosing panencephalitis (SSPE) cases. NFTs contain paired helical filaments formed by hyperphosphorylated tau. The intraneuronal tau metabolism and the rate of formation of paired helical filaments can be regulated by interactions between tau and isoforms of Apolipoprotein E (Apo E). Tau binds in vitro to Apo E3, interferes with the hyperphosphorylation of tau and may reduce the formation of NFTs. We investigated cerebrospinal... Abstract

Cited 19 times since 2011 (1.4 per year) source: Scopus

European heart journal, Volume 32, Issue 22, 23 4 2011, Pages 2806-2813 Influence of left ventricular geometry and function on aortic annular dimensions as assessed with multi-detector row computed tomography: implications for transcatheter aortic valve implantation. Ng AC, Yiu KH, Ewe SH, van der Kley F, Bertini M, de Weger A, de Roos A, Leung DY, Schuijf JD, Schalij MJ, Bax JJ, Delgado V

Aims: Evaluate changes in aortic annular dimensions in relation to severe aortic stenosis (AS) and left ventricular (LV) dysfunction. Methods and results: Mean aortic annular diameters and geometries were compared between 90 severe AS patients and 111 controls by multi-detector row computed tomography (MDCT). All severe AS patients were also dichotomized into two groups based on the presence of preserved (≥ 50%) or impaired ( Abstract