Research

Publications

Below you can find a list of our published research.

6139 results

Cited 11 times since 2018 (1.7 per year) source: EuropePMC

The American journal of cardiology, Volume 122, Issue 10, 21 3 2018, Pages 1732-1737 Prevalence and Prognostic Implications of Mitral and Aortic Valve Calcium in Patients With Chronic Kidney Disease. Hensen LCR, Mahdiui ME, van Rosendael AR, Smit JM, Jukema JW, Bax JJ, Delgado V

Calcium in the cardiac valves can be observed in patients with severe chronic kidney disease (CKD). However, the prevalence and prognostic implications of left-sided cardiac valve calcium in patients with stage 2 and 3 CKD (estimated glomerular filtration rate (eGFR) of 60 to 89 and 30 to 59 ml/min/1.73 m² respectively) is unknown. The present study investigates the prevalence of mitral and aortic valve calcium in patients with stage 2 and 3 CKD and evaluates its association with all-cause morta... Abstract

Cited 9 times since 2018 (1.4 per year) source: EuropePMC

Endocrine, Volume 62, Issue 3, 20 3 2018, Pages 639-647 SSTR2A expression in medullary thyroid carcinoma is correlated with longer survival. de Vries LH, Lodewijk L, Willems SM, Dreijerink KMA, de Keizer B, van Diest PJ, Schepers A, Bonenkamp HJ, van Engen-van Grunsven IACH, Kruijff S, van Hemel BM, Links TP, Nieveen van Dijkum EJM, van Eeden S, Valk GD, Borel Rinkes IHM, Vriens MR

Purpose: Medullary thyroid carcinoma (MTC) derives from the parafollicular C-cells of the thyroid gland. Somatostatin receptors (SSTRs) are expressed in various neuroendocrine tumours including MTC. The aim of this study was to evaluate SSTR2A as a prognostic factor for MTC, to study distribution of SSTR2A expression within tumours and to compare expression of SSTR2A between primary tumours and corresponding lymph node metastases. Methods: Patients who underwent surgery between 1988 and 2014 for... Abstract

Cited 3 times since 2018 (0.5 per year) source: EuropePMC

The American journal of cardiology, Volume 122, Issue 10, 20 3 2018, Pages 1591-1597 Effect of Guideline-Based Therapy on Left Ventricular Systolic Function Recovery After ST-Segment Elevation Myocardial Infarction. Abou R, Leung M, Goedemans L, Hoogslag GE, Schalij MJ, Marsan NA, Bax JJ, Delgado V

Little is known about the proportion of ST-segment elevation myocardial infarction (STEMI) patients treated with primary percutaneous coronary intervention, who have reduced left ventricular ejection fraction (LVEF) within 48 hours (baseline) of admission and exhibit LVEF recovery under optimal guideline-based medical treatment. Therefore, the present study evaluates the evolution of LVEF in patients after STEMI and under guideline-based medical therapy. In 2,853 STEMI patients treated with prim... Abstract

Cited 20 times since 2018 (3 per year) source: EuropePMC

The Journal of thoracic and cardiovascular surgery, Volume 156, Issue 6, 18 3 2018, Pages 2260-2269 Coding of coronary arterial origin and branching in congenital heart disease: The modified Leiden Convention. Gittenberger-de Groot AC, Koenraadt WMC, Bartelings MM, Bökenkamp R, DeRuiter MC, Hazekamp MG, Bogers AJJC, Quaegebeur JM, Schalij MJ, Vliegen HW, Poelmann RE, Jongbloed MRM

Objectives: Variations in coronary anatomy are common and may relate to the position of the coronary ostium relative to the aortic sinus, the angle of coronary take-off, or the course of the coronary arterial branches. Several classification systems have been proposed. However, they all lack a simple rationale that is applicable irrespective of the relative position of the great arteries, as well as in bicuspid aortic valves. We present a modification of a relatively simple system introduced in... Abstract

Accident; analysis and prevention, Volume 125, 18 3 2018, Pages 336-343 Forecasting German crash numbers: The effect of meteorological variables. Diependaele K, Martensen H, Lerner M, Schepers A, Bijleveld F, Commandeur JJF

At the end of each year, the German Federal Highway Research Institute (BASt) publishes the road safety balance of the closing year. They describe the development of accident and casualty numbers disaggregated by road user types, age groups, type of road and the consequences of the accidents. However, at the time of publishing, these series are only available for the first eight or nine months of the year. To make the balance for the whole year, the last three or four months are forecasted. The... Abstract

Cited 11 times since 2018 (1.7 per year) source: EuropePMC

American heart journal, Volume 205, 16 3 2018, Pages 70-76 Mortality differences in acute myocardial infarction patients in the Netherlands: The weekend-effect. Eindhoven DC, Wu HW, Kremer SWF, van Erkelens JA, Cannegieter SC, Schalij MJ, Borleffs CJW

Objective: Several studies have shown that patients admitted with an acute myocardial infarction during the weekends have a higher mortality rate than those admitted during weekdays, possibly attributable to less trained personnel available and a lower use of medical procedures. The current study aimed to assess this ‘weekend-effect’ in a nationwide registry. Methods: In the Netherlands, all inhabitants are, by law, obliged to have health insurance and all claim data are centrally registered. In... Abstract

JACC. Cardiovascular interventions, Volume 11, Issue 17, 15 3 2018, Pages e141-e142 Difficult Vascular Access in Urgent Coronary Artery Angiogram: A Rare Case of a Persistent Sciatic Artery. van Rees JB, Montero-Cabezas JM, Ghariq E, Schalij MJ

Abstract

Cited 48 times since 2018 (7.3 per year) source: EuropePMC

Circulation, Volume 138, Issue 22, 15 3 2018, Pages 2499-2512 Metabolomic consequences of genetic inhibition of PCSK9 compared with statin treatment. Sliz E, Kettunen J, Holmes MV, Williams CO, Boachie C, Wang Q, Männikkö M, Sebert S, Walters R, Lin K, Millwood IY, Clarke R, Li L, Rankin N, Welsh P, Delles C, Jukema JW, Trompet S, Ford I, Perola M, Salomaa V, Järvelin MR, Chen Z, Lawlor DA, Ala-Korpela M, Danesh J, Davey Smith G, Sattar N, Butterworth A, Würtz P

Background: Both statins and PCSK9 inhibitors lower blood low-density lipoprotein cholesterol (LDL-C) levels to reduce risk of cardiovascular events. To assess potential differences between metabolic effects of these two lipid-lowering therapies, we performed detailed lipid and metabolite profiling of a large randomized statin trial and compared the results with the effects of genetic inhibition of PCSK9, acting as a naturally occurring trial. Methods: 228 circulating metabolic measures were qua... Abstract

Cited 4 times since 2018 (0.6 per year) source: EuropePMC

The Annals of thoracic surgery, Volume 106, Issue 5, 14 2 2018, Pages 1371-1378 Vasoplegia After Surgical Left Ventricular Restoration: 2-Year Follow-Up. van Vessem ME, Palmen M, Couperus LE, Stijnen T, Berendsen RR, Aarts LPHJ, de Jonge E, Klautz RJM, Schalij MJ, Beeres SLMA

Background: Vasoplegia is a severe complication that can develop after surgical procedures for heart failure. The current study evaluated the effect of vasoplegia on survival, cardiac function, and renal function 2 years after surgical left ventricular restoration (SVR). Methods: Heart failure patients with a left ventricular ejection fraction (LVEF) of 0.35 or less who underwent SVR in 2006 to 2014 were included. Vasoplegia was defined as the continuous need of vasopressors (norepinephrine ≥0.2... Abstract

Cited 2 times since 2018 (0.3 per year) source: EuropePMC

European heart journal. Case reports, Volume 2, Issue 3, 2 1 2018, Pages yty090 Rupture of a giant aneurysm of the sinus of Valsalva leading to acute heart failure: a case report demonstrating the excellence of echocardiography. Wierda E, Koolbergen DR, de Mol BAJM, Bouma BJ

Abstract

Cited 51 times since 2018 (7.7 per year) source: EuropePMC

Peptides, Volume 107, 1 1 2018, Pages 25-31 Sex differences in body fat distribution are related to sex differences in serum leptin and adiponectin. Christen T, Trompet S, Noordam R, van Klinken JB, van Dijk KW, Lamb HJ, Cobbaert CM, den Heijer M, Jazet IM, Jukema JW, Rosendaal FR, de Mutsert R

It is debated whether sex differences in adiponectin and leptin are due to sex differences in body fat distribution. In this cross-sectional analysis of the Netherlands Epidemiology of Obesity study, associations of measures of body fat and sex with serum adiponectin and leptin concentrations were examined using linear regression analysis (n = 6494, VAT: n = 2516). Sex differences were additionally adjusted for the measure of body fat that was most strongly associated with adiponectin or leptin... Abstract

Cited 22 times since 2018 (3.3 per year) source: EuropePMC

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, Volume 31, Issue 8, 1 1 2018, Pages 916-925 Impact of Diabetes and Increasing Body Mass Index Category on Left Ventricular Systolic and Diastolic Function. Ng ACT, Prevedello F, Dolci G, Roos CJ, Djaberi R, Bertini M, Ewe SH, Allman C, Leung DY, Marsan NA, Delgado V, Bax JJ

Background: Diabetes and obesity are both worldwide growing epidemics, and both are independently associated with increased risk for heart failure and death. The aim of this study was to examine the additive detrimental effect of both diabetes and increasing body mass index (BMI) category on left ventricular (LV) myocardial systolic and diastolic function. Methods: The present retrospective multicenter study included 653 patients (337 with type 2 diabetes and 316 without diabetes) of increasing... Abstract

Cited 6 times since 2018 (0.9 per year) source: EuropePMC

Arrhythmia & electrophysiology review, Volume 7, Issue 3, 1 1 2018, Pages 169-180 The Impact of Advances in Atrial Fibrillation Ablation Devices on the Incidence and Prevention of Complications. Keçe F, Zeppenfeld K, Trines SA

The number of patients with atrial fibrillation currently referred for catheter ablation is increasing. However, the number of trained operators and the capacity of many electrophysiology labs are limited. Accordingly, a steeper learning curve and technical advances for efficient and safe ablation are desirable. During the last decades several catheter-based ablation devices have been developed and adapted to improve not only lesion durability, but also safety profiles, to shorten procedure time... Abstract

Cited 66 times since 2018 (10 per year) source: EuropePMC

Circulation. Cardiovascular imaging, Volume 11, Issue 8, 1 1 2018, Pages e007372 Impact of Epicardial Adipose Tissue, Left Ventricular Myocardial Fat Content, and Interstitial Fibrosis on Myocardial Contractile Function. Ng ACT, Strudwick M, van der Geest RJ, Ng ACC, Gillinder L, Goo SY, Cowin G, Delgado V, Wang WYS, Bax JJ

Background Current understanding of metabolic heart disease consists of a myriad of different pathophysiological mechanisms. Epicardial adipose tissue (EAT) is increasingly recognized as metabolically active and associated with adverse cardiovascular outcomes. The present study aimed to investigate the effect of increased EAT volume index on left ventricular (LV) myocardial fat content and burden of interstitial myocardial fibrosis and their subsequent effects on LV myocardial contractile functi... Abstract

Cited 125 times since 2018 (18.9 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 72, Issue 8, 1 1 2018, Pages 874-882 Long-Term Prognosis of Patients With Takotsubo Syndrome. Ghadri JR, Kato K, Cammann VL, Gili S, Jurisic S, Di Vece D, Candreva A, Ding KJ, Micek J, Szawan KA, Bacchi B, Bianchi R, Levinson RA, Wischnewsky M, Seifert B, Schlossbauer SA, Citro R, Bossone E, Münzel T, Knorr M, Heiner S, D'Ascenzo F, Franke J, Sarcon A, Napp LC, Jaguszewski M, Noutsias M, Katus HA, Burgdorf C, Schunkert H, Thiele H, Bauersachs J, Tschöpe C, Pieske BM, Rajan L, Michels G, Pfister R, Cuneo A, Jacobshagen C, Hasenfuß G, Karakas M, Koenig W, Rottbauer W, Said SM, Braun-Dullaeus RC, Banning A, Cuculi F, Kobza R, Fischer TA, Vasankari T, Airaksinen KEJ, Opolski G, Dworakowski R, MacCarthy P, Kaiser C, Osswald S, Galiuto L, Crea F, Dichtl W, Empen K, Felix SB, Delmas C, Lairez O, El-Battrawy I, Akin I, Borggrefe M, Horowitz J, Kozel M, Tousek P, Widimský P, Gilyarova E, Shilova A, Gilyarov M, Winchester DE, Ukena C, Bax JJ, Prasad A, Böhm M, Lüscher TF, Ruschitzka F, Templin C

Background: Prognosis of Takotsubo syndrome (TTS) remains controversial due to scarcity of available data. Additionally, the effect of the triggering factors remains elusive. Objectives: This study compared prognosis between TTS and acute coronary syndrome (ACS) patients and investigated short- and long-term outcomes in TTS based on different triggers. Methods: Patients with TTS were enrolled from the International Takotsubo Registry. Long-term mortality of patients with TTS was compared to an a... Abstract

Cited 48 times since 2018 (7.2 per year) source: EuropePMC

European heart journal, Volume 39, Issue 31, 1 1 2018, Pages 2867-2875 Whole human heart histology to validate electroanatomical voltage mapping in patients with non-ischaemic cardiomyopathy and ventricular tachycardia. Glashan CA, Androulakis AFA, Tao Q, Glashan RN, Wisse LJ, Ebert M, de Ruiter MC, van Meer BJ, Brouwer C, Dekkers OM, Pijnappels DA, de Bakker JMT, de Riva M, Piers SRD, Zeppenfeld K

Aims: Electroanatomical voltage mapping (EAVM) is an important diagnostic tool for fibrosis identification and risk stratification in non-ischaemic cardiomyopathy (NICM); currently, distinct cut-offs are applied. We aimed to evaluate the performance of EAVM to detect fibrosis by integration with whole heart histology and to identify the fibrosis pattern in NICM patients with ventricular tachycardias (VTs). Methods and results: Eight patients with NICM and VT underwent EAVM prior to death or hear... Abstract

Cited 4 times since 2018 (0.6 per year) source: EuropePMC

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, Volume 56, Issue 4, 1 1 2018, Pages 476-485 The Dutch Audit of Carotid Interventions: Transparency in Quality of Carotid Endarterectomy in Symptomatic Patients in the Netherlands. Karthaus EG, Vahl A, Kuhrij LS, Elsman BHP, Geelkerken RH, Wouters MWJM, Hamming JF, de Borst GJ, Dutch Society of Vascular Surgery, Steering Committee of the Dutch Audit for Carotid Interventions, Dutch Institute for Clinical Auditing

Background: The Dutch Audit for Carotid Interventions (DACI) registers all patients undergoing interventions for carotid artery stenosis in the Netherlands. This study describes the design of the DACI and results of patients with a symptomatic stenosis undergoing carotid endarterectomy (CEA). It aimed to evaluate variation between hospitals in process of care and (adjusted) outcomes, as well as predictors of major stroke/death after CEA. Methods: All patients with a symptomatic stenosis, who und... Abstract

Cited 4 times since 2018 (0.6 per year) source: EuropePMC

Cardiac failure review, Volume 4, Issue 2, 1 1 2018, Pages 78-86 Imaging of Valvular Heart Disease in Heart Failure. Podlesnikar T, Delgado V, Bax JJ

Valvular heart disease (VHD) and heart failure (HF) are major health issues that are steadily increasing in prevalence in Western populations. VHD and HF frequently co-exist, which can complicate the accurate diagnosis of the severity of valve stenosis or regurgitation and affect decisions about therapeutic options. Transthoracic echocardiography is the first-line imaging modality to determine left ventricular (LV) systolic function, to grade valvular stenosis or regurgitation and to characteris... Abstract

Cited 46 times since 2018 (6.9 per year) source: EuropePMC

European heart journal. Cardiovascular Imaging, Volume 19, Issue 8, 1 1 2018, Pages 859-867 Left ventricular global longitudinal strain is predictive of all-cause mortality independent of aortic stenosis severity and ejection fraction. Ng ACT, Prihadi EA, Antoni ML, Bertini M, Ewe SH, Ajmone Marsan N, Leung DY, Delgado V, Bax JJ

Aims: Left ventricular (LV) global longitudinal strain (GLS) may identify subclinical myocardial dysfunction in patients with aortic stenosis (AS). The aims of the present retrospective single centre study were to determine the independent prognostic value of LV GLS over LV ejection fraction (EF) and the role of LV GLS to further risk stratify severe AS patients before aortic valve replacement. Methods and results: A total of 688 patients (median age 72 years, 61.2% men) with mild (n = 130), mod... Abstract

Cited 27 times since 2018 (4.1 per year) source: EuropePMC

Arteriosclerosis, thrombosis, and vascular biology, Volume 38, Issue 8, 1 1 2018, Pages 1796-1805 Systemic Upregulation of IL-10 (Interleukin-10) Using a Nonimmunogenic Vector Reduces Growth and Rate of Dissecting Abdominal Aortic Aneurysm. Adam M, Kooreman NG, Jagger A, Wagenhäuser MU, Mehrkens D, Wang Y, Kayama Y, Toyama K, Raaz U, Schellinger IN, Maegdefessel L, Spin JM, Hamming JF, Quax PHA, Baldus S, Wu JC, Tsao PS

Objective- Recruitment of immunologic competent cells to the vessel wall is a crucial step in formation of abdominal aortic aneurysms (AAA). Innate immunity effectors (eg, macrophages), as well as mediators of adaptive immunity (eg, T cells), orchestrate a local vascular inflammatory response. IL-10 (interleukin-10) is an immune-regulatory cytokine with a crucial role in suppression of inflammatory processes. We hypothesized that an increase in systemic IL-10-levels would mitigate AAA progressio... Abstract