Research

Publications

Below you can find a list of our published research.

8313 results

Cited 8 times since 2018 (1.3 per year) source: EuropePMC

Addiction (Abingdon, England), Volume 114, Issue 2, 30 5 2018, Pages 216-225 Association of alcohol consumption with allergic disease and asthma: a multi-centre Mendelian randomization analysis. Skaaby T, Kilpeläinen TO, Taylor AE, Mahendran Y, Wong A, Ahluwalia TS, Paternoster L, Trompet S, Stott DJ, Flexeder C, Zhou A, Brusselle G, Sajjad A, Lahousse L, Tiemeier H, Have CT, Thuesen BH, Kårhus LL, Møllehave LT, Leth-Møller KB, Shabanzadeh DM, Gonzalez-Quintela A, Power C, Hyppönen E, Kuh D, Hardy R, Meitinger T, Jukema JW, Völker U, Nauck M, Völzke H, Friedrich N, Bonten TN, Noordam R, Mook-Kanamori DO, Tolstrup JS, Taube C, Peters A, Grallert H, Strauch K, Schulz H, Grarup N, Hansen T, Pedersen O, Burgess S, Munafò MR, Linneberg A

Aims: To use the rs1229984 variant associated with alcohol consumption as an instrument for alcohol consumption to test the causality of the association of alcohol consumption with hay fever, asthma, allergic sensitization and serum total immunoglobulin (Ig)E. Design: Observational and Mendelian randomization analyses using genetic variants as unbiased markers of exposure to estimate causal effects, subject to certain assumptions. Setting: Europe. Participants: We included a total of 466 434 peo... Abstract

Cited 32 times since 2018 (5 per year) source: EuropePMC

Radiology, Volume 290, Issue 1, 30 5 2018, Pages 70-78 Automated Cardiac Valve Tracking for Flow Quantification with Four-dimensional Flow MRI. Kamphuis VP, Roest AAW, Ajmone Marsan N, van den Boogaard PJ, Kroft LJM, Aben JP, Bax JJ, de Roos A, Lamb HJ, Westenberg JJM

Purpose To compare four-dimensional flow MRI with automated valve tracking to manual valve tracking in patients with acquired or congenital heart disease and healthy volunteers. Materials and Methods In this retrospective study, data were collected from 114 patients and 46 volunteers who underwent four-dimensional flow MRI at 1.5 T or 3.0 T from 2006 through 2017. Among the 114 patients, 33 had acquired and 81 had congenital heart disease (median age, 17 years; interquartile range [IQR], 13-49 y... Abstract

Cited 4 times since 2018 (0.6 per year) source: EuropePMC

Cartilage, Volume 12, Issue 1, 29 5 2018, Pages 112-120 Development of an Ex Vivo Murine Osteochondral Repair Model. van Schaik TJA, Gaul F, Dorthé EW, Lee EE, Grogan SP, D'Lima DD

Objective: Mouse models are commonly used in research applications due to the relatively low cost, highly characterized strains, as well as the availability of many genetically modified phenotypes. In this study, we characterized an ex vivo murine osteochondral repair model using human infrapatellar fat pad (IPFP) progenitor cells. Design: Femurs from euthanized mice were removed and clamped in a custom multidirectional vise to create cylindrical osteochondral defects 0.5 mm in diameter and 0.5... Abstract

Cited 3 times since 2018 (0.5 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 105, Issue 9, 27 4 2018, Pages 701-707 Coronary anatomy in Turner syndrome versus patients with isolated bicuspid aortic valves. Koenraadt WMC, Siebelink HJ, Bartelings MM, Schalij MJ, van der Vlugt MJ, van den Bosch AE, Budde RPJ, Roos-Hesselink JW, Duijnhouwer AL, van den Hoven AT, DeRuiter MC, Jongbloed MRM

Objective: Variations in coronary anatomy, like absent left main stem and left dominant coronary system, have been described in patients with Turner syndrome (TS) and in patients with bicuspid aortic valves (BAV). It is unknown whether coronary variations in TS are related to BAV and to specific BAV subtypes. Aim: To compare coronary anatomy in patients with TS with/without BAV versus isolated BAV and to study BAV morphology subtypes in these groups. Methods: Coronary anatomy and BAV morphology... Abstract

Cited 11 times since 2018 (1.7 per year) source: EuropePMC

The Journal of thoracic and cardiovascular surgery, Volume 157, Issue 6, 26 4 2018, Pages 2202-2211.e7 AVIATOR: An open international registry to evaluate medical and surgical outcomes of aortic valve insufficiency and ascending aorta aneurysm. de Heer F, Kluin J, Elkhoury G, Jondeau G, Enriquez-Sarano M, Schäfers HJ, Takkenberg JJM, Lansac E, Aortic Valve Repair Research Network Investigators

Objectives: Current national registries are lacking detailed pathology-driven analysis and long-term patients outcomes. The Heart Valve Society (HVS) aortic valve (AV) repair research network started the Aortic Valve Insufficiency and ascending aorta Aneurysm InternATiOnal Registry (AVIATOR) to evaluate long-term patient outcomes of AV repair and replacement. The purpose of the current report is to describe the AVIATOR initiative and report in a descriptive manner the patients included. Methods:... Abstract

Cited 133 times since 2018 (20.9 per year) source: EuropePMC

Nature communications, Volume 9, Issue 1, 26 4 2018, Pages 4455 Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation. Teumer A, Chaker L, Groeneweg S, Li Y, Di Munno C, Barbieri C, Schultheiss UT, Traglia M, Ahluwalia TS, Akiyama M, Appel EVR, Arking DE, Arnold A, Astrup A, Beekman M, Beilby JP, Bekaert S, Boerwinkle E, Brown SJ, De Buyzere M, Campbell PJ, Ceresini G, Cerqueira C, Cucca F, Deary IJ, Deelen J, Eckardt KU, Ekici AB, Eriksson JG, Ferrrucci L, Fiers T, Fiorillo E, Ford I, Fox CS, Fuchsberger C, Galesloot TE, Gieger C, Gögele M, De Grandi A, Grarup N, Greiser KH, Haljas K, Hansen T, Harris SE, van Heemst D, den Heijer M, Hicks AA, den Hollander W, Homuth G, Hui J, Ikram MA, Ittermann T, Jensen RA, Jing J, Jukema JW, Kajantie E, Kamatani Y, Kasbohm E, Kaufman JM, Kiemeney LA, Kloppenburg M, Kronenberg F, Kubo M, Lahti J, Lapauw B, Li S, Liewald DCM, Lifelines Cohort Study, Lim EM, Linneberg A, Marina M, Mascalzoni D, Matsuda K, Medenwald D, Meisinger C, Meulenbelt I, De Meyer T, Meyer Zu Schwabedissen HE, Mikolajczyk R, Moed M, Netea-Maier RT, Nolte IM, Okada Y, Pala M, Pattaro C, Pedersen O, Petersmann A, Porcu E

Thyroid dysfunction is an important public health problem, which affects 10% of the general population and increases the risk of cardiovascular morbidity and mortality. Many aspects of thyroid hormone regulation have only partly been elucidated, including its transport, metabolism, and genetic determinants. Here we report a large meta-analysis of genome-wide association studies for thyroid function and dysfunction, testing 8 million genetic variants in up to 72,167 individuals. One-hundred-and-n... Abstract

Cited 5 times since 2018 (0.8 per year) source: EuropePMC

Heart rhythm, Volume 16, Issue 4, 26 4 2018, Pages 624-631 Evaluation and management of ventricular tachycardia in patients with dilated cardiomyopathy. Ebert M, Richter S, Dinov B, Zeppenfeld K, Hindricks G

Recurrent ventricular tachycardia (VT) is an important cause of increased morbidity and mortality in patients with non-ischemic dilated cardiomyopathy (DCM). Current recommendations for the treatment of VT in patients with structural heart disease mainly rely on data derived from patients with ischemic cardiomyopathy. Unlike postinfarction ischemic cardiomyopathy, DCM comprises multiple different etiologies with variable disease progression and prognosis, which often requires an individualized a... Abstract

Cited 25 times since 2018 (3.9 per year) source: EuropePMC

Journal of human evolution, Volume 125, 25 4 2018, Pages 38-49 The slow ape: High infant survival and long interbirth intervals in wild orangutans. van Noordwijk MA, Utami Atmoko SS, Knott CD, Kuze N, Morrogh-Bernard HC, Oram F, Schuppli C, van Schaik CP, Willems EP

Orangutans (Pongo spp.) are reported to have extremely slow life histories, including the longest average interbirth intervals of all mammals. Such slow life history can be viable only when unavoidable mortality is kept low. Thus, orangutans' survivorship under natural conditions is expected to be extremely high. Previous estimates of orangutan life history were based on captive individuals living under very different circumstances or on small samples from wild populations. Here, we combine... Abstract

Cited 21 times since 2018 (3.3 per year) source: EuropePMC

Pharmacogenomics and personalized medicine, Volume 11, 24 4 2018, Pages 179-191 CYP2D6 genotype can help to predict effectiveness and safety during opioid treatment for chronic low back pain: results from a retrospective study in an Italian cohort. Dagostino C, Allegri M, Napolioni V, D'Agnelli S, Bignami E, Mutti A, van Schaik RH

Background: Opioids are widely used for chronic low back pain (CLBP); however, it is still unclear how to predict their effectiveness and safety. Codeine, tramadol and oxycodone are metabolized by CYP/CYP450 2D6 (CYP2D6), a highly polymorphic enzyme linked to allele-specific related differences in metabolic activity. Purpose: CYP2D6 genetic polymorphisms could potentially help to predict the effectiveness and safety of opioid-based drugs in clinical practice, especially in the treatment of CLBP.... Abstract

Cited 8 times since 2018 (1.3 per year) source: EuropePMC

Molecular plant pathology, Volume 20, Issue 1, 24 4 2018, Pages 137-152 Mediator of tolerance to abiotic stress ERF6 regulates susceptibility of Arabidopsis to Meloidogyne incognita. Warmerdam S, Sterken MG, Van Schaik C, Oortwijn MEP, Lozano-Torres JL, Bakker J, Goverse A, Smant G

Root-knot nematodes transform vascular host cells into permanent feeding structures to selectively withdraw their nutrients from host plants during the course of several weeks. The susceptibility of host plants to root-knot nematode infections is thought to be a complex trait involving many genetic loci. However, genome-wide association (GWA) analysis has so far revealed only four quantitative trait loci (QTLs) linked to the reproductive success of the root-knot nematode Meloidogyne incognita in... Abstract

Cited 9 times since 2018 (1.4 per year) source: EuropePMC

Heart rhythm, Volume 16, Issue 4, 24 4 2018, Pages 536-543 Ablation compared with drug therapy for recurrent ventricular tachycardia in arrhythmogenic right ventricular cardiomyopathy: Results from a multicenter study. Mahida S, Venlet J, Saguner AM, Kumar S, Baldinger SH, AbdelWahab A, Tedrow UB, Castelletti S, Pantazis A, John RM, McKenna WJ, Lambiase PD, Duru F, Sapp JL, Zeppenfeld K, Stevenson WG

Background: The comparative efficacy of antiarrhythmic drug (AAD) therapy vs ventricular tachycardia (VT) ablation in arrhythmogenic right ventricular cardiomyopathy (ARVC) is unknown. Objective: We compared outcomes of AAD and/or β-blocker (BB) therapy with those of VT ablation (with AAD/BB) in patients with ARVC who had recurrent VT. Methods: In a multicenter retrospective study, 110 patients with ARVC (mean age 38 ± 17 years; 91[83%] men) with a minimum of 3 VT episodes were included; 77 (70%... Abstract

Cited 27 times since 2018 (4.2 per year) source: EuropePMC

Diabetes care, Volume 42, Issue 2, 23 4 2018, Pages 208-214 A Type 1 Diabetes Genetic Risk Score Can Identify Patients With GAD65 Autoantibody-Positive Type 2 Diabetes Who Rapidly Progress to Insulin Therapy. Grubb AL, McDonald TJ, Rutters F, Donnelly LA, Hattersley AT, Oram RA, Palmer CNA, van der Heijden AA, Carr F, Elders PJM, Weedon MN, Slieker RC, 't Hart LM, Pearson ER, Shields BM, Jones AG

Objective: Progression to insulin therapy in clinically diagnosed type 2 diabetes is highly variable. GAD65 autoantibodies (GADA) are associated with faster progression, but their predictive value is limited. We aimed to determine if a type 1 diabetes genetic risk score (T1D GRS) could predict rapid progression to insulin treatment over and above GADA testing. Research design and methods: We examined the relationship between T1D GRS, GADA (negative or positive), and rapid insulin requirement (wi... Abstract

Cited 3 times since 2018 (0.5 per year) source: EuropePMC

Open medicine (Warsaw, Poland), Volume 13, 22 4 2018, Pages 520-527 Recurrent Chronic Subdural Hematoma: Report of 13 Cases. Hacıyakupoğlu E, Yılmaz DM, Kınalı B, Arpacı T, Akbaş T, Hacıyakupoğlu S

Chronic subdural hematoma is a frequent type of hemorrhage, which terminates with mortality if not diagnosed and treated early. The aim of this clinical study is to evaluate the patients with unilateral and bilateral recurrent chronic subdural hematoma. The study group consisted of 13 cases with unilateral and bilateral recurrent chronic subdural hematomas who underwent aggressive wide craniotomy, duraectomy, inner and outer membranectomy, dural border coagulation, incision through cortical vein... Abstract

Cited 12 times since 2018 (1.9 per year) source: EuropePMC

Advances in health sciences education : theory and practice, Volume 24, Issue 1, 20 3 2018, Pages 151-165 Peer instruction improves comprehension and transfer of physiological concepts: a randomized comparison with self-explanation. Versteeg M, van Blankenstein FM, Putter H, Steendijk P

Comprehension of physiology is essential for development of clinical reasoning. However, medical students often struggle to understand physiological concepts. Interactive learning through Peer instruction (PI) is known to stimulate students' comprehension, but its relative efficacy and working mechanisms remain to be elucidated. In this study, we investigated if and how PI could optimize comprehension of physiological concepts and transfer relative to Self-explanation (SE) which is consider... Abstract

Cited 33 times since 2018 (5.2 per year) source: EuropePMC

Disease models & mechanisms, Volume 11, Issue 10, 19 3 2018, Pages dmm034637 Bicuspid aortic valve formation: Nos3 mutation leads to abnormal lineage patterning of neural crest cells and the second heart field. Peterson JC, Chughtai M, Wisse LJ, Gittenberger-de Groot AC, Feng Q, Goumans MTH, VanMunsteren JC, Jongbloed MRM, DeRuiter MC

The bicuspid aortic valve (BAV), a valve with two instead of three aortic leaflets, belongs to the most prevalent congenital heart diseases in the world, occurring in 0.5-2% of the general population. We aimed to understand how changes in early cellular contributions result in BAV formation and impact cardiovascular outflow tract development. Detailed 3D reconstructions, immunohistochemistry and morphometrics determined that, during valvulogenesis, the non-coronary leaflet separates from the par... Abstract

Cited 159 times since 2018 (24.9 per year) source: EuropePMC

The Lancet. Oncology, Volume 19, Issue 11, 19 3 2018, Pages 1459-1467 DPYD genotype-guided dose individualisation of fluoropyrimidine therapy in patients with cancer: a prospective safety analysis. Henricks LM, Lunenburg CATC, de Man FM, Meulendijks D, Frederix GWJ, Kienhuis E, Creemers GJ, Baars A, Dezentjé VO, Imholz ALT, Jeurissen FJF, Portielje JEA, Jansen RLH, Hamberg P, Ten Tije AJ, Droogendijk HJ, Koopman M, Nieboer P, van de Poel MHW, Mandigers CMPW, Rosing H, Beijnen JH, Werkhoven EV, van Kuilenburg ABP, van Schaik RHN, Mathijssen RHJ, Swen JJ, Gelderblom H, Cats A, Guchelaar HJ, Schellens JHM

Background: Fluoropyrimidine treatment can result in severe toxicity in up to 30% of patients and is often the result of reduced activity of the key metabolic enzyme dihydropyrimidine dehydrogenase (DPD), mostly caused by genetic variants in the gene encoding DPD (DPYD). We assessed the effect of prospective screening for the four most relevant DPYD variants (DPYD*2A [rs3918290, c.1905+1G>A, IVS14+1G>A], c.2846A>T [rs67376798, D949V], c.1679T>G [rs55886062, DPYD*13, I560S], and c.123... Abstract

Cited 2 times since 2018 (0.3 per year) source: EuropePMC

Turkish neurosurgery, 17 3 2018 Immunohistochemical Evaluation of Hemostatic Changes in Glioblastoma Multiforme and Low-Grade Astrocytoma. Haciyakupoğlu E, Yilmaz DM, Walter J, Erdoğan Ş, Haciyakupoğlu S, Kuhn SA

Aim: In glioblastoma multiforme, the balance between the procoagulant system, anticoagulant system and fibrinolytic system is impaired in favour of hypercoagulability. The aim of this study was to compare glioblastoma multiforme with astrocytoma grade II by subjectively evaluating the levels of prothrombin and biotinylation thrombin, and G protein serum protease activatin receptors, as tissue factors causing hypercoagulation and affecting coagulation. Material and methods: Specimens from 35 case... Abstract

Cited 17 times since 2018 (2.7 per year) source: EuropePMC

European radiology, Volume 29, Issue 4, 15 3 2018, Pages 2117-2126 Noninvasive CT-based hemodynamic assessment of coronary lesions derived from fast computational analysis: a comparison against fractional flow reserve. Siogkas PK, Anagnostopoulos CD, Liga R, Exarchos TP, Sakellarios AI, Rigas G, Scholte AJHA, Papafaklis MI, Loggitsi D, Pelosi G, Parodi O, Maaniitty T, Michalis LK, Knuuti J, Neglia D, Fotiadis DI

Objectives: Application of computational fluid dynamics (CFD) to three-dimensional CTCA datasets has been shown to provide accurate assessment of the hemodynamic significance of a coronary lesion. We aim to test the feasibility of calculating a novel CTCA-based virtual functional assessment index (vFAI) of coronary stenoses > 30% and ≤ 90% by using an automated in-house-developed software and to evaluate its efficacy as compared to the invasively measured fractional flow reserve (FFR). Method... Abstract

Cited 1 times since 2018 (0.2 per year) source: EuropePMC

International journal of chronic obstructive pulmonary disease, Volume 13, 12 2 2018, Pages 3297-3306 A systematic diagnostic evaluation combined with an internet-based self-management support system for patients with asthma or COPD. van Buul AR, Wildschut TS, Bonten TN, Kasteleyn MJ, Slats AM, Chavannes NH, Taube C

Introduction: An (inter)national systematic approach for patients with asthma COPD referred to secondary care is lacking. Therefore, a novel systematic approach was designed and tested in clinical practice. Methods: This was a retrospective observational study of data from the electronic record system of the Leiden University Medical Center. Asthma and COPD patients were included if they were evaluated with a novel systematic approach or if they had a new record for asthma or COPD and received u... Abstract

Cited 3 times since 2018 (0.5 per year) source: EuropePMC

BMC musculoskeletal disorders, Volume 19, Issue 1, 12 2 2018, Pages 366 The acceptance of the clinical photographic posture assessment tool (CPPAT). Fortin C, van Schaik P, Aubin-Fournier JF, Bettany-Saltikov J, Bernard JC, Ehrmann Feldman D

Background: There is a lack of evidence-based quantitative clinical methods to adequately assess posture. Our team developed a clinical photographic posture assessment tool (CPPAT) and implemented this tool in clinical practice to standardize posture assessment. The objectives were to determine the level of acceptance of the CPPAT and to document predictors as well as facilitators of and barriers to the acceptance of this tool by clinicians doing posture re-education. Methods: This is a prospect... Abstract