Research

Publications

Below you can find a list of our published research.

7724 results

Cited 11 times since 2012 (0.9 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 60, Issue 19, 10 2 2012, Pages 1991-1992 Does pregnancy influence the durability of human aortic valve substitutes? Arabkhani B, Heuvelman HJ, Bogers AJ, Mokhles MM, Roos-Hesselink JW, Takkenberg JJ

Abstract

Cited 1 times since 2012 (0.1 per year) source: EuropePMC

Cardiology in the young, Volume 23, Issue 4, 2 1 2012, Pages 540-545 Peri-operative care in adults with congenital heart disease: room for improvement in after care. Schoormans D, Smets EM, Zwart R, Sprangers MA, Veelenturg TH, de Mol BA, Hazekamp MG, Koolbergen DR, Sojak V, Bouma BJ, Groenink M, Boekholdt MS, Backx AP, Mulder BJ

Background: Patient satisfaction with care has received little attention within the field of congenital heart disease. Our objective was to examine patient satisfaction with the care received when undergoing open-heart surgery in order to identify the best and worst aspects of peri-operative care. Moreover, we examined whether having contact with a specialised nurse in addition to usual care is associated with higher patient satisfaction levels. Methods: Patient satisfaction was measured by the... Abstract

Expert review of cardiovascular therapy, Volume 10, Issue 10, 1 1 2012, Pages 1197-1199 Primary prevention implantable cardioverter-defibrillator treatment: how to identify patients most likely to benefit? Thijssen J, van Rees JB, Schalij MJ, Borleffs CJ

Abstract

Cited 8 times since 2012 (0.6 per year) source: EuropePMC

Transplantation, Volume 94, Issue 7, 1 1 2012, Pages 721-728 Late calcineurin inhibitor withdrawal prevents progressive left ventricular diastolic dysfunction in renal transplant recipients. Mourer JS, Ewe SH, Mallat MJ, Ng AC, Rabelink TJ, Bax JJ, Delgado V, de Fijter JW

Background: Calcineurin inhibitor (CNI)-based therapy is associated with adverse cardiovascular effects. We examined the effects of late CNI or mycophenolate mofetil (MMF) withdrawal on echocardiographic parameters. Methods: This study was conducted as a substudy of a randomized trial in stable renal transplant recipients who were on a triple CNI-based regimen with prednisone and MMF that evaluated late concentration-controlled withdrawal of CNI or MMF on renal function. A total of 108 patients... Abstract

Cited 6 times since 2012 (0.5 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 20, Issue 10, 1 1 2012, Pages 419-424 Prosthetic valves in adult patients with congenital heart disease: Rationale and design of the Dutch PROSTAVA study. Freling HG, van Slooten YJ, van Melle JP, Mulder BJ, van Dijk AP, Hillege HL, Post MC, Sieswerda GT, Jongbloed MR, Willems TP, Pieper PG, PROSTAVA investigators

Background: Data on long-term complications in adult patients with congenital heart disease (ACHD) and a prosthetic valve are scarce. Moreover, the influence of prosthetic valves on quality of life (QoL) and functional outcome in ACHD patients with prosthetic valves has not been studied. Objectives: The primary objective of the PROSTAVA study is to investigate the relation between prosthetic valve characteristics (type, size and location) and functional outcome as well as QoL in ACHD patients. T... Abstract

Cited 4 times since 2012 (0.3 per year) source: EuropePMC

Journal of medical physics, Volume 37, Issue 4, 1 1 2012, Pages 235-239 Radiotherapy pre-treatment dose validation: A second verification of monitor units (MU) with a commercial software. Al Amri I, Ravichandran R, Sivakumar SS, Binukumar JP, Davis CA, Al Rahbi Z, Al Shukeili K, Al Kindi F

Inversely planned intensity-modulated radiotherapy (IMRT) and stereotactic small field radiotherapy should be verified before treatment execution. A second verification is carried out for planned treatments in IMRT and 3D conformal radiotherapy (3D-CRT) using a monitor verification commercial dose calculation management software (DCMS). For the same reference point the ion-chamber measured doses are compared for IMRT plans. DCMS (Diamond) computes dose based on modified Clarkson integration, acc... Abstract

Cited 30 times since 2012 (2.4 per year) source: EuropePMC

Journal of cellular and molecular medicine, Volume 16, Issue 10, 1 1 2012, Pages 2440-2450 Shear induced collateral artery growth modulated by endoglin but not by ALK1. Seghers L, de Vries MR, Pardali E, Hoefer IE, Hierck BP, ten Dijke P, Goumans MJ, Quax PH

Transforming growth factor-beta (TGF-β) stimulates both ischaemia induced angiogenesis and shear stress induced arteriogenesis by signalling through different receptors. How these receptors are involved in both these processes of blood flow recovery is not entirely clear. In this study the role of TGF-β receptors 1 and endoglin is assessed in neovascularization in mice. Unilateral femoral artery ligation was performed in mice heterozygous for either endoglin or ALK1 and in littermate controls. C... Abstract

Cited 5 times since 2012 (0.4 per year) source: EuropePMC

Lancet (London, England), Volume 380, Issue 9852, 1 1 2012, Pages 1471-1472 Hypertension in developing countries. Koopman JJ, van Bodegom D, Beenakker KG, Jukema JW, Westendorp RG

Abstract

Cited 16 times since 2012 (1.3 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 98, Issue 20, 1 1 2012, Pages 1529-1536 Late acquired stent malapposition: why, when and how to handle? Karalis I, Ahmed TA, Jukema JW

Abstract

Cited 15 times since 2012 (1.2 per year) source: EuropePMC

The international journal of cardiovascular imaging, Volume 29, Issue 3, 28 4 2012, Pages 609-616 Relationship between left ventricular diastolic function and arterial stiffness in asymptomatic patients with diabetes mellitus. Roos CJ, Auger D, Djaberi R, de Koning EJ, Rabelink TJ, Pereira AM, Bax JJ, Delgado V, Jukema JW, Scholte AJ

Left ventricular (LV) diastolic dysfunction and increased arterial stiffness are common in patients with diabetes mellitus (DM). However, the relation between these two pathophysiological factors remains unclear. The aim of this study was to investigate the relationship between LV diastolic function and arterial stiffness as assessed with applanation tonometry. In 142 asymptomatic patients with DM (mean age 48 years, 75 (53 %) men, 72 (51 %) patients with type 2 DM) LV diastolic function was ass... Abstract

Cited 148 times since 2012 (11.9 per year) source: Scopus

European journal of preventive cardiology, Volume 20, Issue 4, 28 4 2012, Pages 620-640 Lifestyle modification programmes for patients with coronary heart disease: a systematic review and meta-analysis of randomized controlled trials. Janssen V, De Gucht V, Dusseldorp E, Maes S

Background: Lifestyle modification programmes for coronary heart disease patients have been shown to effectively improve risk factors and related health behaviours, quality of life, reincidence, and mortality. However, improvements in routine cardiac care over the recent years may offset the incremental benefit associated with older programmes. Purpose: To determine the efficacy of lifestyle modification programmes for coronary heart disease patients developed over the last decade (1999-2009) by... Abstract

Cited 29 times since 2012 (2.3 per year) source: EuropePMC

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 15, Issue 2, 28 4 2012, Pages 290-296 Incremental prognostic value of an abnormal baseline spatial QRS-T angle in chronic dialysis patients. de Bie MK, Koopman MG, Gaasbeek A, Dekker FW, Maan AC, Swenne CA, Scherptong RW, van Dessel PF, Wilde AA, Schalij MJ, Rabelink TJ, Jukema JW

Aims: In order to improve the abysmal outcome of dialysis patients, it is critical to identify patients with a high mortality risk. The spatial QRS-T angle, which can be easily calculated from the 12 lead electrocardiogram (ECG), might be useful in the prognostication in dialysis patients. The objective of this study was to establish the prognostic value of the spatial QRS-T angle. Methods and results: All patients who initiated dialysis therapy between 2002 and 2009 in the hospitals of Leiden (... Abstract

Cited 2 times since 2012 (0.2 per year) source: EuropePMC

The international journal of cardiovascular imaging, Volume 29, Issue 2, 22 4 2012, Pages 453-461 Effect of dose reduction on image quality and diagnostic performance in coronary computed tomography angiography. van der Bijl N, Joemai RM, Mertens BJ, de Roos A, Veldkamp WJ, Bax JJ, Schuijf JD, Geleijns J, Kroft LJ

To evaluate the effect of radiation dose reduction on image quality and diagnostic accuracy of coronary computed tomography (CT) angiography. Coronary CT angiography studies of 40 patients with (n = 20) and without (n = 20) significant (≥50 %) stenosis were included (26 male, 14 female, 57 ± 11 years). In addition to the original clinical reconstruction (100 % dose), simulated images were created that correspond to 50, 25 and 12.5 % of the original dose. Image quality and diagnostic performance... Abstract

Cited 14 times since 2012 (1.1 per year) source: EuropePMC

The international journal of cardiovascular imaging, Volume 29, Issue 3, 22 4 2012, Pages 633-641 Aortic stiffness is related to left ventricular diastolic function in patients with diabetes mellitus type 1: assessment with MRI and speckle tracking strain analysis. van Schinkel LD, Auger D, van Elderen SG, Ajmone Marsan N, Delgado V, Lamb HJ, Ng AC, Smit JW, Bax JJ, Westenberg JJ, de Roos A

Diabetes mellitus type 1 (DM1) is associated with aortic stiffening and left ventricular (LV) diastolic dysfunction, however the relationship between aortic stiffness and LV diastolic dysfunction in DM1 patients is still largely unknown. The purpose of this study was to evaluate whether an increased aortic stiffness, expressed by increased aortic pulse wave velocity (PWV), is associated with subclinical LV diastolic dysfunction and decreased left atrial (LA) compliance as assessed with speckle t... Abstract

Cited 17 times since 2012 (1.4 per year) source: EuropePMC

Pediatric cardiology, Volume 34, Issue 3, 22 4 2012, Pages 630-638 Tissue Doppler imaging detects impaired biventricular performance shortly after congenital heart defect surgery. Klitsie LM, Hazekamp MG, Roest AA, Van der Hulst AE, Gesink-van der Veer BJ, Kuipers IM, Blom NA, Ten Harkel AD

Cardiac surgery with cardiopulmonary bypass is associated with the development of a systemic inflammatory response, which can lead to myocardial damage. However, knowledge concerning the time course of ventricular performance deterioration and restoration after correction of a congenital heart defect (CHD) in pediatric patients is sparse. Therefore, the authors perioperatively quantified left ventricular (LV) and right ventricular (RV) performance using echocardiography. Their study included 141... Abstract

Cited 26 times since 2012 (2.1 per year) source: EuropePMC

International journal of cardiology, Volume 167, Issue 6, 20 3 2012, Pages 2977-2982 MRI-assessed regional pulse wave velocity for predicting absence of regional aorta luminal growth in marfan syndrome. Kröner ES, Scholte AJ, de Koning PJ, van den Boogaard PJ, Kroft LJ, van der Geest RJ, Hilhorst-Hofstee Y, Lamb HJ, Siebelink HM, Mulder BJ, Groenink M, Radonic T, van der Wall EE, de Roos A, Reiber JH, Westenberg JJ

Background: In patients with Marfan syndrome (MFS), increased aortic wall stiffening may lead to progressive aortic dilatation. Aortic Pulse Wave Velocity (PWV), a marker of wall stiffness can be assessed regionally, using in-plane multi-directional velocity-encoded MRI. This study examined the diagnostic accuracy of regional PWV for prediction of regional aortic luminal growth during 2-year follow-up in MFS patients. Methods: In twenty-one MFS patients (mean age 36 ± 15 years, 11 male) regional... Abstract

Cited 19 times since 2012 (1.5 per year) source: EuropePMC

The Annals of thoracic surgery, Volume 94, Issue 6, 13 2 2012, Pages 2077-2082 Mild residual pulmonary stenosis in tetralogy of fallot reduces risk of pulmonary valve replacement. van der Hulst AE, Hylkema MG, Vliegen HW, Delgado V, Hazekamp MG, Rijlaarsdam ME, Holman ER, Blom NA, Roest AA

Background: Current surgical strategies that aim at preventing pulmonary regurgitation in patients with corrected tetralogy of Fallot (cToF) may result in a certain grade of residual pulmonary stenosis (PS). The clinical implications of a postoperative residual PS in cToF patients remain unclear. Pulmonary valve replacement (PVR) is frequently needed during follow-up of cToF patients. The aim of the current study was to determine the role of residual PS in the need for PVR during follow-up in cT... Abstract

Cited 12 times since 2012 (1 per year) source: EuropePMC

Cardiovascular research, Volume 97, Issue 1, 12 2 2012, Pages 171-181 Similar arrhythmicity in hypertrophic and fibrotic cardiac cultures caused by distinct substrate-specific mechanisms. Askar SF, Bingen BO, Schalij MJ, Swildens J, Atsma DE, Schutte CI, de Vries AA, Zeppenfeld K, Ypey DL, Pijnappels DA

Aims: Cardiac hypertrophy and fibrosis are associated with potentially lethal arrhythmias. As these substrates often occur simultaneously in one patient, distinguishing between pro-arrhythmic mechanisms is difficult. This hampers understanding of underlying pro-arrhythmic mechanisms and optimal treatment. This study investigates and compares arrhythmogeneity and underlying pro-arrhythmic mechanisms of either cardiac hypertrophy or fibrosis in in vitro models. Methods and results: Fibrosis was mi... Abstract

Cited 17 times since 2012 (1.4 per year) source: EuropePMC

Cardiovascular research, Volume 97, Issue 1, 12 2 2012, Pages 161-170 Prolongation of minimal action potential duration in sustained fibrillation decreases complexity by transient destabilization. Bingen BO, Askar SF, Schalij MJ, Kazbanov IV, Ypey DL, Panfilov AV, Pijnappels DA

Aims: Sustained ventricular fibrillation (VF) is maintained by multiple stable rotors. Destabilization of sustained VF could be beneficial by affecting VF complexity (defined by the number of rotors). However, underlying mechanisms affecting VF stability are poorly understood. Therefore, the aim of this study was to correlate changes in arrhythmia complexity with changes in specific electrophysiological parameters, allowing a search for novel factors and underlying mechanisms affecting stability... Abstract

Cited 53 times since 2012 (4.2 per year) source: EuropePMC

Human molecular genetics, Volume 21, Issue 24, 8 2 2012, Pages 5329-5343 Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function. Chasman DI, Fuchsberger C, Pattaro C, Teumer A, Böger CA, Endlich K, Olden M, Chen MH, Tin A, Taliun D, Li M, Gao X, Gorski M, Yang Q, Hundertmark C, Foster MC, O'Seaghdha CM, Glazer N, Isaacs A, Liu CT, Smith AV, O'Connell JR, Struchalin M, Tanaka T, Li G, Johnson AD, Gierman HJ, Feitosa MF, Hwang SJ, Atkinson EJ, Lohman K, Cornelis MC, Johansson A, Tönjes A, Dehghan A, Lambert JC, Holliday EG, Sorice R, Kutalik Z, Lehtimäki T, Esko T, Deshmukh H, Ulivi S, Chu AY, Murgia F, Trompet S, Imboden M, Coassin S, Pistis G, CARDIoGRAM Consortium, ICBP Consortium, CARe Consortium, WTCCC2, Harris TB, Launer LJ, Aspelund T, Eiriksdottir G, Mitchell BD, Boerwinkle E, Schmidt H, Cavalieri M, Rao M, Hu F, Demirkan A, Oostra BA, de Andrade M, Turner ST, Ding J, Andrews JS, Freedman BI, Giulianini F, Koenig W, Illig T, Meisinger C, Gieger C, Zgaga L, Zemunik T, Boban M, Minelli C, Wheeler HE, Igl W, Zaboli G, Wild SH, Wright AF, Campbell H, Ellinghaus D, Nöthlings U, Jacobs G, Biffar R, Ernst F, Homuth G, Kroemer HK, Nauck

In conducting genome-wide association studies (GWAS), analytical approaches leveraging biological information may further understanding of the pathophysiology of clinical traits. To discover novel associations with estimated glomerular filtration rate (eGFR), a measure of kidney function, we developed a strategy for integrating prior biological knowledge into the existing GWAS data for eGFR from the CKDGen Consortium. Our strategy focuses on single nucleotide polymorphism (SNPs) in genes that ar... Abstract