6205 results
Cited 175 times since 2014 (15.7 per year)
source: EuropePMC
Human molecular genetics,
Volume 23, Issue 16, 31 5 2014, Pages 4420-4432
Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age.
Deelen J, Beekman M, Uh HW, Broer L, Ayers KL, Tan Q, Kamatani Y, Bennet AM, Tamm R, Trompet S, Guðbjartsson DF, Flachsbart F, Rose G, Viktorin A, Fischer K, Nygaard M, Cordell HJ, Crocco P, van den Akker EB, Böhringer S, Helmer Q, Nelson CP, Saunders GI, Alver M, Andersen-Ranberg K, Breen ME, van der Breggen R, Caliebe A, Capri M, Cevenini E, Collerton JC, Dato S, Davies K, Ford I, Gampe J, Garagnani P, de Geus EJ, Harrow J, van Heemst D, Heijmans BT, Heinsen FA, Hottenga JJ, Hofman A, Jeune B, Jonsson PV, Lathrop M, Lechner D, Martin-Ruiz C, Mcnerlan SE, Mihailov E, Montesanto A, Mooijaart SP, Murphy A, Nohr EA, Paternoster L, Postmus I, Rivadeneira F, Ross OA, Salvioli S, Sattar N, Schreiber S, Stefánsson H, Stott DJ, Tiemeier H, Uitterlinden AG, Westendorp RG, Willemsen G, Samani NJ, Galan P, Sørensen TI, Boomsma DI, Jukema JW, Rea IM, Passarino G, de Craen AJ, Christensen K, Nebel A, Stefánsson K, Metspalu A, Magnusson P, Blanché H, Christiansen L, Kirkwood TB, van Duijn CM, Franceschi C, Houwing-Duister
The genetic contribution to the variation in human lifespan is ∼ 25%. Despite the large number of identified disease-susceptibility loci, it is not known which loci influence population mortality. We performed a genome-wide association meta-analysis of 7729 long-lived individuals of European descent (≥ 85 years) and 16 121 younger controls (
Abstract
Cited 6 times since 2014 (0.5 per year)
source: EuropePMC
Journal of electrocardiology,
Volume 47, Issue 4, 30 5 2014, Pages 500-504
Directionality and proportionality of the ST and ventricular gradient difference vectors during acute ischemia.
ter Haar CC, Maan AC, Schalij MJ, Swenne CA
Background: The ECG is important in diagnosis and triage in the initial phase of the acute coronary syndrome (ACS). The primary goal of making an ECG at first medical contact should be the reliable detection of cardiac ischemia, thus facilitating a correct triage by corroborating the diagnosis of ACS. Ischemia detection by ST amplitude analysis is limited to situations in which there is an identifiable J point. The ventricular gradient (VG) is independent of conduction and might be an alternativ...
Abstract
Cited 51 times since 2014 (4.6 per year)
source: EuropePMC
European heart journal. Cardiovascular Imaging,
Volume 15, Issue 9, 30 5 2014, Pages 996-1003
For what endpoint does myocardial 123I-MIBG scintigraphy have the greatest prognostic value in patients with chronic heart failure? Results of a pooled individual patient data meta-analysis.
Verschure DO, Veltman CE, Manrique A, Somsen GA, Koutelou M, Katsikis A, Agostini D, Gerson MC, van Eck-Smit BL, Scholte AJ, Jacobson AF, Verberne HJ
Aims: The purpose of this study was to determine the most appropriate prognostic endpoint for myocardial (123)I-metaiodobenzylguanidine (MIBG) scintigraphy in patients with chronic heart failure (CHF) based on aggregate results from multiple studies published in the past decade. Methods and results: Original individual late (3-5 h) heart/mediastinum (H/M) ratio data of 636 CHF patients were retrieved from six studies from Europe and the USA. All-cause mortality, cardiac mortality, arrhythmic eve...
Abstract
Cited 8 times since 2014 (0.7 per year)
source: EuropePMC
Journal of cardiovascular electrophysiology,
Volume 25, Issue 6, 29 5 2014, Pages 631-637
Effect of induced LV dyssynchrony by right ventricular apical pacing on all-cause mortality and heart failure hospitalization rates at long-term follow-up.
Auger D, Hoke U, Marsan NA, Tops LF, Leong DP, Bertini M, Schalij MJ, Bax JJ, Delgado V
Background: Right ventricular apical (RVA) pacing may induce left ventricular (LV) dyssynchrony. The long-term prognostic implications of induction of LV dyssynchrony were retrospectively evaluated in a cohort of patients who underwent RVA pacing. Methods: A total of 169 patients (62 ± 13 years, 69% male) with high RVA pacing burden were included. Echocardiographic evaluation of LV volumes, ejection fraction, and dyssynchrony were performed before and after device implantation. LV dyssynchrony w...
Abstract
Cited 19 times since 2014 (1.7 per year)
source: EuropePMC
Annals of hematology,
Volume 93, Issue 8, 29 5 2014, Pages 1401-1412
Clinical and biological impact of TET2 mutations and expression in younger adult AML patients treated within the EORTC/GIMEMA AML-12 clinical trial.
Aslanyan MG, Kroeze LI, Langemeijer SM, Koorenhof-Scheele TN, Massop M, van Hoogen P, Stevens-Linders E, van de Locht LT, Tönnissen E, van der Heijden A, da Silva-Coelho P, Cilloni D, Saglio G, Marie JP, Tang R, Labar B, Amadori S, Muus P, Willemze R, Marijt EW, de Witte T, van der Reijden BA, Suciu S, Jansen JH
We assessed the prognostic impact of TET2 mutations and mRNA expression in a prospective cohort of 357 adult AML patients < 60 years of age enrolled in the European Organization For Research and Treatment of Cancer (EORTC)/Gruppo Italiano Malattie Ematologiche dell' Adulto (GIMEMA) AML-12 06991 clinical trial. In addition the co-occurrence with other genetic defects and the functional consequences of TET2 mutations were investigated. TET2 mutations occurred in 7.6 % of the patients and w...
Abstract
Cited 68 times since 2014 (6.1 per year)
source: EuropePMC
Heart (British Cardiac Society),
Volume 100, Issue 9, 26 4 2014, Pages 685-690
The dialysis procedure as a trigger for atrial fibrillation: new insights in the development of atrial fibrillation in dialysis patients.
Buiten MS, de Bie MK, Rotmans JI, Gabreëls BA, van Dorp W, Wolterbeek R, Trines SA, Schalij MJ, Jukema JW, Rabelink TJ, van Erven L
Aims: Atrial fibrillation (AF) is common in dialysis patients and is associated with increased morbidity and mortality. The pathophysiology may be related to common risk factors for both AF and renal disease or to dialysis-specific factors. The purpose of this study was to determine whether and how AF onset relates to the dialysis procedure itself. Methods: All dialysis patients enrolled in the implantable cardioverter defibrillator-2 (ICD-2) trial until January 2012, who were implanted with an...
Abstract
Cited 290 times since 2014 (26 per year)
source: EuropePMC
The EMBO journal,
Volume 33, Issue 8, 25 4 2014, Pages 823-841
Role of receptor binding specificity in influenza A virus transmission and pathogenesis.
de Graaf M, Fouchier RA
The recent emergence of a novel avian A/H7N9 influenza virus in poultry and humans in China, as well as laboratory studies on adaptation and transmission of avian A/H5N1 influenza viruses, has shed new light on influenza virus adaptation to mammals. One of the biological traits required for animal influenza viruses to cross the species barrier that received considerable attention in animal model studies, in vitro assays, and structural analyses is receptor binding specificity. Sialylated glycans...
Abstract
Cited 2 times since 2014 (0.2 per year)
source: EuropePMC
Acute cardiac care,
Volume 16, Issue 2, 21 3 2014, Pages 41-48
Networks for improving care in patients with acute coronary syndrome: A framework.
Radke PW, Halvorsen S, Jukema JW, Kolh P, Annemans L, Postma MJ, Ardissino D, Kristensen SD, Bassand JP, Collet JP, Morais J, Tuñón J, Halcox J
In recent years, it has become evident that the level of guideline adherence in patients presenting with acute coronary syndrome (ACS) is highly correlated with patient outcomes. Unfortunately, guideline adherence is low in some geographic areas and especially in those patients at high-risk. Regional networks including ambulance systems and hospitals with catheterization laboratories are able to increase guideline adherence and patient outcomes by streamlining the critical pre- and intra-hospita...
Abstract
Cited 2 times since 2014 (0.2 per year)
source: EuropePMC
Pediatric pulmonology,
Volume 50, Issue 1, 20 3 2014, Pages 79-84
The influence of stents on microbial colonization of the airway in children after slide tracheoplasty: a 14-year single-center experience.
Rijnberg FM, Butler CR, Speggiorin S, Fierens A, Wallis C, Nouraei R, McLaren CA, Roebuck DJ, Hewitt R, Elliott MJ
Objectives: This study describes the microbial colonization profile of the airway in children after slide tracheoplasty (STP) with and without stents, and compares colonization to children undergoing cardiothoracic surgical procedures without airway related disease. Methods: A 14-year retrospective single case note review was performed on patients undergoing STP and stent insertion. Nose and throat (NT) and bronchoalveolar lavage (BAL) specimens were analyzed for microbial profile and expressed...
Abstract
Cited 2 times since 2014 (0.2 per year)
source: EuropePMC
The international journal of cardiovascular imaging,
Volume 30, Issue 5, 19 3 2014, Pages 925-934
Myocardial scar identification based on analysis of Look-Locker and 3D late gadolinium enhanced MRI.
Tao Q, Lamb HJ, Zeppenfeld K, van der Geest RJ
The aim of this study is to introduce and evaluate an approach for objective and reproducible scar identification from late gadolinium enhanced (LGE) MR by analysis of LGE data with post-contrast T(1) mapping from a routinely acquired T(1) scout Look-Locker (LL) sequence. In 90 post-infarction patients, a LL sequence was acquired prior to a three-dimensional LGE sequence covering the entire left ventricle. In 60/90 patients (training set), the T(1) relaxation rates of remote myocardium and dense...
Abstract
Cited 10 times since 2014 (0.9 per year)
source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
Volume 47, Issue 1, 18 3 2014, Pages 146-52; discussion 152
Long-term follow-up of tracheoplasty using autologous pericardial patch and strips of costal cartilage.
Yazdanbakhsh AP, van Rijssen LB, Koolbergen DR, König A, de Mol BA, Hazekamp MG
Objectives: To evaluate long-term results of tracheoplasty using autologous pericardial patch and strips of costal cartilage for relieving severe long-segment tracheal stenosis. Methods: Data were collected retrospectively by clinical chart review. Between 1995 and 2013, 21 patients underwent tracheoplasty. Follow-up was performed by outpatient chart review; otherwise, referring physicians and parents were contacted and asked to fill in a questionnaire. Results: Median age at the time of operati...
Abstract
Cited 18 times since 2014 (1.6 per year)
source: EuropePMC
The American journal of cardiology,
Volume 113, Issue 11, 15 3 2014, Pages 1782-1787
Comparison by computed tomographic angiography-the presence and extent of coronary arterial atherosclerosis in South Asians versus Caucasians with diabetes mellitus.
Roos CJ, Kharagjitsingh AV, Jukema JW, Bax JJ, Scholte AJ
South Asians in the Western world have a high prevalence of diabetes mellitus (DM) and an increased risk of coronary artery disease (CAD) and mortality compared with Caucasians. CAD in asymptomatic South Asian patients with type 2 DM has not been investigated. The aim of this observational cohort study was to investigate CAD in asymptomatic South Asian patients with type 2 DM and to compare with matched Caucasian patients. A total of 120 asymptomatic South Asian patients with type 2 DM and match...
Abstract
Cited 6 times since 2014 (0.5 per year)
source: EuropePMC
European journal of clinical nutrition,
Volume 68, Issue 5, 12 2 2014, Pages 635-637
Vitamin D3 mediated effects on postprandial leukocyte activation and arterial stiffness in men and women.
Klop B, van de Geijn GJ, Birnie E, Njo TL, Janssen HW, Jansen HG, Jukema JW, Elte JW, Castro Cabezas M
Postprandial inflammation is considered to be pro-atherogenic. Vitamin D can reduce inflammation and arterial stiffness. We hypothesized that vitamin D3 improves postprandial arterial elasticity by the modulation of leukocyte activation. Healthy volunteers underwent two oral fat-loading tests (OFLTs). The augmentation index (AIx) and flow cytometric quantification of leukocyte activation markers were measured. After the first OFLT, 100 000 IU of vitamin D3 was administered and a second OFLT was...
Abstract
Cited 74 times since 2014 (6.6 per year)
source: EuropePMC
Journal of the American Society of Nephrology : JASN,
Volume 25, Issue 8, 7 1 2014, Pages 1710-1722
Hematopoietic microRNA-126 protects against renal ischemia/reperfusion injury by promoting vascular integrity.
Bijkerk R, van Solingen C, de Boer HC, van der Pol P, Khairoun M, de Bruin RG, van Oeveren-Rietdijk AM, Lievers E, Schlagwein N, van Gijlswijk DJ, Roeten MK, Neshati Z, de Vries AA, Rodijk M, Pike-Overzet K, van den Berg YW, van der Veer EP, Versteeg HH, Reinders ME, Staal FJ, van Kooten C, Rabelink TJ, van Zonneveld AJ
Ischemia/reperfusion injury (IRI) is a central phenomenon in kidney transplantation and AKI. Integrity of the renal peritubular capillary network is an important limiting factor in the recovery from IRI. MicroRNA-126 (miR-126) facilitates vascular regeneration by functioning as an angiomiR and by modulating mobilization of hematopoietic stem/progenitor cells. We hypothesized that overexpression of miR-126 in the hematopoietic compartment could protect the kidney against IRI via preservation of m...
Abstract
Cited 1 times since 2014 (0.1 per year)
source: EuropePMC
Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft,
Volume 199, 5 1 2014, Pages 23-29
Effects of fly ash and boric acid on Y2O3-stabilized tetragonal ZrO2 dispersed with MgAl2O4: An experimental study on rat subcutaneous tissue.
Ergun G, Guru M, Egilmez F, Cekic-Nagas I, Yilmaz D
The aim of this study was to evaluate the subcutaneous tissue reaction around zirconia-based materials. Forty-eight male Wistar Albino rats were used in this study. Disk-shaped (1mm height and 5mm diameter) samples composed of 67% spinel (MgAl2O4), 27% tetragonal zirconia polycrystal, 4% (m/m) fly ash and 2% (m/m) boric acid were inserted into dorsal muscles of rats. After 1, 4, 8 and 16 weeks, the animals were sacrificed and zirconia materials were removed with the surrounding tissue. Tissue se...
Abstract
Cited 13 times since 2014 (1.2 per year)
source: EuropePMC
Heart rhythm,
Volume 11, Issue 6, 4 1 2014, Pages 1031-1039
Endocardial or epicardial ventricular tachycardia in nonischemic cardiomyopathy? The role of 12-lead ECG criteria in clinical practice.
Piers SR, Silva Mde R, Kapel GF, Trines SA, Schalij MJ, Zeppenfeld K
Background: Specific 12-lead ECG criteria have been reported to predict an epicardial site of origin (SoO) of induced ventricular tachycardias (VTs) in left ventricular nonischemic cardiomyopathy. Objective: The purpose of this study was to (1) determine the value of ECG criteria to predict an epicardial SoO of clinically documented VTs, (2) analyze the effect of VT cycle length (CL) and antiarrhythmic drugs on the accuracy of ECG criteria, and (3) assess interobserver variability. Methods: In 3...
Abstract
Cited 22 times since 2014 (2 per year)
source: Scopus
British journal of anaesthesia,
Volume 112, Issue 6, 3 1 2014, Pages 1005-1014
Cardiospecific sevoflurane treatment quenches inflammation but does not attenuate myocardial cell damage markers: a proof-of-concept study in patients undergoing mitral valve repair.
Kortekaas KA, van der Baan A, Aarts LP, Palmen M, Cobbaert CM, Verhagen JC, Engbers FH, Klautz RJ, Lindeman JH
Background: Inflammation is considered a key mediator of complications after cardiac surgery. Sevoflurane has been shown to quench inflammation and to provide cardioprotection in preclinical studies. Clinical studies using sevoflurane confirm this effect on inflammation but do not consistently show clinical benefits. This paradox may indicate that the contribution of inflammation to postoperative sequalae is less than commonly thought or that systemic doses are too low in their local concentrati...
Abstract
Cited 5 times since 2014 (0.4 per year)
source: EuropePMC
Journal of chromatography. A,
Volume 1338, 2 1 2014, Pages 111-116
Accurate quantitation of pentaerythritol tetranitrate and its degradation products using liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry.
Brust H, van Asten A, Koeberg M, Dalmolen J, van der Heijden A, Schoenmakers P
After an explosion of pentaerythritol tetranitrate (PETN), its degradation products pentaerythritol trinitrate (PETriN), dinitrate (PEDiN) and mononitrate (PEMN) were detected using liquid chromatography-atmospheric-pressure chemical-ionization-mass spectrometry (LC-APCI-MS). Discrimination between post-explosion and naturally degraded PETN could be achieved based on the relative amounts of the degradation products. This information can be used as evidence when investigating a possible relations...
Abstract
Cited 11 times since 2014 (1 per year)
source: EuropePMC
Veterinary microbiology,
Volume 170, Issue 3-4, 2 1 2014, Pages 266-277
Phylogeny of Spanish swine influenza viruses isolated from respiratory disease outbreaks and evolution of swine influenza virus within an endemically infected farm.
Martín-Valls GE, Simon-Grifé M, van Boheemen S, de Graaf M, Bestebroer TM, Busquets N, Martín M, Casal J, Fouchier RA, Mateu E
In the present study, outbreaks of respiratory disease were investigated for the presence of swine influenza virus (SIV). In 14 cases the circulating SIV strains were isolated, fully sequenced and compared with other known SIVs. The viruses causing the outbreaks belonged to the H1N1 (including human pandemic H1N1), H3N2 and H1N2 subtypes. In 11/14 cases the phylogenetic analyses indicated the occurrence of probable reassortment events. In the second part of the study, the genetic evolution of H1...
Abstract
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP,
Volume 24 Suppl 1, 1 1 2014, Pages S46-7
An unusual location for cellular schwannoma.
Golge UH, Komurcu E, Yilmaz D
Schwannomas are solitary benign tumours derived from peripheral nerve sheath that are difficult to diagnose using imaging only. Diagnoses are commonly confirmed with conventional surgical resection. Small proportion of cases are formed by cellular schwannoma usually seen at paravertebral, pelvic, retroperitoneal, or mediastinal location. This patient had a 3 x 2 cm hard mass at the dorsal side of proximal phalanx of the right third toe. Bone destruction was seen on radiography and MR imaging. Cu...
Abstract
