Research

Publications

Below you can find a list of our published research.

7971 results

Nature genetics, Volume 50, Issue 5, 1 1 2018, Pages 765-766 Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. Turcot V, Lu Y, Highland HM, Schurmann C, Justice AE, Fine RS, Bradfield JP, Esko T, Giri A, Graff M, Guo X, Hendricks AE, Karaderi T, Lempradl A, Locke AE, Mahajan A, Marouli E, Sivapalaratnam S, Young KL, Alfred T, Feitosa MF, Masca NGD, Manning AK, Medina-Gomez C, Mudgal P, Ng MCY, Reiner AP, Vedantam S, Willems SM, Winkler TW, Abecasis G, Aben KK, Alam DS, Alharthi SE, Allison M, Amouyel P, Asselbergs FW, Auer PL, Balkau B, Bang LE, Barroso I, Bastarache L, Benn M, Bergmann S, Bielak LF, Blüher M, Boehnke M, Boeing H, Boerwinkle E, Böger CA, Bork-Jensen J, Bots ML, Bottinger EP, Bowden DW, Brandslund I, Breen G, Brilliant MH, Broer L, Brumat M, Burt AA, Butterworth AS, Campbell PT, Cappellani S, Carey DJ, Catamo E, Caulfield MJ, Chambers JC, Chasman DI, Chen YI, Chowdhury R, Christensen C, Chu AY, Cocca M, Collins FS, Cook JP, Corley J, Corominas Galbany J, Cox AJ, Crosslin DS, Cuellar-Partida G, D'Eustacchio A, Danesh J, Davies G, Bakker PIW, Groot MCH, Mutsert R, Deary IJ, Dedoussis G, Demerath EW, Heij

In the published version of this paper, the name of author Emanuele Di Angelantonio was misspelled. This error has now been corrected in the HTML and PDF versions of the article. Abstract

Cited 25 times since 2018 (3.5 per year) source: EuropePMC

JACC. Cardiovascular imaging, Volume 11, Issue 5, 1 1 2018, Pages 736-754 Imaging Needs in Novel Transcatheter Tricuspid Valve Interventions. Prihadi EA, Delgado V, Hahn RT, Leipsic J, Min JK, Bax JJ

The advent of novel transcatheter therapies for severe tricuspid regurgitation (TR) has attracted much attention. Novel 3-dimensional imaging techniques have permitted analysis of the tricuspid valve (TV) anatomy from unparalleled views and better understanding of the underlying pathophysiology of TR. Grading TR and assessment of right ventricular function remain challenging, and although 2-dimensional echocardiography is the mainstay imaging technique to evaluate patients with severe TR the use... Abstract

Cited 61 times since 2018 (8.6 per year) source: EuropePMC

European heart journal. Cardiovascular Imaging, Volume 19, Issue 5, 1 1 2018, Pages 475-481 Focus cardiac ultrasound core curriculum and core syllabus of the European Association of Cardiovascular Imaging. Neskovic AN, Skinner H, Price S, Via G, De Hert S, Stankovic I, Galderisi M, Donal E, Muraru D, Sloth E, Gargani L, Cardim N, Stefanidis A, Cameli M, Habib G, Cosyns B, Lancellotti P, Edvardsen T, Popescu BA, Reviewers: This document was reviewed by members of the 2016–2018 EACVI Scientific Documents Committee

There is a growing trend of using ultrasound examination of the heart as a first-line diagnostic tool for initial patient evaluation in acute settings. Focus cardiac ultrasound (FoCUS) is a standardized but restricted cardiac ultrasound examination that may be undertaken by a range of medical professionals with diverse backgrounds. The intention of this core curriculum and syllabus is to define a unifying framework for educational and training processes/programmes that should result in competenc... Abstract

The Lancet. Neurology, Volume 17, Issue 5, 1 1 2018, Pages 393-394 Intravenous versus subcutaneous immunoglobulin - Authors' reply. van Schaik IN, Mielke O, PATH study group

Abstract

Cited 18 times since 2018 (2.5 per year) source: EuropePMC

Journal of intensive care medicine, Volume 35, Issue 6, 1 1 2018, Pages 595-605 Early Prediction of Intensive Care Unit-Acquired Weakness: A Multicenter External Validation Study. Witteveen E, Wieske L, Sommers J, Spijkstra JJ, de Waard MC, Endeman H, Rijkenberg S, de Ruijter W, Sleeswijk M, Verhamme C, Schultz MJ, van Schaik IN, Horn J

Objectives: An early diagnosis of intensive care unit-acquired weakness (ICU-AW) is often not possible due to impaired consciousness. To avoid a diagnostic delay, we previously developed a prediction model, based on single-center data from 212 patients (development cohort), to predict ICU-AW at 2 days after ICU admission. The objective of this study was to investigate the external validity of the original prediction model in a new, multicenter cohort and, if necessary, to update the model. Metho... Abstract

Cited 8 times since 2018 (1.1 per year) source: EuropePMC

European heart journal. Cardiovascular Imaging, Volume 19, Issue 5, 1 1 2018, Pages 516-523 Right ventricular outflow tract dimensions in arrhythmogenic right ventricular cardiomyopathy/dysplasia-a multicentre study comparing echocardiography and cardiovascular magnetic resonance. Gotschy A, Saguner AM, Niemann M, Hamada S, Akdis D, Yoon JN, Parmon EV, Delgado V, Bax JJ, Kozerke S, Brunckhorst C, Duru F, Tanner FC, Manka R

Aims: Right ventricular outflow tract (RVOT) dilation is one of the echocardiographic criteria in the 2010 revised Task Force Criteria (TFC) of arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D). However, studies comparing cardiac magnetic resonance (CMR) and transthoracic echocardiography (TTE) suggest a lower diagnostic accuracy of TTE due to its operator dependence and limited reproducibility. The goal of this study was to compare the 2010 TFC measures of RVOT dilation with th... Abstract

Cited 35 times since 2018 (4.9 per year) source: EuropePMC

Scientific reports, Volume 8, Issue 1, 30 5 2018, Pages 6753 Annexin A5 reduces infarct size and improves cardiac function after myocardial ischemia-reperfusion injury by suppression of the cardiac inflammatory response. de Jong RCM, Pluijmert NJ, de Vries MR, Pettersson K, Atsma DE, Jukema JW, Quax PHA

Annexin A5 (AnxA5) is known to have anti-inflammatory and anti-apoptotic properties. Inflammation and apoptosis are key processes in post-ischemic cardiac remodeling. In this study, we investigated the effect of AnxA5 on left ventricular (LV) function and remodeling three weeks after myocardial ischemia-reperfusion (MI-R) injury in hypercholesterolemic ApoE*3-Leiden mice. Using a mouse model for MI-R injury, we demonstrate AnxA5 treatment resulted in a 27% reduction of contrast-enhanced MRI asse... Abstract

Cited 76 times since 2018 (10.7 per year) source: EuropePMC

Journal of cardiovascular computed tomography, Volume 12, Issue 3, 30 5 2018, Pages 204-209 Maximization of the usage of coronary CTA derived plaque information using a machine learning based algorithm to improve risk stratification; insights from the CONFIRM registry. van Rosendael AR, Maliakal G, Kolli KK, Beecy A, Al'Aref SJ, Dwivedi A, Singh G, Panday M, Kumar A, Ma X, Achenbach S, Al-Mallah MH, Andreini D, Bax JJ, Berman DS, Budoff MJ, Cademartiri F, Callister TQ, Chang HJ, Chinnaiyan K, Chow BJW, Cury RC, DeLago A, Feuchtner G, Hadamitzky M, Hausleiter J, Kaufmann PA, Kim YJ, Leipsic JA, Maffei E, Marques H, Pontone G, Raff GL, Rubinshtein R, Shaw LJ, Villines TC, Gransar H, Lu Y, Jones EC, Peña JM, Lin FY, Min JK

Introduction: Machine learning (ML) is a field in computer science that demonstrated to effectively integrate clinical and imaging data for the creation of prognostic scores. The current study investigated whether a ML score, incorporating only the 16 segment coronary tree information derived from coronary computed tomography angiography (CCTA), provides enhanced risk stratification compared with current CCTA based risk scores. Methods: From the multi-center CONFIRM registry, patients were inclu... Abstract

Cited 9 times since 2018 (1.3 per year) source: EuropePMC

Clinical oral investigations, Volume 22, Issue 5, 30 5 2018, Pages 2135-2140 Gingival crevicular fluid levels of human beta-defensin-1 in type 2 diabetes mellitus and periodontitis. Yilmaz D, Caglayan F, Buber E, Könönen E, Aksoy Y, Gursoy UK, Guncu GN

Objectives: Human β-defensin (hBD)-1 is an important gatekeeper of the gingiva against constant bacterial challenge, and glucose levels are involved in its optimal expression. The aims of the study were to investigate hBD-1 levels in gingival crevicular fluid (GCF) and to compare these levels between type 2 diabetics with or without periodontitis and healthy individuals. Materials and methods: Altogether, 81 subjects were included in the study: 21 subjects with type 2 diabetes mellitus (T2DM) su... Abstract

PloS one, Volume 13, Issue 4, 26 4 2018, Pages e0196448 Evaluating the relationship between lesion burden and aging among the skeletons of an 18th-19th century London cemetery using osteological and radiological analysis. van Schaik K, Eisenberg R, Bekvalac J, Rühli F

Study of disease in the past can help illuminate patterns of human health, disease, and aging in the present. As average human life expectancy and incidence of chronic disease have increased in the last century, efforts to understand this epidemiologic shift have led to more investigation of healthy aging. Using osteological and radiological methods of analysis, this study examined 212 mostly nineteenth century adult skeletons from the crypt of St. Bride's in London, in order to investigate... Abstract

Cited 42 times since 2018 (5.9 per year) source: EuropePMC

British journal of cancer, Volume 118, Issue 10, 26 4 2018, Pages 1296-1301 Association between single-nucleotide polymorphisms and adverse events in nivolumab-treated non-small cell lung cancer patients. Bins S, Basak EA, El Bouazzaoui S, Koolen SLW, Oomen-de Hoop E, van der Leest CH, van der Veldt AAM, Sleijfer S, Debets R, van Schaik RHN, Aerts JGJV, Mathijssen RHJ

Background: Treatment with PD-1 inhibitors can be hampered by severe auto-immune-related toxicities. Our objective was to identify single-nucleotide polymorphisms (SNPs) in genes previously associated with auto-immunity, which are associated with toxicities in nivolumab-treated NSCLC patients. This was in order to identify patients prone to develop severe toxicities and to gain more insight into the underlying pathobiology. Methods: We analysed 322 nivolumab-treated patients and assessed the ass... Abstract

Cited 33 times since 2018 (4.7 per year) source: EuropePMC

Diabetes/metabolism research and reviews, Volume 34, Issue 5, 26 4 2018, Pages e3004 Risk of dipeptidyl peptidase-4 (DPP-4) inhibitors on site-specific cancer: A systematic review and meta-analysis. Overbeek JA, Bakker M, van der Heijden AAWA, van Herk-Sukel MPP, Herings RMC, Nijpels G

The long-term impact of dipeptidyl peptidase-4 (DPP-4) inhibition is unknown, and there are concerns about the influence of DPP-4 inhibition on carcinogenesis of the pancreas and thyroid. As DPP-4 is a rather unselective enzyme present in many tissues, we focused on all specific cancer types. PubMed and EMBASE were searched between January 2005 and April 2017 to identify studies comparing DPP-4 inhibitors with either placebo or active drugs on cancer risk. Studies were included if they reported... Abstract

Cited 33 times since 2018 (4.6 per year) source: EuropePMC

The Canadian journal of cardiology, Volume 34, Issue 8, 25 4 2018, Pages 1069-1078 Prognostic Value of Right Ventricular Strain Using Speckle-Tracking Echocardiography in Pulmonary Hypertension: A Systematic Review and Meta-analysis. Shukla M, Park JH, Thomas JD, Delgado V, Bax JJ, Kane GC, Howlett JG, White JA, Fine NM

Background: Right ventricular (RV) strain imaging using speckle-tracking echocardiography (STE) is a quantitative method of assessing RV systolic function that has shown prognostic utility in patients with pulmonary hypertension (PH). However, its prognostic value for a large and mixed PH population remains poorly defined. Methods: A systematic review and meta-analysis was performed using the MedLine, Embase, and Cochrane Library databases for publications reporting the prognostic value of RV st... Abstract

Cited 5 times since 2018 (0.7 per year) source: EuropePMC

The American journal of pathology, Volume 188, Issue 7, 22 4 2018, Pages 1524-1529 Leukocyte Dynamics during the Evolution of Human Coronary Atherosclerosis: Conclusions from a Sevenfold, Chromogen-Based, Immunohistochemical Evaluation. Zuiderwijk M, Geerts M, van Rhijn CJ, van den Bogaerdt A, Hamming JF, van Dijk RA, Lindeman JH

Atherosclerosis is a complex process with strong inflammatory component. We developed a straightforward sevenfold staining protocol for simultaneous assessment of dominant leukocyte classes, vascularization, and expression of the putative foam cell maker CD36. The method was applied on human coronaries covering the full spectrum of atherosclerotic disease. Results confirm the progressive association of macrophages and T cells with the process and a global presence of mast cells. B cells are excl... Abstract

Cited 12 times since 2018 (1.7 per year) source: EuropePMC

The Journal of thoracic and cardiovascular surgery, Volume 156, Issue 4, 18 3 2018, Pages 1368-1377.e5 One-year outcomes associated with a novel stented bovine pericardial aortic bioprosthesis. Sabik JF, Rao V, Lange R, Kappetein AP, Dagenais F, Labrousse L, Bapat V, Moront M, Weissman NJ, Patel HJ, Reardon MJ, Asch FM, Zeng C, Klautz RJM, PERIGON Investigators

Objectives: The study objectives were to evaluate the safety, effectiveness, and hemodynamic performance of a new stented bovine pericardial aortic valve. Methods: This trial enrolled patients with symptomatic moderate or severe aortic stenosis or chronic, severe aortic regurgitation. We assessed death, valve-related adverse events, functional recovery, and hemodynamic performance at discharge, 3 to 6 months, and 1 year, as required by the US Food and Drug Administration for regulatory approval.... Abstract

Cited 3 times since 2018 (0.4 per year) source: EuropePMC

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, Volume 26, Issue 5, 12 2 2018, Pages 1731-1733 Chronic total occlusion without collateral blood flow does not exclude myocardial viability and subsequent recovery after revascularization. Bax JJ, Delgado V

Abstract

Cited 6 times since 2018 (0.8 per year) source: EuropePMC

Frontiers in neuroscience, Volume 12, 10 2 2018, Pages 198 A FPGA Implementation of the CAR-FAC Cochlear Model. Xu Y, Thakur CS, Singh RK, Hamilton TJ, Wang RM, van Schaik A

This paper presents a digital implementation of the Cascade of Asymmetric Resonators with Fast-Acting Compression (CAR-FAC) cochlear model. The CAR part simulates the basilar membrane's (BM) response to sound. The FAC part models the outer hair cell (OHC), the inner hair cell (IHC), and the medial olivocochlear efferent system functions. The FAC feeds back to the CAR by moving the poles and zeros of the CAR resonators automatically. We have implemented a 70-section, 44.1 kHz sampling rate C... Abstract

Anatolian journal of cardiology, Volume 19, Issue 5, 10 2 2018, Pages 303-310 Increased microvolt T-wave alternans in children and adolescents with Eisenmenger syndrome. Karpuz D, Hallıoğlu O, Yılmaz DÇ

Objective: To determine the values of microvolt T-wave alternans (MTWA) in children and adolescents with Eisenmenger syndrome (ES) and controls. Methods: Thirteen were included in the study. After analyzing the 24-h ECG recordings, MTWA was considered using three leads (V5, V1, and aVF). Right heart catheterization and 6-minute walk test (6-MWD) were applied to the patients and pro-brain natriuretic peptide levels were assessed; echocardiographic parameters were obtained from both the groups and... Abstract

Cited 11 times since 2018 (1.5 per year) source: EuropePMC

Journal of cellular biochemistry, Volume 119, Issue 7, 10 2 2018, Pages 6146-6153 Cardiomyogenic differentiation of human adipose-derived mesenchymal stem cells transduced with Tbx20-encoding lentiviral vectors. Neshati V, Mollazadeh S, Fazly Bazzaz BS, de Vries AA, Mojarrad M, Naderi-Meshkin H, Neshati Z, Kerachian MA

Ischemic heart disease often results in myocardial infarction and is the leading cause of mortality and morbidity worldwide. Improvement in the function of infarcted myocardium is a main purpose of cardiac regenerative medicine. One possible way to reach this goal is via stem cell therapy. Mesenchymal stem cells (MSCs) are multipotent stromal cells that can differentiate into a variety of cell types but display limited cardiomyogenic differentiation potential. Members of the T-box family of tran... Abstract

Cited 13 times since 2018 (1.8 per year) source: EuropePMC

Frontiers in neuroscience, Volume 12, 10 2 2018, Pages 213 An FPGA-Based Massively Parallel Neuromorphic Cortex Simulator. Wang RM, Thakur CS, van Schaik A

This paper presents a massively parallel and scalable neuromorphic cortex simulator designed for simulating large and structurally connected spiking neural networks, such as complex models of various areas of the cortex. The main novelty of this work is the abstraction of a neuromorphic architecture into clusters represented by minicolumns and hypercolumns, analogously to the fundamental structural units observed in neurobiology. Without this approach, simulating large-scale fully connected netw... Abstract