Research

Publications

Below you can find a list of our published research.

7971 results

Cited 10 times since 2018 (1.4 per year) source: EuropePMC

JACC. Clinical electrophysiology, Volume 4, Issue 6, 28 4 2018, Pages 781-793 Slow Conducting Electroanatomic Isthmuses: An Important Link Between QRS Duration and Ventricular Tachycardia in Tetralogy of Fallot. Kapel GFL, Brouwer C, Jalal Z, Sacher F, Venlet J, Schalij MJ, Thambo JB, Jongbloed MRM, Blom NA, de Riva M, Zeppenfeld K

Objectives: This study sought to evaluate the influence of slow conducting anatomic isthmuses (SCAI) as dominant ventricular tachycardia (VT) substrate on QRS duration. Background: QRS prolongation has been associated with VT in repaired tetralogy of Fallot. Methods: Seventy-eight repaired tetralogy of Fallot patients (age 37 ± 15 years, 52 male, QRS duration 153 ± 29 ms, 67 right bundle branch blocks [RBBB]) underwent programmed stimulation and electroanatomic activation mapping during sinus rh... Abstract

Cited 8 times since 2018 (1.1 per year) source: EuropePMC

Cytokine, Volume 108, 26 4 2018, Pages 96-104 CXCL8 hyper-signaling in the aortic abdominal aneurysm. Kokje VBC, Gäbel G, Dalman RL, Koole D, Northoff BH, Holdt LM, Hamming JF, Lindeman JHN

There are indications for elevated CXCL8 levels in abdominal aortic aneurysm disease (AAA). CXCL8 is concurrently involved in neutrophil-mediated inflammation and angiogenesis, two prominent and distinctive characteristics of AAA. As such we considered an evaluation of a role for CXCL8 in AAA progression relevant. ELISA's, real time PCR and array analysis were used to explore CXCL8 signaling in AAA wall samples. A role for CXCL8 in AAA disease was tested through the oral CXCR1/2 antagonist... Abstract

Cited 17 times since 2018 (2.4 per year) source: EuropePMC

Applied biochemistry and biotechnology, Volume 186, Issue 1, 24 4 2018, Pages 245-255 MicroRNA-499a-5p Promotes Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells to Cardiomyocytes. Neshati V, Mollazadeh S, Fazly Bazzaz BS, de Vries AAF, Mojarrad M, Naderi-Meshkin H, Neshati Z, Mirahmadi M, Kerachian MA

Since the adult mammalian heart has limited regenerative capacity, cardiac trauma, disease, and aging cause permanent loss of contractile tissue. This has fueled the development of stem cell-based strategies to provide the damaged heart with new cardiomyocytes. Bone marrow-derived mesenchymal stem cells (BM-MSCs) are capable of self-renewal and differentiation into cardiomyocytes, albeit inefficiently. MicroRNAs (miRNAs, miRs) are non-coding RNAs that have the potential to control stem cell fate... Abstract

Cited 21 times since 2018 (2.9 per year) source: EuropePMC

Behavioural processes, Volume 161, 23 4 2018, Pages 17-30 Zoon politikon: The evolutionary origins of human socio-political systems. Gintis H, van Schaik C, Boehm C

We deploy the most up-to-date evidence available in various behavioral fields in support of the following hypothesis: The emergence of bipedalism and cooperative breeding in the hominin line, together with environmental developments that made a diet of meat from large animals adaptive, as well as cultural innovations in the form of fire, cooking, and lethal weapons, created a niche for hominins in which there was a significant advantage to individuals with the ability to communicate and persuade... Abstract

Cited 15 times since 2018 (2.1 per year) source: EuropePMC

BMJ open, Volume 8, Issue 3, 22 4 2018, Pages e019003 Prevalence of potentially inappropriate prescribing in a subpopulation of older European clinical trial participants: a cross-sectional study. O Riordan D, Aubert CE, Walsh KA, Van Dorland A, Rodondi N, Du Puy RS, Poortvliet RKE, Gussekloo J, Sinnott C, Byrne S, Galvin R, Jukema JW, Mooijaart SP, Baumgartner C, McCarthy V, Walsh EK, Collet TH, Dekkers OM, Blum MR, Kearney PM

Objectives: To estimate and compare the prevalence and type of potentially inappropriate prescribing (PIP) and potential prescribing omissions (PPOs) among community-dwelling older adults (≥65 years) enrolled to a clinical trial in three European countries. Design: A secondary analysis of the Thyroid Hormone Replacement for Subclinical Hypothyroidism Trial dataset. Participants: A subset of 48/80 PIP and 22/34 PPOs indicators from the Screening Tool of Older Persons Prescriptions/Screening Tool... Abstract

Cited 50 times since 2018 (6.9 per year) source: EuropePMC

JACC. Clinical electrophysiology, Volume 4, Issue 3, 19 3 2018, Pages 316-327 Targeting the Hidden Substrate Unmasked by Right Ventricular Extrastimulation Improves Ventricular Tachycardia Ablation Outcome After Myocardial Infarction. de Riva M, Naruse Y, Ebert M, Androulakis AFA, Tao Q, Watanabe M, Wijnmaalen AP, Venlet J, Brouwer C, Trines SA, Schalij MJ, Zeppenfeld K

Objectives: This study sought to determine whether ablation of hidden substrate unmasked by right ventricular extrastimulation (RVE) improves ablation outcome of post-myocardial infarction (MI) ventricular tachycardia (VT). Background: In patients with small or nontransmural scars after MI, part of the VT substrate may be functional and, in addition, masked by high-voltage far-field signals arising from adjacent normal myocardium. Methods: In 60 consecutive patients, systematic analysis of elect... Abstract

Cited 4 times since 2018 (0.6 per year) source: EuropePMC

Atherosclerosis, Volume 272, 16 3 2018, Pages 94-100 Associations between normal range albuminuria, renal function and cardiovascular function in a population-based imaging study. Dekkers IA, de Mutsert R, Rabelink TJ, Jukema JW, de Roos A, Rosendaal FR, Lamb HJ, de Vries APJ

Background and aims: In patients with impaired renal function and macroalbuminuria, cardiovascular risk factors are highly prevalent, however, whether this is also present in the general population is unclear. We investigated whether normal-range albuminuria and renal function are associated with cardiovascular function in the general population. Methods: In this cross-sectional analysis of the NEO study, urinary albumin-creatinine ratio (UACR), estimated glomerular filtration rate (eGFR), and i... Abstract

Cited 2 times since 2018 (0.3 per year) source: EuropePMC

American journal of translational research, Volume 10, Issue 3, 15 3 2018, Pages 816-826 No indications for platelet activation in acute clinical myocardial or renal ischemia/reperfusion injury. Kortekaas KA, de Vries DK, Roest M, Reinders ME, van der Veer EP, Klautz RJ, de Groot PG, Schaapherder AF, Lindeman JH

The pathophysiology of ischemia/reperfusion (I/R) injury is complex and poorly understood. Animal studies imply platelet activation as an initiator of the inflammatory response upon reperfusion. However, it remains unclear whether and how these results translate to clinical I/R. This study evaluates putative platelet activation in the context of two forms of clinical I/R (heart valve surgery with aortic-cross clamping, n = 39 and kidney transplantation, n = 34). The technique of sequential selec... Abstract

Cited 74 times since 2018 (10.3 per year) source: EuropePMC

Circulation research, Volume 122, Issue 12, 15 3 2018, Pages 1648-1660 The COMMD Family Regulates Plasma LDL Levels and Attenuates Atherosclerosis Through Stabilizing the CCC Complex in Endosomal LDLR Trafficking. Fedoseienko A, Wijers M, Wolters JC, Dekker D, Smit M, Huijkman N, Kloosterhuis N, Klug H, Schepers A, Willems van Dijk K, Levels JHM, Billadeau DD, Hofker MH, van Deursen J, Westerterp M, Burstein E, Kuivenhoven JA, van de Sluis B

Rationale: COMMD (copper metabolism MURR1 domain)-containing proteins are a part of the CCC (COMMD-CCDC22 [coiled-coil domain containing 22]-CCDC93 [coiled-coil domain containing 93]) complex facilitating endosomal trafficking of cell surface receptors. Hepatic COMMD1 inactivation decreases CCDC22 and CCDC93 protein levels, impairs the recycling of the LDLR (low-density lipoprotein receptor), and increases plasma low-density lipoprotein cholesterol levels in mice. However, whether any of the oth... Abstract

Cited 23 times since 2018 (3.2 per year) source: EuropePMC

Pediatric pulmonology, Volume 53, Issue 6, 12 2 2018, Pages 809-815 Early predictors of unresponsiveness to high-flow nasal cannula therapy in a pediatric emergency department. Er A, Çağlar A, Akgül F, Ulusoy E, Çitlenbik H, Yılmaz D, Duman M

Aim: High-flow nasal cannula (HFNC) is a new treatment option for pediatric respiratory distress and we aimed to assess early predictive factors of unresponsiveness to HFNC therapy in a pediatric emergency department (ED). Method: Patients who presented with respiratory distress and were treated by HFNC, were included. The age, gender, weight, medical history, diagnosis, vital signs, oxygen saturation/fraction of inspired oxygen (SpO2 /FiO2 ) ratio, modified Respiratory Distress Assessment Instr... Abstract

Cited 1050 times since 2018 (145.4 per year) source: EuropePMC

Nature genetics, Volume 50, Issue 4, 12 2 2018, Pages 524-537 Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes. Malik R, Chauhan G, Traylor M, Sargurupremraj M, Okada Y, Mishra A, Rutten-Jacobs L, Giese AK, van der Laan SW, Gretarsdottir S, Anderson CD, Chong M, Adams HHH, Ago T, Almgren P, Amouyel P, Ay H, Bartz TM, Benavente OR, Bevan S, Boncoraglio GB, Brown RD, Butterworth AS, Carrera C, Carty CL, Chasman DI, Chen WM, Cole JW, Correa A, Cotlarciuc I, Cruchaga C, Danesh J, de Bakker PIW, DeStefano AL, den Hoed M, Duan Q, Engelter ST, Falcone GJ, Gottesman RF, Grewal RP, Gudnason V, Gustafsson S, Haessler J, Harris TB, Hassan A, Havulinna AS, Heckbert SR, Holliday EG, Howard G, Hsu FC, Hyacinth HI, Ikram MA, Ingelsson E, Irvin MR, Jian X, Jiménez-Conde J, Johnson JA, Jukema JW, Kanai M, Keene KL, Kissela BM, Kleindorfer DO, Kooperberg C, Kubo M, Lange LA, Langefeld CD, Langenberg C, Launer LJ, Lee JM, Lemmens R, Leys D, Lewis CM, Lin WY, Lindgren AG, Lorentzen E, Magnusson PK, Maguire J, Manichaikul A, McArdle PF, Meschia JF, Mitchell BD, Mosley TH, Nalls MA, Ninomiya T, O'Donnell MJ, Psaty BM, Pulit SL, Rannikmäe K,

Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown. We conducted a multiancestry genome-wide-association meta-analysis in 521,612 individuals (67,162 cases and 454,450 controls) and discovered 22 new stroke risk loci, bringing the total to 32. We further found shared genetic variation with related vascular traits, including blood pressure, cardiac traits, and venous thromboembolism, at individual loci (n = 18), and using genetic risk scores and linkage-dise... Abstract

Cited 15 times since 2018 (2.1 per year) source: EuropePMC

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, Volume 31, Issue 7, 10 2 2018, Pages 777-783 Left Ventricular Mechanical Dispersion and Global Longitudinal Strain and Ventricular Arrhythmias in Predialysis and Dialysis Patients. Hensen LCR, Goossens K, Podlesnikar T, Rotmans JI, Jukema JW, Delgado V, Bax JJ

Background: Patients with advanced chronic kidney disease (CKD) have high risk for sudden cardiac death (SCD) and may benefit from implantable cardioverter-defibrillators (ICDs). However, the risk for ICD-related complications is also high in this population. Therefore, there is an unmet need for accurate risk stratification tools to identify patients with CKD at risk for ventricular arrhythmias (VAs), who may benefit from ICD implantation. The aim of this hypothesis-generating study was to inve... Abstract

Cited 19 times since 2018 (2.6 per year) source: EuropePMC

Journal of vascular surgery, Volume 68, Issue 1, 8 2 2018, Pages 100-108.e3 Gore Iliac Branch Endoprosthesis for treatment of bilateral common iliac artery aneurysms. Maldonado TS, Mosquera NJ, Lin P, Bellosta R, Barfield M, Moussa A, Rhee R, Schermerhorn ML, Weinberger J, Wikkeling M, Heyligers J, Veith FJ, Milner R, Reijnen MPJ, Gore Bilateral IBE Study Group

Objective: The Gore Iliac Branch Endoprosthesis (IBE; W. L. Gore & Associates, Flagstaff, Ariz) has recently been approved by the Food and Drug Administration for treatment of common iliac artery (CIA) aneurysms. Despite early excellent results in clinical trial, none of 63 patients were treated for bilateral iliac aneurysms. The goal of this study was to examine real-world experience using the Gore IBE for bilateral CIA aneurysms. Methods: A retrospective review of an international multicen... Abstract

Cited 8 times since 2018 (1.1 per year) source: EuropePMC

International journal of cardiology, Volume 268, 8 2 2018, Pages 156-161 Right heart function interacts with left ventricular remodeling after CRT: A pressure volume loop study. Schmeisser A, Rauwolf T, Ghanem A, Groscheck T, Adolf D, Grothues F, Fischbach K, Kosiek O, Huth C, Kropf S, Lange S, Luani B, Smid J, Schäfer MH, Schreiber J, Tanev I, Wengler F, Yeritsyan NB, Steendijk P, Braun-Dullaeus RC

Background: Right ventricular (RV) dysfunction is recognized as a cardinal prognostic marker in systolic heart failure patients. Conflicting data exist on the interaction of RV function and left ventricular (LV) reverse remodeling after cardiac resynchronization therapy (CRT). This prospective monocentric trial was set up to assess the predictive value of baseline RV function and corresponding RV-pulmonary artery (PA) coupling on LV reverse remodeling after CRT. Methods: 110 patients with a CRT... Abstract

Cited 3 times since 2018 (0.4 per year) source: EuropePMC

PloS one, Volume 13, Issue 3, 7 1 2018, Pages e0194102 Modulating mimicry: Exploring the roles of inhibitory control and social understanding in 5-year-olds' behavioral mimicry. van Schaik JE, Hunnius S

During adult interactions, behavioral mimicry, the implicit copying of an interaction partner's postures and mannerisms, communicates liking and affiliation. While this social behavior likely develops during early childhood, it is unclear which factors contribute to its emergence. Here, the roles of inhibitory control and social understanding on 5-year-olds' behavioral mimicry were investigated. Following a social manipulation in which one experimenter shared a sticker with the child a... Abstract

Cited 9 times since 2018 (1.2 per year) source: EuropePMC

Developmental psychology, Volume 54, Issue 6, 5 1 2018, Pages 999-1010 Cross-cultural differences in parental beliefs about infant motor development: A quantitative and qualitative report of middle-class Israeli and Dutch parents. van Schaik SDM, Oudgenoeg-Paz O, Atun-Einy O

The present study explored cultural differences in parental beliefs about motor development across 2 Western cultures: Israel and the Netherlands. Can 2 cultural models be distinguished regarding infant motor development in Israel and the Netherlands or are parental beliefs about motor development similar across these cultures? Using a questionnaire containing closed and open questions, beliefs of 206 Israeli and 198 Dutch parents of first-born children between 2 and 7 months old were analyzed.... Abstract

Cited 4 times since 2018 (0.6 per year) source: EuropePMC

Transplant international : official journal of the European Society for Organ Transplantation, Volume 31, Issue 6, 5 1 2018, Pages 610-619 The center effect in liver transplantation in the Eurotransplant region: a retrospective database analysis. Blok JJ, de Boer JD, Putter H, Rogiers X, Guba MO, Strassburg CP, Samuel U, van Hoek B, Hamming JF, Braat AE, Eurotransplant Liver Intestine Advisory Committee

Apart from donor and recipient risk factors, the effect of center-related factors has significant impact on graft survival after liver transplantation (LT). To investigate this effect in Eurotransplant, a retrospective database analysis was performed, including all LT's in adult recipients (≥18 years) in the Eurotransplant region from 1.1.2007 until 31.12.2013. Additionally, a survey was sent out to all transplant centers requesting information on surgeons' experience and exposure. In... Abstract

Cited 9 times since 2018 (1.2 per year) source: EuropePMC

BMC family practice, Volume 19, Issue 1, 2 1 2018, Pages 35 Disentangling the effect of illness perceptions on health status in people with type 2 diabetes after an acute coronary event. Vos RC, Kasteleyn MJ, Heijmans MJ, de Leeuw E, Schellevis FG, Rijken M, Rutten GE, Diacourse study group

Background: Chronically ill patients such as people with type 2 diabetes develop perceptions of their illness, which will influence their coping behaviour. Perceptions are formed once a health threat has been recognised. Many people with type 2 diabetes suffer from multimorbidity, for example the combination with cardiovascular disease. Perceptions of one illness may influence perceptions of the other condition. The aim of the current study was to evaluate the effect of an intervention in type 2... Abstract

Drug metabolism and personalized therapy, Volume 33, Issue 1, 1 1 2018, Pages 33-39 Accurate determination of the CYP2D6 (*1/*4)xN genotype by quantitative PCR. Pondman KM, van Schaik RHN, van der Weide J

Background: CYP2D6 is responsible for the metabolism of approximately 25% of all drugs. The expression of cytochrome P450 2D6 (CYP2D6) is influenced by a combination of factors including polymorphisms in the CYP2D6 gene. Analysis of the CYP2D6 genotype is used to personalize the medication to a patient's metabolism. Although many genotypes can be determined using standard genotype analysis, in some cases, an incomplete analysis is performed. The CYP2D6 genotype *1/*4 often occurs in combina... Abstract

Cited 1 times since 2018 (0.1 per year) source: EuropePMC

Circulation. Cardiovascular imaging, Volume 11, Issue 3, 1 1 2018, Pages e007643 Aortic Valve Calcium Load: Diagnostic and Prognostic Implications in Aortic Stenosis. Vollema EM, Delgado V, Bax JJ

Abstract