Research

Publications

Below you can find a list of our published research.

8684 results

Cited 11 times since 2017 (1.4 per year) source: EuropePMC

European heart journal. Cardiovascular pharmacotherapy, Volume 3, Issue 4, 1 1 2017, Pages 198-213 Diabetic patients with acute coronary syndromes in contemporary European registries: characteristics and outcomes. Lettino M, Andell P, Zeymer U, Widimsky P, Danchin N, Bardaji A, Barrabes JA, Cequier A, Claeys MJ, De Luca L, Dörler J, Erlinge D, Erne P, Goldstein P, Koul SM, Lemesle G, Lüscher TF, Matter CM, Montalescot G, Radovanovic D, Sendón JL, Tousek P, Weidinger F, Weston CFM, Zaman A, Li J, Jukema JW, PIRAEUS group

Aims: Among patients with acute coronary syndromes (ACS), those with diabetes mellitus (DM) are at particularly high risk of recurrent cardiovascular events and premature death. We aimed to provide a descriptive overview of unadjusted analyses of patient characteristics, ACS management, and outcomes up to 1 year after hospital admission for an ACS/index-ACS event, in patients with DM in contemporary registries in Europe. Methods and results: A total of 10 registries provided data in a systematic... Abstract

Cited 2 times since 2017 (0.3 per year) source: EuropePMC

The Annals of thoracic surgery, Volume 104, Issue 5, 28 4 2017, Pages 1464-1470 Restrictive Mitral Valve Annuloplasty: Prognostic Implications of Left Ventricular Forward Flow. Kamperidis V, van Wijngaarden SE, van Rosendael PJ, Kong WK, Leung M, Sianos G, Ajmone Marsan N, Delgado V, Bax JJ

Background: Surgical mitral valve repair for severe secondary mitral regurgitation (MR) remains controversial. The association of MR reduction and changes in left ventricular (LV) hemodynamics with survival has not been investigated. We investigated the independent associates of outcomes in heart failure patients with severe secondary MR who underwent surgical mitral valve repair. Methods: Patients (n = 130, 62 ± 12 years old, 55% men) with chronic severe secondary MR and impaired LV ejection fr... Abstract

Cited 15 times since 2017 (2 per year) source: EuropePMC

Journal of vascular surgery, Volume 67, Issue 3, 28 4 2017, Pages 735-739 A registry-based rationale for discrete intervention thresholds for open and endovascular elective abdominal aortic aneurysm repair in female patients. Tomee SM, Lijftogt N, Vahl A, Hamming JF, Lindeman JHN

Objective: An evidence-based consensus for a female-specific intervention threshold for abdominal aortic aneurysms (AAAs) is missing. This study aims to analyze sex-related differences in the epidemiology of ruptured AAA to establish an intervention threshold for women. Methods: The Dutch Surgical Aneurysm Audit (DSAA) is a compulsory, nation-wide registry of AAA repairs in The Netherlands. All patients with emergency or elective AAA repair between January 1, 2013, and December 31, 2015, were in... Abstract

Cited 5 times since 2017 (0.7 per year) source: EuropePMC

Preventive veterinary medicine, Volume 150, 28 4 2017, Pages 168-175 Quantification of the probability of reintroduction of IBR in the Netherlands through cattle imports. Santman-Berends IMGA, Mars MH, Waldeck HWF, van Duijn L, Wever P, van den Broek KWH, van Schaik G

In the Netherlands, the feasibility of a national control program for infectious bovine rhinotracheitis (IBR) is discussed. The aim of this program would be to achieve freedom from BoHV1 circulation (the causal agent of IBR), in the Dutch cattle population. When IBR would be eradicated, maintaining the free status is essential and insight in the probability of introduction of IBR through cattle imports is crucial. Values for input parameters such as the number of imports per country of origin, h... Abstract

Cited 3 times since 2017 (0.4 per year) source: EuropePMC

Atherosclerosis, Volume 266, 28 4 2017, Pages 196-204 Identification of a novel proinsulin-associated SNP and demonstration that proinsulin is unlikely to be a causal factor in subclinical vascular remodelling using Mendelian randomisation. Strawbridge RJ, Silveira A, Hoed MD, Gustafsson S, Luan J, Rybin D, Dupuis J, Li-Gao R, Kavousi M, Dehghan A, Haljas K, Lahti J, Gådin JR, Bäcklund A, de Faire U, Gertow K, Giral P, Goel A, Humphries SE, Kurl S, Langenberg C, Lannfelt LL, Lind L, Lindgren CCM, Mannarino E, Mook-Kanamori DO, Morris AP, de Mutsert R, Rauramaa R, Saliba-Gustafsson P, Sennblad B, Smit AJ, Syvänen AC, Tremoli E, Veglia F, Zethelius B, Björck HM, Eriksson JG, Hofman A, Franco OH, Watkins H, Jukema JW, Florez JC, Wareham NJ, Meigs JB, Ingelsson E, Baldassarre D, Hamsten A, IMPROVE study group

Background and aims: Increased proinsulin relative to insulin levels have been associated with subclinical atherosclerosis (measured by carotid intima-media thickness (cIMT)) and are predictive of future cardiovascular disease (CVD), independently of established risk factors. The mechanisms linking proinsulin to atherosclerosis and CVD are unclear. A genome-wide meta-analysis has identified nine loci associated with circulating proinsulin levels. Using proinsulin-associated SNPs, we set out to u... Abstract

Cited 90 times since 2017 (11.7 per year) source: EuropePMC

PloS one, Volume 12, Issue 9, 28 4 2017, Pages e0185403 Body fat distribution, in particular visceral fat, is associated with cardiometabolic risk factors in obese women. Elffers TW, de Mutsert R, Lamb HJ, de Roos A, Willems van Dijk K, Rosendaal FR, Jukema JW, Trompet S

Background: Body fat distribution is, next to overall obesity, an important risk factor for cardiometabolic outcomes in the general population. In particular, visceral adipose tissue (VAT) is strongly associated with cardiometabolic risk factors. Since it is unclear whether body fat distribution is also important in men and women with obesity we investigated the associations between measures of body fat distribution and cardiometabolic risk factors in men and women with obesity. Methods: In this... Abstract

Cited 1 times since 2017 (0.1 per year) source: EuropePMC

International urology and nephrology, Volume 49, Issue 12, 27 4 2017, Pages 2105-2109 Management of urinary tract infection with intravesical amikacin may increase the risk of bladder oxidative stress in children with neurogenic bladder. Amasyali AS, Yilmaz D, Yilmaz M, Kucukdurmaz F, Sonmez F, Erol H

Introduction: We evaluated the bladder oxidative stress in neurogenic bladder children treated with intravesical amikacin for recurrent UTI and whether urinary isoprostane f2 alpha (F2-IsoP) is a good biomarker in this particular condition. Methods: This prospectively designed controlled study was approved by the Adnan Menderes University institutional ethics committee (Adnan Menderes University, 2015/649). Between January 2016 and January 2017, twenty-six children with meningomyelocele who had... Abstract

Cited 9 times since 2017 (1.2 per year) source: EuropePMC

Journal of internal medicine, Volume 282, Issue 6, 27 4 2017, Pages 522-536 A protective role of IRF3 and IRF7 signalling downstream TLRs in the development of vein graft disease via type I interferons. Simons KH, Peters HAB, Jukema JW, de Vries MR, Quax PHA

Background: Toll like receptors (TLR) play an important role in vein graft disease (VGD). Interferon regulatory factors (IRF) 3 and 7 are the transcriptional regulators of type I interferons (IFN) and type I IFN responsive genes and are downstream factors of TLRs. Relatively little is known with regard to the interplay of IRFs and TLRs in VGD development. The aim of this study was to investigate the role of IRF3 and IRF7 signaling downstream TLRs and the effect of IRF3 and IRF7 in VGD. Methods a... Abstract

Cited 2 times since 2017 (0.3 per year) source: EuropePMC

Frontiers in aging neuroscience, Volume 9, 27 4 2017, Pages 307 Lower Performance in Orientation to Time and Place Associates with Greater Risk of Cardiovascular Events and Mortality in the Oldest Old: Leiden 85-Plus Study. Rostamian S, van Buchem MA, Jukema JW, Gussekloo J, Poortvliet RKE, de Cren AJM, Sabayan B

Background: Impairment in orientation to time and place is commonly observed in community-dwelling older individuals. Nevertheless, the clinical significance of this has been not fully explored. In this study, we investigated the link between performance in orientation domains and future risk of cardiovascular events and mortality in a non-hospital setting of the oldest old adults. Methods: We included 528 subjects free of myocardial infarction (Group A), 477 individuals free of stroke/transient... Abstract

Cited 2 times since 2017 (0.3 per year) source: EuropePMC

The Journal of dermatological treatment, Volume 29, Issue 4, 26 4 2017, Pages 375-382 Thiopurine metabolite levels in patients with atopic dermatitis and/or chronic hand/foot eczema treated with azathioprine. Garritsen FM, van der Schaft J, Bruijnzeel-Koomen CAF, van Schaik RH, de Graaf M, van den Broek MPH, de Bruin-Weller MS

Background: Azathioprine is frequently used in severe eczema. It is converted in the liver into active metabolites, including 6-thioguanine nucleotide (6-TGN) and methylated 6-methylmercaptopurine (6-MMP). In the past, the therapeutic potential of azathioprine may have not been fully utilized. Recent investigations on inflammatory bowel disease have led to a better understanding of azathioprine metabolism and optimizing treatment. Objective: To investigate whether measuring thiopurine metabolite... Abstract

Multimedia manual of cardiothoracic surgery : MMCTS, Volume 2017, 25 4 2017 The Ross reimplantation technique. Schneider A, Klautz RJM, Hazekamp M

Pulmonary autograft replacement of a diseased aortic valve (the Ross procedure) is effective in children, where growth is essential, and in young patients for whom a biological solution is preferred. Long-term outcomes are generally good. However eventual autograft dilatation may necessitate reoperation. In order to diminish the risk of autograft dilatation, several 'wrapping' techniques have been developed. Here, we present our technique of choice: the reimplantation of the pulmonary... Abstract

Cited 8 times since 2017 (1 per year) source: EuropePMC

Journal of bodywork and movement therapies, Volume 22, Issue 3, 23 4 2017, Pages 817-828 A randomised crossover trial comparing Thai and Swedish massage for fatigue and depleted energy. MacSween A, Lorrimer S, van Schaik P, Holmes M, van Wersch A

Background: The aim of this study was to compare the efficacy and social constructions of Thai massage (TM) and Swedish massage (SM) for patients experiencing fatigue or depleted energy. Method: Twenty participants were randomised to receive three once-weekly TM treatments and three once-weekly SM treatments, with crossover after three massages. Symptom checklists were administered at three time points and included Activation-Deactivation Adjective Check List and VAS Scale. Qualitative data were... Abstract

Cited 11 times since 2017 (1.4 per year) source: EuropePMC

JMIR research protocols, Volume 6, Issue 9, 22 4 2017, Pages e186 Using Smart Technology to Improve Outcomes in Myocardial Infarction Patients: Rationale and Design of a Protocol for a Randomized Controlled Trial, The Box. Treskes RW, van Winden LA, van Keulen N, Atsma DE, van der Velde ET, van den Akker-van Marle E, Mertens B, Schalij MJ

Background: Recent evidence suggests that frequent monitoring using smartphone-compatible wearable technologies might improve clinical effectiveness and patient satisfaction of care. Objective: The aim of this study is to investigate the clinical effectiveness and patient satisfaction of a smart technology intervention in patients admitted with a ST elevation myocardial infarction (STEMI) or non-ST acute coronary syndrome (NST-ACS). Methods: In this single center, open, randomized controlled tri... Abstract

Cited 17 times since 2017 (2.2 per year) source: EuropePMC

Journal of cardiovascular computed tomography, Volume 11, Issue 6, 22 4 2017, Pages 423-428 Coronary lumen volume to myocardial mass ratio in primary microvascular angina. Grover R, Leipsic JA, Mooney J, Kueh SH, Ohana M, Nørgaard BL, Eftekhari A, Bax JJ, Murphy DT, Hague CJ, Seidman MA, Blanke P, Sedlak T, Sellers SL

Background: Microvascular angina (MVA) is an incompletely understood clinical entity. Computational analysis of coronary Computed Tomography Angiography (CTA) has shown an association between low coronary lumen volume to myocardial mass (V/M) ratio and lower Fractional Flow Reserve values, independent of plaque measures. We hypothesized that low V/M ratio may be present in patients with MVA. Methods: A retrospective case-control analysis was performed using patients fulfilling guideline criteria... Abstract

Cited 44 times since 2017 (5.7 per year) source: EuropePMC

Journal of cardiovascular computed tomography, Volume 11, Issue 6, 21 3 2017, Pages 462-467 Fractional flow reserve derived from coronary computed tomography angiography reclassification rate using value distal to lesion compared to lowest value. Kueh SH, Mooney J, Ohana M, Kim U, Blanke P, Grover R, Sellers S, Ellis J, Murphy D, Hague C, Bax JJ, Nørgaard BL, Rabbat M, Leipsic JA

Introduction: A standardised approach to the interpretation of FFRCT data is currently lacking. We evaluated the rate of reclassification of FFRCT positivity using the FFRCT value distal to an anatomical stenoses compared to the lowest FFRCT value. Method: Patients who underwent coronary CTA and FFRCT analysis were eligible. FFRCT value of ≤ 0.80 was considered positive. Positive FFRCT distal to stenosis was defined as those with a stenoses of ≥ 25% with an associated FFRCT value of ≤ 0.80 withi... Abstract

Cited 6 times since 2017 (0.8 per year) source: EuropePMC

Nurse education in practice, Volume 28, 19 3 2017, Pages 34-39 Evaluation of students' knowledge about paediatric dosage calculations. Özyazıcıoğlu N, Aydın Aİ, Sürenler S, Çinar HG, Yılmaz D, Arkan B, Tunç GÇ

Medication errors are common and may jeopardize the patient safety. As paediatric dosages are calculated based on the child's age and weight, risk of error in dosage calculations is increasing. In paediatric patients, overdose drug prescribed regardless of the child's weight, age and clinical picture may lead to excessive toxicity and mortalities while low doses may delay the treatment. This study was carried out to evaluate the knowledge of nursing students about paediatric dosage cal... Abstract

Cited 9 times since 2017 (1.2 per year) source: EuropePMC

The American journal of cardiology, Volume 120, Issue 12, 18 3 2017, Pages 2226-2232 Prevalence and Prognostic Relevance of Ventricular Conduction Disturbances in Patients With Aortic Stenosis. Prihadi EA, Leung M, Vollema EM, Ng ACT, Ajmone Marsan N, Bax JJ, Delgado V

The prevalence and prognostic implications of ventricular conduction disturbances in aortic stenosis (AS) have not been extensively evaluated. The present retrospective study investigated the prevalence and prognostic implications of ventricular conduction abnormalities (including the QRS morphology and duration) in AS. A total of 1,245 patients (mean age 66 ± 14 years, 62.8% men) with varying AS severity (aortic sclerosis 33.9%, mild AS 11.5%, moderate AS 29.9%, and severe AS 24.7%) were evalua... Abstract

Cited 6 times since 2017 (0.8 per year) source: EuropePMC

Oncotarget, Volume 8, Issue 49, 15 3 2017, Pages 86056-86065 Patients with NSCLC may display a low ratio of p.T790M <i>vs.</i> activating EGFR mutations in plasma at disease progression: implications for personalised treatment. Del Re M, Bordi P, Petrini I, Rofi E, Mazzoni F, Belluomini L, Vasile E, Restante G, Di Costanzo F, Falcone A, Frassoldati A, van Schaik RHN, Steendam CMJ, Chella A, Tiseo M, Morganti R, Danesi R

Introduction: NSCLC harboring activating mutations of EGFR is highly sensitive to first-line EGFR-tyrosine kinase inhibitors (TKIs), but drug resistance depending on the EGFR mutation p.T790M will occur in about 50-60% of patients. Detailed information on the amount of p.T790M plasmatic level associated with resistance to EGFR-TKIs and guidance to treatment with p.T790M-effective TKI depending on these levels, is lacking. Methods: This study enrolled p.T790M-positive patients (n=49) affected by... Abstract

Cited 26 times since 2017 (3.4 per year) source: EuropePMC

JACC. Clinical electrophysiology, Volume 3, Issue 13, 13 2 2017, Pages 1592-1598 Temporal Relationship of Asystole to Onset of Transient Loss of Consciousness in Tilt-Induced Reflex Syncope. Saal DP, Thijs RD, van Zwet EW, Bootsma M, Brignole M, Benditt DG, van Dijk JG

Objectives: The purpose of this study was to investigate the relationship between the onset of asystole and transient loss of consciousness (TLOC) in tilt-induced reflex syncope and estimate how often asystole was the principal cause of TLOC. Background: The presence of asystole in vasovagal syncope (VVS) may prompt physicians to consider pacemaker therapy for syncope prevention, but the benefit of pacing is limited in VVS. Methods: We evaluated electrocardiography, electroencephalography, blood... Abstract

Cited 13 times since 2017 (1.7 per year) source: EuropePMC

Scientific reports, Volume 7, Issue 1, 12 2 2017, Pages 11303 Genetic Interactions with Age, Sex, Body Mass Index, and Hypertension in Relation to Atrial Fibrillation: The AFGen Consortium. Weng LC, Lunetta KL, Müller-Nurasyid M, Smith AV, Thériault S, Weeke PE, Barnard J, Bis JC, Lyytikäinen LP, Kleber ME, Martinsson A, Lin HJ, Rienstra M, Trompet S, Krijthe BP, Dörr M, Klarin D, Chasman DI, Sinner MF, Waldenberger M, Launer LJ, Harris TB, Soliman EZ, Alonso A, Paré G, Teixeira PL, Denny JC, Shoemaker MB, Van Wagoner DR, Smith JD, Psaty BM, Sotoodehnia N, Taylor KD, Kähönen M, Nikus K, Delgado GE, Melander O, Engström G, Yao J, Guo X, Christophersen IE, Ellinor PT, Geelhoed B, Verweij N, Macfarlane P, Ford I, Heeringa J, Franco OH, Uitterlinden AG, Völker U, Teumer A, Rose LM, Kääb S, Gudnason V, Arking DE, Conen D, Roden DM, Chung MK, Heckbert SR, Benjamin EJ, Lehtimäki T, März W, Smith JG, Rotter JI, van der Harst P, Jukema JW, Stricker BH, Felix SB, Albert CM, Lubitz SA

It is unclear whether genetic markers interact with risk factors to influence atrial fibrillation (AF) risk. We performed genome-wide interaction analyses between genetic variants and age, sex, hypertension, and body mass index in the AFGen Consortium. Study-specific results were combined using meta-analysis (88,383 individuals of European descent, including 7,292 with AF). Variants with nominal interaction associations in the discovery analysis were tested for association in four independent st... Abstract