Research

Publications

Below you can find a list of our published research.

8684 results

Heart (British Cardiac Society), Volume 104, Issue 4, 1 1 2017, Pages 332-339 Impact of presynaptic sympathetic imbalance in long-QT syndrome by positron emission tomography. Zumhagen S, Vrachimis A, Stegger L, Kies P, Wenning C, Ernsting M, Müller J, Seebohm G, Paul M, Schäfers K, Stallmeyer B, Schäfers M, Schulze-Bahr E

Objective: We investigated the impact of cardiac presynaptic norepinephrine recycling in patients with long-QT syndrome (LQTS) using positron emission tomography (PET) with 11C-meta-hydroxyephedrine ([11C]mHED-PET). Methods: [11C]mHED-PET was performed in 25 patients with LQTS (LQT1: n=14; LQT2: n=11) and 20 healthy controls and correlated with clinical parameters. [11C]mHED-PET images were analysed for global and regional retention indices (RI) and washout rates (WO) reflecting dynamic paramete... Abstract

Cited 19 times since 2017 (2.4 per year) source: EuropePMC

Scientific reports, Volume 7, Issue 1, 31 5 2017, Pages 10269 Deficiency of TLR4 homologue RP105 aggravates outward remodeling in a murine model of arteriovenous fistula failure. Bezhaeva T, Wong C, de Vries MR, van der Veer EP, van Alem CMA, Que I, Lalai RA, van Zonneveld AJ, Rotmans JI, Quax PHA

Arteriovenous access dysfunction is a major cause of morbidity for hemodialysis patients. The pathophysiology of arteriovenous fistula (AVF) maturation failure is associated with inflammation, impaired outward remodeling (OR) and intimal hyperplasia. RP105 is a critical physiologic regulator of TLR4 signaling in numerous cell types. In the present study, we investigated the impact of RP105 on AVF maturation, and defined cell-specific effects of RP105 on macrophages and vascular smooth muscle cel... Abstract

Cited 4 times since 2017 (0.5 per year) source: EuropePMC

European radiology, Volume 28, Issue 2, 30 5 2017, Pages 844-850 Accurate late gadolinium enhancement prediction by early T1- based quantitative synthetic mapping. van Dijk R, Kuijpers D, Kaandorp TAM, van Dijkman PRM, Vliegenthart R, van der Harst P, Oudkerk M

Objectives: Early synthetic gadolinium enhancement (ESGE) imaging from post-contrast T1 mapping after adenosine stress-perfusion cardiac magnetic resonance (CMR) was compared to conventional late gadolinium enhancement (LGE) imaging for assessing myocardial scar. Methods: Two hundred fourteen consecutive patients suspected of myocardial ischaemia were referred for stress-perfusion CMR. Myocardial infarct volume was quantified on a per-subsegment basis in both synthetic (2-3 min post-gadolinium)... Abstract

Cited 13 times since 2017 (1.7 per year) source: EuropePMC

The American journal of cardiology, Volume 120, Issue 11, 30 5 2017, Pages 2008-2016 Usefulness of the CRT-SCORE for Shared Decision Making in Cardiac Resynchronization Therapy in Patients With a Left Ventricular Ejection Fraction of ≤35. Höke U, Mertens B, Khidir MJH, Schalij MJ, Bax JJ, Delgado V, Ajmone Marsan N

Individualized estimation of prognosis after cardiac resynchronization therapy (CRT) remains challenging. Our aim was to develop a multiparametric prognostic risk score (CRT-SCORE) that could be used for patient-specific clinical shared decision making about CRT implantation. The CRT-SCORE was derived from an ongoing CRT registry, including 1,053 consecutive patients (age 67 ± 10 years, 76% male). Using preimplantation variables, 100 multiple imputed datasets were generated for model calibration... Abstract

Cited 19 times since 2017 (2.4 per year) source: EuropePMC

The American journal of cardiology, Volume 120, Issue 11, 30 5 2017, Pages 2065-2072 Influence of Aging on Level and Layer-Specific Left Ventricular Longitudinal Strain in Subjects Without Structural Heart Disease. Abou R, Leung M, Khidir MJH, Wolterbeek R, Schalij MJ, Ajmone Marsan N, Bax JJ, Delgado V

Values for level- (apical, mid, and basal) and layer-based (endocardial, mid-myocardial, and epicardial) left ventricular (LV) longitudinal strain across age are scarce. The present study evaluates the effect of aging on level- and layer-specific LV longitudinal strain in subjects without structural heart disease. A total of 408 subjects (mean age 58 years [range 16 to 91]; 49% men) were evaluated retrospectively. Subjects were divided into equal groups based on age and gender. Subjects with evi... Abstract

Cited 14 times since 2017 (1.8 per year) source: EuropePMC

Trials, Volume 18, Issue 1, 29 5 2017, Pages 402 Mobile phones in cryptogenic strOke patients Bringing sIngle Lead ECGs for Atrial Fibrillation detection (MOBILE-AF): study protocol for a randomised controlled trial. Treskes RW, Gielen W, Wermer MJ, Grauss RW, van Alem AP, Dehnavi RA, Kirchhof CJ, van der Velde ET, Maan AC, Wolterbeek R, Overbeek OM, Schalij MJ, Trines SA

Background: Recently published randomised clinical trials indicate that prolonged electrocardiom (ECG) monitoring might enhance the detection of paroxysmal atrial fibrillation (AF) in cryptogenic stroke or transient ischaemic attack (TIA) patients. A device that might be suitable for prolonged ECG monitoring is a smartphone-compatible ECG device (Kardia Mobile, Alivecor, San Francisco, CA, USA) that allows the patient to record a single-lead ECG without the presence of trained health care staff.... Abstract

Cited 9 times since 2017 (1.2 per year) source: EuropePMC

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, Volume 25, Issue 3, 28 4 2017, Pages 860-871 Invasive assessment of coronary artery disease. Pyxaras SA, Wijns W, Reiber JHC, Bax JJ

Coronary artery disease is associated to high mortality and morbidity rates and an accurate diagnostic assessment during heart catheterization has a fundamental role in prognostic stratification and treatment choices. Coronary angiography has been integrated by intravascular imaging modalities, namely intravascular ultrasound and optical coherence tomography, which allow the precise quantification of the atherosclerotic burden of coronary arteries. The hemodynamic relevance of a given coronary s... Abstract

Cited 10 times since 2017 (1.3 per year) source: EuropePMC

Frontiers in microbiology, Volume 8, 28 4 2017, Pages 1596 Characterization of <i>Enterococcus</i> Isolates Colonizing the Intestinal Tract of Intensive Care Unit Patients Receiving Selective Digestive Decontamination. Bello Gonzalez TDJ, Pham P, Top J, Willems RJL, van Schaik W, van Passel MWJ, Smidt H

Enterococci have emerged as important opportunistic pathogens in intensive care units (ICUs). In this study, enterococcal population size and Enterococcus isolates colonizing the intestinal tract of ICU patients receiving Selective Digestive Decontamination (SDD) were investigated. All nine patients included in the study showed substantial shifts in the enterococcal 16S rRNA gene copy number in the gut microbiota during the hospitalization period. Furthermore, 41 Enterococcus spp. strains were i... Abstract

Cited 39 times since 2017 (5 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 104, Issue 7, 28 4 2017, Pages 574-580 Factors associated with coronary artery disease and stroke in adults with congenital heart disease. Bokma JP, Zegstroo I, Kuijpers JM, Konings TC, van Kimmenade RRJ, van Melle JP, Kiès P, Mulder BJM, Bouma BJ

Objective: To determine factors associated with coronary artery disease (CAD) and ischaemic stroke in ageing adult congenital heart disease (ACHD) patients. Methods: We performed a multicentre case-control study, using data from the national CONgenital CORvitia (CONCOR) registry to identify ACHD patients within five participating centres. Patients with CAD were matched (1:2 ratio) with ACHD patients without CAD on age, CHD defect group and gender. Patients with ischaemic stroke (or transient isc... Abstract

Cited 7 times since 2017 (0.9 per year) source: EuropePMC

Travel medicine and infectious disease, Volume 19, 24 4 2017, Pages 33-36 Travel-related acquisition of diarrhoeagenic bacteria, enteral viruses and parasites in a prospective cohort of 98 Dutch travellers. van Hattem JM, Arcilla MS, Grobusch MP, Bart A, Bootsma MC, van Genderen PJ, van Gool T, Goorhuis A, van Hellemond JJ, Molenkamp R, Molhoek N, Oude Lashof AM, Stobberingh EE, de Wever B, Verbrugh HA, Melles DC, Penders J, Schultsz C, de Jong MD

Background: Limited prospective data are available on the acquisition of viral, bacterial and parasitic diarrhoeagenic agents by healthy individuals during travel. Methods: To determine the frequency of travel associated acquisition of 19 pathogens in 98 intercontinental travellers, qPCR was used to detect 8 viral pathogens, 6 bacterial enteric pathogens and 5 parasite species in faecal samples collected immediately before and after travel. Results: We found high pre-travel carriage rates of Bla... Abstract

Cited 18 times since 2017 (2.3 per year) source: EuropePMC

Scientific reports, Volume 7, Issue 1, 23 4 2017, Pages 9193 Leukocytic Toll-Like Receptor 2 Deficiency Preserves Cardiac Function And Reduces Fibrosis In Sustained Pressure Overload. Wang JW, Fontes MSC, Wang X, Chong SY, Kessler EL, Zhang YN, de Haan JJ, Arslan F, de Jager SCA, Timmers L, van Veen TAB, Lam CSP, Kleijn DPV

An involement of Toll-like receptor 2 (TLR2) has been established in cardiac dysfunction after acute myocardial infarction; however, its role in chronic pressure overload is unclear. We sought to evaluate the role of TLR2 in cardiac hypertrophy, fibrosis and dysfunction in sustained pressure overload. We induced pressure overload via transverse aortic constriction (TAC) in TLR2-/- and wild type (WT) mice, and followed temporal changes over 8 weeks. Despite similar increases in heart weight, left... Abstract

Cited 155 times since 2017 (19.9 per year) source: EuropePMC

Microbial genomics, Volume 3, Issue 10, 18 3 2017, Pages e000128 On the (im)possibility of reconstructing plasmids from whole-genome short-read sequencing data. Arredondo-Alonso S, Willems RJ, van Schaik W, Schürch AC

To benchmark algorithms for automated plasmid sequence reconstruction from short-read sequencing data, we selected 42 publicly available complete bacterial genome sequences spanning 12 genera, containing 148 plasmids. We predicted plasmids from short-read data with four programs (PlasmidSPAdes, Recycler, cBar and PlasmidFinder) and compared the outcome to the reference sequences. PlasmidSPAdes reconstructs plasmids based on coverage differences in the assembly graph. It reconstructed most of the... Abstract

Cited 3 times since 2017 (0.4 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 104, Issue 6, 16 3 2017, Pages 454-455 Surgical treatment of Marfan syndrome and related disorders is all about dealing with uncertainties. Groenink M, Koolbergen DR

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Cited 19 times since 2017 (2.4 per year) source: EuropePMC

Nano letters, Volume 17, Issue 9, 16 3 2017, Pages 5238-5243 Transport Properties of a Two-Dimensional PbSe Square Superstructure in an Electrolyte-Gated Transistor. Alimoradi Jazi M, Janssen VAEC, Evers WH, Tadjine A, Delerue C, Siebbeles LDA, van der Zant HSJ, Houtepen AJ, Vanmaekelbergh D

Self-assembled nanocrystal solids show promise as a versatile platform for novel optoelectronic materials. Superlattices composed of a single layer of lead-chalcogenide and cadmium-chalcogenide nanocrystals with epitaxial connections between the nanocrystals, present outstanding questions to the community regarding their predicted band structure and electronic transport properties. However, the as-prepared materials are intrinsic semiconductors; to occupy the bands in a controlled way, chemical... Abstract

Cited 66 times since 2017 (8.5 per year) source: EuropePMC

Microbiome, Volume 5, Issue 1, 14 2 2017, Pages 88 Comparative gut microbiota and resistome profiling of intensive care patients receiving selective digestive tract decontamination and healthy subjects. Buelow E, Bello González TDJ, Fuentes S, de Steenhuijsen Piters WAA, Lahti L, Bayjanov JR, Majoor EAM, Braat JC, van Mourik MSM, Oostdijk EAN, Willems RJL, Bonten MJM, van Passel MWJ, Smidt H, van Schaik W

Background: The gut microbiota is a reservoir of opportunistic pathogens that can cause life-threatening infections in critically ill patients during their stay in an intensive care unit (ICU). To suppress gut colonization with opportunistic pathogens, a prophylactic antibiotic regimen, termed "selective decontamination of the digestive tract" (SDD), is used in some countries where it improves clinical outcome in ICU patients. Yet, the impact of ICU hospitalization and SDD on the gut m... Abstract

Cited 4 times since 2017 (0.5 per year) source: EuropePMC

The American journal of hospice & palliative care, Volume 35, Issue 3, 10 2 2017, Pages 390-397 Pilot Study of an Interprofessional Palliative Care Curriculum: Course Content and Participant-Reported Learning Gains. Starks H, Coats H, Paganelli T, Mauksch L, van Schaik E, Lindhorst T, Hurd C, Doorenbos A

Context: The National Consensus Project for Quality Palliative Care Clinical Practice Guidelines recommend that palliative care clinicians work together as interprofessional teams. We created and piloted a 9-month curriculum that focused on 3 related domains: (1) patient-centered, narrative communication skills; (2) interprofessional team practice; and (3) metrics and systems integration. The multifaceted curriculum was delivered through 16 webinars, 8 online modules, 4 in-person workshops, refl... Abstract

Cited 1 times since 2017 (0.1 per year) source: EuropePMC

European urology, Volume 73, Issue 1, 9 2 2017, Pages e11-e12 Reply to Ugo De Giorgi, Vincenza Conteduca, and Emanuela Scarpi's Letter to the Editor re: Marzia Del Re, Elisa Biasco, Stefania Crucitta, et al. The Detection of Androgen Receptor Splice Variant 7 in Plasma-derived Exosomal RNA Strongly Predicts Resistance to Hormonal Therapy in Metastatic Prostate Cancer Patients. Eur Urol 2017;71:680-7. Del Re M, Biasco E, Crucitta S, Derosa L, Rofi E, Orlandini C, Miccoli M, Galli L, Falcone A, Jenster GW, van Schaik RH, Danesi R

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Cited 6 times since 2017 (0.8 per year) source: EuropePMC

Journal of clinical lipidology, Volume 11, Issue 6, 8 2 2017, Pages 1407-1414 Low levels of apolipoprotein-CII in normotriglyceridemic patients with very premature coronary artery disease: Observations from the MISSION! Intervention study. Hermans MPJ, Bodde MC, Jukema JW, Schalij MJ, van der Laarse A, Cobbaert CM

Background: While the overall acute myocardial infarction rates declined in women and men, premature acute myocardial infarction rates remained stable in men and increased in women. Objective: The purpose of this study was to assess whether baseline apolipoprotein (apo) levels, clinical characteristics, and follow-up of patients with very premature coronary artery disease (CAD) could provide novel clues for the identification of high-risk individuals. Methods: Apos were measured with a validated... Abstract

Cited 17 times since 2017 (2.2 per year) source: EuropePMC

Preventive veterinary medicine, Volume 146, 5 1 2017, Pages 103-113 A quantitative risk-analysis for introduction of Bovine Viral Diarrhoea Virus in the Netherlands through cattle imports. Santman-Berends IMGA, Mars MH, Van Duijn L, Van den Broek KWH, Van Schaik G

Many countries have implemented control programmes aiming to eradicate Bovine Viral Diarrhoea Virus (BVDV). After obtaining the free status, a risk of re-introduction of the virus through import may remain. Therefore the risk of introduction of BVDV through cattle imports in the Netherlands was quantified and the effectiveness of subsequent intervention measures was assessed. Data, literature and expert opinion were used to estimate values for input parameters to feed a stochastic simulation mod... Abstract

Cited 5 times since 2017 (0.6 per year) source: EuropePMC

EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, Volume 13, Issue 5, 4 1 2017, Pages e564-e571 Call-to-balloon time dashboard in patients with ST-segment elevation myocardial infarction results in significant improvement in the logistic chain. Hermans MPJ, Velders MA, Smeekes M, Drexhage OS, Hautvast RWM, Ytsma T, Schalij MJ, Umans VAWM

Aims: Timely reperfusion with primary percutaneous coronary intervention (pPCI) in ST-segment elevation myocardial infarction (STEMI) patients is associated with superior clinical outcomes. Aiming to reduce ischaemic time, an innovative system for home-to-hospital (H2H) time monitoring was implemented, which enabled real-time evaluation of ischaemic time intervals, regular feedback and improvements in the logistic chain. The objective of this study was to assess the results after implementation... Abstract