Research

Publications

Below you can find a list of our published research.

9026 results

Cited 15 times since 2015 (1.4 per year) source: EuropePMC

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, Volume 23, Issue 1, 9 2 2015, Pages 24-36 Prognostic value of coronary computed tomography angiography in diabetic patients without chest pain syndrome. van den Hoogen IJ, de Graaf MA, Roos CJ, Leen AC, Kharagjitsingh AV, Wolterbeek R, Kroft LJ, Wouter Jukema J, Bax JJ, Scholte AJ

Aims: Diabetic patients with coronary artery disease (CAD) are often free of chest pain syndrome. A useful modality for non-invasive assessment of CAD is coronary computed tomography angiography (CTA). However, the prognostic value of CAD on coronary CTA in diabetic patients without chest pain syndrome is relatively unknown. Therefore, the aim was to investigate the long-term prognostic value of coronary CTA in a large population diabetic patients without chest pain syndrome. Methods: Between 20... Abstract

Cited 1 times since 2015 (0.1 per year) source: EuropePMC

Interactive cardiovascular and thoracic surgery, Volume 21, Issue 4, 9 2 2015, Pages 459-464 Transthoracic echocardiography for selection of tubular graft size in David reimplantation technique. Regeer MV, Versteegh MI, Klautz RJ, Schalij MJ, Bax JJ, Ajmone Marsan N, Delgado V

Objectives: Selection of tubular graft size during David reimplantation technique for aortic root dilatation is based on perioperative leaflet height measurements. The present study evaluated whether transthoracic echocardiography (TTE)-based algorithms may help in selecting the graft size preoperatively. Methods: Thirty patients (52 ± 11 years old, 73% men) who underwent David reimplantation technique were evaluated. The implanted graft size was based on the David's formula. Leaflet height... Abstract

Cited 20 times since 2015 (1.9 per year) source: EuropePMC

PloS one, Volume 10, Issue 7, 8 2 2015, Pages e0130850 Bats Swarm Where They Hibernate: Compositional Similarity between Autumn Swarming and Winter Hibernation Assemblages at Five Underground Sites. van Schaik J, Janssen R, Bosch T, Haarsma AJ, Dekker JJ, Kranstauber B

During autumn in the temperate zone of both the new and old world, bats of many species assemble at underground sites in a behaviour known as swarming. Autumn swarming behaviour is thought to primarily serve as a promiscuous mating system, but may also be related to the localization and assessment of hibernacula. Bats subsequently make use of the same underground sites during winter hibernation, however it is currently unknown if the assemblages that make use of a site are comparable across swar... Abstract

Cited 39 times since 2015 (3.8 per year) source: EuropePMC

Scientific reports, Volume 5, 8 2 2015, Pages 11981 Mining microbial metatranscriptomes for expression of antibiotic resistance genes under natural conditions. Versluis D, D'Andrea MM, Ramiro Garcia J, Leimena MM, Hugenholtz F, Zhang J, Öztürk B, Nylund L, Sipkema D, van Schaik W, de Vos WM, Kleerebezem M, Smidt H, van Passel MW

Antibiotic resistance genes are found in a broad range of ecological niches associated with complex microbiota. Here we investigated if resistance genes are not only present, but also transcribed under natural conditions. Furthermore, we examined the potential for antibiotic production by assessing the expression of associated secondary metabolite biosynthesis gene clusters. Metatranscriptome datasets from intestinal microbiota of four human adults, one human infant, 15 mice and six pigs, of whi... Abstract

Cited 17 times since 2015 (1.6 per year) source: EuropePMC

American journal of hypertension, Volume 29, Issue 3, 8 2 2015, Pages 311-318 Blood Pressure Lowering Medication, Visit-to-Visit Blood Pressure Variability, and Cognitive Function in Old Age. Wijsman LW, de Craen AJ, Muller M, Sabayan B, Stott D, Ford I, Trompet S, Jukema JW, Westendorp RG, Mooijaart SP

Background: Visit-to-visit blood pressure (BP) variability is associated with cognitive impairment. We assessed to what extent the association between BP variability and cognitive impairment is mediated by the association of BP lowering medication (BPLM) with both BP variability and cognition. Methods: We studied 5,606 participants from the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER). BP was measured every 3 months during 3.2 years; BP variability was defined as the SD of B... Abstract

Cited 5 times since 2015 (0.5 per year) source: EuropePMC

Cardiovascular research, Volume 107, Issue 4, 3 1 2015, Pages 601-612 Forced fusion of human ventricular scar cells with cardiomyocytes suppresses arrhythmogenicity in a co-culture model. Engels MC, Askar SF, Jangsangthong W, Bingen BO, Feola I, Liu J, Majumder R, Versteegh MI, Braun J, Klautz RJ, Ypey DL, De Vries AA, Pijnappels DA

Aims: Fibrosis increases arrhythmogenicity in myocardial tissue by causing structural and functional disruptions in the cardiac syncytium. Forced fusion of fibroblastic cells with adjacent cardiomyocytes may theoretically resolve these disruptions. Therefore, the electrophysiological effects of such electrical and structural integration of fibroblastic cells into a cardiac syncytium were studied. Methods and results: Human ventricular scar cells (hVSCs) were transduced with lentiviral vectors en... Abstract

Cited 169 times since 2015 (16.3 per year) source: EuropePMC

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, Volume 20, Issue 26, 2 1 2015, Pages 21178 Emergence of a novel GII.17 norovirus – End of the GII.4 era? de Graaf M, van Beek J, Vennema H, Podkolzin AT, Hewitt J, Bucardo F, Templeton K, Mans J, Nordgren J, Reuter G, Lynch M, Rasmussen LD, Iritani N, Chan MC, Martella V, Ambert-Balay K, Vinjé J, White PA, Koopmans MP

In the winter of 2014/15 a novel GII.P17-GII.17 norovirus strain (GII.17 Kawasaki 2014) emerged, as a major cause of gastroenteritis outbreaks in China and Japan. Since their emergence these novel GII.P17-GII.17 viruses have replaced the previously dominant GII.4 genotype Sydney 2012 variant in some areas in Asia but were only detected in a limited number of cases on other continents. This perspective provides an overview of the available information on GII.17 viruses in order to gain insight in... Abstract

Cited 150 times since 2015 (14.5 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 66, Issue 3, 1 1 2015, Pages 278-307 Clinical Trial Design Principles and Endpoint Definitions for Transcatheter Mitral Valve Repair and Replacement: Part 1: Clinical Trial Design Principles: A Consensus Document From the Mitral Valve Academic Research Consortium. Stone GW, Vahanian AS, Adams DH, Abraham WT, Borer JS, Bax JJ, Schofer J, Cutlip DE, Krucoff MW, Blackstone EH, Généreux P, Mack MJ, Siegel RJ, Grayburn PA, Enriquez-Sarano M, Lancellotti P, Filippatos G, Kappetein AP, Mitral Valve Academic Research Consortium (MVARC)

Mitral regurgitation (MR) is one of the most prevalent valve disorders and has numerous etiologies, including primary (organic) MR, due to underlying degenerative/structural mitral valve (MV) pathology, and secondary (functional) MR, which is principally caused by global or regional left ventricular remodeling and/or severe left atrial dilation. Diagnosis and optimal management of MR requires integration of valve disease and heart failure specialists, MV cardiac surgeons, interventional cardiolo... Abstract

Cited 37 times since 2015 (3.6 per year) source: EuropePMC

Heart and vessels, Volume 31, Issue 5, 1 1 2015, Pages 795-806 Histopathology of aortic complications in bicuspid aortic valve versus Marfan syndrome: relevance for therapy? Grewal N, Franken R, Mulder BJ, Goumans MJ, Lindeman JH, Jongbloed MR, DeRuiter MC, Klautz RJ, Bogers AJ, Poelmann RE, Groot AC

Patients with bicuspid aortic valve (BAV) and patients with Marfan syndrome (MFS) are more prone to develop aortic dilation and dissection compared to persons with a tricuspid aortic valve (TAV). To elucidate potential common and distinct pathways of clinical relevance, we compared the histopathological substrates of aortopathy. Ascending aortic wall biopsies were divided in five groups: BAV (n = 36) and TAV (n = 23) without and with dilation and non-dilated MFS (n = 8). General histologic featu... Abstract

Cited 658 times since 2015 (63.5 per year) source: EuropePMC

JAMA, Volume 314, Issue 1, 1 1 2015, Pages 52-60 Association of Cardiometabolic Multimorbidity With Mortality. Emerging Risk Factors Collaboration, Di Angelantonio E, Kaptoge S, Wormser D, Willeit P, Butterworth AS, Bansal N, O'Keeffe LM, Gao P, Wood AM, Burgess S, Freitag DF, Pennells L, Peters SA, Hart CL, Håheim LL, Gillum RF, Nordestgaard BG, Psaty BM, Yeap BB, Knuiman MW, Nietert PJ, Kauhanen J, Salonen JT, Kuller LH, Simons LA, van der Schouw YT, Barrett-Connor E, Selmer R, Crespo CJ, Rodriguez B, Verschuren WM, Salomaa V, Svärdsudd K, van der Harst P, Björkelund C, Wilhelmsen L, Wallace RB, Brenner H, Amouyel P, Barr EL, Iso H, Onat A, Trevisan M, D'Agostino RB, Cooper C, Kavousi M, Welin L, Roussel R, Hu FB, Sato S, Davidson KW, Howard BV, Leening MJ, Leening M, Rosengren A, Dörr M, Deeg DJ, Kiechl S, Stehouwer CD, Nissinen A, Giampaoli S, Donfrancesco C, Kromhout D, Price JF, Peters A, Meade TW, Casiglia E, Lawlor DA, Gallacher J, Nagel D, Franco OH, Assmann G, Dagenais GR, Jukema JW, Sundström J, Woodward M, Brunner EJ, Khaw KT, Wareham NJ, Whitsel EA, Njølstad I, Hedblad B, Wassertheil-Smoller S, Engström G

Importance: The prevalence of cardiometabolic multimorbidity is increasing. Objective: To estimate reductions in life expectancy associated with cardiometabolic multimorbidity. Design, setting, and participants: Age- and sex-adjusted mortality rates and hazard ratios (HRs) were calculated using individual participant data from the Emerging Risk Factors Collaboration (689,300 participants; 91 cohorts; years of baseline surveys: 1960-2007; latest mortality follow-up: April 2013; 128,843 deaths). T... Abstract

Cited 10 times since 2015 (1 per year) source: EuropePMC

Arthritis care & research, Volume 67, Issue 7, 1 1 2015, Pages 981-988 Do knee osteoarthritis and fat-free mass interact in their impact on health-related quality of life in men? Results from a population-based cohort. Visser AW, de Mutsert R, Bloem JL, Reijnierse M, Kazato H, le Cessie S, den Heijer M, Rosendaal FR, Kloppenburg M, Netherlands Epidemiology of Obesity Study Group

Objective: To investigate whether obesity and other risk factors interact with knee osteoarthritis (OA) in its adverse impact on health-related quality of life (HRQOL). Methods: In 1,262 participants of the Netherlands Epidemiology of Obesity Study, a population-based cohort (age 45-65 years, 53% women, and median body mass index [BMI] 27 kg/m(2) ), knee OA was defined following modified American College of Rheumatology criteria. BMI and fat-free mass (as proxy for muscle mass) were assessed by... Abstract

Cited 127 times since 2015 (12.2 per year) source: EuropePMC

Nature, Volume 523, Issue 7561, 1 1 2015, Pages 459-462 Directional dominance on stature and cognition in diverse human populations. Joshi PK, Esko T, Mattsson H, Eklund N, Gandin I, Nutile T, Jackson AU, Schurmann C, Smith AV, Zhang W, Okada Y, Stančáková A, Faul JD, Zhao W, Bartz TM, Concas MP, Franceschini N, Enroth S, Vitart V, Trompet S, Guo X, Chasman DI, O'Connel JR, Corre T, Nongmaithem SS, Chen Y, Mangino M, Ruggiero D, Traglia M, Farmaki AE, Kacprowski T, Bjonnes A, van der Spek A, Wu Y, Giri AK, Yanek LR, Wang L, Hofer E, Rietveld CA, McLeod O, Cornelis MC, Pattaro C, Verweij N, Baumbach C, Abdellaoui A, Warren HR, Vuckovic D, Mei H, Bouchard C, Perry JRB, Cappellani S, Mirza SS, Benton MC, Broeckel U, Medland SE, Lind PA, Malerba G, Drong A, Yengo L, Bielak LF, Zhi D, van der Most PJ, Shriner D, Mägi R, Hemani G, Karaderi T, Wang Z, Liu T, Demuth I, Zhao JH, Meng W, Lataniotis L, van der Laan SW, Bradfield JP, Wood AR, Bonnefond A, Ahluwalia TS, Hall LM, Salvi E, Yazar S, Carstensen L, de Haan HG, Abney M, Afzal U, Allison MA, Amin N, Asselbergs FW, Bakker SJL, Barr RG, Baumeister SE, Benjamin DJ, Bergmann S, Boerwinkle E, Bott

Homozygosity has long been associated with rare, often devastating, Mendelian disorders, and Darwin was one of the first to recognize that inbreeding reduces evolutionary fitness. However, the effect of the more distant parental relatedness that is common in modern human populations is less well understood. Genomic data now allow us to investigate the effects of homozygosity on traits of public health importance by observing contiguous homozygous segments (runs of homozygosity), which are inferr... Abstract

Cited 1 times since 2015 (0.1 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 23, Issue 7-8, 1 1 2015, Pages 366-367 Acute pontine infarction after percutaneous coronary intervention: a very rare but devastating complication. Arslan F, Mair J, Franz WM, Otten M, van Lelyveld L

A 64-year-old man suffering from an acute posterior wall myocardial infarction underwent primary percutaneous coronary intervention. After several aspiration attempts, tirofiban infusion and pre- and post-dilatation, a bare-metal stent was successfully implanted in the culprit right coronary artery. While the patient did not show any neurological symptoms before or during the procedure, he exhibited hemiplegia and loss of spontaneous speech. Additional magnetic resonance imaging showed an extens... Abstract

Cited 42 times since 2015 (4 per year) source: EuropePMC

American journal of primatology, Volume 77, Issue 10, 26 4 2015, Pages 1109-1121 Contrasting responses to novelty by wild and captive orangutans. Forss SI, Schuppli C, Haiden D, Zweifel N, van Schaik CP

Several studies have suggested that wild primates tend to behave with caution toward novelty, whereas captive primates are thought to be less neophobic, more exploratory, and more innovative. However, few studies have systematically compared captive and wild individuals of the same species to document this "captivity effect" in greater detail. Here we report the responses of both wild and captive orangutans to the same novel items. Novel objects were presented to wild orangutans on mul... Abstract

Cited 17 times since 2015 (1.6 per year) source: EuropePMC

PloS one, Volume 10, Issue 6, 26 4 2015, Pages e0129899 Assessment of Myocardial Fibrosis in Mice Using a T2*-Weighted 3D Radial Magnetic Resonance Imaging Sequence. van Nierop BJ, Bax NA, Nelissen JL, Arslan F, Motaal AG, de Graaf L, Zwanenburg JJ, Luijten PR, Nicolay K, Strijkers GJ

Background: Myocardial fibrosis is a common hallmark of many diseases of the heart. Late gadolinium enhanced MRI is a powerful tool to image replacement fibrosis after myocardial infarction (MI). Interstitial fibrosis can be assessed indirectly from an extracellular volume fraction measurement using contrast-enhanced T1 mapping. Detection of short T2* species resulting from fibrotic tissue may provide an attractive non-contrast-enhanced alternative to directly visualize the presence of both repl... Abstract

Cited 59 times since 2015 (5.7 per year) source: EuropePMC

Clinical immunology (Orlando, Fla.), Volume 161, Issue 2, 25 4 2015, Pages 316-323 STK4 (MST1) deficiency in two siblings with autoimmune cytopenias: A novel mutation. Halacli SO, Ayvaz DC, Sun-Tan C, Erman B, Uz E, Yilmaz DY, Ozgul K, Tezcan İ, Sanal O

Combined immunodeficiencies (CIDs) are heterogeneous group of disorders characterized by abrogated/impaired T cell development and/or functions that resulted from diverse genetic defects. In addition to the susceptibility to infections with various microorganisms, the patients may have lymphoproliferation, autoimmunity, inflammation, allergy and malignancy. Recently, three groups have independently reported patients having mutations in STK4 gene that cause a novel autosomal recessive (AR) CID. W... Abstract

Cited 2 times since 2015 (0.2 per year) source: EuropePMC

Cardiovascular and interventional radiology, Volume 38, Issue 6, 24 4 2015, Pages 1674-1675 Testicular Embolism After Endovascular Aneurysm Repair: A Rare Complication of Endovascular Repair of Abdominal Aortic Aneurysms. Vervoort M, Hoencamp R, Eefting D

Abstract

Cited 13 times since 2015 (1.2 per year) source: EuropePMC

Diabetic medicine : a journal of the British Diabetic Association, Volume 32, Issue 12, 15 3 2015, Pages 1580-1587 Policy evaluation in diabetes prevention and treatment using a population-based macro simulation model: the MICADO model. van der Heijden AA, Feenstra TL, Hoogenveen RT, Niessen LW, de Bruijne MC, Dekker JM, Baan CA, Nijpels G

Aims: To test a simulation model, the MICADO model, for estimating the long-term effects of interventions in people with and without diabetes. Methods: The MICADO model includes micro- and macrovascular diseases in relation to their risk factors. The strengths of this model are its population scope and the possibility to assess parameter uncertainty using probabilistic sensitivity analyses. Outcomes include incidence and prevalence of complications, quality of life, costs and cost-effectiveness.... Abstract

Cited 30 times since 2015 (2.9 per year) source: EuropePMC

Immunobiology, Volume 220, Issue 11, 10 2 2015, Pages 1219-1226 Overexpressions of hBD-2, hBD-3, and hCAP18/LL-37 in Gingiva of Diabetics with Periodontitis. Yılmaz D, Güncü GN, Könönen E, Barış E, Çağlayan F, Gursoy UK

Antimicrobial peptides of the epithelium play a significant role in the innate immune response in the oral cavity, which is constantly exposed to microbes. Type 2 diabetes mellitus (T2DM) is a highly prevalent metabolic disease which is related to periodontal disease. To date, little is known about expressions of antimicrobial peptides in gingival epithelia of diabetics. Our aim was to examine the expression and localization of human beta-defensins (hBD)-2 and -3 and cathelicidin (hCAP18/LL-37)... Abstract

Cited 52 times since 2015 (5 per year) source: EuropePMC

PloS one, Volume 10, Issue 6, 10 2 2015, Pages e0126946 A Paleolatitude Calculator for Paleoclimate Studies. van Hinsbergen DJ, de Groot LV, van Schaik SJ, Spakman W, Bijl PK, Sluijs A, Langereis CG, Brinkhuis H

Realistic appraisal of paleoclimatic information obtained from a particular location requires accurate knowledge of its paleolatitude defined relative to the Earth's spin-axis. This is crucial to, among others, correctly assess the amount of solar energy received at a location at the moment of sediment deposition. The paleolatitude of an arbitrary location can in principle be reconstructed from tectonic plate reconstructions that (1) restore the relative motions between plates based on (mar... Abstract