Research

Publications

Below you can find a list of our published research.

9529 results

Cited 30 times since 2015 (2.9 per year) source: EuropePMC

Immunobiology, Volume 220, Issue 11, 10 2 2015, Pages 1219-1226 Overexpressions of hBD-2, hBD-3, and hCAP18/LL-37 in Gingiva of Diabetics with Periodontitis. Yılmaz D, Güncü GN, Könönen E, Barış E, Çağlayan F, Gursoy UK

Antimicrobial peptides of the epithelium play a significant role in the innate immune response in the oral cavity, which is constantly exposed to microbes. Type 2 diabetes mellitus (T2DM) is a highly prevalent metabolic disease which is related to periodontal disease. To date, little is known about expressions of antimicrobial peptides in gingival epithelia of diabetics. Our aim was to examine the expression and localization of human beta-defensins (hBD)-2 and -3 and cathelicidin (hCAP18/LL-37)... Abstract

Cited 52 times since 2015 (5 per year) source: EuropePMC

PloS one, Volume 10, Issue 6, 10 2 2015, Pages e0126946 A Paleolatitude Calculator for Paleoclimate Studies. van Hinsbergen DJ, de Groot LV, van Schaik SJ, Spakman W, Bijl PK, Sluijs A, Langereis CG, Brinkhuis H

Realistic appraisal of paleoclimatic information obtained from a particular location requires accurate knowledge of its paleolatitude defined relative to the Earth's spin-axis. This is crucial to, among others, correctly assess the amount of solar energy received at a location at the moment of sediment deposition. The paleolatitude of an arbitrary location can in principle be reconstructed from tectonic plate reconstructions that (1) restore the relative motions between plates based on (mar... Abstract

Cited 44 times since 2015 (4.2 per year) source: EuropePMC

European heart journal. Cardiovascular Imaging, Volume 17, Issue 1, 9 2 2015, Pages 96-105 Tricuspid valve remodelling in functional tricuspid regurgitation: multidetector row computed tomography insights. van Rosendael PJ, Joyce E, Katsanos S, Debonnaire P, Kamperidis V, van der Kley F, Schalij MJ, Bax JJ, Ajmone Marsan N, Delgado V

Aims: Multidetector row computed tomography (MDCT) may help to understand the underlying mechanisms of functional tricuspid regurgitation (TR), a highly prevalent valve disease with novel transcatheter therapies under development. The purpose of the present study was to assess the geometrical changes of the tricuspid valve in patients with functional TR using MDCT and to correlate these changes with the TR grade assessed with echocardiography. Methods and results: In 114 patients undergoing tran... Abstract

Cited 25 times since 2015 (2.4 per year) source: EuropePMC

Breast cancer research and treatment, Volume 152, Issue 1, 7 1 2015, Pages 119-128 Circadian variation in tamoxifen pharmacokinetics in mice and breast cancer patients. Binkhorst L, Kloth JSL, de Wit AS, de Bruijn P, Lam MH, Chaves I, Burger H, van Alphen RJ, Hamberg P, van Schaik RHN, Jager A, Koch BCP, Wiemer EAC, van Gelder T, van der Horst GTJ, Mathijssen RHJ

The anti-estrogen tamoxifen is characterized by a large variability in response, partly due to pharmacokinetic differences. We examined circadian variation in tamoxifen pharmacokinetics in mice and breast cancer patients. Pharmacokinetic analysis was performed in mice, dosed at six different times (24-h period). Tissue samples were used for mRNA expression analysis of drug-metabolizing enzymes. In patients, a cross-over study was performed. During three 24-h periods, after tamoxifen dosing at 8... Abstract

Cited 22 times since 2015 (2.1 per year) source: EuropePMC

European journal of heart failure, Volume 17, Issue 10, 4 1 2015, Pages 1042-1049 Anaemia in patients with aortic stenosis: influence on long-term prognosis. Ng AC, Kong WK, Kamperidis V, Bertini M, Antoni ML, Leung DY, Marsan NA, Delgado V, Bax JJ

Aims: The prognostic implications of anaemia in patients with aortic stenosis (AS) remain unclear. Accordingly, the present study aimed to evaluate the prognostic implications of anaemia in AS patients before and after aortic valve replacement (AVR). Methods and results: A total of 856 AS patients (age 71 ± 12 years, 60.2% male, 47.4% severe AS) were included. The mean haemoglobin (Hb) level was 13.2 ± 1.8 g/dL, and the prevalence of anaemia (Hb Abstract

Cited 48 times since 2015 (4.6 per year) source: EuropePMC

Atherosclerosis, Volume 241, Issue 2, 3 1 2015, Pages 289-296 Mast cells mediate neutrophil recruitment during atherosclerotic plaque progression. Wezel A, Lagraauw HM, van der Velden D, de Jager SC, Quax PH, Kuiper J, Bot I

Aims: Activated mast cells have been identified in the intima and perivascular tissue of human atherosclerotic plaques. As mast cells have been described to release a number of chemokines that mediate leukocyte fluxes, we propose that activated mast cells may play a pivotal role in leukocyte recruitment during atherosclerotic plaque progression. Methods and results: Systemic IgE-mediated mast cell activation in apoE(-/-)μMT mice resulted in an increase in atherosclerotic lesion size as compared... Abstract

Cited 489 times since 2015 (46.8 per year) source: EuropePMC

Clinical pharmacology and therapeutics, Volume 98, Issue 1, 3 1 2015, Pages 19-24 Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for CYP3A5 Genotype and Tacrolimus Dosing. Birdwell KA, Decker B, Barbarino JM, Peterson JF, Stein CM, Sadee W, Wang D, Vinks AA, He Y, Swen JJ, Leeder JS, van Schaik R, Thummel KE, Klein TE, Caudle KE, MacPhee IA

Tacrolimus is the mainstay immunosuppressant drug used after solid organ and hematopoietic stem cell transplantation. Individuals who express CYP3A5 (extensive and intermediate metabolizers) generally have decreased dose-adjusted trough concentrations of tacrolimus as compared with those who are CYP3A5 nonexpressers (poor metabolizers), possibly delaying achievement of target blood concentrations. We summarize evidence from the published literature supporting this association and provide dosing... Abstract

Cited 42 times since 2015 (4 per year) source: EuropePMC

Atherosclerosis, Volume 241, Issue 2, 3 1 2015, Pages 547-554 Individual contributions of visceral fat and total body fat to subclinical atherosclerosis: The NEO study. Gast KB, den Heijer M, Smit JW, Widya RL, Lamb HJ, de Roos A, Jukema JW, Rosendaal FR, de Mutsert R, NEO study group

Background: Both overall and abdominal adiposity are established risk factors for cardiovascular disease. Visceral adipose tissue (VAT) and total body fat (TBF) are strongly correlated and previous studies did not make this distinction. Objective: We aimed to distinguish individual contributions of TBF, VAT, and the ratio of VAT to abdominal subcutaneous adipose tissue (VAT/SAT) to subclinical atherosclerosis in men and women. Methods: In this cross-sectional analysis of the Netherlands Epidemio... Abstract

Cited 2673 times since 2015 (255.9 per year) source: EuropePMC

The New England journal of medicine, Volume 372, Issue 25, 3 1 2015, Pages 2387-2397 Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes. Cannon CP, Blazing MA, Giugliano RP, McCagg A, White JA, Theroux P, Darius H, Lewis BS, Ophuis TO, Jukema JW, De Ferrari GM, Ruzyllo W, De Lucca P, Im K, Bohula EA, Reist C, Wiviott SD, Tershakovec AM, Musliner TA, Braunwald E, Califf RM, IMPROVE-IT Investigators

Background: Statin therapy reduces low-density lipoprotein (LDL) cholesterol levels and the risk of cardiovascular events, but whether the addition of ezetimibe, a nonstatin drug that reduces intestinal cholesterol absorption, can reduce the rate of cardiovascular events further is not known. Methods: We conducted a double-blind, randomized trial involving 18,144 patients who had been hospitalized for an acute coronary syndrome within the preceding 10 days and had LDL cholesterol levels of 50 to... Abstract

Cited 14 times since 2015 (1.3 per year) source: EuropePMC

Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery, Volume 43, Issue 7, 2 1 2015, Pages 1059-1064 Do altitude and climate affect paranasal sinus volume? Selcuk OT, Erol B, Renda L, Osma U, Eyigor H, Gunsoy B, Yagci B, Yılmaz D

Objective: The aim of this study was to evaluate the effect of climate and altitude differences on the volume of paranasal sinuses and on the frequency of anatomic variations by comparing the paranasal sinus tomograms (PNSCT) of patients who were born and living in a cold, dry climate at high altitude with those of patients who were born and living on the coast at sea level in a temperate climate. We also aimed to determine differences relating to gender. Material and methods: A total of 55 PNSC... Abstract

Guang pu xue yu guang pu fen xi = Guang pu, Volume 35, Issue 6, 1 1 2015, Pages 1501-1505 Radiation Parameters of Some Potential Bioactive Compounds. Gedik Z, Tugrak M, Dastan A, Gul HI, Yilmaz D

In this study, we aimed to determine the radiation parameters of some potential bioactive compounds. 1-Aryl-3-dibenzylamino-propane-1-on hydrochloride type Mannich bases were synthesized via classical conventional heating method. Aryl part was changed as phenyl (C6H5), 4-methylphenyl (4-CH3C6H4), 4-fluorophenyl ( 4-FC6H4), 4-nitrophenyl (4-NO2C6H4), 4-chlorophenyl (4-ClC6H4), 4-bromophenyl (4-BrC6H4), and 2-thienyl (C4H3S-2-yl). Mass attenuation coefficient (μm), effective atomic number (Z(eff))... Abstract

Cited 75 times since 2015 (7.2 per year) source: EuropePMC

European heart journal, Volume 36, Issue 31, 1 1 2015, Pages 2087-2096 Low gradient severe aortic stenosis with preserved ejection fraction: reclassification of severity by fusion of Doppler and computed tomographic data. Kamperidis V, van Rosendael PJ, Katsanos S, van der Kley F, Regeer M, Al Amri I, Sianos G, Marsan NA, Delgado V, Bax JJ

Aims: Low gradient severe aortic stenosis (AS) with preserved left ventricular ejection fraction (LVEF) may be attributed to aortic valve area index (AVAi) underestimation due to the assumption of a circular shape of the left ventricular outflow tract (LVOT) with 2-dimensional echocardiography. The current study evaluated whether fusing Doppler and multidetector computed tomography (MDCT) data to calculate AVAi results in significant reclassification of inconsistently graded severe AS. Methods a... Abstract

Cited 226 times since 2015 (21.6 per year) source: EuropePMC

Philosophical transactions of the Royal Society of London. Series B, Biological sciences, Volume 370, Issue 1670, 1 1 2015, Pages 20140087 The human gut resistome. van Schaik W

In recent decades, the emergence and spread of antibiotic resistance among bacterial pathogens has become a major threat to public health. Bacteria can acquire antibiotic resistance genes by the mobilization and transfer of resistance genes from a donor strain. The human gut contains a densely populated microbial ecosystem, termed the gut microbiota, which offers ample opportunities for the horizontal transfer of genetic material, including antibiotic resistance genes. Recent technological advan... Abstract

Cited 1 times since 2015 (0.1 per year) source: EuropePMC

Acta orthopaedica Belgica, Volume 81, Issue 2, 1 1 2015, Pages 321-326 Evaluation of current treatment techniques for distal radius fractures amongst Belgian orthopaedic surgeons. van Schaik DE, Goorens CK, Wernaers P, Hendrickx B, Scheerlinck T, Goubau JF

This online questionnaire was initiated to investigate if a consensus on the treatment of distal radius fractures amongst orthopaedic surgeons in Belgium exist. Two cases were presented: an extra-articular fracture, with dorsal displacement (Frykman type I) and a displaced intra-articular fracture (Frykman type VII). Treatment of choice and rationale of choice were investigated. 158 responses were collected. In case of a Frykman type I, the majority of surgeons would have performed a closed redu... Abstract

Cited 10 times since 2015 (1 per year) source: EuropePMC

Clinical chemistry and laboratory medicine, Volume 53, Issue 7, 1 1 2015, Pages 981-988 Is laboratory medicine ready for the era of personalized medicine? A survey addressed to laboratory directors of hospitals/academic schools of medicine in Europe. Malentacchi F, Mancini I, Brandslund I, Vermeersch P, Schwab M, Marc J, van Schaik RH, Siest G, Theodorsson E, Pazzagli M, Di Resta C, European Federation of Clinical Chemistry and Laboratory Medicine (EFLM), European Society of Pharmacogenomics and Personalised Therapy (ESPT) Joint Working Group on Personalized Laboratory Medicine (WG-PLM)

Developments in "-omics" are creating a paradigm shift in laboratory medicine leading to personalized medicine. This allows the increase in diagnostics and therapeutics focused on individuals rather than populations. In order to investigate whether laboratory medicine is ready to play a key role in the integration of personalized medicine in routine health care and set the state-of-the-art knowledge about personalized medicine and laboratory medicine in Europe, a questionnaire was cons... Abstract

Cited 4 times since 2015 (0.4 per year) source: EuropePMC

Drug metabolism and personalized therapy, Volume 30, Issue 2, 1 1 2015, Pages 121-128 Is laboratory medicine ready for the era of personalized medicine? A survey addressed to laboratory directors of hospitals/academic schools of medicine in Europe. Malentacchi F, Mancini I, Brandslund I, Vermeersch P, Schwab M, Marc J, van Schaik RH, Siest G, Theodorsson E, Pazzagli M, Di Resta C, European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) – European Society of Pharmacogenomics and Personalised Therapy (ESPT) Joint Working Group on Personalized Laboratory Medicine (WG-PLM)

Cited 11 times since 2015 (1.1 per year) source: EuropePMC

Neurocritical care, Volume 22, Issue 3, 1 1 2015, Pages 385-394 Feasibility and diagnostic accuracy of early electrophysiological recordings for ICU-acquired weakness: an observational cohort study. Wieske L, Verhamme C, Witteveen E, Bouwes A, Dettling-Ihnenfeldt DS, van der Schaaf M, Schultz MJ, van Schaik IN, Horn J

Background: An early diagnosis of ICU-acquired weakness (ICU-AW) is difficult because disorders of consciousness frequently preclude muscle strength assessment. In this study, we investigated feasibility and accuracy of electrophysiological recordings to diagnose ICU-AW early in non-awake critically ill patients. Methods: Newly admitted patients, mechanically ventilated ≥2 days and unreactive to verbal stimuli, were included in this study. Electrophysiological recordings comprised nerve conducti... Abstract

Cited 13 times since 2015 (1.2 per year) source: EuropePMC

Human nature (Hawthorne, N.Y.), Volume 26, Issue 2, 1 1 2015, Pages 143-160 Chimpanzees' Bystander Reactions to Infanticide: An Evolutionary Precursor of Social Norms? von Rohr CR, van Schaik CP, Kissling A, Burkart JM

Social norms-generalized expectations about how others should behave in a given context-implicitly guide human social life. However, their existence becomes explicit when they are violated because norm violations provoke negative reactions, even from personally uninvolved bystanders. To explore the evolutionary origin of human social norms, we presented chimpanzees with videos depicting a putative norm violation: unfamiliar conspecifics engaging in infanticidal attacks on an infant chimpanzee. T... Abstract

Cited 12 times since 2015 (1.1 per year) source: EuropePMC

Journal of cardiovascular medicine (Hagerstown, Md.), Volume 16, Issue 6, 1 1 2015, Pages 465-471 B-type natriuretic peptide vs. cardiac risk scores for prediction of outcome following major orthopedic surgery. Katsanos S, Babalis D, Kafkas N, Mavrogenis A, Leong D, Parissis J, Varounis C, Makris K, van der Heijden A, Anastasiou-Nana M, Filippatos G

Aims: The clinical role of B-type natriuretic peptide (BNP) in preoperative evaluation is not clear. We designed a prospective study to investigate the predictive value of BNP in comparison with established clinical risk scores for the outcome of major orthopedic surgery. Methods: Overall 242 elderly patients [80 (74-85) years] undergoing orthopedic surgery were included. Inhospital cardiovascular events and 1-year mortality were the main endpoints. Results: In total 20 (8.3%) patients had major... Abstract

Cited 26 times since 2015 (2.5 per year) source: EuropePMC

Journal of nuclear medicine : official publication, Society of Nuclear Medicine, Volume 56 Suppl 4, 1 1 2015, Pages 25S-30S 123I-MIBG SPECT for Evaluation of Patients with Heart Failure. Dimitriu-Leen AC, Scholte AJ, Jacobson AF

Heart failure (HF) is characterized by activation of the sympathetic cardiac nerves. The condition of cardiac sympathetic nerves can be evaluated by (123)I-metaiodobenzylguanidine ((123)I-MIBG) imaging. Most cardiac (123)I-MIBG studies have relied on measurements from anterior planar images of the chest. However, it has become progressively more common to include SPECT imaging in clinical and research protocols. This review examines recent trends in (123)I-MIBG SPECT imaging and evidence that pr... Abstract