Research

Publications

Below you can find a list of our published research.

6173 results

Cited 9 times since 1997 (0.3 per year) source: EuropePMC

International journal of cardiac imaging, Volume 13, Issue 3, 1 1 1997, Pages 179-189 Ischemic heart disease: value of MR techniques. van der Wall EE, van Rugge FP, Vliegen HW, Reiber JH, de Roos A, Bruschke AV

Background: The cardiovascular applications of magnetic resonance (MR) techniques in coronary artery disease have increased considerably in recent years. Technical advantages of MR imaging are the excellent spatial resolution, the characterization of myocardial tissue, and the potential for three-dimensional imaging. These characteristics allow the accurate assessment of left ventricular mass and volume, the differentiation of infarcted from normal tissue, and the determination of systolic wall... Abstract

Cited 137 times since 1997 (4.9 per year) source: EuropePMC

Proceedings of the National Academy of Sciences of the United States of America, Volume 94, Issue 11, 1 1 1997, Pages 5843-5847 Apoptin induces apoptosis in human transformed and malignant cells but not in normal cells. Danen-Van Oorschot AA, Fischer DF, Grimbergen JM, Klein B, Zhuang S, Falkenburg JH, Backendorf C, Quax PH, Van der Eb AJ, Noteborn MH

The chicken anemia virus protein apoptin induces a p53-independent, Bcl-2-insensitive type of apoptosis in various human tumor cells. Here, we show that, in vitro, apoptin fails to induce programmed cell death in normal lymphoid, dermal, epidermal, endothelial, and smooth-muscle cells. However, when normal cells are transformed they become susceptible to apoptosis by apoptin. Long-term expression of apoptin in normal human fibroblasts revealed that apoptin has no toxic or transforming activity i... Abstract

Cited 20 times since 1997 (0.7 per year) source: EuropePMC

Theriogenology, Volume 47, Issue 6, 1 1 1997, Pages 1275-1295 Equine arteritis virus. Glaser AL, Chirnside ED, Horzinek MC, de Vries AA

Equine arteritis virus (EAV) is a small, enveloped, positive-stranded RNA virus, in the family Arteriviridae , W.H.ich can infect both horses and donkeys. While the majority of EAV infections are asymptomatic, acutely infected animals may develop a wide range of clinical signs, including pyrexia, limb and ventral edema, depression, rhinitis, and conjunctivitis. The virus may cause abortion and has caused mortality in neonates. After natural EAV infection, most horses develop a solid, long-term i... Abstract

Cited 16 times since 1997 (0.6 per year) source: EuropePMC

Pediatric research, Volume 41, Issue 3, 1 1 1997, Pages 321-326 Oxidative stress during post-hypoxic-ischemic reperfusion in the newborn lamb: the effect of nitric oxide synthesis inhibition. Dorrepaal CA, van Bel F, Moison RM, Shadid M, van de Bor M, Steendijk P, Berger HM

Post-hypoxic-ischemic (HI) reperfusion induces endothelium and neurons to produce excessive amounts of nitric oxide and superoxide, leading to peroxynitrite formation, release of protein-bound metal ions (i.e. iron), and cytotoxic oxidants. We produced severe HI in 18 newborn lambs and serially determined plasma prooxidants (non-protein-bound iron), lipid peroxidation (malondialdehyde), and antioxidative capacity [ratio of ascorbic acid/dehydroascorbic acid (AA/DHA), alpha-tocopherol, sulfhydryl... Abstract

Cited 76 times since 1997 (2.7 per year) source: EuropePMC

The American journal of cardiology, Volume 79, Issue 6, 1 1 1997, Pages 773-776 Value of fast gradient echo magnetic resonance angiography as an adjunct to coronary arteriography in detecting and confirming the course of clinically significant coronary artery anomalies. Vliegen HW, Doornbos J, de Roos A, Jukema JW, Bekedam MA, van der Wall EE

We investigated the additional value of magnetic resonance (MR) angiography in 12 patients with clinically significant coronary anomalies. In 5 patients, the referring cardiologist requested additional evaluation because coronary arteriography was inconclusive about the course of the anomaly. For comparison, 7 patients with known anomalous coronary arteries were collected from our database. In these patients, there had been no doubt about the course of the anomalous coronary arteries. MR angiogr... Abstract

Cited 95 times since 1997 (3.4 per year) source: EuropePMC

Circulation, Volume 95, Issue 4, 1 1 1997, Pages 924-931 Detection and quantification of dysfunctional myocardium by magnetic resonance imaging. A new three-dimensional method for quantitative wall-thickening analysis. Holman ER, Buller VG, de Roos A, van der Geest RJ, Baur LH, van der Laarse A, Bruschke AV, Reiber JH, van der Wall EE

Background: Regional left ventricular dysfunction is a major consequence of myocardial ischemia, and its extent determines long-term prognosis. Accurate and reproducible analysis of left ventricular dysfunction is therefore useful for risk stratification and patient management. Methods and results: Short-axis cardiac cine magnetic resonance (MR) imaging was performed in 25 patients after anterior myocardial infarction at 21 +/- 2.1 days after the acute onset. The MR images were analyzed with the... Abstract

Cited 19 times since 1997 (0.7 per year) source: EuropePMC

British journal of rheumatology, Volume 36, Issue 1, 1 1 1997, Pages 9-15 Bone matrix degradation by the plasminogen activation system. Possible mechanism of bone destruction in arthritis. Ronday HK, Smits HH, Quax PH, van der Pluijm G, Löwik CW, Breedveld FC, Verheijen JH

The observed increase in urokinase-type plasminogen activator (u-PA) and its receptor (u-PAR) in synovial tissue of patients with rheumatoid arthritis (RA) suggests pathophysiological involvement of the plasminogen activation (PA) system in inflammatory joint disease. In the present study, we investigated the capacity of the PA system to degrade non-mineralized and mineralized bone-like matrix in vitro as a model for bone destruction. Transfected mouse LB6 cell lines, that expressed either human... Abstract

Cited 3 times since 1997 (0.1 per year) source: EuropePMC

Tijdschrift voor diergeneeskunde, Volume 122, Issue 1, 1 1 1997, Pages 2-7 [Equine arteritis virus: clinical symptoms and prevention]. Glaser AL, de Vries AA, Rottier PJ, Horzinek MC, Colenbrander B

Sero-epidemiological surveys have revealed that equine arteritis virus (EAV) is prevalent in most European countries. The virus causes sporadic cases of respiratory disease and abortion in horses, the incidence of which has increased in recent years. Mares and geldings eliminate virus after acute infection, but 30% to 60% of stallions become persistently infected. In these animals, EAV is maintained within the reproductive tract and is shed continuously in the semen. Persistent infection with EA... Abstract

Cited 2 times since 1997 (0.1 per year) source: EuropePMC

Pediatric research, Volume 41, Issue 1, 1 1 1997, Pages 57-64 Perinatal left ventricular performance in fetal sheep: interaction between oxygen ventilation and contractility. Berning RA, Klautz RJ, Teitel DF

Left ventricular (LV) output nearly triples at birth, in association with increases in serum catecholamines. Similar increases in catecholamines in utero, however, do not increase output. We hypothesized that catecholamines increase contractility in utero, but that output cannot increase until LV loading conditions are changed by oxygen ventilation. To address this hypothesis, we studied nine fetal sheep acutely placed in a warm water bath (40 degrees C). Conductance and manometric catheters wer... Abstract

Cited 1 times since 1997 (0 per year) source: EuropePMC

Biology of the neonate, Volume 72, Issue 4, 1 1 1997, Pages 227-234 Nitric oxide inhibition after hypoxia-ischemia elevates pulmonary arterial pressure and increases oxygen need. de Beaufort AJ, Lopes Cardozo RH, Dorrepaal CA, Steendijk P, Van Der Velde ET, Van Bel F

Inhibition of nitric oxide (NO) production may reduce post-hypoxic-ischemic (HI) neonatal brain damage, but may also induce pulmonary hypertension by inhibiting endogenous NO production in the pulmonary vascular bed. The aim of this study was to evaluate the effect of nitric oxide inhibition on pulmonary artery pressure and oxygen need after hypoxic ischemia. Severe HI was produced in 18 newborn lambs. After completion of HI the lambs were divided into three groups of 6 animals receiving either... Abstract

Cited 7 times since 1997 (0.2 per year) source: EuropePMC

Advances in peritoneal dialysis. Conference on Peritoneal Dialysis, Volume 13, 1 1 1997, Pages 72-76 Restriction coefficients of low molecular weight solutes and macromolecules during peritoneal dialysis. Ho-dac-Pannekeet MM, Koopmans JG, Struijk DG, Krediet RT

The intrinsic permeability of the peritoneal membrane can be functionally represented by the restriction coefficient (RC). The RC can be calculated as the exponent of the power relation between the mass transfer area coefficients (MTACs) of various solutes and their free diffusion coefficients in water. When the RC = 1.0, transport is determined by free diffusion only, as is expected for low molecular weight (LMW) solutes. A RC > 1.0 suggests that transport is restricted by the peritoneal mem... Abstract

Cited 13 times since 1997 (0.5 per year) source: EuropePMC

British journal of cancer, Volume 75, Issue 10, 1 1 1997, Pages 1447-1453 Isolated hepatic perfusion in the pig with TNF-alpha with and without melphalan. Borel Rinkes IH, de Vries MR, Jonker AM, Swaak TJ, Hack CE, Nooyen PT, Wiggers T, Eggermont AM

Isolated limb perfusion with tumour necrosis factor alpha (TNF-alpha) and melphalan is well tolerated and highly effective in irresectable sarcoma and melanoma. No data are available on isolated hepatic perfusion (IHP) with these drugs for irresectable hepatic malignancies. This study was undertaken to assess the feasibility of such an approach by analysing hepatic and systemic toxicity of IHP with TNF-alpha with and without melphalan in pigs. Ten healthy pigs underwent IHP. After vascular isola... Abstract

Cited 16 times since 1997 (0.6 per year) source: EuropePMC

Biology of the neonate, Volume 72, Issue 4, 1 1 1997, Pages 216-226 Effect of post-hypoxic-ischemic inhibition of nitric oxide synthesis on cerebral blood flow, metabolism and electrocortical brain activity in newborn lambs. Dorrepaal CA, Shadid M, Steendijk P, Van der Velde ET, Van de Bor M, Baan J, Van Bel F

Since an excessive production of nitric oxide upon reperfusion/reoxygenation may play an important role in post-hypoxic-ischemic (HI) brain injury, we investigated whether immediate post-HI blockade of nitric oxide synthesis by N-omega-nitro-L-arginine (NLA) may reduce this injury. In 18 newborn lambs, subjected to severe HI, changes from pre-HI values were measured for carotid blood flow (Qcar [ml/min]) as a measure of changes in brain blood flow, (relative) cerebral metabolic rate of oxygen (C... Abstract

Cited 1 times since 1996 (0 per year) source: EuropePMC

Nederlands tijdschrift voor geneeskunde, Volume 140, Issue 52, 1 1 1996, Pages 2632-2635 [Hypertension caused by licorice consumption]. Seelen MA, de Meijer PH, Braun J, Swinkels LM, Waanders H, Meinders AE

In a 38-year-old woman who was hospitalized because of hypertension and hypokalaemic alkalosis, the intake of liquorice (200 g per day) was proven to be the cause. A liquorice provocation test produced all the expected clinical and biochemical abnormalities. Some kinds of liquorice contain glycyrrhetic acid which inhibits the enzyme 11-beta-hydroxysteroid dehydrogenase (e.g. in the kidney) leading to decreased transformation of cortisol into cortisone. The mineralocorticoid action of cortisol ca... Abstract

Cited 4 times since 1996 (0.1 per year) source: EuropePMC

Basic research in cardiology, Volume 91, Issue 6, 1 1 1996, Pages 468-478 Systolic coronary flow reduction in the canine heart in situ: effects of left ventricular pressure and elastance. Baan J, Steendijk P, Mikuniya A, Baan J

In the externally perfused coronary bed of the isolated heart, LV elastance (Elv) rather than LV pressure (Plv) appears to be the major factor responsible for systolic coronary flow reduction, although effects of both have been demonstrated. However, normal perfusion in the presence of intact autoregulation in the heart in situ may modify these effects. To investigate the systolic coronary flow (Qsyst) responses to changes in end-systolic Elv and in systolic Plv in the intact coronary bed, we st... Abstract

Cited 6 times since 1996 (0.2 per year) source: EuropePMC

Journal of magnetic resonance imaging : JMRI, Volume 6, Issue 6, 1 1 1996, Pages 948-949 Development of an MRI-compatible catheter for pacing the heart: initial in vitro and in vivo results. Jerzewski A, Pattynama PM, Steendijk P, Doornbos J, de Roos A, Baan J

An MRI-compatible catheter was developed for pacing the heart during MRI imaging. The device was tested in vitro and in vivo in 10 animal experiments, using spin-echo, gradient-echo, and echo-planar MRI sequences. Images were of good quality in all sequences. Pacing was effective without induced arrhythmias. Therefore, pacing the heart during MRI is feasible and seems to be safe when using dedicated hardware. Abstract

Cited 92 times since 1996 (3.2 per year) source: EuropePMC

Circulation, Volume 94, Issue 7, 1 1 1996, Pages 1503-1505 Reduction of transient myocardial ischemia with pravastatin in addition to the conventional treatment in patients with angina pectoris. REGRESS Study Group. van Boven AJ, Jukema JW, Zwinderman AH, Crijns HJ, Lie KI, Bruschke AV

Background: Lipid-lowering therapy reduces cardiac morbidity and mortality. Less is known about its potential anti-ischemic effect. Methods and results: In a 2-year prospective randomized placebo-controlled study, the effect of pravastatin 40 mg on transient myocardial ischemia was assessed. Forty-eight-hour ambulatory ECGs with continuous ST-segment analysis were performed in 768 male patients with stable angina pectoris, documented coronary artery disease, and serum cholesterol between 4 and 8... Abstract

Cited 60 times since 1996 (2.1 per year) source: EuropePMC

Circulation, Volume 94, Issue 8, 1 1 1996, Pages 1913-1918 The Asp9 Asn mutation in the lipoprotein lipase gene is associated with increased progression of coronary atherosclerosis. REGRESS Study Group, Interuniversity Cardiology Institute, Utrecht, The Netherlands. Regression Growth Evaluation Statin Study. Jukema JW, van Boven AJ, Groenemeijer B, Zwinderman AH, Reiber JH, Bruschke AV, Henneman JA, Molhoek GP, Bruin T, Jansen H, Gagné E, Hayden MR, Kastelein JJ

Background: Many patients suffering from premature coronary artery disease report a family history for such events. A mutation in a particular gene, which confers susceptibility for atherosclerosis, will be found more frequently in individuals suffering from coronary atherosclerosis than in the general population. We have recently reported the identification of an Asp9 Asn substitution in the lipoprotein lipase (LPL) enzyme. We analyzed the impact of this mutation on the progression of coronary... Abstract

Cited 27 times since 1996 (0.9 per year) source: EuropePMC

The veterinary quarterly, Volume 18, Issue 3, 1 1 1996, Pages 95-99 Equine arteritis virus: a review of clinical features and management aspects. Glaser AL, de Vries AA, Rottier PJ, Horzinek MC, Colenbrander B

Cited 3 times since 1996 (0.1 per year) source: EuropePMC

Lung cancer (Amsterdam, Netherlands), Volume 15, Issue 1, 1 1 1996, Pages 131-135 Actinomycosis, a sheep in wolves' clothes. Neijens V, van Heerde P, van der Heijden A, Baas P

We present a patient referred for radiotherapy for a presumed pulmonary malignancy, who was found to suffer from an actinomycotic infection. This case illustrates the importance of early consideration of actinomycosis when diagnostic methods are negative for malignancy or specific chestwall and bony lesions are observed. Abstract