Research

Publications

Below you can find a list of our published research.

9618 results

Neural computation, Volume 37, Issue 5, 1 1 2025, Pages 926-956 The Leaky Integrate-and-Fire Neuron Is a Change-Point Detector for Compound Poisson Processes. Mani S, Hurley P, van Schaik A, Monk T

Animal nervous systems can detect changes in their environments within hundredths of a second. They do so by discerning abrupt shifts in sensory neural activity. Many neuroscience studies have employed change-point detection (CPD) algorithms to estimate such abrupt shifts in neural activity. But very few studies have suggested that spiking neurons themselves are online change-point detectors. We show that a leaky integrate-and-fire (LIF) neuron implements an online CPD algorithm for a compound P... Abstract

The clinical teacher, Volume 22, Issue 2, 1 1 2025, Pages e70063 Navigating Crossroads: Collaborative Strategies to Assess and Enhance the Quality of Clinical Learning Environments. Daya S, Bernal J, van Schaik S

Abstract

Cited 2 times since 2025 (5.2 per year) source: EuropePMC

Circulation. Cardiovascular imaging, Volume 18, Issue 6, 31 5 2025, Pages e018235 AI-Quantitative CT Coronary Plaque Features Associate With a Higher Relative Risk in Women: CONFIRM2 Registry. Feuchtner GM, Lacaita PG, Bax JJ, Rodriguez F, Nakanishi R, Pontone G, Mushtaq S, Buechel RR, Gräni C, Patel AR, Singulane CC, Choi AD, Al-Mallah M, Andreini D, Karlsberg RP, Cho G, Rochitte CE, Alasnag M, Hamdan A, Cademartiri F, Maffei E, Marques H, Gonçalves Pereira PM, Gupta H, Hadamitzky M, Khalique O, Kalra D, Mills JD, Nurmohamed NS, Knaapen P, Budoff M, Shaikh K, Martin E, German DM, Ferencik M, Oehler AC, Deaño R, Nagpal P, Van Assen M, De Cecco CN, Foldyna B, Brendel JM, Cheng VY, Branch K, Bittencourt M, Bhatti S, Polsani V, Wesbey G, Cardoso R, Blankstein R, Delago A, Pursnani A, Alsaid A, Bloom S, Kamperidis V, Barbieri F, Aquino M, Danad I, van Rosendael A

Background: Coronary plaque features are imaging biomarkers of cardiovascular risk, but less is known about sex-specific patterns in their prognostic value. This study aimed to define sex differences in the coronary atherosclerotic phenotypes assessed by artificial intelligence-based quantitative computed tomography (AI-QCT) and the associated risk of major adverse cardiovascular events (MACEs). Methods: Global multicenter registry including symptomatic patients with suspicion of coronary artery... Abstract

JACC. Cardiovascular imaging, 29 5 2025, Pages S1936-878X(25)00138-X The Last Decade in Tricuspid Regurgitation: How Imaging Shaped a Field. Hahn RT, Badano L, Praz F, Muraru D, Agricola E, Ajmone Marsan N, Bartkowiak J, Delgado V, Dreyfus J, Hausleiter J, Lurz P, Maisano F, Margonato D, Messika-Zeitoun D, Enriquez-Sarano M, Cavalcante JL

The tricuspid valve has become a major focus of novel structural heart interventions, with the Conformité Européenne approval of 5 devices in Europe and the U.S. Food and Drug Administration approval of 2 devices in the United States. Multiple meta-analyses and large population-based registries have shown that although significant tricuspid regurgitation (TR) often accompanies left heart or pulmonary vascular diseases, it is associated with an increased risk of mortality and a reduced quality of... Abstract

Journal of cardiothoracic and vascular anesthesia, Volume 39, Issue 7, 29 5 2025, Pages 1681-1688 Anesthesia Management for the Personalized External Aortic Root Support (PEARS) Procedure: A Single-Center Experience. Pandey AK, Kougioumtzoglou AM, Lam BCY, Kho E, Eberl S, Dilai J, Koolbergen DR, Hermanns H

Objective: To delineate anesthesia management during the personalized external aortic root support (PEARS) procedure, with a focus on the use of multimodal monitoring and deliberate profound hypotension. Design: A single-center retrospective cohort study. Setting: Tertiary academic hospital. Participants: Patients undergoing the PEARS procedure due to aortic aneurysm. Interventions: None. Methods: Patient characteristics and anesthesia management are described, with particular emphasis on multim... Abstract

The international journal of cardiovascular imaging, Volume 41, Issue 5, 29 5 2025, Pages 991-1000 Prognostic impact of left ventricular myocardial work in patients undergoing surgery for primary mitral regurgitation. Nabeta T, Peters F, Wu HW, Chua AP, Palmen M, Tomšič A, Marsan NA, Bax JJ, van der Bijl P

Purpose: Echocardiography-based, left ventricular myocardial work (LVMW) can assess LV function by incorporating LV afterload. This study aims to evaluate the prognostic value of LVMW indices in patients with primary mitral regurgitation (MR) undergoing mitral valve surgery. Methods and results: A total of 306 patients (mean age 63 ± 12 years, 68% male) with severe, primary MR who underwent surgery, were included. All patients underwent transthoracic echocardiography and LVMW indices were assess... Abstract

Scientific reports, Volume 15, Issue 1, 28 4 2025, Pages 10694 Phylodynamic assessment of SNP distances from whole genome sequencing for determining Mycobacterium tuberculosis transmission. Van der Roest BR, Bootsma MCJ, Fischer EAJ, Gröschel MI, Anthony RM, de Zwaan R, Kretzschmar MEE, Klinkenberg D

The global tuberculosis (TB) epidemic is driven by primary transmission. Pathogen genome sequencing is increasingly used in molecular epidemiology and outbreak investigations. Based on contact tracing and epidemiological links, Single Nucleotide Polymorphism (SNP) cut-offs, ranging from 3 to 12 SNPs, identify probable transmission clusters or exclude direct transmission. However, contact tracing can be limited by recall bias and inconsistent methodologies across TB settings. We propose phylodyna... Abstract

Clinical case reports, Volume 13, Issue 4, 28 4 2025, Pages e70282 A <i>PDLIM7</i> Variant in Familial Mitral Valve Prolapse: A Case Series. van Wijngaarden AL, Koopmann TT, Ruivenkamp CAL, Wu HW, Ajmone Marsan N, Barge-Schaapveld DQCM

In the presented case of familial mitral valve prolapse, whole exome sequencing was used to reveal a missense variant in the PDLIM7 gene. This gene is considered a possible novel candidate gene for familial MVP based on PDLIM7 knock-out mice and zebrafish showing mitral valve abnormalities. Abstract

Cited 2 times since 2025 (5.1 per year) source: EuropePMC

European heart journal. Quality of care & clinical outcomes, 28 4 2025, Pages qcae106 Key priorities for the implementation of the 2023 ESC Guidelines for the management of endocarditis in low-resource settings. Borger MA, de Waha S, Marsan NA, Zühlke L, Mestres CA, Fosbol E, Bonaros N, Pizzi MN, Brida M, Sionis A, Delgado V, Members of the Task Force for the 2023 ESC Guidelines for the management of endocarditis

European Society of Cardiology (ESC) Guidelines provide best practice, evidence-based recommendations for diagnosing and treating patients with cardiovascular diseases. It is not always possible for best practices to be followed, however, particularly in low-resource settings. To address this issue, a set of guideline-related documents were created to identify key priorities for users in these settings. The documents highlight the related recommendations and describe key strategies for clinician... Abstract

American heart journal plus : cardiology research and practice, Volume 53, 26 4 2025, Pages 100534 The clinical impact of prophylactic concomitant left atrial appendage occlusion during cardiac surgery: A systematic review and meta-analysis. Zhao C, Girdauskas E, Schoones JW, Klautz RJM, Palmen M, Tomšič A

Background: Recently, concomitant left atrial appendage occlusion (LAAO) has emerged as prophylactic treatment option for preventing thromboembolic events in patients undergoing cardiac surgery with no known history of atrial fibrillation. The efficacy of prophylactic LAAO remains unknown. Methods: PubMed, Embase, Web of Science, Emcare, and the Cochrane Library were searched for studies on prophylactic LAAO in patients undergoing cardiac surgery. The primary endpoints were postoperative thrombo... Abstract

JACC. Clinical electrophysiology, Volume 11, Issue 6, 26 4 2025, Pages 1360-1365 Impact of Anterior Right Ventricular Outflow Tract Conduction Block on QRS Morphology in Repaired Tetralogy of Fallot. Moore JP, Zeppenfeld K

Abstract

Scientific reports, Volume 15, Issue 1, 25 4 2025, Pages 10321 Assessing differential application of thromboprophylaxis regimes related to risk of pulmonary embolism and mortality in COVID-19 patients through instrumental variable analysis. Nab L, Visser C, van Bussel BCT, Beishuizen A, Bemelmans RHH, Ten Cate H, Croles FN, van Guldener C, de Jager CPC, Huisman MV, Nijziel MR, Kamphuisen PW, Klok FA, Koster SCE, Kuşadasi N, Meijer K, den Uil CA, Schutgens REG, Stam F, Vlaar APJ, Vlot EA, Linschoten MPM, Asselbergs FW, Kruip MJHA, le Cessie S, Cannegieter SC, Dutch Covid and Thrombosis Coalition & the CAPACITY-COVID collaborative consortium

Thrombotic complications are common in Coronavirus disease 2019 (COVID-19) patients, with pulmonary embolism (PE) being the most frequent. Randomised trials have provided inconclusive results on the optimal dosage of thromboprophylaxis in critically ill COVID-19 patients. We utilized data from the multicentre CAPACITY-COVID patient registry to assess the effect of differential application of Low Molecular Weight Heparin (LMWH) dose protocols on PE and in-hospital mortality risk in critically ill... Abstract

ESC heart failure, 23 4 2025 Prognostic implications of functional tricuspid regurgitation in asymptomatic degenerative mitral regurgitation. Tribouilloy C, Bohbot Y, Essayagh B, Benfari G, Bax JJ, Le Tourneau T, Topilsky Y, Antoine C, Rusinaru D, Grigioni F, Ajmone Marsan N, van Wijngaarden A, Hochstadt A, Roussel JC, Thapa P, Hector M, Enriquez-Sarano M

Aims: Functional tricuspid regurgitation (FTR) associated with degenerative mitral regurgitation (DMR) accentuates the severity of heart failure and is a marker of poor prognosis. Little is known about FTR associated with asymptomatic DMR. Methods and results: The study included 1249 asymptomatic patients with moderate or severe DMR from the Mitral Regurgitation International Database-Quantitative (MIDA-Q) registry (mean age 64 ± 15 years, 25% female). Despite the asymptomatic status, absent/tri... Abstract

Journal of the American Heart Association, Volume 14, Issue 7, 21 3 2025, Pages e037531 Blockade of YAP Mechanoactivation Prevents Neointima Formation and Adverse Remodeling in Arterialized Vein Grafts. Garoffolo G, Sluiter TJ, Thomas A, Piacentini L, Ruiter MS, Schiavo A, Salvi M, Saccu C, Zoli S, Chiesa M, Yokoyama T, Agrifoglio M, Soncini M, Fiore GB, Martelli F, Condorelli G, Madeddu P, Molinari F, Morbiducci U, Quax PHA, Spinetti G, de Vries MR, Pesce M

Background: Bypass surgery using saphenous vein (SV) grafts is commonly performed to revascularize the ischemic heart and lower limbs. These interventions have limited success due to adverse remodeling caused by overproliferation of smooth muscle cells in the intima layer, leading to progressive bypass stenosis. We previously showed that cyclic strain deriving from exposure to coronary flow induces the expression of the matricellular protein thrombospondin-1 in the human SV, promoting activation... Abstract

Structural heart : the journal of the Heart Team, Volume 9, Issue 6, 20 3 2025, Pages 100460 Impact of Baseline Anteroposterior Mitral Annular Dimensions on Clinical Outcomes after MitraClip for Secondary Mitral Regurgitation. Rogers JH, Smith TW, Bax JJ, Asch FM, Lim DS, Wong N, Aiyer J, Abraham WT, Lindenfeld J, Mack MJ, Stone GW, Bolling SF

Background: In the randomized Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients with Functional Mitral Regurgitation (COAPT; NCT01626079) trial, mitral transcatheter edge-to-edge repair (M-TEER) improved clinical outcomes in patients with severe secondary mitral regurgitation (MR). A prior post hoc analysis from the COAPT trial showed that increasing anteroposterior mitral annular diameter (APMAD) was the sole independent echocardiographic predic... Abstract

Cited 5 times since 2025 (12.1 per year) source: EuropePMC

European urology, Volume 87, Issue 5, 20 3 2025, Pages 582-600 European Association of Urology Guidelines on Muscle-invasive and Metastatic Bladder Cancer: Summary of the 2025 Guidelines. van der Heijden AG, Bruins HM, Carrion A, Cathomas R, Compérat E, Dimitropoulos K, Efstathiou JA, Fietkau R, Kailavasan M, Lorch A, Martini A, Mertens LS, Meijer RP, Mariappan P, Milowsky MI, Neuzillet Y, Panebianco V, Sæbjørnsen S, Smith EJ, Thalmann GN, Rink M

Background and objective: This publication represents a summary of the updated 2025 European Association of Urology (EAU) guidelines for muscle-invasive and metastatic bladder cancer (MMIBC). The aim is to provide practical recommendations on the clinical management of MMIBC with a focus on diagnosis, treatment, and follow-up. Methods: For the 2025 guidelines, new and relevant evidence was identified, collated, and appraised via a structured assessment of the literature. Databases searched inclu... Abstract

European journal of heart failure, 19 3 2025 Ventricular arrhythmias in acute heart failure. A clinical consensus statement of the Association for Acute CardioVascular Care (ACVC), the European Heart Rhythm Association (EHRA) and the Heart Failure Association (HFA) of the ESC. Gorenek B, Wijnmaalen AP, Goette A, Mert GO, Porter B, Gustafsson F, Dan GA, Ector J, Stuehlinger M, Spartalis M, Gosau N, Amir O, Chioncel O

Patients presenting with or alerting emergency networks due to acute heart failure (AHF) form a diverse group with a plethora of symptoms, risks, comorbidities, and aetiologies. During AHF, there is an increased risk of destabilizing the functional substrate and modulatory adding to the risk of ventricular arrhythmias (VAs) already created by the structural substrate. New VAs during AHF have previously identified patients with higher in-hospital and 60-day morbidity and mortality. Risk stratific... Abstract

Cited 1 times since 2025 (2.4 per year) source: EuropePMC

Scientific data, Volume 12, Issue 1, 19 3 2025, Pages 458 Reusability challenges of livestock production data to improve animal health. Delavenne C, van Schaik G, Frössling J, Cameron A, Faverjon C

In veterinary epidemiology, using data routinely generated by stakeholders of the livestock production chains offers an opportunity for researchers to access a large amount of information that could be used to improve animal health. However, (re)using these non-scholarly data doesn't come without challenges. This study assesses the reusability for research purposes of 30 European datasets generated by the livestock sector to meet legislative or operational needs. Information about each data... Abstract

Annals of medicine and surgery (2012), Volume 87, Issue 4, 19 3 2025, Pages 1995-1999 Fostering an open surgical culture: strategies to eliminate inappropriate behavior in surgical practice. Blok JJ, Snijders HS, Huizing F, Schmitz RF, Kerstjens LJ, Sier VQ, Blok CC, Lijkwan MA, Schepers A

Surgery is a demanding and stressful profession. Unfortunately, inappropriate behavior is still not banished from the daily surgical practice and we are dealing with the negative consequences (e.g. negative working environments or burn-out). To adequately treat this type of behavior we first have to acknowledge its existence and create a proper path to discuss it inside our own ranks. The only manner to achieve this, is through an open culture. An 'open surgical culture' is the key, as... Abstract

Biomedicines, Volume 13, Issue 3, 18 3 2025, Pages 740 Biomarker-Based Nomogram to Predict Neoadjuvant Chemotherapy Response in Muscle-Invasive Bladder Cancer. Pérez M, Lozano JJ, Ingelmo-Torres M, Domenech M, Fernández Ramón C, Witjes JA, van der Heijden AG, Requena MJ, Coy A, Calderon R, Mellado B, Alcaraz A, Vilaseca A, Ribal MJ

Background/Objectives: The aim of this study was to identify response prediction and prognostic biomarkers in muscle-invasive bladder cancer (MIBC) patients undergoing neoadjuvant chemotherapy (NAC). Methods: A retrospective multicentre study including 191 patients with MIBC who received NAC previous to radical cystectomy (RC) between 1996 and 2013. Gene expression patterns were analysed in 34 samples from transurethral resection of the bladder (TURB) using Illumina microarrays. The expression l... Abstract