Research

Publications

Below you can find a list of our published research.

9618 results

ERJ open research, Volume 11, Issue 2, 3 1 2025, Pages 619-2024 Enzymatic therapy versus video-assisted thoracoscopic surgery for pleural infections: a systematic review and meta-analysis. de Jonge WR, Smits B, Ket JCF, Altenburg J, Annema J, Daniels JMA, Dickhoff C, van Dorp M, Braun J, Korevaar DA, Heineman DJ

Aims: Parapneumonic pleural infections are frequently encountered, but the optimal treatment regimen remains controversial. The aim of this systematic review was to investigate whether immediate video-assisted thoracoscopic surgery (VATS) has advantages over intrapleural enzymatic therapy (IET). Methods: We searched MEDLINE, Embase and Web of Science Core Collection till November 2023 and included studies comparing IET and VATS in adult patients with parapneumonic pleural infections. Primary out... Abstract

Cited 1 times since 2025 (2.2 per year) source: EuropePMC

Chemphyschem : a European journal of chemical physics and physical chemistry, Volume 26, Issue 8, 3 1 2025, Pages e202400688 Mechanistic Insights into the Photocatalytic Indigo Carmine Dye Decolorization by Co3O4/TiO2. de Graaf ME, Godec N, Kappé BT, Grote RL, Flapper J, Hutter EM, Weckhuysen BM

TiO2 is widely studied as an efficient UV-light photocatalyst for organic compound degradation through reactive oxygen species (ROS) generation. TiO2 can be modified to show photocatalytic activity under visible light illumination by combining with visible-light absorbing metal oxides. Here, we investigated Co3O4/TiO2 composite materials as visible-light absorbing photocatalysts, with various weight loadings of Co3O4, for the decolorization of wastewater pollutant indigo carmine. Under green LED... Abstract

Frontiers in medicine, Volume 12, 3 1 2025, Pages 1492596 Quality assessment of a training program for undergraduate sonography peer tutors: paving the future way for peer-assisted learning in medical ultrasound education. Weimer J, Yilmaz D, Ille C, Weinmann-Menke J, Müller L, Büchner H, Buggenhagen H, Stäuber M, Neubauer R, Winter L, Weimer A, Dirks K, Künzel J, Rink M, Dionysopoulou A, Lorenz L, Kloeckner R, Recker F, Schiestl L

Introduction: Peer tutoring has been increasingly used to support university sonography teaching, necessitating well-qualified tutors. This study aims to evaluate the quality of a training program for sonography peer tutors developed and implemented at a university hospital. Materials and methods: A training program consisting of 11 modules was developed and subsequently evaluated for success with two subjective and two objective assessments of peer-tutoring quality. The two subjective assessmen... Abstract

Journal of the peripheral nervous system : JPNS, Volume 30, Issue 1, 1 1 2025, Pages e70006 Unique Nerve Tissue-Restricted T-Cell Clones in Chronic Inflammatory Demyelinating Polyneuropathy. van Lieverloo GGA, Anang DC, Adrichem ME, Coert BA, Aronica AE, Wieske L, van Schaik IN, de Vries N, Eftimov F

Background and aims: Chronic inflammatory demyelinating polyneuropathy (CIDP) is an immune-mediated disorder characterized by peripheral nerve damage. Although T lymphocytes (T-cells) are implicated in the pathogenesis of CIDP, we previously observed that the frequency of highly expanded T-cell clones (HECs) in peripheral blood of CIDP patients was not different from healthy controls. To investigate if local T-cells might be pathogenic, we employed next-generation sequencing to compare the TCRβ... Abstract

Interdisciplinary cardiovascular and thoracic surgery, Volume 40, Issue 3, 1 1 2025, Pages ivaf071 The arterial switch operation for transposition of the great arteries with left ventricular outflow tract obstruction and ventricular septal defect: clinical outcomes and specimen study. van der Palen RLF, den Ouden A, Knobbe I, Bouma BJ, Koolbergen DR, Jongbloed MRM, Hazekamp MG

Objectives: In selected patients with transposition of the great arteries (TGA), ventricular septal defect (VSD) and left ventricular outflow tract obstruction (LVOTO), the arterial switch operation (ASO) may be the procedure of choice. This study reviews the clinical outcomes of TGA-VSD-LVOTO patients after ASO and compares mechanisms of LVOTO in this patient group to a historical series of cardiac specimens. Methods: This retrospective analysis included all cases with TGA-VSD-LVOTO who underwe... Abstract

Cited 3 times since 2025 (6.4 per year) source: EuropePMC

European heart journal. Cardiovascular Imaging, Volume 26, Issue 3, 1 1 2025, Pages 385-413 The role of multi-modality imaging for the assessment of left atrium and left atrial appendage: a clinical consensus statement of the European Association of Cardiovascular Imaging (EACVI), European Heart Rhythm Association (EHRA) of the European Society of Cardiology (ESC). Sade LE, Faletra FF, Pontone G, Gerber BLM, Muraru D, Edvardsen T, Cosyns B, Popescu BA, Klein A, Marwick TH, Cameli M, Saric M, Thomas L, Ajmone Marsan N, Fontes-Carvalho R, Podlesnikar T, Fontana M, La Gerche A, Petersen SE, Moharem-Elgamal S, Bittencourt MS, Vannan MA, Glikson M, Peichl P, Cochet H, Stankovic I, Donal E, Thomas D, Marta RS

Structural, architectural, contractile, or electrophysiological alterations may occur in the left atrium (LA). The concept of LA cardiopathy is supported by accumulating scientific evidence demonstrating that LA remodelling has become a cornerstone diagnostic and prognostic marker. The structure and the function of the LA and left atrial appendage (LAA), which is an integral part of the LA, are key elements for a better understanding of multiple clinical conditions, most notably atrial fibrillat... Abstract

Cureus, Volume 17, Issue 3, 1 1 2025, Pages e79898 Synovial Sarcoma of the Hand: A Case Report and Literature Review on a Significant Challenge in Treatment. Tajammul SS, Mohammed K, Al Farii H, Shalaby A, Munir J, Al-Amri I, Alfishawy M, Al Mandhari Z

Soft tissue sarcomas (STS) of the hand are extremely uncommon, with synovial sarcomas being even rarer. Despite their small size at presentation, hand sarcomas can indeed be aggressive and may result in significant morbidity and mortality if not effectively managed. A considerable proportion of these tumors are treated by unplanned excision before referral to a specialist oncological center. Additionally, hand sarcomas can mimic benign lesions, leading to misinterpretation and delayed diagnosis.... Abstract

World journal of biological chemistry, Volume 16, Issue 1, 1 1 2025, Pages 104535 Therapeutic potential of elafibranor in alcohol-associated liver disease: Insights into macrophage modulation and fibrosis reduction. Farhadi S, Mohammadi S, AlKindi AY, Al-Amri IS

Alcohol-associated liver disease (ALD) is a major global health concern, contributing to liver injury, morbidity, and mortality. Elafibranor (EFN), a dual peroxisome proliferator-activated receptor α/δ agonist, has shown promise as a therapeutic candidate in preclinical studies. EFN reduces liver fibrosis by inhibiting lipid accumulation, apoptosis, and inflammatory pathways (LPS/TLR4/NF-κB), while enhancing autophagy and antioxidant responses. It also improves intestinal barrier function and mo... Abstract

Cited 2 times since 2025 (4.3 per year) source: EuropePMC

European heart journal. Cardiovascular Imaging, Volume 26, Issue 4, 1 1 2025, Pages 593-608 The role of multi-modality imaging in multiple valvular heart diseases: a clinical consensus statement of the European Association of Cardiovascular Imaging of the European Society of Cardiology. Donal E, Unger P, Coisne A, Pibarot P, Magne J, Sitges M, Habib G, Clavel MA, von Bardeleben RS, Plein S, Pezel T, Dweck MR, Zamorano PL, Bertrand PB, Dahl JS, Popescu BA, Cosyns B, Ajmone-Marsan N, Bohbot Y, Di Salvo G, Keenan N, Petrescu AM, Stankovic I

With this document, the European Association of Cardiovascular Imaging provides an Expert Consensus on the role of multi-modality imaging (MMI) in the management of patients with multiple valvular heart disease (MVD). Emphasis is given to the use of MMI to unravel the diagnostic challenges that characterize these patients and to improve risk stratification. Complementing the last European Society of Cardiology and European Association of Cardio-Thoracic Surgery guidelines on valvular heart disea... Abstract

Cited 2 times since 2025 (4.3 per year) source: EuropePMC

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 27, Issue 4, 1 1 2025, Pages euaf055 Epicardial ventricular arrhythmia ablation: a clinical consensus statement of the European Heart Rhythm Association of the European Society of Cardiology and the Heart Rhythm Society, the Asian Pacific Heart Rhythm Society, the Latin American Heart Rhythm Society, and the Canadian Heart Rhythm Society. Arya A, Di Biase L, Bazán V, Berruezo A, d'Avila A, Della Bella P, Enriquez A, Hocini M, Kautzner J, Pak HN, Stevenson WG, Zeppenfeld K, Sepehri Shamloo A, Meyer C, de Chillou C, Deneke T, de Riva M, Porta-Sanchez A, Sapp J, Schmidt B, Shivkumar K, Sommer P, Soejima K, Supple GE, Wilde A, Zucchelli G

Epicardial access during electrophysiology procedures offers valuable insights and therapeutic options for managing ventricular arrhythmias (VAs). The current clinical consensus statement on epicardial VA ablation aims to provide clinicians with a comprehensive understanding of this complex clinical scenario. It offers structured advice and a systematic approach to patient management. Specific sections are devoted to anatomical considerations, criteria for epicardial access and mapping evaluatio... Abstract

Cited 6 times since 2025 (12.9 per year) source: EuropePMC

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 27, Issue 4, 1 1 2025, Pages euae214 Patient selection, ventricular tachycardia substrate delineation, and data transfer for stereotactic arrhythmia radioablation: a clinical consensus statement of the European Heart Rhythm Association of the European Society of Cardiology and the Heart Rhythm Society. Zeppenfeld K, Rademaker R, Al-Ahmad A, Carbucicchio C, De Chillou C, Cvek J, Ebert M, Ho G, Kautzner J, Lambiase P, Merino JL, Merino JL, Lloyd M, Misra S, Pruvot E, Sapp J, Schiappacasse L, Sramko M, Stevenson WG, Zei PC, Wichterle D, Chrispin J, Siklody CH, Neuwirth R, Pelargonio G, Reichlin T, Robinson C, Tondo C

Stereotactic arrhythmia radioablation (STAR) is a novel, non-invasive, and promising treatment option for ventricular arrhythmias (VAs). It has been applied in highly selected patients mainly as bailout procedure, when (multiple) catheter ablations, together with anti-arrhythmic drugs, were unable to control the VAs. Despite the increasing clinical use, there is still limited knowledge of the acute and long-term response of normal and diseased myocardium to STAR. Acute toxicity appeared to be re... Abstract

Cited 1 times since 2025 (2.1 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 85, Issue 10, 1 1 2025, Pages 1042-1055 Best Practices for Imaging of Transcatheter Valve Failure: An Update From the Heart Valve Collaboratory. Khalique OK, Zaid S, Tang GHL, Abdel-Wahab M, Akodad M, Bapat VN, Bax JJ, Blackman DJ, Blanke P, Bleiziffer S, Capodanno D, Cavalcante JL, Dasi LP, De Backer O, De Beuel M, Duncan A, Dweck MR, Fukui M, Gupta A, Hayashida K, Herrmann HC, Kaneko T, Karam N, Khan JM, Kovac J, Landes U, Leipsic JA, Leon MB, Mack MJ, Madhavan MV, Makar MM, Makkar RR, Al Mallah M, Meier D, Modine T, Okada A, Parikh RK, Parma R, Patel D, Pibarot P, Prendergast B, Quader N, Reardon MJ, Rogers T, Safi LM, Sellers SL, Skaf S, Tarantini G, Tchetche D, van Mieghem N, Wang DD, Webb JG, Windecker S, Yakubov SJ, Delgado V, Hahn RT, Jilaihawi H

This updated Heart Valve Collaboratory framework addresses the growing concern for transcatheter valve failure (TVF) following transcatheter aortic valve replacement (TAVR). With the increasing volume of redo-TAV and surgical TAV explantation, there is a critical need for standardized pathways and protocols for evaluating TVF using echocardiography and cardiac computed tomography (CT) angiography. This document clarifies prior definitions of bioprosthetic valve deterioration and bioprosthetic va... Abstract

Cited 2 times since 2025 (4.3 per year) source: EuropePMC

Interdisciplinary cardiovascular and thoracic surgery, Volume 40, Issue 3, 1 1 2025, Pages ivaf009 Survival outcomes after surgery for type A aortic dissection: a contemporary Dutch nationwide registry study. Timmermans PT, Velders BJJ, Groenwold RHH, Vos RJ, Roefs MM, Braun J, Klautz RJM, Mecozzi G, Hjortnaes J, Cardiothoracic Surgery Registration Committee and the Aortic Surgery Work Group of the Netherlands Heart Registration

Objectives: To describe the nationwide survival outcomes after surgery for type A aortic dissection. Methods: All patients who underwent surgery for type A aortic dissection in the Netherlands between 2018 and 2021 were identified in the Netherlands Heart Registration (NHR) database. The NHR data were linked to lifelong survival data from Statistics Netherlands (98% match). Time trends for in-hospital and mid-term mortality were described, and age- and sex-adjusted regression analysis was perfor... Abstract

Cited 3 times since 2025 (6.4 per year) source: EuropePMC

Preventive veterinary medicine, Volume 239, 28 4 2025, Pages 106493 The impact of bluetongue serotype 3 on cattle mortality, abortions and premature births in the Netherlands in the first year of the epidemic. van den Brink KMJA, Brouwer-Middelesch H, van Schaik G, Lam TJGM, Stegeman JA, van den Brom R, Spierenburg MAH, Santman-Berends IMGA

In September 2023, bluetongue virus serotype 3 (BTV-3) was identified among sheep and cattle in the Netherlands. Severe clinical signs and increased mortality were reported in sheep and cattle. The aim of this study was to quantify the impact of BTV-3 on mortality, abortions and premature births in cattle in the Netherlands in 2023. Data were available from 1 January 2020-31 December 2023 and were aggregated at herd-month level. Cattle herds were assigned a BTV-3 status for each herd-month: 1) h... Abstract

British journal of anaesthesia, Volume 134, Issue 4, 28 4 2025, Pages 1009-1017 Regulation of cerebrovascular resistance below the lower limit of cerebral autoregulation during induced hypotension: an observational study. Kho E, van den Dool REC, Mahes SS, Corsmit OT, Vlaar APJ, Koolbergen DR, Veelo DP, Sperna Weiland NH, Immink RV

Background: To maintain adequate perfusion, cerebral blood flow (CBF) is preserved by changes in cerebrovascular resistance (CVR) inversely related to fluctuations in mean arterial blood pressure (MAP). It has been hypothesised that during progressive hypotension, a lower limit of cerebral autoregulation (LLCA) is reached beyond which cerebrovascular dilation becomes exhausted and CBF starts to decrease together with BP. We tested this hypothesis by assessing CVR above and below the LLCA. Method... Abstract

Endocrine connections, Volume 14, Issue 4, 27 4 2025, Pages e240533 BMI trajectories in the first 3 months after childhood craniopharyngioma resection: a plea for early management of BMI changes. Hulsmann SC, Hoving EW, Bakker B, Janssens GO, van Schaik J, de Vos-Kerkhof E, Tissing WJE, van Santen HM

Objective: Hypothalamic obesity (HO) is a severe condition following childhood craniopharyngioma (cCP) treatment. Despite multidisciplinary and centralized care, severe body mass index (BMI) changes are still often encountered after cCP surgery. We aimed to perform an in-depth analysis of BMI trajectories in our cCP cohort in the first year after surgery and to identify characteristics associated with BMI change. Methods: Data were collected of cCP patients diagnosed since January 2018. Change (... Abstract

STAR protocols, Volume 6, Issue 1, 27 4 2025, Pages 103679 Massive expansion and cryopreservation of functional human induced pluripotent stem cell-derived cardiomyocytes. Maas RGC, Lee S, Harakalova M, Snijders Blok CJB, Goodyer WR, Hjortnaes J, Doevendans PAFM, Van Laake LW, van der Velden J, Asselbergs FW, Wu JC, Sluijter JPG, Wu SM, Buikema JW

Abstract

JACC. Advances, Volume 4, Issue 3, 26 4 2025, Pages 101633 Developing a Systematic Approach for the Implementation of Medical Extended Reality Learning Modules in Cardiothoracic Health Care: Recommendations From an International Expert Group. Mahtab EAF, Max SA, Braun J, Regeer MV, Kaufman B, Dunning J, Bibleraaj B, Andreas M, Rodríguez Lecoq R, Klinceva M, Rosalia R, Lorusso R, Bruining N, Egorova AD

Extended reality (XR) modalities in health care are quickly evolving. There is a lack of systematically described developmental process and the "how to" execute a business-case guidance. This article formulates a systematic approach on the technical developmental steps and generation of business-case to guide the iterative development of an XR tool. An international expert group was established and several available frameworks related to entrepreneurship and business-case development w... Abstract

Cited 1 times since 2025 (2.1 per year) source: EuropePMC

European heart journal. Digital health, Volume 6, Issue 3, 26 4 2025, Pages 496-507 The environmental impact of telemonitoring vs. on-site cardiac follow-up: a mixed-method study. van Bree EM, Snijder LE, Ter Haak S, Atsma DE, Brakema EA

Aims: Digital health technologies are considered promising innovations to reduce healthcare's environmental footprint. However, this assumption remains largely unstudied. We compared the environmental impact of telemonitoring and care on site (CoS) in post-myocardial infarction (MI) follow-up and explored how it influenced patients' and healthcare professionals' (HPs) perceptions of using telemonitoring. Methods and results: We conducted a mixed-method study; a standardized life c... Abstract

PloS one, Volume 20, Issue 2, 26 4 2025, Pages e0317826 The value of vector ECG in predicting residual pulmonary hypertension in CTEPH patients after pulmonary endarterectomy. Luijten D, Rodenburg T, Bogaard HJ, Kianzad A, Ruigrok D, Croon P, Smeele P, Vliegen HW, Vonk Noordegraaf A, Meijboom LJ, Klok FA

Introduction: Right heart catheterization (RHC) is the diagnostic standard for establishing residual pulmonary hypertension (PH) after pulmonary endarterectomy (PEA) in patients with chronic thromboembolic pulmonary hypertension (CTEPH). A potential non-invasive alternative diagnostic test could be electrocardiography (ECG)-derived ventricular gradient optimized for right ventricular pressure overload (VG-RVPO). Methods: We studied 66 CTEPH patients who underwent PEA. A subgroup of 20 patients a... Abstract