7971 results
Cited 85 times since 2020 (17.6 per year)
source: EuropePMC
Cancer immunology research,
Volume 8, Issue 10, 5 1 2020, Pages 1311-1321
CD39 Identifies the CD4<sup>+</sup> Tumor-Specific T-cell Population in Human Cancer.
Kortekaas KE, Santegoets SJ, Sturm G, Ehsan I, van Egmond SL, Finotello F, Trajanoski Z, Welters MJP, van Poelgeest MIE, van der Burg SH
The accumulation of tumor-specific CD4+ and CD8+ effector T cells is key to an effective antitumor response. Locally, CD4+ T cells promote the recruitment and effector function of tumor-specific CD8+ T cells and activate innate killer cells in the tumor. Here, we show that tumor-specific CD4+ T cells were predominantly present in the CD39+ subset of tumor-infiltrating lymphocytes (TIL). The CD39+ CD4+ and CD8+ TILs were detected in three different tumor types, and displayed an activated (PD-1+,...
Abstract
BMC medical education,
Volume 20, Issue 1, 5 1 2020, Pages 250
Refuting misconceptions in medical physiology.
Versteeg M, van Loon MH, Wijnen-Meijer M, Steendijk P
Background: In medical physiology, educators and students face a serious challenge termed misconceptions. Misconceptions are incorrect ideas that do not match current scientific views. Accordingly, they have shown to hamper teaching and learning of physiological concepts. Conceptual Change Theory forms the basis of new teaching and learning practices that may alleviate misconceptions and facilitate critical thinking skills that are essential in becoming knowledgeable, self-regulated health profe...
Abstract
Cited 21 times since 2020 (4.4 per year)
source: EuropePMC
Molecular ecology resources,
Volume 20, Issue 6, 4 1 2020, Pages 1706-1722
A GT-seq panel for walleye (Sander vitreus) provides important insights for efficient development and implementation of amplicon panels in non-model organisms.
Bootsma ML, Gruenthal KM, McKinney GJ, Simmons L, Miller L, Sass GG, Larson WA
Targeted amplicon sequencing methods, such as genotyping-in-thousands by sequencing (GT-seq), facilitate rapid, accurate, and cost-effective analysis of hundreds of genetic loci in thousands of individuals. Development of GT-seq panels is nontrivial, but studies describing trade-offs associated with different steps of GT-seq panel development are rare. Here, we construct a dual-purpose GT-seq panel for walleye (Sander vitreus), discuss trade-offs associated with different development and genotyp...
Abstract
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology,
Volume 28, Issue 5, 4 1 2020, Pages 2343-2345
Hybrid Positron emission tomography/magnetic resonance imaging in viability assessment.
Bax JJ, Ng ACT, Delgado V
Abstract
Cited 4 times since 2020 (0.8 per year)
source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 28, Issue Suppl 1, 1 1 2020, Pages 115-121
The role of long-term mechanical circulatory support in patients with advanced heart failure.
Felix SEA, de Jonge N, Caliskan K, Birim O, Damman K, Kuijpers M, Tops LF, Palmen M, Ramjankhan FZ
In patients with end-stage heart failure, advanced therapies such as heart transplantation and long-term mechanical circulatory support (MCS) with a left ventricular assist device (LVAD) have to be considered. LVADs can be implanted as a bridge to transplantation or as an alternative to heart transplantation: destination therapy. In the Netherlands, long-term LVAD therapy is gaining importance as a result of increased prevalence of heart failure together with a low number of heart transplantatio...
Abstract
Cited 32 times since 2020 (6.6 per year)
source: EuropePMC
Lab on a chip,
Volume 20, Issue 17, 1 1 2020, Pages 3132-3143
Multiplexed blood-brain barrier organ-on-chip.
Zakharova M, Palma do Carmo MA, van der Helm MW, Le-The H, de Graaf MNS, Orlova V, van den Berg A, van der Meer AD, Broersen K, Segerink LI
Organ-on-chip devices are intensively studied in academia and industry due to their high potential in pharmaceutical and biomedical applications. However, most of the existing organ-on-chip models focus on proof of concept of individual functional units without the possibility of testing multiple experimental stimuli in parallel. Here we developed a polydimethylsiloxane (PDMS) multiplexed chip with eight parallel channels branching from a common access port through which all eight channels can b...
Abstract
Cited 7 times since 2020 (1.4 per year)
source: EuropePMC
European heart journal. Cardiovascular Imaging,
Volume 21, Issue 8, 1 1 2020, Pages 828-832
EACVI survey on the evaluation of infective endocarditis.
Holte E, Dweck MR, Marsan NA, D'Andrea A, Manka R, Stankovic I, Haugaa KH
Aims: To evaluate the diagnosis and imaging of patients with suspected endocarditis and the management in routine clinical practice across Europe, the EACVI Scientific Initiatives Committee performed a survey across European centres. In particular, the routine use of echocardiography, advanced imaging modalities and multidisciplinary team was explored. Methods and results: A total of 100 European Echocardiography Laboratories from 29 different countries responded to the survey, which consisted o...
Abstract
Cited 8 times since 2020 (1.7 per year)
source: EuropePMC
European journal of emergency medicine : official journal of the European Society for Emergency Medicine,
Volume 27, Issue 4, 1 1 2020, Pages 243-244
The new era of chest pain evaluation in the Netherlands.
Backus BE, Tolsma RT, Boogers MJ
Abstract
Cited 1 times since 2020 (0.2 per year)
source: EuropePMC
Cardiovascular research,
Volume 116, Issue 10, 1 1 2020, Pages e115-e117
Gender balance at the heart of science.
Small HY, Timoteo AT, Buchanan GL, Gimelli A, Jurcut R, Marsan NA, Schüpke S, Zuhlke L
Abstract
Cited 1 times since 2020 (0.2 per year)
source: EuropePMC
European heart journal,
Volume 41, Issue 30, 1 1 2020, Pages 2828-2829
EHRA 2020 during COVID-19 days.
Burri H, Zeppenfeld K, Heidbuchel H
Abstract
Cited 8 times since 2020 (1.7 per year)
source: EuropePMC
European heart journal. Cardiovascular Imaging,
Volume 21, Issue 8, 1 1 2020, Pages 937-938
Echocardiography-computed tomography fusion imaging for guidance of transcatheter tricuspid valve annuloplasty.
Fortuni F, Marques AI, Bax JJ, Ajmone Marsan N, Delgado V
Abstract
Cited 5 times since 2020 (1 per year)
source: EuropePMC
Journal of neurology,
Volume 268, Issue 1, 31 5 2020, Pages 133-139
Presentation outside office hours does not negatively influence treatment times for reperfusion therapy for acute ischemic stroke.
Groot AE, de Bruin H, Nguyen TTM, Kappelhof M, de Beer F, Visser MC, Zwetsloot CP, Halkes PHA, de Kruijk J, van der Meulen WDM, van der Ree TC, Kwa VIH, van Schaik SM, Hani L, van den Berg R, Sprengers MES, Roosendaal SD, Emmer BJ, Nederkoorn PJ, Majoie CBLM, Roos YBWEM, Coutinho JM
Background: Treatment outside office hours has been associated with increased workflow times for intravenous thrombolysis (IVT) in acute ischemic stroke (AIS). Limited data suggest that this "off-hours effect" also exists for endovascular treatment (EVT). We investigated this phenomenon in a well-organized acute stroke care region in the Netherlands. Methods: Retrospective, observational cohort study of consecutive patients with AIS who received reperfusion therapy in the Greater Amste...
Abstract
Cited 15 times since 2020 (3.1 per year)
source: EuropePMC
Journal of dairy science,
Volume 103, Issue 10, 31 5 2020, Pages 9446-9463
Quantification of risk factors for bovine viral diarrhea virus in cattle herds: A systematic search and meta-analysis of observational studies.
van Roon AM, Mercat M, van Schaik G, Nielen M, Graham DA, More SJ, Guelbenzu-Gonzalo M, Fourichon C, Madouasse A, Santman-Berends IMGA
Bovine viral diarrhea virus (BVDV) is endemic in many parts of the world, and multiple countries have implemented surveillance activities for disease control or eradication. In such control programs, the disease-free status can be compromised by factors that pose risks for introduction or persistence of the virus. The aim of the present study was to gain a comprehensive overview of possible risk factors for BVDV infection in cattle herds in Europe and to assess their importance. Papers that cons...
Abstract
Cited 6 times since 2020 (1.2 per year)
source: EuropePMC
Diabetologia,
Volume 63, Issue 11, 31 5 2020, Pages 2452-2461
A personalised screening strategy for diabetic retinopathy: a cost-effectiveness perspective.
Emamipour S, van der Heijden AAWA, Nijpels G, Elders P, Beulens JWJ, Postma MJ, van Boven JFM, Feenstra TL
Aims/hypothesis: In this study we examined the cost-effectiveness of three different screening strategies for diabetic retinopathy: using a personalised adaptive model, annual screening (fixed intervals), and the current Dutch guideline (stratified based on previous retinopathy grade). Methods: For each individual, optimal diabetic retinopathy screening intervals were determined, using a validated risk prediction model. Observational data (1998-2017) from the Hoorn Diabetes Care System cohort of...
Abstract
Cited 21 times since 2020 (4.3 per year)
source: EuropePMC
JACC. Clinical electrophysiology,
Volume 6, Issue 9, 29 5 2020, Pages 1103-1114
Prevalence and Prognostic Impact of Pathogenic Variants in Patients With Dilated Cardiomyopathy Referred for Ventricular Tachycardia Ablation.
Ebert M, Wijnmaalen AP, de Riva M, Trines SA, Androulakis AFA, Glashan CA, Schalij MJ, Peter van Tintelen J, Jongbloed JDH, Zeppenfeld K
Objectives: This study aimed to assess the frequency of (likely) pathogenic variants (LP/Pv) among dilated cardiomyopathy (DCM) ventricular tachycardia (VT) patients referred for CA and their impact on procedural outcome and long-term prognosis. Background: The prevalence of genetic variants associated with monomorphic VT among DCM is unknown. Methods: Ninety-eight consecutive patients (age 56 ± 15 years; 84% men, left ventricular ejection fraction [LVEF] 39 ± 12%) referred for DCM-VT ablation w...
Abstract
Cited 4 times since 2020 (0.8 per year)
source: EuropePMC
Philosophical transactions of the Royal Society of London. Series B, Biological sciences,
Volume 375, Issue 1805, 29 5 2020, Pages 20190423
Spontaneous (minimal) ritual in non-human great apes?
Tennie C, van Schaik CP
The potential for rituals in non-human great apes (apes) is an understudied topic. We derive a minimal definition of ritual and then examine the currently available evidence for it in untrained and non-enculturated apes. First, we examine whether such apes show evidence for the two main components of our minimal definition of ritual: symbolism and copying. Second, we examine if there are actual cases already identifiable today that may fit all aspects of our minimal definition of ritual-or wheth...
Abstract
Cited 6 times since 2020 (1.2 per year)
source: EuropePMC
Pediatric nephrology (Berlin, Germany),
Volume 36, Issue 2, 29 5 2020, Pages 417-423
Evaluation of non-infectious complications of peritoneal dialysis in children: a multicenter study.
Aksoy GK, Ekim M, Bakkaloğlu SA, Coşkun S, Delibaş A, Conkar S, Yılmaz D, Kara A, Saygılı SK, Büyükkaragöz B, Yıldırım ZY, Çomak E, Gürgöze MK, Sever L, Noyan A, Bayazıt AK, Düşünsel R
Background: Peritoneal dialysis (PD) is the most common kidney replacement therapy in children. Complications associated with PD affect treatment success and sustainability. The aim of this study was to investigate the frequency of PD-related non-infectious complications and the predisposing factors. Methods: Retrospective data from 11 centers in Turkey between 1998 and 2018 was collected. Non-infectious complications of peritoneal dialysis (NICPD), except metabolic ones, in pediatric patients w...
Abstract
Cited 18 times since 2020 (3.7 per year)
source: EuropePMC
EJNMMI research,
Volume 10, Issue 1, 28 4 2020, Pages 87
Molecular imaging of the urokinase plasminogen activator receptor: opportunities beyond cancer.
Baart VM, Houvast RD, de Geus-Oei LF, Quax PHA, Kuppen PJK, Vahrmeijer AL, Sier CFM
The urokinase plasminogen activator receptor (uPAR) plays a multifaceted role in almost any process where migration of cells and tissue-remodeling is involved such as inflammation, but also in diseases as arthritis and cancer. Normally, uPAR is absent in healthy tissues. By its carefully orchestrated interaction with the protease urokinase plasminogen activator and its inhibitor (plasminogen activator inhibitor-1), uPAR localizes a cascade of proteolytic activities, enabling (patho)physiologic c...
Abstract
Cited 10 times since 2020 (2.1 per year)
source: EuropePMC
The American journal of cardiology,
Volume 133, 28 4 2020, Pages 39-47
Five-Year Outcomes and Prognostic Value of Feature-Tracking Cardiovascular Magnetic Resonance in Patients Receiving Early Prereperfusion Metoprolol in Acute Myocardial Infarction.
Podlesnikar T, Pizarro G, Fernández-Jiménez R, Montero-Cabezas JM, Sánchez-González J, Bucciarelli-Ducci C, Ajmone Marsan N, Fras Z, Bax JJ, Fuster V, Ibáñez B, Delgado V
The aim of the present study was to investigate the long-term impact of early intravenous metoprolol in ST-segment elevation myocardial infarction (STEMI) patients in terms of left ventricular (LV) strain with feature-tracking cardiovascular magnetic resonance (CMR) and its association with prognosis. A total of 270 patients with first anterior STEMI enrolled in the randomized METOCARD-CNIC clinical trial, assigned to receive up to 15 mg intravenous metoprolol before primary percutaneous coronar...
Abstract
Cited 25 times since 2020 (5.2 per year)
source: EuropePMC
European journal of preventive cardiology,
Volume 28, Issue 1, 27 4 2020, Pages 33-43
Intensity of statin treatment after acute coronary syndrome, residual risk, and its modification by alirocumab: insights from the ODYSSEY OUTCOMES trial.
Diaz R, Li QH, Bhatt DL, Bittner VA, Baccara-Dinet MT, Goodman SG, Jukema JW, Kimura T, Parkhomenko A, Pordy R, Reiner Ž, Roe MT, Szarek M, Tse HF, White HD, Zahger D, Zeiher AM, Schwartz GG, Steg PG, ODYSSEY OUTCOMES Committees and Investigators
Aims: Statins are pivotal to the secondary prevention of major adverse cardiovascular events, but some patients are statin-intolerant. We examined the effects of the proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor alirocumab on the risk of major adverse cardiovascular events according to the intensity of background statin treatment. Methods and results: The ODYSSEY OUTCOMES trial compared alirocumab with placebo in 18,924 patients with acute coronary syndrome and dyslipidaemia de...
Abstract
