9618 results
Cited 1 times since 2025 (7.7 per year)
source: EuropePMC
Cardiovascular research,
Volume 121, Issue 8, 1 1 2025, Pages 1215-1227
Sex and sex hormonal regulation of the atrial inward rectifier potassium current (IK1): insights into potential pro-arrhythmic mechanisms.
Giammarino L, Matas L, Alerni N, Horváth A, Vashanthakumar V, Nimani S, Barbieri M, Bains S, Lopez R, Louradour J, Ördög B, Hof T, Maguy A, Conte G, Auricchio A, Schotten U, Odening KE
Aims: Pronounced sex-differences are known in the incidence of atrial fibrillation (AF). In this study, we aimed to investigate the atrial electrophysiological properties that may underlie sex-differences in AF incidence in the younger population, focusing on IK1, a cardiac ion current important for action potential (AP) stability and triggered activity. Methods and results: We assessed sex-differences in P-wave morphology in 12-lead ECG in healthy young New Zealand White rabbits. Males presente...
Abstract
Frontiers in physiology,
Volume 16, 1 1 2025, Pages 1631426
Functional conduction system mapping in sheep reveals Purkinje spikes in the free wall of the right ventricular outflow tract.
Blok M, den Ouden BL, Kuiper M, Ophelders DRMG, Jongbloed MRM, Zeemering S, Jensen B, van Hunnik A, Boukens BJ
Ablation of sites displaying Purkinje activity is highly effective against idiopathic ventricular fibrillation which often originates in the right ventricular outflow tract. However, during endocardial mapping Purkinje potentials are rarely, if never, detected in the right ventricular outflow tract. In the present study, we aimed to determine whether the Purkinje system extends into the right ventricular outflow tract. Hearts of five female sheep were blood-perfused in a Langendorff setup in whi...
Abstract
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
Volume 67, Issue 7, 1 1 2025, Pages ezaf137
Reply to Xiao et al.
Sabik JF, Rao V, Dagenais F, Reardon MJ, PERIGON Investigators
Abstract
Heart rhythm,
Volume 22, Issue 7, 1 1 2025, Pages 1877-1879
Top stories on proactive ventricular arrhythmia assessment in repaired tetralogy of Fallot.
Zeppenfeld K, Kimura Y
Abstract
Scientific reports,
Volume 15, Issue 1, 1 1 2025, Pages 21482
Systematic assessment of bone and soft tissue tumors on whole-body CTs of 45 mummies from ancient Egypt.
Panzer S, Wörtler K, Paladin A, Zesch S, Rosendahl W, van Schaik KD, Sutherland ML, Sutherland JD, Hergan K, Thompson RC, Zink AR
There is a growing interest in the antiquity of cancer and ongoing discussion of the apparent scarcity of malignant tumors in ancient human remains, especially those of soft tissues. We systematically assessed bone and soft tissue tumors on 45 whole-body computed tomography (CT) scans of ancient Egyptian mummies. In one of 45 cases (2%), malignant skeletal disease (probably skeletal metastases) was detected. In five of 45 cases (11%), probably malignant soft tissue masses were identified. The so...
Abstract
Cited 1 times since 2025 (7.7 per year)
source: EuropePMC
Clinical cancer research : an official journal of the American Association for Cancer Research,
Volume 31, Issue 13, 1 1 2025, Pages 2793-2813
Antitumor Immunity Mediated by Engineered Stem Cells Exploiting TRAIL-Induced Cell Death and FLT3L Immunomodulation.
van Schaik TA, Chen KS, Kanaya N, Moreno-Lama L, Freeman NW, Wang M, Li W, Zhang YS, Vrbanac V, Huang R, Wakimoto H, Reardon D, Shah K
Purpose: Death receptor (DR)-targeted therapies offer a promising tumor cell-specific therapeutic strategy for highly malignant brain tumors, such as glioblastoma (GBM). However, whether DR-mediated cell death leads to activation of the adaptive immune system and impacts the tumor immune microenvironment (TIME) remains unknown. In this study, we explored the (i) immunomodulatory role of secretable human DR4/5 ligand, TNF-related apoptosis-inducing ligand (S-TRAIL) and (ii) the therapeutic potent...
Abstract
Current heart failure reports,
Volume 22, Issue 1, 1 1 2025, Pages 21
Impact of Multisensor CIED-based Heart Failure Monitoring on Mortality, Heart Failure Hospitalizations and Outpatient Visits: A Systematic Review.
Zwaenepoel BAC, Kluft A, Feijen M, Schoones JW, Heggermont WA, Egorova AD, Beeres SLMA
Purpose of review: Cardiac Implantable Electronic Device (CIED)-based remote monitoring has been proposed to improve heart failure (HF) management by enabling early detection of decompensation. This systematic review evaluates the effectiveness of multisensor CIED-based monitoring in reducing mortality, HF hospitalizations, and unplanned HF outpatient visits. Recent findings: Earlier CIED-based remote monitoring strategies were mainly based on single-sensor impedance-based algorithms, and showed...
Abstract
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology,
Volume 27, Issue 7, 1 1 2025, Pages euaf122
Excellent interobserver agreement and steep learning curve for target volume delineation for stereotactic arrhythmia radioablation using a commercial software.
Rademaker R, Cirkel S, Omara S, Dankers FJWM, Sramko M, Solana Munoz J, Kaya YS, Ter Bekke RMA, Schiappacasse L, Teres C, Verhoeven K, Pruvot E, Rasch CRN, Zeppenfeld K
Aims: Stereotactic arrhythmia radioablation (STAR) has emerged as bail-out treatment for ventricular tachycardia (VT). Accurate, reproducible, and easy-to-use data transfer from electroanatomical mapping (EAM) systems to radiotherapy planning CT is desirable. We aim to evaluate interobserver variability, ease of use, and learning curve for EAM based target volume (CardTV-EPinv) creation and transfer using available software packages. Methods and results: In patients considered for STAR, CardTV-E...
Abstract
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology,
Volume 27, Issue 7, 1 1 2025, Pages euaf134
Regionalization of the atria for 3D electroanatomical mapping, cardiac imaging, and computational modelling: a clinical consensus statement of the European Heart Rhythm Association and the European Association of Cardiovascular Imaging of the ESC.
Althoff TF, Anderson RH, Goetz C, Petersen SE, Díaz PM, Nijveldt R, Maurovich-Horvat P, Bax J, Hussain S, Schmidt C, Spicer DE, Sanchez-Quintana D, Corsi C, Dössel O, Climent AM, Rodriguez B, Schotten U, Loewe A, Guillem MS, Cabrera JÁ, Merino JL, Wijnmaalen AP, Bertrand PB, de Groot N, Derval N, Didenko M, Donal E, Dweck MR, Ho SY
This clinical consensus document proposes standardized atrial segments for 3D imaging, electroanatomical mapping and computational modelling, based on anatomical, electrophysiological and clinical considerations, with precise definitions of regional borders allowing for reproducible and automated regionalization. 3D imaging and high-resolution electroanatomical mapping have become an integral part of cardiac electrophysiology and the management of patients with arrhythmias. However, to perform r...
Abstract
Journal of magnetic resonance imaging : JMRI,
30 5 2025
Aortic Function in a Longitudinal 4D Flow MRI Study in Marfan Syndrome Patients Receiving Resveratrol.
Bosshardt D, van Andel MM, Schrauben EM, van Kimmenade RRJ, Scholte AJ, Cox MGJP, Robbers-Visser D, Zwinderman AH, Mulder BJM, Nederveen AJ, de Waard V, Groenink M, van Ooij P
Background: New treatment strategies are required to reduce aortic events in Marfan syndrome (MFS). Resveratrol is a dietary supplement that intervenes in aortic wall cellular metabolism and may benefit MFS patients. Purpose: To evaluate whether treatment with Resveratrol affects aorta hemodynamics derived from 4D flow MRI in MFS. Study type: Prospective single-arm open-label multicenter trial. Population: 46 MFS patients (mean age 36 ± 9 years, 23 female), 20 with and 26 without a history of ao...
Abstract
Nederlands tijdschrift voor geneeskunde,
Volume 169, 30 5 2025, Pages D8346
[Unfounded objections against the use of salbutamol/ipratropium].
Lucassen EA, Rood R, Tibboel J, Piers SRD
In acute bronchospasm due to asthma/COPD exacerbations two bronchodilators are frequently used: ipratropium, an acetylcholine antagonist, and salbutamol, a β2-agonist. The combination ipratropium/salbutamol gives more bronchodilation than ipratropium monotherapy in asthma/COPD exacerbations, but there are concerns about cardiac safety of salbutamol. Salbutamol in regular dosage does not affect heart rate in diverse populations (ED, ICU and children). Only a dosage 5-10x the standard dosage of 2,...
Abstract
mBio,
30 5 2025, Pages e0035325
A redundant isoprenoid biosynthetic pathway supports <i>Staphylococcus aureus</i> metabolic versatility.
Burtchett TA, Ottosen EN, Jitsukawa T, Kaneko M, Yasui M, Lysne JA, Kies PJ, Bailey JA, Thomas SM, Fujisaki S, Hammer ND
Isoprenoids are ubiquitous molecules that serve as fundamental building blocks for life. In bacteria, isoprenoids are precursors for carotenoid pigments, respiratory cofactors, and essential sugar carrier lipids, such as lipid II. Isoprenoid synthesis initiates via condensation of the five-carbon (C5) precursors, isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). This initial reaction condenses one DMAPP and two IPPs, resulting in C15 farnesyl diphosphate (FPP), an intermediate...
Abstract
International journal of cancer,
30 5 2025
Physical activity and risks of recurrence and progression among patients with non-muscle invasive bladder cancer.
Beeren I, Kiebach J, Hof JP, Buffart LM, Aben KKH, Witjes JA, van der Heijden AG, Kiemeney LALM, Vrieling A
Previous studies in solid tumors link high physical activity (PA) levels to lower cancer recurrence risk, but evidence is lacking for patients with non-muscle invasive bladder cancer (NMIBC). We evaluated the association between (changes in) PA (total, moderate-to-vigorous PA, leisure-time PA, and Dutch PA guideline adherence) and risks of NMIBC recurrence and progression. Patients diagnosed between 2014 and 2021 were recruited for the multi-center prospective cohort UroLife. Participants report...
Abstract
Clinical pharmacokinetics,
30 5 2025
A Population Pharmacokinetic Model and Dosing Algorithm to Guide the Tacrolimus Starting and Follow-Up Dose in Living and Deceased Donor Kidney Transplant Recipients.
Francke MI, Sassen SDT, Lloberas N, Colom H, Elens L, Moudio S, de Vries APJ, Moes DJAR, van Schaik RHN, Hesselink DA, de Winter BCM
Introduction: Tacrolimus treatment is complicated by its narrow therapeutic range and large inter- and intra-patient variability. This study aimed to develop a population pharmacokinetic model and dosing algorithm to predict an individual's dose requirement following living and deceased donor kidney transplantation. Methods: In this international, multicenter, retrospective study, data was collected from patients who had received a living or a deceased donor kidney and received tacrolimus t...
Abstract
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology,
Volume 210, 27 4 2025, Pages 111004
Transfer of arrhythmia substrate targets from the cardiac electroanatomical and imaging modalities to the planning computed tomography scan for stereotactic arrhythmia radioablation for refractory ventricular tachycardia - a state-of-the-art review on software developments on behalf of the STOPSTORM.eu consortium.
Ter Bekke RMA, Hohmann S, Xie J, Grehn M, Verhoeven K, Volders PGA, Mihl C, Kaya YS, Manninger M, Scherr D, Corradini S, Schweikard A, Rademaker R, Hoeksema WF, Schiappacasse L, Knybel L, Pruvot E, Postema PG, Peichl P, Cvek J, Zeppenfeld K, Blanck O, Boda-Heggemann J
Stereotactic arrhythmia radioablation (STAR) for ventricular tachycardia (VT) is a non-invasive treatment modality to reduce the VT burden by delivering a single high radiation dose to the arrhythmogenic substrate. Identification and delineation of the arrhythmogenic substrate, definition of the radiation target, and transfer of this target across different imaging modalities from the invasive electroanatomic map (EAM) to the planning computed tomography (CT) scan are key to the success of thera...
Abstract
Physics in medicine and biology,
Volume 70, Issue 13, 27 4 2025
Analysis and generation of the fibrosis textures based on histology data of the human hearts with non-ischemic cardiomyopathy.
Okenov A, Nezlobinsky T, Glashan CA, Zeppenfeld K, Vandersickel N, Panfilov AV
Objective.Cardiac arrhythmias, marked by irregular and/or fast heartbeats, can severely compromise heart function and pose serious health risks. Fibrosis alters the propagation of electrical signals in the heart and plays a critical role in arrhythmogenesis. The impact of fibrosis depends not only on its amount, but also on its geometric features and spatial distribution. Therefore, understanding and replicating the structural characteristics of fibrotic tissue is essential for accurate arrhythm...
Abstract
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology,
26 4 2025
Measurement of Tralokinumab Concentrations in Serum and Tear Fluid of Atopic Dermatitis Patients and the Relationship With Treatment Response and Ocular Surface Disease.
Dekkers C, Smeijsters EH, El Amrani M, Jager CDH, van der Elst KCM, van Luin M, van Luijk C, Bakker DS, Huitema ADR, de Graaf M, van Wijk F, de Bruin-Weller MS
Abstract
Cited 3 times since 2025 (21 per year)
source: EuropePMC
Philosophical transactions of the Royal Society of London. Series B, Biological sciences,
Volume 380, Issue 1929, 26 4 2025, Pages 20240124
The fish challenge to vertebrate cognitive evolution.
Triki Z, van Schaik C, Bshary R
There is tremendous taxonomic variation in the size, shape and structure of vertebrate brains. While many studies use cross-species comparisons to aim at identifying the ecological factors (social and environmental) that explain what cognitive advantages larger brains confer, a more fundamental divide exists between endotherm and ectotherm vertebrates. Relative to body size, ectotherms have ten times smaller brains than endotherms. Existing ecological hypotheses cannot explain this divide, as so...
Abstract
Circulation. Arrhythmia and electrophysiology,
Volume 18, Issue 7, 25 4 2025, Pages e013670
Race Comparisons in Patients With Cardiac Sarcoidosis: Insights From the Cardiac Sarcoidosis Consortium.
Trongtorsak A, De La Rosa Martinez J, Crawford TC, Bogun FM, Gu X, Puroll E, Ellenbogen KA, Chicos AB, Roukoz H, Zimetbaum PJ, Kalbfleisch SJ, Murgatroyd FD, Steckman DA, Rosenfeld LE, Soejima K, Bhan AK, Vedantham V, Dickfeld TL, DeLurgio DB, Platonov PG, Zipse MM, Nishiuchi S, Ortman ML, Narasimhan C, Patton KK, Rosenthal DG, Mukerji SS, Hoogendoorn JC, Zeppenfeld K, Torosoff M, Judson MA, Martin K, Madias C, Hermel M, Nour K, Torbey E, Sauer WH, Kron J, Cardiac Sarcoidosis Consortium
Background: Differences in cardiac sarcoidosis between racial groups remain understudied. Therefore, this study aims to explore race differences in patients with cardiac sarcoidosis. Methods: We analyzed data from the Cardiac Sarcoidosis Consortium, an international registry including over 25 centers. The primary clinical outcome was a composite end point of all-cause mortality, left ventricular assist device implantation, heart transplantation, or implantable cardioverter defibrillator therapy....
Abstract
Cited 1 times since 2025 (6.9 per year)
source: EuropePMC
PloS one,
Volume 20, Issue 6, 25 4 2025, Pages e0327044
Exploring the potential of blood and urine protein electrophoresis in predicting 1-year mortality in acute kidney injury.
Yilmaz D, Sahin E, Batar G, Caglayan K, Gulturk E, Aydin Yoldemir S
This retrospective cohort study aimed to assess the predictive value of protein fractions obtained from blood and urine protein electrophoresis, along with various clinical and laboratory parameters, for 1-year all-cause mortality in acute kidney injury (AKI) patients. Data were collected from hospitalized patients who had been diagnosed with AKI. Demographics, smoking status, blood and urine electrophoresis results, serum gamma globulin levels, monoclonal gammopathy status, immunofixation resul...
Abstract
