Research

Publications

Below you can find a list of our published research.

6173 results

Cited 42 times since 2005 (2.2 per year) source: EuropePMC

Stem cells (Dayton, Ohio), Volume 23, Issue 10, 1 1 2005, Pages 1598-1607 Endowing human adenovirus serotype 5 vectors with fiber domains of species B greatly enhances gene transfer into human mesenchymal stem cells. Knaän-Shanzer S, van de Watering MJ, van der Velde I, Gonçalves MA, Valerio D, de Vries AA

Bone marrow-derived human mesenchymal stem cells (hMSCs) lack the Coxsackie-adenovirus (Ad) receptor and thus are poorly transduced by vectors based on human Ad serotype 5 (Ad5). We investigated whether this problem could be overcome by using tropism-modified Ad5 vectors carrying fiber shaft domains and knobs of different human species B Ads (Ad5FBs). To allow quantitative analyses, these vectors coded for the enhanced green fluorescent protein (eGFP). Transgene expression analysis showed superi... Abstract

Cited 25 times since 2005 (1.3 per year) source: EuropePMC

Pediatric cardiology, Volume 26, Issue 6, 1 1 2005, Pages 756-761 High mortality rate after extubation failure after pediatric cardiac surgery. Harkel AD, van der Vorst MM, Hazekamp MG, Ottenkamp J

The objective of this study was to evaluate the different causes of extubation failure and the consequent mortality rates in a pediatric population after cardiac surgery. We studied 184 consecutive patients with a median age of 9 months (range, 0-165). In 158 patients, extubation was successful (group A). Nine patients were reintubated for upper airway obstruction and finally extubated successfully (group B). Seventeen patients were reintubated for cardiorespiratory failure, finally leading to d... Abstract

Cited 98 times since 2005 (5 per year) source: EuropePMC

Atherosclerosis, Volume 187, Issue 2, 28 4 2005, Pages 415-422 C-reactive protein levels and coronary artery disease incidence and mortality in apparently healthy men and women: the EPIC-Norfolk prospective population study 1993-2003. Boekholdt SM, Hack CE, Sandhu MS, Luben R, Bingham SA, Wareham NJ, Peters RJ, Jukema JW, Day NE, Kastelein JJ, Khaw KT

Introduction: Measurement of C-reactive protein (CRP) levels has been proposed as a useful marker to improve the prediction of future coronary artery disease (CAD) risk, but this notion has been challenged recently. Methods and results: We performed a prospective case-control study among apparently healthy men and women. The odds ratio (OR) for future CAD incidence was 2.49 (95% CI=2.02-3.08, p for linearity Abstract

Cited 10 times since 2005 (0.5 per year) source: EuropePMC

Radiology, Volume 237, Issue 3, 26 4 2005, Pages 861-867 Intraatrial repair of transposition of the great arteries: use of MR imaging after exercise to evaluate regional systemic right ventricular function. Tops LF, Roest AA, Lamb HJ, Vliegen HW, Helbing WA, van der Wall EE, de Roos A

Purpose: To prospectively assess regional systemic right ventricular (RV) function at rest and in response to exercise by using magnetic resonance (MR) imaging in patients who have undergone surgical correction at the atrial level for transposition of the great arteries (TGA). Materials and methods: Informed consent was obtained, and the medical review board approved this study. In 25 adult patients (mean age, 25.8 years +/- 4.7 [standard deviation]; 13 men) who had undergone correction for TGA... Abstract

Cited 67 times since 2005 (3.4 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 46, Issue 10, 21 3 2005, Pages 1943-1952 Human adult bone marrow mesenchymal stem cells repair experimental conduction block in rat cardiomyocyte cultures. Beeres SL, Atsma DE, van der Laarse A, Pijnappels DA, van Tuyn J, Fibbe WE, de Vries AA, Ypey DL, van der Wall EE, Schalij MJ

Objectives: We evaluated whether human adult bone marrow-derived mesenchymal stem cells (hMSCs) could repair an experimentally induced conduction block in cardiomyocyte cultures. Background: Autologous stem cell therapy is a novel treatment option for patients with heart disease. However, detailed electrophysiological characterization of hMSCs is still lacking. Methods: Neonatal rat cardiomyocytes were seeded on multi-electrode arrays. After 48 h, abrasion of a 200- to 450-microm-wide channel ca... Abstract

Cited 61 times since 2005 (3.1 per year) source: EuropePMC

European journal of heart failure, Volume 8, Issue 2, 7 1 2005, Pages 115-121 Diltiazem treatment prevents diastolic heart failure in mice with familial hypertrophic cardiomyopathy. Westermann D, Knollmann BC, Steendijk P, Rutschow S, Riad A, Pauschinger M, Potter JD, Schultheiss HP, Tschöpe C

Background: The cardiac troponin T I79N mutation, linked to familial hypertrophic cardiomyopathy, carries a high risk of sudden cardiac death even in the absence of significant cardiac hypertrophy. The pathology underlying this mechanism has not yet been identified. Aims: To study the underlying mechanism of this phenomenon we characterized the left ventricular (LV) performance of transgenic mice carrying the human troponin T mutation I79N under basal and isoproterenol-induced stress conditions.... Abstract

Cited 5 times since 2005 (0.3 per year) source: EuropePMC

European heart journal, Volume 26, Issue 22, 4 1 2005, Pages 2358-2360 Should the ACC/AHA guidelines be changed in patients undergoing vascular surgery? Hoeks SE, Bax JJ, Poldermans D

Abstract

Cited 23 times since 2005 (1.2 per year) source: EuropePMC

The Journal of allergy and clinical immunology, Volume 116, Issue 5, 3 1 2005, Pages 1007-1013 Adding salmeterol to an inhaled corticosteroid reduces allergen-induced serum IL-5 and peripheral blood eosinophils. Koopmans JG, Lutter R, Jansen HM, van der Zee JS

Background: Adding a long-acting beta(2)-agonist to inhaled corticosteroids results in better symptomatic asthma control than increasing the dose of inhaled corticosteroids. Objective: Investigating whether adding the long-acting beta(2)-agonist salmeterol to the inhaled corticosteroid fluticasone propionate has an effect on allergen-induced allergic inflammation in asthma. Methods: Bronchial allergen challenges were performed in 26 patients with allergic asthma, pretreating them with a single d... Abstract

Cited 22 times since 2005 (1.1 per year) source: EuropePMC

Cardiovascular research, Volume 68, Issue 1, 1 1 2005, Pages 136-143 Involvement of furin-like proprotein convertases in the arterial response to injury. Sluijter JP, Verloop RE, Pulskens WP, Velema E, Grimbergen JM, Quax PH, Goumans MJ, Pasterkamp G, de Kleijn DP

Background: Furin-like proprotein convertases (PCs) are proteolytic activators of proproteins, like membrane type 1-matrix metalloproteinase (MT1-MMP) and transforming growth factor beta (TGF-beta), that are described in the arterial response to injury. However, the involvement of furin-like PCs in the arterial response to injury has not been studied yet. We studied furin, MT1-MMP, MMP levels and TGF-beta signaling after arterial injury. We also investigated the effect of an inhibitor of furin-l... Abstract

Cited 16 times since 2005 (0.8 per year) source: EuropePMC

Journal of cardiovascular electrophysiology, Volume 16, Issue 10, 1 1 2005, Pages 1049-1056 Determinants of recurrent ventricular arrhythmia or death in 300 consecutive patients with ischemic heart disease who experienced aborted sudden death: data from the Leiden out-of-hospital cardiac arrest study. Kiès P, Boersma E, Bax JJ, van der Burg AE, Bootsma M, van Erven L, van der Wall EE, Schalij MJ

Objective: Evaluation of the relation between clinical characteristics and incidence of recurrent ventricular arrhythmias (VAs) or death during long-term follow-up in a cohort of 300 consecutive ischemic heart disease (IHD) patients who had survived an episode of sudden cardiac arrest (SCA). Background: Survivors of life-threatening VA are at high risk for recurrent events. Methods: A total of 300 consecutive survivors of SCA with IHD were included in a standardized screening and evaluation prot... Abstract

Cited 127 times since 2005 (6.5 per year) source: EuropePMC

Heart rhythm, Volume 2, Issue 10, 1 1 2005, Pages 1076-1081 Fusion of multislice computed tomography imaging with three-dimensional electroanatomic mapping to guide radiofrequency catheter ablation procedures. Tops LF, Bax JJ, Zeppenfeld K, Jongbloed MR, Lamb HJ, van der Wall EE, Schalij MJ

Background: The outcome of catheter ablation procedures of cardiac arrhythmias depends on the ability to evaluate the underlying mechanism and to depict target sites for ablation. Fusion of different imaging modalities within one system may improve electroanatomic modeling and facilitate ablation procedures. Objectives: The purpose of this study was to study the feasibility of fusion of multislice computed tomography (MSCT) with electroanatomic mapping to guide radiofrequency catheter ablation o... Abstract

Cited 38 times since 2005 (1.9 per year) source: EuropePMC

The American journal of cardiology, Volume 96, Issue 7, 1 1 2005, Pages 996-1001 Role of disease status and type D personality in outcomes in patients with peripheral arterial disease. Aquarius AE, Denollet J, Hamming JF, De Vries J

Patients with peripheral arterial disease (PAD) often experience diminishing quality of life (QOL) in many domains of their lives. However, factors associated with impaired QOL and perceived stress in these patients are not completely understood. The relative effects of disease status and type D ("distressed") personality (tendencies to experience negative emotions and be socially inhibited) on these patient-based outcomes were examined. It has been argued that type D personality might... Abstract

Cited 16 times since 2005 (0.8 per year) source: EuropePMC

The journals of gerontology. Series A, Biological sciences and medical sciences, Volume 60, Issue 10, 1 1 2005, Pages 1333-1338 Long-term prediction of mortality in elderly persons by dobutamine stress echocardiography. Biagini E, Elhendy A, Schinkel AF, Rizzello V, Bax JJ, Sozzi FB, Kertai MD, van Domburg RT, Krenning BJ, Branzi A, Rapezzi C, Simoons ML, Poldermans D

Background: Dobutamine stress echocardiography (DSE) was shown to provide incremental prognostic information. However, its role in the prediction of mortality in elderly persons is not well defined. We assessed the value of DSE in the prediction of mortality and hard cardiac events during long-term follow-up in patients older than 65 years. Methods: We studied 1434 patients >65 years old (mean age 72 +/- 3 years) who underwent DSE for evaluation of coronary artery disease. Ischemia was define... Abstract

Cited 54 times since 2005 (2.8 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 46, Issue 7, 1 1 2005, Pages 1264-1269 The extent of perfusion-F18-fluorodeoxyglucose positron emission tomography mismatch determines mortality in medically treated patients with chronic ischemic left ventricular dysfunction. Desideri A, Cortigiani L, Christen AI, Coscarelli S, Gregori D, Zanco P, Komorovsky R, Bax JJ

Objectives: The purpose of this study was to assess the determinants of mortality in a large group of patients with ischemic cardiomyopathy who are treated medically and the impact of the extent of viable tissue on prognosis. Background: Whether the presence of viability drives mortality in patients with ischemic cardiomyopathy who are treated medically and whether the extent of viability is important are issues that are currently unclear. Methods: Two hundred sixty-one patients with ischemic ca... Abstract

Cited 180 times since 2005 (9.2 per year) source: EuropePMC

The American journal of medicine, Volume 118, Issue 10, 1 1 2005, Pages 1134-1141 Perioperative cardiovascular mortality in noncardiac surgery: validation of the Lee cardiac risk index. Boersma E, Kertai MD, Schouten O, Bax JJ, Noordzij P, Steyerberg EW, Schinkel AF, van Santen M, Simoons ML, Thomson IR, Klein J, van Urk H, Poldermans D

Purpose: The Lee risk index was developed to predict major cardiac complications in noncardiac surgery. We retrospectively evaluated its ability to predict cardiovascular death in the large cohort of patients who recently underwent noncardiac surgery in our institution. Methods: The administrative database of the Erasmus MC, Rotterdam, The Netherlands, contains information on 108 593 noncardiac surgical procedures performed from 1991 to 2000. The Lee index assigns 1 point to each of the followin... Abstract

Cited 12 times since 2005 (0.6 per year) source: EuropePMC

The international journal of cardiovascular imaging, Volume 21, Issue 5, 1 1 2005, Pages 519-529 Evaluation of the Quantitative Gated SPECT (QGS) software program in the presence of large perfusion defects. America YG, Bax JJ, Dibbets-Schneider P, Pauwels EK, Van der Wall EE

Objectives: To evaluate the reproducibility and operator dependence for the quantitative regional left ventricular functional parameters (LVFP) assessed by Cedars-Sinai's Quantitative automated gated SPECT (QGS) software. Methods: The QGS algorithm was reviewed in detail and potential operator dependencies were defined. Series of prototypes were selected, consisting of (a) normal perfusion, (b) perfusion defects in all perfusion regions, (c) perfusion studies of patients with angiographic c... Abstract

Cited 10 times since 2005 (0.5 per year) source: EuropePMC

Journal of nuclear medicine : official publication, Society of Nuclear Medicine, Volume 46, Issue 10, 1 1 2005, Pages 1589-1595 Association of ischemia on stress (99m)Tc-tetrofosmin myocardial perfusion imaging with all-cause mortality in patients with diabetes mellitus. Elhendy A, Huurman A, Schinkel AF, Bax JJ, van Domburg RT, Valkema R, Biagini E, Poldermans D

Unlabelled: Stress myocardial perfusion imaging is a useful method for evaluation of coronary artery disease (CAD) in patients with diabetes mellitus. However, its role in predicting all-cause mortality is not well defined. The aim of this study was to determine whether myocardial ischemia on stress myocardial perfusion imaging can predict all causes of death in patients with diabetes mellitus. Methods: We studied 297 patients with diabetes mellitus and known or suspected CAD by exercise or dobu... Abstract

Cited 2 times since 2005 (0.1 per year) source: EuropePMC

Journal of vascular surgery, Volume 42, Issue 4, 1 1 2005, Pages 825; author reply 826 Regarding "Perioperative beta-blockade (POBBLE) for patients undergoing infrarenal vascular surgery: results of a randomized double-blind controlled trial". Schouten O, van Urk H, Feringa HH, Bax JJ, Poldermans D

Abstract

Cited 32 times since 2005 (1.6 per year) source: EuropePMC

Cancer research, Volume 65, Issue 20, 1 1 2005, Pages 9398-9405 Tissue inhibitor of metalloproteinase-3 expression from an oncolytic adenovirus inhibits matrix metalloproteinase activity in vivo without affecting antitumor efficacy in malignant glioma. Lamfers ML, Gianni D, Tung CH, Idema S, Schagen FH, Carette JE, Quax PH, Van Beusechem VW, Vandertop WP, Dirven CM, Chiocca EA, Gerritsen WR

Oncolytic adenoviruses exhibiting tumor-selective replication are promising anticancer agents. Insertion and expression of a transgene encoding tissue inhibitor of metalloproteinase-3 (TIMP-3), which has been reported to inhibit angiogenesis and tumor cell infiltration and induce apoptosis, may improve the antitumor activity of these agents. To assess the effects of TIMP-3 gene transfer to glioma cells, a replication-defective adenovirus encoding TIMP-3 (Ad.TIMP-3) was employed. Ad.TIMP-3 infect... Abstract

Cited 52 times since 2005 (2.7 per year) source: EuropePMC

American heart journal, Volume 150, Issue 4, 1 1 2005, Pages 775-781 Comprehensive assessment of patients after coronary artery bypass grafting by 16-detector-row computed tomography. Salm LP, Bax JJ, Jukema JW, Schuijf JD, Vliegen HW, Lamb HJ, van der Wall EE, de Roos A

Background: Multidetector-row computed tomography (MDCT) is a versatile modality to evaluate stenoses in native coronary arteries and bypass grafts. Acquired MDCT data can additionally be used to assess left ventricular ejection fraction (LVEF). The purpose was to use MDCT for the assessment of bypass graft and coronary artery disease combined with evaluation of LVEF. Methods: Twenty-five patients underwent 16-detector-row CT examination and coronary angiography. Bypass grafts and nongrafted cor... Abstract