Research

Publications

Below you can find a list of our published research.

8900 results

Cited 157 times since 2014 (14 per year) source: EuropePMC

Journal of lipid research, Volume 55, Issue 10, 19 3 2014, Pages 2103-2112 Alirocumab inhibits atherosclerosis, improves the plaque morphology, and enhances the effects of a statin. Kühnast S, van der Hoorn JW, Pieterman EJ, van den Hoek AM, Sasiela WJ, Gusarova V, Peyman A, Schäfer HL, Schwahn U, Jukema JW, Princen HM

Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibition is a potential novel strategy for treatment of CVD. Alirocumab is a fully human PCSK9 monoclonal antibody in phase 3 clinical development. We evaluated the antiatherogenic potential of alirocumab in APOE*3Leiden.CETP mice. Mice received a Western-type diet and were treated with alirocumab (3 or 10 mg/kg, weekly subcutaneous dosing) alone and in combination with atorvastatin (3.6 mg/kg/d) for 18 weeks. Alirocumab alone dose-dependen... Abstract

European heart journal. Cardiovascular Imaging, Volume 15, Issue 12, 19 3 2014, Pages 1428 Three-dimensional transoesophageal echocardiographic visualization of malignant anomalous left main coronary origin and course causing sudden cardiac death. Kamperidis V, Katsanos S, Bertels RA, Schalij MJ, Delgado V

Abstract

Cited 26 times since 2014 (2.3 per year) source: EuropePMC

European journal of heart failure, Volume 16, Issue 10, 19 3 2014, Pages 1104-1111 Super-responders to cardiac resynchronization therapy remain at risk for ventricular arrhythmias and benefit from defibrillator treatment. van der Heijden AC, Höke U, Thijssen J, Borleffs CJ, van Rees JB, van der Velde ET, Schalij MJ, van Erven L

Aims: Mortality and ventricular arrhythmias are reduced in patients responding to cardiac resynchronization therapy (CRT). This response is accompanied by improvement in LVEF, and some patients even outgrow original eligibility criteria for implantable cardioverter-defibrillator (ICD) implantation. It is however unclear if these patients still benefit from ICD treatment. The current study aimed to evaluate if the incidence of ICD therapy is related to the extent of CRT response. Methods and resu... Abstract

Cited 22 times since 2014 (2 per year) source: EuropePMC

The Annals of thoracic surgery, Volume 98, Issue 5, 19 3 2014, Pages 1680-1686 More than 25 years of experience in managing pulmonary atresia with intact ventricular septum. Schneider AW, Blom NA, Bruggemans EF, Hazekamp MG

Background: Management of pulmonary atresia with intact ventricular septum (PAIVS) is challenging and depends on the individual patient's morphologic characteristics. We evaluated outcomes of 25 years of experience in morphologically driven management of PAIVS. Methods: Between January 1985 and December 2011, 60 patients were treated for PAIVS. Patients were retrospectively categorized into mild (n=27), moderate (n=18), and severe (n=15) right ventricular (RV) hypoplasia subgroups based on... Abstract

Cited 23 times since 2014 (2.1 per year) source: EuropePMC

International journal of cardiology, Volume 176, Issue 3, 17 3 2014, Pages 776-781 Increased carotid intima-media thickness predicts cardiovascular events in aortic coarctation. Luijendijk P, Lu H, Heynneman FB, Huijgen R, de Groot EE, Vriend JW, Vliegen HW, Groenink M, Bouma BJ, Mulder BJ

Background: Adult post-coarctectomy patients (CoA) demonstrate increased cardiovascular morbidity and mortality. The carotid intima-media thickness (CIMT), a marker for atherosclerosis, is increased in CoA. The aim was to evaluate the predictive value of CIMT for cardiovascular events. Methods and results: Consecutive CoA patients were prospectively studied during 10.1±0.7 years follow-up. At baseline and follow-up echocardiography, MRI imaging and CIMT imaging were performed, while cardiovascul... Abstract

Cited 4 times since 2014 (0.4 per year) source: Scopus

The international journal of cardiovascular imaging, Volume 31, Issue 1, 17 3 2014, Pages 37-43 Pericardial effusion following transcatheter aortic valve implantation: echocardiography and multi-detector row computed tomography evaluation. Katsanos S, van Rosendael P, Kamperidis V, van der Kley F, Regeer M, Al-Amri I, Karalis I, Palmen M, de Weger A, Marsan NA, Bax JJ, Delgado V

Although pericardial effusion (PE) early after transcatheter aortic valve implantation (TAVI) has been reported in few registries, late PE at follow-up remains unexplored. Particularly, after transapical TAVI, diagnosis of PE with transthoracic echocardiography (TTE) may be challenging. The present evaluation assessed the incidence of PE early after TAVI and at 1 month follow-up using TTE and multi-detector computed tomography (MDCT). The agreement between TTE and MDCT to diagnose the presence a... Abstract

Cited 38 times since 2014 (3.4 per year) source: EuropePMC

Journal of cellular and molecular medicine, Volume 18, Issue 10, 15 3 2014, Pages 2020-2030 Complement factor C5a induces atherosclerotic plaque disruptions. Wezel A, de Vries MR, Lagraauw HM, Foks AC, Kuiper J, Quax PH, Bot I

Complement factor C5a and its receptor C5aR are expressed in vulnerable atherosclerotic plaques; however, a causal relation between C5a and plaque rupture has not been established yet. Accelerated atherosclerosis was induced by placing vein grafts in male apoE(-/-) mice. After 24 days, when advanced plaques had developed, C5a or PBS was applied locally at the lesion site in a pluronic gel. Three days later mice were killed to examine the acute effect of C5a on late stage atherosclerosis. A signi... Abstract

Cited 146 times since 2014 (13 per year) source: EuropePMC

Circulation, Volume 130, Issue 15, 14 2 2014, Pages 1225-1235 Integrating genetic, transcriptional, and functional analyses to identify 5 novel genes for atrial fibrillation. Sinner MF, Tucker NR, Lunetta KL, Ozaki K, Smith JG, Trompet S, Bis JC, Lin H, Chung MK, Nielsen JB, Lubitz SA, Krijthe BP, Magnani JW, Ye J, Gollob MH, Tsunoda T, Müller-Nurasyid M, Lichtner P, Peters A, Dolmatova E, Kubo M, Smith JD, Psaty BM, Smith NL, Jukema JW, Chasman DI, Albert CM, Ebana Y, Furukawa T, Macfarlane PW, Harris TB, Darbar D, Dörr M, Holst AG, Svendsen JH, Hofman A, Uitterlinden AG, Gudnason V, Isobe M, Malik R, Dichgans M, Rosand J, Van Wagoner DR, METASTROKE Consortium, AFGen Consortium, Benjamin EJ, Milan DJ, Melander O, Heckbert SR, Ford I, Liu Y, Barnard J, Olesen MS, Stricker BH, Tanaka T, Kääb S, Ellinor PT

Background: Atrial fibrillation (AF) affects >30 million individuals worldwide and is associated with an increased risk of stroke, heart failure, and death. AF is highly heritable, yet the genetic basis for the arrhythmia remains incompletely understood. Methods and results: To identify new AF-related genes, we used a multifaceted approach, combining large-scale genotyping in 2 ethnically distinct populations, cis-eQTL (expression quantitative trait loci) mapping, and functional validation. F... Abstract

Cited 8 times since 2014 (0.7 per year) source: EuropePMC

PloS one, Volume 9, Issue 8, 14 2 2014, Pages e105019 Increased platelet reactivity is associated with circulating platelet-monocyte complexes and macrophages in human atherosclerotic plaques. Rutten B, Tersteeg C, Vrijenhoek JE, van Holten TC, Elsenberg EH, Mak-Nienhuis EM, de Borst GJ, Jukema JW, Pijls NH, Waltenberger J, van Zonneveld AJ, Moll FL, McClellan E, Stubbs A, Pasterkamp G, Hoefer I, de Groot PG, Roest M

Objective: Platelet reactivity, platelet binding to monocytes and monocyte infiltration play a detrimental role in atherosclerotic plaque progression. We investigated whether platelet reactivity was associated with levels of circulating platelet-monocyte complexes (PMCs) and macrophages in human atherosclerotic carotid plaques. Methods: Platelet reactivity was determined by measuring platelet P-selectin expression after platelet stimulation with increasing concentrations of adenosine diphosphate... Abstract

Cited 14 times since 2014 (1.3 per year) source: EuropePMC

European journal of psychotraumatology, Volume 5, 14 2 2014 Do soldiers seek more mental health care after deployment? Analysis of mental health consultations in the Netherlands Armed Forces following deployment to Afghanistan. Taal EL, Vermetten E, van Schaik DA, Leenstra T

Background: Military deployment to combat zones puts military personnel to a number of physical and mental challenges that may adversely affect mental health. Until now, few studies have been performed in Europe on mental health utilization after military deployment. Objective: We compared the incidence of mental health consultations with the Military Mental Health Service (MMHS) of military deployed to Afghanistan to that of non-deployed military personnel. Method: We assessed utilization of th... Abstract

Cited 25 times since 2014 (2.2 per year) source: EuropePMC

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, Volume 104, Issue 10, 13 2 2014, Pages 680-687 Monitoring of non-communicable diseases such as hypertension in South Africa: challenges for the post-2015 global development agenda. Day C, Groenewald P, Laubscher R, Chaudhry S, Van Schaik N, Bradshaw D

Background: Examining the non-communicable disease (NCD) profile for South Africa (SA) is crucial when developing health interventions that aim to reduce the burden of NCDs. Objective: To review NCD indicators in national data sources in order to describe the burden of NCDs in SA, using hypertension as an example. Methods: Age, gender, district of death and underlying cause of death data were obtained for 2008 and 2009 mortality unit records from Statistics SA and adjusted using STATA 11. Data f... Abstract

Cited 11 times since 2014 (1 per year) source: EuropePMC

PloS one, Volume 9, Issue 8, 12 2 2014, Pages e105052 Estimation of the use of antibiotics in the small ruminant industry in The Netherlands in 2011 and 2012. Santman-Berends I, Luttikholt S, Van den Brom R, Van Schaik G, Gonggrijp M, Hage H, Vellema P

The aim of this study was to estimate the quantity of antibiotics and classes of antibiotics used in the small ruminant industry in the Netherlands in 2011 and 2012. Twelve large veterinary practices, located throughout the Netherlands were selected for this study. All small ruminant farms associated with these practices that had complete records on the quantity of antibiotics prescribed were included. The veterinary practices provided data on all antibiotics prescribed, and the estimated animal... Abstract

Cited 1 times since 2014 (0.1 per year) source: EuropePMC

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, Volume 21, Issue 6, 12 2 2014, Pages 1072-1074 The potential role of gated myocardial perfusion SPECT imaging in patient selection for cardiac resynchronization therapy. Marsan NA, Bax JJ

Abstract

Cited 35 times since 2014 (3.1 per year) source: EuropePMC

Journal of surgical oncology, Volume 110, Issue 7, 11 2 2014, Pages 845-850 Optimization of sentinel lymph node mapping in bladder cancer using near-infrared fluorescence imaging. Schaafsma BE, Verbeek FP, Elzevier HW, Tummers QR, van der Vorst JR, Frangioni JV, van de Velde CJ, Pelger RC, Vahrmeijer AL

Background and objectives: Unlike other cancers, the Sentinel Lymph Node (SLN) procedure in bladder cancer requires special attention to the injection technique. The aim of this study was to assess feasibility and to optimize tracer injection technique for SLN mapping in bladder cancer patients using NIR fluorescence imaging. Methods: Twenty patients with invasive bladder cancer scheduled for radical cystectomy were prospectively enrolled. Indocyanine green (ICG) bound to human serum albumin (co... Abstract

Cited 16 times since 2014 (1.4 per year) source: EuropePMC

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, Volume 73, 10 2 2014, Pages 105-112 Evaluation of in vitro cytotoxicity and genotoxicity of copper-zinc alloy nanoparticles in human lung epithelial cells. Kumbıçak U, Cavaş T, Cinkılıç N, Kumbıçak Z, Vatan O, Yılmaz D

In the present study, in vitro cytotoxic and genotoxic effect of copper-zinc alloy nanoparticles (Cu-Zn ANPs) on human lung epithelial cells (BEAS-2B) were investigated. XTT test and clonogenic assay were used to determine cytotoxic effects. Cell death mode and intracellular reactive oxygen species formations were analyzed using M30, M65 and ROS Elisa assays. Genotoxic effects were evaluated using micronucleus, comet and γ-H2AX foci assays. Cu-Zn ANPs were characterized by transmission electron... Abstract

Cited 62 times since 2014 (5.5 per year) source: EuropePMC

International journal of cancer, Volume 136, Issue 6, 8 2 2014, Pages 1434-1444 Sorafenib synergizes with metformin in NSCLC through AMPK pathway activation. Groenendijk FH, Mellema WW, van der Burg E, Schut E, Hauptmann M, Horlings HM, Willems SM, van den Heuvel MM, Jonkers J, Smit EF, Bernards R

The multikinase inhibitor sorafenib is under clinical investigation for the treatment of many solid tumors, but in most cases, the molecular target responsible for the clinical effect is unknown. Furthermore, enhancing the effectiveness of sorafenib using combination strategies is a major clinical challenge. Here, we identify sorafenib as an activator of AMP-activated protein kinase (AMPK), in a manner that involves either upstream LKB1 or CAMKK2. We further show in a phase II clinical trial in... Abstract

Cited 266 times since 2014 (23.7 per year) source: EuropePMC

American heart journal, Volume 168, Issue 5, 7 1 2014, Pages 682-689 Effect of alirocumab, a monoclonal antibody to PCSK9, on long-term cardiovascular outcomes following acute coronary syndromes: rationale and design of the ODYSSEY outcomes trial. Schwartz GG, Bessac L, Berdan LG, Bhatt DL, Bittner V, Diaz R, Goodman SG, Hanotin C, Harrington RA, Jukema JW, Mahaffey KW, Moryusef A, Pordy R, Roe MT, Rorick T, Sasiela WJ, Shirodaria C, Szarek M, Tamby JF, Tricoci P, White H, Zeiher A, Steg PG

Background: Following acute coronary syndrome (ACS), the risk for future cardiovascular events is high and is related to levels of low-density lipoprotein cholesterol (LDL-C) even within the setting of intensive statin treatment. Proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates LDL receptor expression and circulating levels of LDL-C. Antibodies to PCSK9 can produce substantial and sustained reductions of LDL-C. The ODYSSEY Outcomes trial tests the hypothesis that treatment with al... Abstract

Cited 41 times since 2014 (3.7 per year) source: EuropePMC

Psychotherapy and psychosomatics, Volume 83, Issue 5, 6 1 2014, Pages 263-269 The effectiveness of the cognitive behavioral analysis system of psychotherapy for chronic depression: a randomized controlled trial. Wiersma JE, Van Schaik DJ, Hoogendorn AW, Dekker JJ, Van HL, Schoevers RA, Blom MB, Maas K, Smit JH, McCullough JP, Beekman AT, Van Oppen P

Background: It is widely agreed that chronic depression is difficult to treat, knowledge about optimal treatment approaches is emerging. Method: A multisite randomized controlled trial was conducted comparing the cognitive behavioral analysis system of psychotherapy (CBASP), a psychotherapy model developed specifically to treat chronic depression (n = 67) with care as usual (CAU; evidence-based treatments, n = 72) over a period of 52 weeks, with 23 sessions on average, in 3 outpatient clinics in... Abstract

Cited 2 times since 2014 (0.2 per year) source: EuropePMC

American journal of physical anthropology, Volume 155, Issue 3, 6 1 2014, Pages 430-435 Why do chimpanzee males attack the females of neighboring communities? Pradhan GR, Pandit SA, Van schaik CP

Our closest nonhuman primate relatives, chimpanzees, engage in potentially lethal between-group conflict; this collective aggressive behavior shows parallels with human warfare. In some communities, chimpanzee males also severely attack and even kill females of the neighboring groups. This is surprising given their system of resource defense polygyny, where males are expected to acquire potential mates. We develop a simple mathematical model based on reproductive skew among primate males to solv... Abstract

Cited 920 times since 2014 (82 per year) source: EuropePMC

Lancet (London, England), Volume 384, Issue 9959, 6 1 2014, Pages 2027-2035 Screening and prostate cancer mortality: results of the European Randomised Study of Screening for Prostate Cancer (ERSPC) at 13 years of follow-up. Schröder FH, Hugosson J, Roobol MJ, Tammela TL, Zappa M, Nelen V, Kwiatkowski M, Lujan M, Määttänen L, Lilja H, Denis LJ, Recker F, Paez A, Bangma CH, Carlsson S, Puliti D, Villers A, Rebillard X, Hakama M, Stenman UH, Kujala P, Taari K, Aus G, Huber A, van der Kwast TH, van Schaik RH, de Koning HJ, Moss SM, Auvinen A, ERSPC Investigators

Background: The European Randomised study of Screening for Prostate Cancer (ERSPC) has shown significant reductions in prostate cancer mortality after 9 years and 11 years of follow-up, but screening is controversial because of adverse events such as overdiagnosis. We provide updated results of mortality from prostate cancer with follow-up to 2010, with analyses truncated at 9, 11, and 13 years. Methods: ERSPC is a multicentre, randomised trial with a predefined centralised database, analysis pl... Abstract