6173 results
Cited 20 times since 2002 (0.9 per year)
source: EuropePMC
Atherosclerosis,
Volume 162, Issue 1, 1 1 2002, Pages 103-110
VLDL receptor deficiency enhances intimal thickening after vascular injury but does not affect atherosclerotic lesion area.
Tacken PJ, Delsing DJ, Gijbels MJ, Quax PH, Havekes LM, Hofker MH, van Dijk KW
The very low density lipoprotein receptor (VLDLR) has been shown to modulate cell migration and foam cell formation in vitro. This suggests a role for the VLDLR in vascular pathology associated with intimal thickening and atherogenesis. In the present paper both intimal thickening and atherosclerosis were studied using VLDLR knockout and transgenic mouse models. The role of the VLDLR in intimal thickening was established in an in vivo model for vascular injury. A non-restrictive cuff was placed...
Abstract
Cited 22 times since 2002 (1 per year)
source: EuropePMC
Circulation research,
Volume 90, Issue 10, 1 1 2002, Pages 1128-1134
Adenoviral activin a expression prevents intimal hyperplasia in human and murine blood vessels by maintaining the contractile smooth muscle cell phenotype.
Engelse MA, Lardenoye JH, Neele JM, Grimbergen JM, De Vries MR, Lamfers ML, Pannekoek H, Quax PH, De Vries CJ
Activin A alters the characteristics of human arterial smooth muscle cells (SMCs) toward a contractile, quiescent phenotype. We hypothesize that activin A may prevent SMC-rich neointimal hyperplasia. Here, we study the effect of adenovirus-mediated expression of activin A on neointima formation in vitro and in vivo. Human saphenous vein organ cultures, in which a neointima is formed spontaneously, were infected either with activin A- or lacZ-adenovirus. Activin A-overexpression reduces neointima...
Abstract
Cited 15 times since 2002 (0.7 per year)
source: EuropePMC
European journal of nuclear medicine and molecular imaging,
Volume 29, Issue 6, 10 2 2002, Pages 721-727
Accuracy of PET in predicting functional recovery after revascularisation in patients with chronic ischaemic dysfunction: head-to-head comparison between blood flow, glucose utilisation and water-perfusable tissue fraction.
Bax JJ, Fath-Ordoubadi F, Boersma E, Wijns W, Camici PG
Accurate prediction of improvement in left ventricular ejection fraction (LVEF) after revascularisation is critical in the therapeutic decision-making process in patients with chronic ischaemic dysfunction. Positron emission tomography (PET) allows non-invasive evaluation of myocardial blood flow (MBF), metabolic rate of glucose (MRG, absolute and relative) and the water-perfusable tissue fraction (PTF). Each of these indices has been proposed for the prediction of functional recovery. Their rel...
Abstract
Cited 26 times since 2002 (1.1 per year)
source: EuropePMC
The American journal of cardiology,
Volume 89, Issue 8, 1 1 2002, Pages 964-968
Prediction of mortality in heart transplant recipients by stress technetium-99m tetrofosmin myocardial perfusion imaging.
Elhendy A, van Domburg RT, Vantrimpont P, Poldermans D, Bax JJ, van Gelder T, Baan CC, Schinkel A, Roelandt JR, Balk AH
Cardiac allograft vasculopathy is a major cause of mortality in heart transplant recipients. The aim of this study was to assess the prognostic value of stress myocardial perfusion imaging in heart transplant recipients. We studied 166 patients (age 54 +/- 10 years, 140 men) by symptom-limited bicycle exercise or dobutamine (up to 40 microg/kg/min) stress myocardial perfusion imaging 7.4 +/- 2.5 years after heart transplantation. An intravenous dose of 370 MBq of technetium-99m tetrofosmin was i...
Abstract
Cited 12 times since 2002 (0.5 per year)
source: EuropePMC
The Journal of thoracic and cardiovascular surgery,
Volume 123, Issue 4, 1 1 2002, Pages 826-828
Carotid artery patch plasty as a last resort repair for long-segment congenital tracheal stenosis.
Dodge-Khatami A, Nijdam NC, Broekhuis E, Von Rosenstiel IA, Dahlem PG, Hazekamp MG
Abstract
Cited 100 times since 2002 (4.3 per year)
source: EuropePMC
Heart (British Cardiac Society),
Volume 87, Issue 4, 1 1 2002, Pages 356-362
Health related quality of life and health status in adult survivors with previously operated complex congenital heart disease.
Kamphuis M, Ottenkamp J, Vliegen HW, Vogels T, Zwinderman KH, Kamphuis RP, Verloove-Vanhorick SP
Objective: To examine the impact of previously operated complex congenital heart disease on health related quality of life and subjective health status and to determine the relation between these parameters and physical status. Design: Cross sectional; information on medical follow up was sought retrospectively. Setting: Patients were randomly selected from the archives of the paediatric cardiology department, Leiden University Medical Centre, Leiden, The Netherlands, and approached irrespective...
Abstract
Cited 74 times since 2002 (3.2 per year)
source: EuropePMC
Radiology,
Volume 223, Issue 1, 1 1 2002, Pages 204-211
Exercise MR imaging in the assessment of pulmonary regurgitation and biventricular function in patients after tetralogy of fallot repair.
Roest AA, Helbing WA, Kunz P, van den Aardweg JG, Lamb HJ, Vliegen HW, van der Wall EE, de Roos A
Purpose: To assess the responses of pulmonary regurgitation (PR) and biventricular function to submaximal exercise by using a magnetic resonance (MR) imaging exercise protocol with young adult patients who underwent tetralogy of Fallot repair at a young age. Materials and methods: Fifteen patients with corrected tetralogy of Fallot (mean age, 17.5 years +/- 2.5 [SD]) underwent MR imaging at rest and during exercise for the evaluation of PR and biventricular function. Results were compared with f...
Abstract
Cited 71 times since 2002 (3.1 per year)
source: EuropePMC
American journal of physiology. Heart and circulatory physiology,
Volume 282, Issue 4, 1 1 2002, Pages H1350-8
Indexes of diastolic RV function: load dependence and changes after chronic RV pressure overload in lambs.
Leeuwenburgh BP, Steendijk P, Helbing WA, Baan J
Diastolic function is a major determinant of ventricular performance, especially when loading conditions are altered. We evaluated biventricular diastolic function in lambs and studied possible load dependence of diastolic parameters [minimum first derivative of pressure vs. time (dP/dt(min)) and time constant of isovolumic relaxation (tau)] in normal (n = 5) and chronic right ventricular (RV) pressure-overloaded (n = 5) hearts by using an adjustable band on the pulmonary artery (PAB). Pressure-...
Abstract
Cited 2 times since 2002 (0.1 per year)
source: EuropePMC
Nederlands tijdschrift voor geneeskunde,
Volume 146, Issue 10, 1 1 2002, Pages 473-477
[Surgery and referral for subsequent 131I therapy for patients with differentiated thyroid carcinoma in the south-east of the Netherlands, 1983-1996, compared to the consensus guidelines from 1987].
Kuijpens JL, Hoekstra OS, Hamming JF, Haak HR, Ribot JG, Coebergh JW
Objective: To evaluate the treatment of patients with differentiated (papillary or follicular) thyroid cancer in general hospitals in the south-east of the Netherlands during the period 1983-1996, in relation to the 1987 national consensus recommendations. Design: Population-based, retrospective, descriptive. Method: For the period 1 January 1983-31 December 1996, data on the histology, TNM-stage and treatment (hospital, specialist, type of operation, referral for 131I therapy) of all 236 patien...
Abstract
Cited 23 times since 2002 (1 per year)
source: EuropePMC
British journal of cancer,
Volume 86, Issue 5, 1 1 2002, Pages 811-818
A fully human anti-Ep-CAM scFv-beta-glucuronidase fusion protein for selective chemotherapy with a glucuronide prodrug.
de Graaf M, Boven E, Oosterhoff D, van der Meulen-Muileman IH, Huls GA, Gerritsen WR, Haisma HJ, Pinedo HM
Monoclonal antibodies against tumour-associated antigens could be useful to deliver enzymes selectively to the site of a tumour for activation of a non-toxic prodrug. A completely human fusion protein may be advantageous for repeated administration, as host immune responses may be avoided. We have constructed a fusion protein consisting of a human single chain Fv antibody, C28, against the epithelial cell adhesion molecule and the human enzyme beta-glucuronidase. The sequences encoding C28 and h...
Abstract
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 10, Issue 3, 1 1 2002, Pages 109-110
Vitamins C. E and β-carotene fired and statins for president?
Jukema JW, Liem AH
Abstract
Cited 6 times since 2002 (0.3 per year)
source: EuropePMC
European journal of nuclear medicine and molecular imaging,
Volume 29, Issue 4, 19 3 2002, Pages 452-457
Feasibility, safety and image quality of cardiac FDG studies during hyperinsulinaemic-euglycaemic clamping.
Bax JJ, Visser FC, Poldermans D, van Lingen A, Elhendy A, Boersma E, Visser CA
Fluorine-18 fluorodeoxyglucose (FDG) imaging for the assessment of myocardial viability has become an integral part of the diagnostic and prognostic work-up of patients with ischaemic cardiomyopathy. To ensure good image quality, in particular in patients with diabetes mellitus, hyperinsulinaemic-euglycaemic clamping has been proposed. In this study we evaluated the safety and the image quality of cardiac FDG imaging during clamping in a large group of patients, including a subgroup with diabete...
Abstract
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 10, Issue 2, 1 1 2002, Pages 101-103
Einthoven meeting 2002: 9-11 June, Leiden.
Schalij MJ, Van der Wall EE
Abstract
Cited 1 times since 2002 (0 per year)
source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 10, Issue 2, 1 1 2002, Pages 43-47
Rhythmic sensory stimulation improves fitness by conditioning the autonomic nervous system.
Frederiks J, Swenne CA, Ghafoerkhan A, Lalmahomed H, Maan AC, Schalij MJ, Bruschke AV, van der Wall EE
Background: Endurance training is known to alter the functioning of the autonomic nervous system, a major goal when pursuing fitness. Here, we test the hypothesis that the training-associated rhythmic sensations alone, hence without the usual accompanying physical exercise, accomplish this effect. Method: We studied sixteen resting healthy male volunteers, age (mean±SD) 25.9±3.7 years. During one hour we applied, at marching pace (2 bursts per second), bipolar transcutaneous electrical sensory n...
Abstract
Cited 16 times since 2002 (0.7 per year)
source: EuropePMC
British journal of cancer,
Volume 86, Issue 3, 1 1 2002, Pages 436-442
Prerequisites for effective adenovirus mediated gene therapy of colorectal liver metastases in the rat using an intracellular neutralizing antibody fragment to p21-Ras.
van Etten B, ten Hagen TL, de Vries MR, Ambagtsheer G, Huet T, Eggermont AM
Ras mutations are present in 40-50% of colorectal cancers. Inactivating this oncogene may therefore reduce proliferation capacity. In order to target ras we studied the transduction efficacy and anti tumour activity of an adenoviral vector expressing an intracellular, neutralizing single chain antibody to p21-ras (Y28). In in vitro studies transfection levels of the K-ras mutated rat colon carcinoma cell line CC531 were studied using the LacZ marker gene. In our in vivo liver metastases model di...
Abstract
Cited 12 times since 2002 (0.5 per year)
source: EuropePMC
Cardiovascular surgery (London, England),
Volume 10, Issue 1, 1 1 2002, Pages 62-64
Organized thrombus in the ascending aorta originating from the ostium of the right coronary artery.
Shahin GM, Bosker HA, Knaepen PJ, Morshuis WJ, Lindeboom JE
This case report describes the rare finding of a pedunculate thrombus in the ascending aorta originating from the ostium of the right coronary artery (RCA) detected after an inferior wall myocardial infarction in a young female. The thrombus was removed surgically during an emergency cardiopulmonary bypass procedure
Abstract
The Annals of thoracic surgery,
Volume 73, Issue 2, 1 1 2002, Pages 699
Double-inlet left ventricle: successfully staged ventricular septation with 12.5 years follow-up.
Ottenkamp J, Hazekamp MG
Abstract
Cited 4 times since 2002 (0.2 per year)
source: EuropePMC
The Journal of thoracic and cardiovascular surgery,
Volume 123, Issue 2, 1 1 2002, Pages 348-349
Quadricuspid aortic valve in transposition of the great arteries.
Portela FA, Hazekamp MG, Bartelings MM, Gittenberger-De Groot AC
Abstract
Cited 89 times since 2002 (3.8 per year)
source: EuropePMC
Circulation,
Volume 105, Issue 6, 1 1 2002, Pages 702-706
Cardiac autonomic dysfunction in Brugada syndrome.
Wichter T, Matheja P, Eckardt L, Kies P, Schäfers K, Schulze-Bahr E, Haverkamp W, Borggrefe M, Schober O, Breithardt G, Schäfers M
Background: Patients with Brugada syndrome present with characteristic ECG abnormalities (atypical right bundle-branch block and ST-segment elevation) and life-threatening ventricular tachyarrhythmias despite structurally normal hearts. Involvement of the autonomic nervous system is suggested by the occurrence of ventricular tachyarrhythmias and sudden death at rest or during sleep and by changes of typical ECG signs under pharmacological modulation of the myocardial autonomic tone. Methods and...
Abstract
Cited 71 times since 2002 (3.1 per year)
source: EuropePMC
Clinical genetics,
Volume 61, Issue 2, 1 1 2002, Pages 115-125
ABCA1 regulatory variants influence coronary artery disease independent of effects on plasma lipid levels.
Zwarts KY, Clee SM, Zwinderman AH, Engert JC, Singaraja R, Loubser O, James E, Roomp K, Hudson TJ, Jukema JW, Kastelein JJ, Hayden MR
The authors have previously shown that individuals heterozygous for ABCA1 mutations have decreased high density lipoprotein cholesterol, increased triglycerides and an increased frequency of coronary artery disease (CAD), and that single nucleotide polymorphisms (SNPs) in the coding region of the ABCA1 gene significantly impact plasma lipid levels and the severity of CAD in the general population. They have now identified several SNPs in non-coding regions of ABCA1 which may be important for the...
Abstract
