Research

Publications

Below you can find a list of our published research.

9618 results

Science advances, Volume 11, Issue 26, 25 4 2025, Pages eadt7718 The evolution of infant-directed communication: Comparing vocal input across all great apes. Wegdell F, Fryns C, Schick J, Nellissen L, Laporte M, Surbeck M, van Noordwijk MA, Masi S, Hellwig B, Willems EP, Zuberbühler K, van Schaik CP, Stoll S, Townsend SW

Human language is unique among communication systems since many elements are learned and transmitted across generations. Previous research suggests that this process is best predicted by infant-directed communication, i.e., a mode of communication directed by caregivers to children. Despite its importance for language, whether infant-directed communication is unique to humans or rooted more deeply in the primate lineage remains unclear. To assess this, we investigated directed and surrounding vo... Abstract

Journal of cardiothoracic and vascular anesthesia, 23 4 2025, Pages S1053-0770(25)00499-9 Toward a Consensus for the Definition of Vasoplegia in Cardiac Surgery. Papazisi O, Palmen M, Rao V, Billia F, de Waal EEC

Abstract

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 23 4 2025 Intravascular Lithotripsy for Calcific Coronary Bifurcations: Procedural Success and 1-Year Clinical Outcomes. Oliveri F, D'Acunto G, Oort MJHV, Phagu A, Amri IA, Bingen BO, Paradies V, Mincione G, Claessen BE, Dimitriu-Leen AC, Kefer J, Girgis H, Vossenberg T, Van der Kley F, Jukema JW, Montero-Cabezas JM

Background: Intravascular lithotripsy (IVL) has emerged as a promising treatment for heavily calcified coronary lesions. However, evidence regarding its effectiveness in calcific bifurcation lesions remains limited. Objective: We aimed to evaluate the technical success and 1-year clinical outcomes of IVL in calcified coronary bifurcation lesions. Methods: Patients undergoing PCI with the use of IVL from the ongoing prospective BENELUX-IVL registry were included. Participants were stratified into... Abstract

Gut microbes, Volume 17, Issue 1, 22 4 2025, Pages 2519700 <i>Staphylococcus haemolyticus</i> is a reservoir of antibiotic resistance genes in the preterm infant gut. Lamberte LE, Darby EM, Kiu R, Moran RA, Acuna-Gonzalez A, Sim K, Shaw AG, Kroll JS, Belteki G, Clarke P, Felgate H, Webber MA, Rowe W, Hall LJ, Van Schaik W

Staphylococcus haemolyticus is an important cause of sepsis in preterm infants, with gut colonization being recognized as a risk factor for infection. To better understand the diversity of S. haemolyticus among preterm infants, we generated genome sequences of S. haemolyticus strains (n = 140) from 44 stool samples of 22 preterm infants from four hospitals in England. Core genome phylogenetic analyses, incorporating 126 publicly available S. haemolyticus genome sequences, showed that 85/140 (60.... Abstract

Acta biomaterialia, Volume 202, 21 3 2025, Pages 262-275 Multilayered trabecular meshwork for dynamic in vitro studies in glaucoma research. Gładysz MZ, Fernandes M, Li X, Koch M, Marchena F, Hofman A, de Graaf M, Wolters JC, Kamperman M, Nagelkerke A, Włodarczyk-Biegun MK

Glaucoma, an eye disease causing incremental vision loss, currently has no cure. Its primary cause is the malfunction of the trabecular meshwork (TM), a multilayered tissue in the eye responsible for draining aqueous humor (AH) from the anterior chamber. TM clogging increases outflow resistance, elevates intraocular pressure (IOP), and damages optic nerves, leading to irreversible blindness. Existing in vitro TM models are suboptimal, as they lack the hierarchical structure of the TM. This artic... Abstract

International journal of cardiology. Congenital heart disease, Volume 21, 21 3 2025, Pages 100603 Echocardiographic effects of sodium-glucose cotransporter 2 inhibitors in single ventricle circulatory failure. Neijenhuis RML, Regeer MV, Walker NL, Hunter A, Kiès P, Holman ER, Jukema JW, Jongbloed MRM, Veldtman GR, Egorova AD

Background: Single ventricle patients are at high risk of developing circulatory failure. There is limited evidence for pharmacological treatment. This study assessed the echocardiographic changes in ventricular function during sodium-glucose cotransporter 2 inhibitor (SGLT2i) therapy in patients with single ventricle failure (SVF). Methods: SVF patients with a baseline transthoracic echocardiogram within six months before starting SGLT2i and at least one echocardiographic examination within twe... Abstract

Critical reviews in oncology/hematology, Volume 214, 20 3 2025, Pages 104815 Trimodal treatment vs radical cystectomy for muscle-invasive bladder cancer: The neglected impact of informative censoring. A systematic review and meta-analysis. Robesti D, Micheli F, Rai SN, Fallara G, Gallina A, Montorsi F, Briganti A, Fossati N, van der Heijden AG, Ploussard G, Malavaud B, Martini A

Introduction: Informative censoring (IC) is a statistical bias that occurs when there is an imbalance in the dropout rate among study arms and this imbalance is not random, but can be ascribed to information that is not accounted for. Studies on trimodal therapy (TMT) versus radical cystectomy (RC) yielded conflicting results. We conducted a meta-analysis to assess the potential impact of informative censoring in influencing study outcomes. Materials and methods: A systematic literature search i... Abstract

International journal of cardiology, Volume 438, 19 3 2025, Pages 133526 Sex-specific response to cardiac resynchronization therapy: the BIO|WOMEN trial. Zamorano JL, Vörös G, Calvi V, Osca J, Quesada A, Vernooy K, Martinez JG, Maass AH, Nof E, Tolosana JM, Pardo M, Barr C, Fernández I, Merino JL, Ellery S, Ricoy-Martínez E, Belotti G, Seidlmayer L, Garcia S, Tönnis T, Campbell NG, Foley P, Brockmeier J, Nürnberg M, Ruiz-Granell R, Prinzen FW, Lorente-Ros Á, Moreno A, Pinart M, Ver Heyen M, Van Erven L

Background: Variable evidence exists about the efficacy of Cardiac resynchronization therapy (CRT) in women vs. men with reduced left ventricular ejection fraction (LVEF) and wide QRS complex. Current guidelines, hindered by underrepresentation of women in clinical trials, lack definitive recommendations. The present study was designed to achieve an equal distribution of women and men to prospectively evaluate sex-specific response to CRT. Methods: The primary endpoint was the absolute increase... Abstract

Frontiers in big data, Volume 8, 19 3 2025, Pages 1596615 Conceptualization and scale development for big data-based learning organization capability. Alkan N, Yilmaz DE, Alkan BB

Introduction: In today's competitive business landscape, organizations must enhance learning and adaptability to gain a strategic edge. While big data significantly influences organizational learning, a comprehensive tool to measure this capability has been lacking in the literature. This study aims to develop a valid and reliable scale to assess big data-based learning organization capability. Methods: A two-phase research design was employed. In the first phase, Exploratory Factor Analysi... Abstract

Inflammatory bowel diseases, 16 3 2025, Pages izaf126 Food Compounds Associated With Disease Activity in Inflammatory Bowel Disease. Meima M, Westerhout J, Meijerink M, Bijlsma S, van Schaik F, Oldenburg B, Houben G

Background: Diet plays a modulatory role in inflammatory bowel disease (IBD), but specific relevant dietary factors have yet to be identified. To advance our understanding, we performed multivariate analyses of food compound intakes using dietary data from an IBD cohort. Methods: We used dietary and disease status data from IBD patients at the University Medical Center Utrecht, The Netherlands. Intake levels for 768 compounds from 135 patients were calculated. Using random forest analyses, we ex... Abstract

Archives of microbiology, Volume 207, Issue 8, 13 2 2025, Pages 174 Biochemical characterization of lipase from Cryptococcus albidus (D24) and its application in sugar fatty acid ester synthesis. Yilmaz DE, Kula C, Demirci H

Microbial lipases are widely used in industrial applications. The lipase enzyme from Cryptococcus albidus (D24) strain was biochemically characterized and evaluated for its potential in catalyzing esterification reactions, particularly in the synthesis of sugar fatty acid esters. The enzyme demonstrated enhanced activity in solvents like acetone, isopropanol, and dimethylformamide. The effects of different metal ions on the stability of the enzyme were also evaluated, and the results revealed an... Abstract

Open medicine (Warsaw, Poland), Volume 20, Issue 1, 12 2 2025, Pages 20251219 Factors affecting the measurements of peripheral oxygen saturation values in healthy young adults. Uysal O, Yılmaz D

Objectives: The aim of the study was to examine peripheral oxygen saturation values in the index and middle fingers of the dominant hand in healthy young adults measured while lying in a supine position or sitting straight up. Methods: This study was a non-randomized and non-controlled, quasi-experimental repeated measures study. It was conducted with 200 healthy young adults in Turkey. A pulse oximeter was located at the same time on the index and middle fingers of the active hand of each parti... Abstract

Therapeutic advances in chronic disease, Volume 16, 12 2 2025, Pages 20406223251333570 Systematic review: the use of tacrolimus in steroid-refractory ulcerative colitis. Jangra V, Yilmaz D, Soares D, Taylor F, Andreani S, Hotouras A

Background: Steroid-refractory ulcerative colitis (SR-UC) is a severe form of ulcerative colitis (UC) that persists despite high-dose corticosteroid therapy. Management is challenging and often requires biologics, immunosuppressants or colectomy. Tacrolimus, a calcineurin inhibitor with immunomodulatory effects, has emerged as a potential alternative, though its efficacy, safety and long-term outcomes remain uncertain. Objectives: This systematic review evaluates the efficacy and safety of tacro... Abstract

Microbiology spectrum, Volume 13, Issue 7, 10 2 2025, Pages e0062825 Transposon-directed insertion-site sequencing (TraDIS) analysis of <i>Enterococcus faecium</i> using nanopore sequencing and a WebAssembly analysis platform. Krause AL, Wirth W, Turner AM, Judd L, Li L, van Schaik W, Howden BP, Carter GP, Seemann T, Wick R, Stinear TP, Buultjens AH, Monk IR

Vancomycin-resistant Enterococcus faecium (VREfm) are healthcare-associated opportunistic pathogens of global significance. Genetic tools are needed to understand the molecular basis for VREfm clinically relevant phenotypes, such as persistence within the human gut or antimicrobial resistance. Here, we present a transposon-directed insertion-site sequencing (TraDIS) platform optimized for E. faecium. We engineered a transposon delivery plasmid, pIMTA(tetM), that can generate high-density transpo... Abstract

Human vaccines & immunotherapeutics, Volume 21, Issue 1, 10 2 2025, Pages 2516949 A new quadrivalent meningococcal tetanus toxoid conjugate vaccine: Menquadfi® (MENACWY-TT). Dinleyici EC, Ciftci E, Somer A, Yilmaz D, Tezer H

Neisseria meningitidis (Nm) remains a major global health concern, causing invasive meningococcal disease (IMD) with significant morbidity and mortality. Despite vaccination efforts, Nm serogroup prevalence and antibiotic resistance continue to evolve, necessitating ongoing surveillance and novel immunization strategies. This review aims to assess the role of MenACWY-TT, a quadrivalent meningococcal conjugate vaccine, in IMD prevention by evaluating its immunogenicity, safety, and real-world eff... Abstract

Cited 1 times since 2025 (5.2 per year) source: EuropePMC

International journal of cardiology, Volume 437, 8 2 2025, Pages 133493 Prognostic utility of hybrid coronary computed tomography angiography and myocardial perfusion imaging in elderly patients with suspected coronary artery disease. Nammas W, Ajosenpää I, Maaniitty T, Stenström I, Bax JJ, Knuuti J, Saraste A

Background: The prognostic utility of sequential hybrid imaging strategy (coronary computed tomography angiography (CCTA) followed by positron emission tomography (PET) myocardial perfusion imaging in those with obstruction) in the elderly remains unclear. We explored the predictors of adverse outcome in patients ≥65, versus those Abstract

Cited 1 times since 2025 (5.1 per year) source: EuropePMC

Communications biology, Volume 8, Issue 1, 7 1 2025, Pages 890 Observational social learning of "know-how" and "know-what" in wild orangutans: evidence from nest-building skill acquisition. Permana AL, Permana JJ, Nellissen L, Prayogi ES, Prasetyo D, Wich SA, van Schaik CP, Schuppli C

Immature great apes learn how to build their nests over multiple years, yet how they do so has remained largely unclear. We investigated the detailed role of social learning in the acquisition of nest-building skills in wild Sumatran orangutans (Pongo abelii) using data on nest-building, nest practice, and nest peering behaviour from 44 individuals, collected over 17 years. We found that nest peering (but not being close to a nesting individual without peering) is associated with a significant i... Abstract

Clinical cancer research : an official journal of the American Association for Cancer Research, 6 1 2025 Biomarker analysis and treatment dynamics following preoperative ipilimumab plus nivolumab in locally advanced urothelial cancer from the phase 1B NABUCCO study. Stockem CF, Gil-Jimenez A, Ali H, van Dorp J, van Dijk N, van Montfoort ML, Alkemade M, Broeks A, Seignette IM, Hooijberg E, Brugman W, Voogd R, van Rhijn BWG, Mertens LS, Feijter JM, Mehra N, van der Heijden AG, Meijer RP, Suelmann BBM, Scheper W, Wessels LFA, Vis DJ, van der Heijden MS

Purpose: In NABUCCO, safety and efficacy of preoperative ipilimumab plus nivolumab were assessed in stage III urothelial cancer. Encouraging responses were achieved and ipilimumab 3 mg/kg (ipilimumab-high) appeared more effective than ipilimumab 1 mg/kg (ipilimumab-low). We explored ipilimumab plus nivolumab response biomarkers and tumor micro environment (TME) treatment dynamics. Experimental design: Baseline FFPE tumor tissue was analyzed using PD-L1 immunohistochemistry (n=51), whole-exome an... Abstract

Cited 1 times since 2025 (5 per year) source: EuropePMC

JCI insight, Volume 10, Issue 13, 5 1 2025, Pages e190992 Distinct cell types along thick ascending limb express pathways for monovalent and divalent cation transport. Demirci H, Bahena-Lopez JP, Smorodchenko A, Su XT, Nelson JW, Yang CL, Curry JN, Duan XP, Wang WH, Sharkovska Y, Liu R, Yilmaz DE, Quintanova C, Emberley K, Emery B, Himmerkus N, Bleich M, Ellison DH, Bachmann S

Kidney thick ascending limb (TAL) cells reabsorb sodium, potassium, calcium, and magnesium and contribute to urinary concentration. These cells are typically viewed as a single type that recycles potassium across the apical membrane and generates a lumen-positive transepithelial voltage driving calcium and magnesium reabsorption, though variability in potassium channel expression has been reported. Additionally, recent transcriptomic analyses suggest that different cell types exist along this se... Abstract

Expert review of respiratory medicine, Volume 19, Issue 8, 4 1 2025, Pages 887-897 The relation between visceral fat and lung function in the general population is in part mediated by CRP and leptin. Oosterom-Eijmael MJP, le Cessie S, Slats AM, Hiemstra PS, Thijs W, Lamb HJ, Willems van Dijk K, Rosendaal FR, de Mutsert R

Background: Abdominal obesity is associated with reduced lung function. It remains unclear whether this results from mechanical pressure or whether visceral fat also plays a role via inflammation. Our aim was to examine the association between visceral fat and lung function, and the role of inflammation. Methods: In this cross-sectional analysis, visceral fat was measured by magnetic resonance imaging and lung function by spirometry. We examined the association between visceral fat and lung func... Abstract