8892 results
FEMS microbes,
Volume 5, 20 3 2024, Pages xtae017
YajC, a predicted membrane protein, promotes <i>Enterococcus faecium</i> biofilm formation <i>in vitro</i> and in a rat endocarditis model.
Top J, Zhang X, Hendrickx APA, Boeren S, van Schaik W, Huebner J, Willems RJL, Leavis HL, Paganelli FL
Biofilm formation is a critical step in the pathogenesis of difficult-to-treat Gram-positive bacterial infections. We identified that YajC, a conserved membrane protein in bacteria, plays a role in biofilm formation of the clinically relevant Enterococcus faecium strain E1162. Deletion of yajC conferred significantly impaired biofilm formation in vitro and was attenuated in a rat endocarditis model. Mass spectrometry analysis of supernatants of washed ΔyajC cells revealed increased amounts in cy...
Abstract
Cited 5 times since 2024 (3.5 per year)
source: EuropePMC
Nature ecology & evolution,
Volume 8, Issue 6, 20 3 2024, Pages 1118-1128
Directed conservation of the world's reef sharks and rays.
Goetze JS, Heithaus MR, MacNeil MA, Harvey E, Simpfendorfer CA, Heupel MR, Meekan M, Wilson S, Bond ME, Speed CW, Currey-Randall LM, Fisher R, Sherman CS, Kiszka JJ, Rees MJ, Udyawer V, Flowers KI, Clementi GM, Asher J, Beaufort O, Bernard ATF, Berumen ML, Bierwagen SL, Boslogo T, Brooks EJ, Brown JJ, Buddo D, Cáceres C, Casareto S, Charloo V, Cinner JE, Clua EEG, Cochran JEM, Cook N, D'Alberto BM, de Graaf M, Dornhege-Lazaroff MC, Fanovich L, Farabaugh NF, Fernando D, Ferreira CEL, Fields CYA, Flam AL, Floros C, Fourqurean V, Barcia LG, Garla R, Gastrich K, George L, Graham R, Hagan V, Hardenstine RS, Heck SM, Heithaus P, Henderson AC, Hertler H, Hueter RE, Johnson M, Jupiter SD, Kaimuddin M, Kasana D, Kelley M, Kessel ST, Kiilu B, Kyne F, Langlois T, Lawe J, Lédée EJI, Lindfield S, Maggs JQ, Manjaji-Matsumoto BM, Marshall A, Matich P, McCombs E, McLean D, Meggs L, Moore S, Mukherji S, Murray R, Newman SJ, O'Shea OR, Osuka KE, Papastamatiou YP, Perera N, Peterson BJ, Pina-Amargós F, Ponzo A, Prasetyo A, Quam
Many shark populations are in decline around the world, with severe ecological and economic consequences. Fisheries management and marine protected areas (MPAs) have both been heralded as solutions. However, the effectiveness of MPAs alone is questionable, particularly for globally threatened sharks and rays ('elasmobranchs'), with little known about how fisheries management and MPAs interact to conserve these species. Here we use a dedicated global survey of coral reef elasmobranchs t...
Abstract
Cited 13 times since 2024 (9.2 per year)
source: EuropePMC
BMC cardiovascular disorders,
Volume 24, Issue 1, 18 3 2024, Pages 258
The role of hemoadsorption in cardiac surgery - a systematic review.
Matejic-Spasic M, Lindstedt S, Lebreton G, Dzemali O, Suwalski P, Folliguet T, Geidel S, Klautz RJM, Baufreton C, Livi U, Gunaydin S, Deliargyris EN, Wendt D, Thielmann M
Background: Extracorporeal blood purification has been widely used in intensive care medicine, nephrology, toxicology, and other fields. During the last decade, with the emergence of new adsorptive blood purification devices, hemoadsorption has been increasingly applied during CPB in cardiac surgery, for patients at different inflammatory risks, or for postoperative complications. Clinical evidence so far has not provided definite answers concerning this adjunctive treatment. The current systema...
Abstract
Cited 4 times since 2024 (2.8 per year)
source: EuropePMC
ESC heart failure,
Volume 11, Issue 5, 16 3 2024, Pages 2825-2834
Cardiac amyloidosis is not a single disease: a multiparametric comparison between the light chain and transthyretin forms.
Neculae G, Adam R, Jercan A, Bădeliță S, Tjahjadi C, Draghici M, Stan C, Bax JJ, Popescu BA, Marsan NA, Coriu D, Jurcuț R
Aims: Systemic amyloidosis represents a heterogeneous group of diseases resulting from amyloid fibre deposition. The purpose of this study is to establish a differential diagnosis algorithm targeted towards the two most frequent subtypes of CA. Methods and results: We prospectively included all consecutive patients with ATTR and AL evaluated between 2018 and 2022 in two centres in a score derivation cohort and a different validation sample. All patients had a complete clinical, biomarker, electr...
Abstract
Cited 31 times since 2024 (21.7 per year)
source: EuropePMC
JACC. Cardiovascular interventions,
Volume 17, Issue 12, 16 3 2024, Pages 1485-1495
Prognostic Implications of Residual Tricuspid Regurgitation Grading After Transcatheter Tricuspid Valve Repair.
Dreyfus J, Taramasso M, Kresoja KP, Omran H, Iliadis C, Russo G, Weber M, Nombela-Franco L, Estevez Loureiro R, Hausleiter J, Latib A, Stolz L, Praz F, Windecker S, Zamorano JL, von Bardeleben RS, Tang GHL, Hahn R, Lubos E, Webb J, Schofer J, Fam N, Lauten A, Pedrazzini G, Rodés-Cabau J, Nejjari M, Badano L, Alessandrini H, Himbert D, Sievert H, Piayda K, Donal E, Modine T, Nickenig G, Pfister R, Rudolph V, Bernick J, Wells GA, Bax J, Lurz P, Enriquez-Sarano M, Maisano F, Messika-Zeitoun D, TRIGISTRY Investigators
Background: The safety profile of transcatheter tricuspid valve (TTV) repair techniques is well established, but residual tricuspid regurgitation (TR) remains a concern. Objectives: The authors sought to assess the impact of residual TR severity post-TTV repair on survival. Methods: We evaluated the survival rate at 2 years of 613 patients with severe isolated functional TR who underwent TTV repair in TRIGISTRY according to the severity of residual TR at discharge using a 3-grade (mild, moderate...
Abstract
Cited 9 times since 2024 (6.3 per year)
source: EuropePMC
The Lancet. Neurology,
Volume 23, Issue 8, 16 3 2024, Pages 807-815
Safety and efficacy of active blood-pressure reduction to the recommended thresholds for intravenous thrombolysis in patients with acute ischaemic stroke in the Netherlands (TRUTH): a prospective, observational, cluster-based, parallel-group study.
Zonneveld TP, Vermeer SE, van Zwet EW, Groot AED, Algra A, Aerden LAM, Alblas KCL, de Beer F, Brouwers PJAM, de Gans K, van Gemert HMA, van Ginneken BCAM, Grooters GS, Halkes PHA, van der Heijden-Montfroy TAMHG, Jellema K, de Jong SW, Lövenich-Ciccarello H, van der Meulen WDM, Peters EW, van der Ree TC, Remmers MJM, Richard E, Rovers JMP, Saxena R, van Schaik SM, Schonewille WJ, Schreuder TAHCML, de Schryver ELLM, Schuiling WJ, Spaander FH, van Tuijl JH, Visser MC, Zinkstok SM, Zock E, Dippel DWJ, Kappelle LJ, van Oostenbrugge RJ, Roos YBWEM, Vermeij FH, Wermer MJH, van der Worp HB, Nederkoorn PJ, Kruyt ND
Background: Intravenous thrombolysis is contraindicated in patients with ischaemic stroke with blood pressure higher than 185/110 mm Hg. Prevailing guidelines recommend to actively lower blood pressure with intravenous antihypertensive agents to allow for thrombolysis; however, there is no robust evidence for this strategy. Because rapid declines in blood pressure can also adversely affect clinical outcomes, several Dutch stroke centres use a conservative strategy that does not involve the reduc...
Abstract
Clinics (Sao Paulo, Brazil),
Volume 79, 16 3 2024, Pages 100382
The decline in postural balance has a negative impact on the performance of functional tasks in individuals with Parkinson's Disease.
Luna NMS, Bobbio TG, de Graaf M, Greve JMD, Ernandes RC, Dias AS, Lino MHDS, Soares-Junior JM, Baracat EC, Mochizuki L, Brech GC, Alonso AC
Introduction: An accurate assessment of balance problems is critical for decreasing the risk of falling in patients with Parkinson's Disease (PD). Reliable diagnostic tools such as Computerized Dynamic Posturography (CDP) are not feasible for the clinical setting. Therefore, the present study's aim was to assess the correlation between the clinical Balance Evaluation Systems Test (BESTest) and CDP. Methods: 20 male older adults with Parkinson's Disease (PD) were included in this s...
Abstract
International journal of nursing practice,
Volume 30, Issue 4, 15 3 2024, Pages e13262
Effects of traditional and dry bed baths on patients admitted in intensive units: A randomized crossover clinical trial.
Ayhan D, Yılmaz D
Background: The bed bath is an important part of nursing care. There are few studies evaluating the effects of traditional and dry bed baths on patients. Aim: This study was performed with the aim of investigating the effect of traditional and dry bed baths given to intensive care unit patients on the patients' hemodynamic parameters, the duration of the bathing procedure and the cost of consumable items. Methods: This was a randomized crossover clinical trial and a prospective study. The s...
Abstract
Cited 30 times since 2024 (21 per year)
source: EuropePMC
JACC. Cardiovascular imaging,
Volume 17, Issue 9, 15 3 2024, Pages 1062-1076
Artificial Intelligence-Enabled Quantitative Coronary Plaque and Hemodynamic Analysis for Predicting Acute Coronary Syndrome.
Koo BK, Yang S, Jung JW, Zhang J, Lee K, Hwang D, Lee KS, Doh JH, Nam CW, Kim TH, Shin ES, Chun EJ, Choi SY, Kim HK, Hong YJ, Park HJ, Kim SY, Husic M, Lambrechtsen J, Jensen JM, Nørgaard BL, Andreini D, Maurovich-Horvat P, Merkely B, Penicka M, de Bruyne B, Ihdayhid A, Ko B, Tzimas G, Leipsic J, Sanz J, Rabbat MG, Katchi F, Shah M, Tanaka N, Nakazato R, Asano T, Terashima M, Takashima H, Amano T, Sobue Y, Matsuo H, Otake H, Kubo T, Takahata M, Akasaka T, Kido T, Mochizuki T, Yokoi H, Okonogi T, Kawasaki T, Nakao K, Sakamoto T, Yonetsu T, Kakuta T, Yamauchi Y, Bax JJ, Shaw LJ, Stone PH, Narula J
Background: A lesion-level risk prediction for acute coronary syndrome (ACS) needs better characterization. Objectives: This study sought to investigate the additive value of artificial intelligence-enabled quantitative coronary plaque and hemodynamic analysis (AI-QCPHA). Methods: Among ACS patients who underwent coronary computed tomography angiography (CTA) from 1 month to 3 years before the ACS event, culprit and nonculprit lesions on coronary CTA were adjudicated based on invasive coronary a...
Abstract
Cited 4 times since 2024 (2.8 per year)
source: EuropePMC
Royal Society open science,
Volume 11, Issue 5, 15 3 2024, Pages 231541
Short-term memory, attentional control and brain size in primates.
van Schaik CP, Jacobs I, Burkart JM, Sauciuc GA, Schuppli C, Persson T, Song Z
Brain size variability in primates has been attributed to various domain-specific socio-ecological factors. A recently published large-scale study of short-term memory abilities in 41 primate species (ManyPrimates 2022 Anim. Behav. Cogn. 9, 428-516. (doi:10.26451/abc.09.04.06.2022)) did not find any correlations with 11 different proxies of external cognitive demands. Here, we found that the interspecific variation in test performance shows correlated evolution with total brain size, with the re...
Abstract
Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing,
Volume 67, Issue 7, 14 2 2024, Pages 1623-1634
Validation of a prediction model for early reconnection after cryoballoon ablation.
van Waaij K, Keçe F, de Riva M, Alizadeh Dehnavi R, Wijnmaalen AP, Piers SRD, Mertens BJ, Zeppenfeld K, Trines SA
Background: We previously developed an early reconnection/dormant conduction (ERC) prediction model for cryoballoon ablation to avoid a 30-min waiting period with adenosine infusion. We now aimed to validate this model based on time to isolation, number of unsuccessful cryo-applications, and nadir balloon temperature. Methods: Consecutive atrial fibrillation patients who underwent their first cryoballoon ablation in 2018-2019 at the Leiden University Medical Center were included. Model performan...
Abstract
Cited 7 times since 2024 (4.9 per year)
source: EuropePMC
Frontiers in immunology,
Volume 15, 13 2 2024, Pages 1327051
CCL18 aggravates atherosclerosis by inducing CCR6-dependent T-cell influx and polarization.
Singh A, Kraaijeveld AO, Curaj A, Wichapong K, Hammerich L, de Jager SCA, Bot I, Atamas SP, van Berkel TJC, Jukema JW, Comerford I, McColl SR, Mees B, Heemskerk JWM, Nicolaes GAF, Hackeng T, Liehn EA, Tacke F, Biessen EAL
Introduction: The CC chemokine ligand 18 (CCL18) is a chemokine highly expressed in chronic inflammation in humans. Recent observations of elevated CCL18 plasma levels in patients with acute cardiovascular syndromes prompted an investigation into the role of CCL18 in the pathogenesis of human and mouse atherosclerosis. Methods and results: CCL18 was profoundly upregulated in ruptured human atherosclerotic plaque, particularly within macrophages. Repeated administration of CCL18 in Western-type d...
Abstract
Cited 16 times since 2024 (11.1 per year)
source: EuropePMC
European journal of heart failure,
Volume 26, Issue 7, 12 2 2024, Pages 1549-1560
Contemporary guideline-directed medical therapy in de novo, chronic, and worsening heart failure patients: First data from the TITRATE-HF study.
Malgie J, Wilde MI, Clephas PRD, Emans ME, Koudstaal S, Schaap J, Mosterd A, van Ramshorst J, Wardeh AJ, van Wijk S, van den Heuvel M, Wierda E, Borleffs CJW, Saraber C, Beeres SLMA, van Kimmenade R, Jansen Klomp W, Denham R, da Fonseca CA, Klip IT, Manintveld OC, van der Boon RMA, van Ofwegen CEE, Yilmaz A, Pisters R, Linssen GCM, Faber N, van Heerebeek L, van de Swaluw JEC, Bouhuijzen LJ, Post MC, Kuijper AFM, Wu KW, van Beek EA, Hesselink T, Kleijn L, Kurvers MJM, Tio RA, Langerveld J, van Dalen BM, van Eck JWM, Handoko ML, Hermans WRM, Koornstra-Wortel HJJ, Szymanski MK, Rooker D, Tandjung K, Eijsbouts SCM, Asselbergs FW, van der Meer P, Brunner-La Rocca HP, de Boer RA, Brugts JJ
Aims: Despite clear guideline recommendations for initiating four drug classes in all patients with heart failure (HF) with reduced ejection fraction (HFrEF) and the availability of rapid titration schemes, information on real-world implementation lags behind. Closely following the 2021 ESC HF guidelines and 2023 focused update, the TITRATE-HF study started to prospectively investigate the use, sequencing, and titration of guideline-directed medical therapy (GDMT) in HF patients, including the i...
Abstract
Cited 2 times since 2024 (1.4 per year)
source: EuropePMC
Gut,
Volume 73, Issue 6, 10 2 2024, Pages 883-884
Selective decontamination of the digestive tract in critically ill children: fighting fire with fire or burning down the house?
Bogaert D, van Schaik W
Abstract
The American journal of cardiology,
Volume 222, 8 2 2024, Pages 78-86
Significant Mitral Regurgitation After Permanent Right Ventricular Pacemaker Implantation: Prognostic Implications.
Nabeta T, Galloo X, Tops L, Stassen J, Marsan NA, van der Bijl P, Bax JJ
The underlying mechanisms leading to the development of mitral regurgitation (MR) after right ventricular (RV) pacemaker (PM) implantation and its prognostic value have yet to be fully understood. The purpose of this study was to evaluate the prevalence and clinical variables associated with the development of MR after RV pacing and its association with outcomes. A total of 451 patients (mean age 69 ± 15 years, 61% male) who underwent de novo RV PM implantation were included. The development of...
Abstract
Cited 2 times since 2024 (1.4 per year)
source: EuropePMC
Research and practice in thrombosis and haemostasis,
Volume 8, Issue 4, 6 1 2024, Pages 102437
Performance of risk scores in predicting major bleeding in left ventricular assist device recipients: a comparative external validation.
van der Horst SFB, de Jong Y, van Rein N, Jukema JW, Palmen M, Janssen E, Bonneville EF, Klok FA, Huisman MV, Tops LF, den Exter PL
Background: Implantation of a left ventricular assist device (LVAD) is a crucial therapeutic option for selected end-stage heart failure patients. However, major bleeding (MB) complications postimplantation are a significant concern. Objectives: We evaluated current risk scores' predictive accuracy for MB in LVAD recipients. Methods: We conducted an observational, single-center study of LVAD recipients (HeartWare or HeartMate-3, November 2010-December 2022) in the Netherlands. The primary o...
Abstract
Trials,
Volume 25, Issue 1, 6 1 2024, Pages 303
Refraining from closed reduction of displaced distal radius fractures in the emergency department-in short: the RECORDED trial.
Derksen BM, Jawahier PA, Wijers O, Knops SP, de Vries MR, van Hooff CCD, Verhofstad MHJ, Schep NWL
Background: With roughly 45,000 adult patients each year, distal radius fractures are one of the most common fractures in the emergency department. Approximately 60% of all these fractures are displaced and require surgery. The current guidelines advise to perform closed reduction of these fractures awaiting surgery, as it may lead to post-reduction pain relief and release tension of the surrounding neurovascular structures. Recent studies have shown that successful reduction does not warrant co...
Abstract
Cited 2 times since 2024 (1.4 per year)
source: EuropePMC
American journal of medical genetics. Part A,
Volume 194, Issue 9, 6 1 2024, Pages e63645
Exploring metabolic alterations in PYCR2 deficiency: Unveiling pathways and clinical presentations of hypomyelinating leukodystrophy 10.
Gürbüz BB, Gülbakan B, Özgül RK, Yalnızoğlu D, Yılmaz DY, Göçmen R, Koşukcu C, Kandemir N, Acar NV, Salih B, Dursun A
Proline-5-carboxylate reductase 2, encoded by PYCR2 gene, is an enzyme that catalyzes the last step of proline synthesis from pyrroline-5-carboxylate synthetase to proline. PYCR2 gene defect causes hypomyelinating leukodystrophy 10. Up until now, to our knowledge around 38 patients with PYCR2 defect have been reported. Herein, we describe clinical, neuroradiological, biochemical findings, and metabolomic profiling of three new genetically related cases of PYCR2 defects from a large family. Cereb...
Abstract
Cited 1 times since 2024 (0.7 per year)
source: EuropePMC
Death studies,
Volume 49, Issue 5, 6 1 2024, Pages 597-608
Their final words: An analysis of suicide notes from the United States.
Gunn J, McGrain P, Ördög B, Guerin M
The present study sought to explore motivations (affective, relationships, life events, injury/medical diagnosis) in suicide notes (N = 49) from the U.S. Authors ranged in age from 18 to 74 years and were majority male (73.5%). Four raters analyzed the notes and, through a series of meetings, came to a consensus on the motives behind each note writers' suicide in terms of the broader motivational themes and the narrower second-level themes. All notes were primarily affectional in nature, wi...
Abstract
Cited 5 times since 2024 (3.4 per year)
source: EuropePMC
Cell reports. Medicine,
Volume 5, Issue 5, 3 1 2024, Pages 101529
Genetic variants for head size share genes and pathways with cancer.
Knol MJ, Poot RA, Evans TE, Satizabal CL, Mishra A, Sargurupremraj M, van der Auwera S, Duperron MG, Jian X, Hostettler IC, van Dam-Nolen DHK, Lamballais S, Pawlak MA, Lewis CE, Carrion-Castillo A, van Erp TGM, Reinbold CS, Shin J, Scholz M, Håberg AK, Kämpe A, Li GHY, Avinun R, Atkins JR, Hsu FC, Amod AR, Lam M, Tsuchida A, Teunissen MWA, Aygün N, Patel Y, Liang D, Beiser AS, Beyer F, Bis JC, Bos D, Bryan RN, Bülow R, Caspers S, Catheline G, Cecil CAM, Dalvie S, Dartigues JF, DeCarli C, Enlund-Cerullo M, Ford JM, Franke B, Freedman BI, Friedrich N, Green MJ, Haworth S, Helmer C, Hoffmann P, Homuth G, Ikram MK, Jack CR, Jahanshad N, Jockwitz C, Kamatani Y, Knodt AR, Li S, Lim K, Longstreth WT, Macciardi F, Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium, Mäkitie O, Mazoyer B, Medland SE, Miyamoto S, Moebus S, Mosley TH, Muetzel R, Mühleisen TW, Nagata M, Nakahara S, Palmer ND, Pausova Z, Preda A, Quidé
The size of the human head is highly heritable, but genetic drivers of its variation within the general population remain unmapped. We perform a genome-wide association study on head size (N = 80,890) and identify 67 genetic loci, of which 50 are novel. Neuroimaging studies show that 17 variants affect specific brain areas, but most have widespread effects. Gene set enrichment is observed for various cancers and the p53, Wnt, and ErbB signaling pathways. Genes harboring lead variants are enriche...
Abstract
