9618 results
Biological cybernetics,
Volume 119, Issue 2-3, 4 1 2025, Pages 12
Decreased spinal inhibition leads to undiversified locomotor patterns.
de Graaf ML, Wagner H, Mochizuki L, Le Mouel C
During walking and running, animals display rich and coordinated motor patterns that are generated and controlled within the central nervous system. Previous computational and experimental results suggest that the balance between excitation and inhibition in neural circuits may be critical for generating such structured motor patterns. In this paper, we explore the influence of this balance on the ability of a reservoir computing artificial neural network to learn human locomotor patterns, using...
Abstract
Neurology,
Volume 104, Issue 12, 3 1 2025, Pages e213673
Epigenetic Aging in Pediatric-Onset Multiple Sclerosis.
Goyne C, Fair AE, Yilmaz D, Race J, Schuette A, Caillier SJ, Aaen GS, Abrams AW, Benson LA, Casper TC, Chitnis T, Gorman MP, Lotze TE, Krupp LB, Mar SS, Ness JM, Rensel M, Rodriguez M, Rose JW, Schreiner TL, Tillema JM, Waldman AT, Wheeler YS, Barcellos LF, Waubant E, Graves JS, as the US Network of Pediatric MS Centers
Background and objectives: Older chronological age is associated with decreased multiple sclerosis (MS) relapse rates and increased risk of progressive disease. Measurement of biological age may be more precise than birthdate in understanding these aging effects. In addition to normal aging, MS-related accelerated aging may contribute. Measurement of biological age in adults may be confounded by the effects of natural aging and age-related comorbidities. Examining age extremes can be informative...
Abstract
BMC medical imaging,
Volume 25, Issue 1, 3 1 2025, Pages 201
Multimodality comparison of aorta morphology in patients with aortopathy: 4D flow CMR, CTA, mDIXON.
Te Kiefte BJC, Gholamiankhah F, Juffermans JF, Van Den Boogaard P, Scholte AJHA, Lamb HJ, Westenberg JJM
Background: Four-dimensional cardiovascular magnetic resonance flow imaging (4D flow CMR) enables analysing of aortic blood flow dynamics. In order to examine the relationship between morphology and hemodynamics, additional anatomical imaging is required. This study aims to assess if 4D flow CMR segmentations can be used to determine morphological parameters by comparing with segmentations from Computed Tomography Angiography (CTA) and mDIXON CMR. Methods: This study included 18 patients with va...
Abstract
American heart journal plus : cardiology research and practice,
Volume 56, 3 1 2025, Pages 100562
Impact of aortic valve calcification volume on left ventricular systolic function in patients with severe aortic stenosis undergoing transcatheter aortic valve implantation.
Anwar HS, Algowhary M, Abdelmegid MAF, Helmy HA, Montero-Cabezas JM, Van Der Kley F
Background: Aortic valve calcification (AVC) has been linked to negative cardiac outcomes in patients with aortic stenosis (AS). Given the limited understanding of its specific contributions, we aimed to investigate the interaction between AVC and the left ventricular (LV) systolic function in patients with severe AS and LV systolic dysfunction who underwent transcatheter aortic valve implantation (TAVI). Materials and methods: An observational study of 75 patients with severe AS and LV ejection...
Abstract
Animals : an open access journal from MDPI,
Volume 15, Issue 11, 3 1 2025, Pages 1653
Prospects for Data Collection to Optimise Kid Rearing in Dutch Dairy Goat Herds.
Dijkstra E, Santman-Berends I, de Haan T, van Schaik G, van den Brom R, Stegeman A
Optimising kid rearing is essential for sustainable dairy goat farming, yet validated parameters and practical benchmark data are lacking. This study aimed to develop and evaluate a set of key performance indicators (KPIs) for monitoring kid-rearing practices through a participatory approach. Researchers, veterinarians and five dairy goat farms participated developed a prototype set of KPIs covering birth, colostrum management, average daily gain (ADG), and mortality, which were stratified acros...
Abstract
Journal of applied physiology (Bethesda, Md. : 1985),
Volume 138, Issue 6, 2 1 2025, Pages 1560-1570
Intraoperative evaluation of right ventricular mechanics in a pressure-overload swine model.
Lo Muzio FP, Zirngast B, Karner B, Manninger M, Fontana M, Steendijk P, Mächler H, Rozzi G, Alogna A
Assessment of right ventricular (RV) mechanical performance during open chest surgery is typically based on invasive methods and subjective evaluations. This study developed a porcine model of acute progressive RV pressure overload to evaluate hemodynamic changes and validate the three- dimensional (3-D) video kinematic assessment of the videocardiograph (VCG). Seven healthy Landrace pigs were instrumented under fluoroscopic guidance with Swan-Ganz and RV conductance catheters. Following a media...
Abstract
JACC. Cardiovascular imaging,
Volume 18, Issue 6, 1 1 2025, Pages 745-746
Reply: Transcatheter Edge-to-Edge Repair for Degenerative Mitral Regurgitation in the Setting of Mitral Annular Disjunction.
van der Bijl P, Stassen J, Ajmone Marsan N, Bax JJ
Abstract
Cited 1 times since 2025 (4.7 per year)
source: EuropePMC
European heart journal. Cardiovascular Imaging,
Volume 26, Issue 7, 1 1 2025, Pages 1163-1173
Derivation and validation of an artificial intelligence-based plaque burden safety cut-off for long-term acute coronary syndrome from coronary computed tomography angiography.
Bär S, Knuuti J, Saraste A, Klén R, Kero T, Nabeta T, Bax JJ, Danad I, Nurmohamed NS, Jukema RA, Knaapen P, Maaniitty T
Aims: Artificial intelligence (AI) has enabled accurate and fast plaque quantification from coronary computed tomography angiography (CCTA). However, AI detects any coronary plaque in up to 97% of patients. To avoid overdiagnosis, a plaque burden safety cut-off for future coronary events is needed. Methods and results: Percent atheroma volume (PAV) was quantified with AI-guided quantitative computed tomography in a blinded fashion. Safety cut-off derivation was performed in the Turku CCTA regist...
Abstract
Cited 5 times since 2025 (23.7 per year)
source: EuropePMC
European heart journal,
Volume 46, Issue 22, 1 1 2025, Pages 2079-2088
Transcatheter vs. surgical aortic valve replacement in women: the RHEIA trial.
Tchetche D, Pibarot P, Bax JJ, Bonaros N, Windecker S, Dumonteil N, Nietlispach F, Messika-Zeitoun D, Pocock SJ, Berthoumieu P, Swaans MJ, Timmers L, Rudolph TK, Bleiziffer S, Leroux L, Modine T, van der Kley F, Auffret V, Tomasi J, Stastny L, Hengstenberg C, Andreas M, Leclercq F, Gandet T, Mascherbauer J, Trescher K, Prendergast B, Vasa-Nicotera M, Chieffo A, Mares J, Wesselink W, Rakova R, Kurucova J, Bramlage P, Eltchaninoff H
Background and aims: Although women with severe symptomatic aortic stenosis have more complications than men when undergoing surgical valve replacement, they are under-represented in clinical trials. The Randomized researcH in womEn all comers wIth Aortic stenosis (RHEIA) trial investigates the balance of benefits and risks of transcatheter aortic valve implantation (TAVI) vs. surgery in women. Methods: Women were randomized 1:1 to transfemoral TAVI with a balloon-expandable valve or surgery. Th...
Abstract
Cited 1 times since 2025 (4.7 per year)
source: EuropePMC
JACC. Cardiovascular interventions,
Volume 18, Issue 12, 1 1 2025, Pages 1540-1553
Aortic Valve Replacement in Women: A Pooled Analysis of the RHEIA and PARTNER 3 Trials.
Eltchaninoff H, Windecker S, Mack MJ, Pibarot P, Thourani VH, Bax JJ, Cohen DJ, Bonaros N, Makkar R, Bleiziffer S, Szeto WY, Berthoumieu P, Hahn RT, Hovorka T, Mareš J, Taylor J, Tchetche D, Leon MB
Background: In women with severe aortic stenosis, there are limited data regarding outcome differences following transcatheter (TAVR) vs surgical aortic valve replacement (SAVR). Objectives: The authors sought to examine outcomes of TAVR vs SAVR in a patient-level pooled analysis of women in the RHEIA and PARTNER 3 trials. Methods: Patients in both trials were randomly allocated to a balloon-expandable SAPIEN 3/Ultra valve or to surgical bioprostheses. Individual patient data of female participa...
Abstract
Lancet (London, England),
Volume 405, Issue 10495, 1 1 2025, Pages 2153-2163
Surgery versus corticosteroid injection for carpal tunnel syndrome (DISTRICTS): an open-label, multicentre, randomised controlled trial.
Palmbergen WAC, Beekman R, Heeren AM, van Nuenen BFL, Alleman TWH, Verstraete E, Jellema K, Verhagen WIM, Visser LH, de Ruiter GCW, van de Beek D, de Borgie CAJM, Bogaards JA, de Bie RMA, Verhamme C, Dutch CTS study group
Background: Surgery and corticosteroid injections are established treatments for carpal tunnel syndrome, but the optimal treatment strategy remains unclear. This study aimed to compare starting treatment with surgery versus starting with a corticosteroid injection. Methods: We conducted an open-label, randomised controlled trial across 31 hospitals in the Netherlands. Eligible patients, diagnosed with carpal tunnel syndrome for at least 6 weeks and confirmed by electrophysiological or sonographi...
Abstract
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
Volume 67, Issue 6, 1 1 2025, Pages ezaf161
Sex difference in aortic root replacement with a stentless bioprosthesis†.
Dagnegård H, Schneider AW, Timmermans PT, Glaser N, Kolseth SM, Vanky F, Gudbjartsson T, Haaverstad R, Cotovanu A, Sartipy U, Klautz RJM, Smerup M, Hjortnaes J, North Atlantic Freestyle Collaboration
Objectives: To investigate and quantify differences in survival and reinterventions between sexes after aortic root replacement with a stentless bioprosthesis, stratified for preoperative valve lesion. Methods: Elective adults undergoing aortic root replacement with the Freestyle bioprosthesis at six North-Atlantic centres were included. Survival analyses were performed using the Kaplan-Meier method or Aalen-Johansen with death as competing risk as relevant. Results were quantified using uni- an...
Abstract
Nucleic acids research,
Volume 53, Issue 12, 1 1 2025, Pages gkaf549
Extrusion fountains are restricted by WAPL-dependent cohesin release and CTCF barriers.
Liu NQ, Magnitov M, Schijns MMGA, van Schaik T, Teunissen H, van Steensel B, de Wit E
Interphase chromosomes are mainly shaped by loop extrusion and compartmentalisation mechanisms. However, their temporal component and cause-effect relationships remain largely unknown. In this study, we use acute degradation of WAPL, CTCF and cohesin in mouse embryonic stem cells to investigate the dynamics of loop extrusion and its relationship to compartmentalisation. Stabilisation of cohesin on chromatin by depletion of WAPL results in the formation of extended loops and promotes looping betw...
Abstract
Cited 1 times since 2025 (4.7 per year)
source: EuropePMC
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology,
Volume 36, Issue 6, 1 1 2025, Pages e70113
ADRB2 genotype-guided treatment for childhood asthma: Cost analysis of the PUFFIN and PACT trials.
Slob EMA, Frederix GWJ, Vijverberg SJH, Noij LCE, Ruffles T, Vasbinder EC, Mukhopadhyay S, van Schaik RHN, Kersten ETG, Pijnenburg MW, Koppelman GH, Maitland-van der Zee AH, PUFFIN and PACT investigators
Background: Long-acting β2-agonists (LABA) are commonly used to treat asthma. Some children do not respond well to LABA, which may be due to +46G>A-/rs1042713 (Arg16 amino acid) in the ADRB2 gene encoding the β2 receptor. Arg16Gly ADRB2 genotyping to guide treatment step-up decisions in children with uncontrolled asthma despite inhaled corticosteroids (ICS) has been shown to reduce asthma exacerbations. We investigated whether ADRB2 genotype-guided treatment is cost-saving. Methods: Total sem...
Abstract
Radiology. Cardiothoracic imaging,
Volume 7, Issue 3, 1 1 2025, Pages e240200
Pericoronary Adipose Tissue Attenuation in Patients with Future Acute Coronary Syndromes: The ICONIC Study.
Kwan AC, Tzolos E, Klein E, Han D, Lin A, Kuronuma K, Chen B, Flores Tomasino G, Gransar H, Slomka PJ, Cheng S, Gebhard C, Kaufmann P, Bax JJ, Cademartiri F, Chinnaiyan K, Chow BJW, Conte E, Cury RC, Feuchtner G, Hadamitzky M, Kim YJ, Leipsic JA, Maffei E, Marques H, Plank F, Pontone G, Villines TC, Al-Mallah MH, Gonçalves PA, Danad I, Lu Y, Lee JH, Lee SE, Baskaran L, Al'Aref SJ, Budoff MJ, Samady H, Stone PH, Virmani R, Achenbach S, Narula J, Chang HJ, Shaw LJ, Berman DS, Lin F, Dey D
Purpose Pericoronary adipose tissue attenuation (PCATa) measured at coronary CT angiography (CCTA) is an imaging biomarker of coronary inflammation associated with long-term adverse cardiac events. The authors hypothesized that PCATa may independently identify patients at risk for acute coronary syndromes (ACS). Materials and Methods The authors performed a retrospective substudy of the Incident Coronary Syndromes Identified by Computed Tomography (ICONIC) study, a propensity-matched case-contro...
Abstract
Journal of the peripheral nervous system : JPNS,
Volume 30, Issue 2, 1 1 2025, Pages e70031
Validity and Responsiveness of Balance Measurements Using Posturography in Patients With Immune-Mediated Neuropathies.
Michael MR, van Veen R, Wieske L, Merkies ISJ, van Schaik IN, Eftimov F
Background and aims: Validated objective measures for balance in immune mediated neuropathies are lacking. In this study, we investigated the clinimetric properties of posturography using a force platform, a quantitative assessment of postural control. Methods: We assessed patients with chronic inflammatory demyelinating polyneuropathy (CIDP) and IgM-related polyneuropathy (IgM-PNP) using sway parameters (path, area and amplitude) measured at multiple time points. Validity was investigated by as...
Abstract
Cited 1 times since 2025 (4.7 per year)
source: EuropePMC
The clinical teacher,
Volume 22, Issue 3, 1 1 2025, Pages e70073
Faculty Development for the People: Workplace-Based Solutions for Busy Clinicians.
Brode EC, Bernal JM, Cornes SB, Santhosh L, Rivera JA, Kulkarni SA, Mandal JR, Henry DM, Bartz KS, Van Schaik SM
Background: Across clinical learning environments (CLEs), learners often encounter supervising clinicians who do not self-identify as educators and, therefore, may not seek out faculty development to augment their teaching skills. To reach those faculty, we conducted a proof-of-concept project framed by Billet's theory on workplace learning, bringing tailored faculty development to the clinical workplace. Approach: We recruited 22 faculty champions from 8 clinical departments at our institu...
Abstract
FASEB journal : official publication of the Federation of American Societies for Experimental Biology,
Volume 39, Issue 12, 1 1 2025, Pages e70735
Fibrogenic Gene Signature as Early Prediction for the Efficacy of Pharmacological Interventions for MASH-Associated Fibrosis.
Inia JA, Morrison MC, van Koppen A, Gart E, Caspers MPM, Menke AL, Worms N, Kleemann R, Verschuren L, Jukema JW, Princen HMG, Hanemaaijer R, van den Hoek AM
The incidence of metabolic dysfunction-associated steatohepatitis (MASH) and associated liver fibrosis is rapidly increasing, while pharmacological treatment options remain limited. Despite great efforts in developing novel MASH therapeutics, many investigative therapeutics that reduced fibrosis in preclinical models ultimately failed in clinical trials. To this end, we explored the possibility of predicting the efficacy of therapeutics by evaluating changes in the expression of a fibrogenic gen...
Abstract
Substance abuse treatment, prevention, and policy,
Volume 20, Issue 1, 28 4 2025, Pages 23
Effect and acceptability of an mHealth smoking cessation intervention 'Stopcoach' combined with smoking cessation counseling for people from multiple levels of socioeconomic position: a multi-methods study.
de Frel DL, Zijp A, van den Putte B, Troelstra S, Hermsen S, Heemskerk E, Janssen VR, Atsma DE, Chavannes NH, Meijer E
Introduction: Smoking cessation interventions tend to be less effective for people of lower socioeconomic position (SEP) compared to those of higher SEP. Mobile phone-based interventions have been shown to increase abstinence from smoking. Stopcoach is an mHealth smoking cessation intervention that specifically targets people with a lower SEP. A pilot study showed the potential and feasibility of Stopcoach but as yet no research exists that assesses the effectiveness of Stopcoach. Objective: Thi...
Abstract
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions,
27 4 2025
Comparison of Procedural and Clinical Outcomes of Angiography- Versus Imaging-Guided Percutaneous Coronary Intervention With Intravascular Lithotripsy.
Phagu AAS, van Oort MJH, Oliveri F, Bingen BO, Mincione G, Paradies V, Claessen BEPM, Dimitriu-Leen AC, Vossenberg TN, Kefer J, Girgis H, van der Kley F, Jukema JW, Al Amri I, Montero-Cabezas JM
Background: Intravascular lithotripsy (IVL) is an innovative treatment for coronary artery calcification (CAC). Aims: This study aimed to compare procedural and clinical outcomes of intracoronary imaging (ICI)-guided percutaneous coronary intervention (PCI) versus angiography-guided PCI with IVL in patients with CAC. Methods: A total of 509 patients were analyzed from the BENELUX-IVL registry (May 2019 to September 2024). Angiography-guided PCI with IVL was defined as therapy under solely fluoro...
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