9618 results
Cited 9 times since 2022 (2.8 per year)
source: EuropePMC
BMC infectious diseases,
Volume 22, Issue 1, 20 3 2022, Pages 482
Transmission routes of antibiotic resistant bacteria: a systematic review.
Godijk NG, Bootsma MCJ, Bonten MJM
Background: Quantification of acquisition routes of antibiotic resistant bacteria (ARB) is pivotal for understanding transmission dynamics and designing cost-effective interventions. Different methods have been used to quantify the importance of transmission routes, such as relative risks, odds ratios (OR), genomic comparisons and basic reproduction numbers. We systematically reviewed reported estimates on acquisition routes' contributions of ARB in humans, animals, water and the environmen...
Abstract
Cited 8 times since 2022 (2.5 per year)
source: EuropePMC
Circulation research,
Volume 131, Issue 1, 19 3 2022, Pages 24-41
Sbk2, a Newly Discovered Atrium-Enriched Regulator of Sarcomere Integrity.
van Gorp PRR, Zhang J, Liu J, Tsonaka R, Mei H, Dekker SO, Bart CI, De Coster T, Post H, Heck AJR, Schalij MJ, Atsma DE, Pijnappels DA, de Vries AAF
Background: Heart development relies on tight spatiotemporal control of cardiac gene expression. Genes involved in this intricate process have been identified using animals and pluripotent stem cell-based models of cardio(myo)genesis. Recently, the repertoire of cardiomyocyte differentiation models has been expanded with iAM-1, a monoclonal line of conditionally immortalized neonatal rat atrial myocytes (NRAMs), which allows toggling between proliferative and differentiated (ie, excitable and co...
Abstract
Cited 2 times since 2022 (0.6 per year)
source: EuropePMC
BMC microbiology,
Volume 22, Issue 1, 18 3 2022, Pages 135
Using unique ORFan genes as strain-specific identifiers for Escherichia coli.
Ferrandis-Vila M, Tiwari SK, Mamerow S, Semmler T, HECTOR consortium, Menge C, Berens C
Background: Bacterial identification at the strain level is a much-needed, but arduous and challenging task. This study aimed to develop a method for identifying and differentiating individual strains among multiple strains of the same bacterial species. The set used for testing the method consisted of 17 Escherichia coli strains picked from a collection of strains isolated in Germany, Spain, the United Kingdom and Vietnam from humans, cattle, swine, wild boars, and chickens. We targeted unique...
Abstract
Cited 7 times since 2022 (2.2 per year)
source: EuropePMC
International journal of colorectal disease,
Volume 37, Issue 6, 18 3 2022, Pages 1385-1391
Accuracy of imaging in discriminating complicated from uncomplicated appendicitis in daily clinical practice.
Bolmers MDM, Bom WJ, Scheijmans JCG, van Geloven AAW, Boermeester MA, Bemelman WA, van Rossem CC, SNAPSHOT collaborators
Background: Radiologic imaging can accurately diagnose acute appendicitis, but little is known about its discriminatory capacity between complicated and uncomplicated appendicitis. Objective: This study aims to investigate the accuracy of imaging in discriminating complicated from uncomplicated appendicitis. Methods: Data was used from the prospective, nationwide, observational SNAPSHOT appendicitis database, including patients with suspected acute appendicitis who were planned for an appendecto...
Abstract
Cited 10 times since 2022 (3.1 per year)
source: EuropePMC
Proceedings. Biological sciences,
Volume 289, Issue 1975, 18 3 2022, Pages 20220200
Individual variation and plasticity in the infant-directed communication of orang-utan mothers.
Fröhlich M, van Schaik CP, van Noordwijk MA, Knief U
Between-individual variation in behavioural expression, such as social responsiveness, has been shown to have important eco-evolutionary consequences. However, most comparative research on non-human primate communication has focused on species- or population-level variation, while among- and within-individual variation has been largely ignored or considered as noise. Here, we apply a behavioural reaction norm framework to repeated observations of mother-offspring interactions in wild and zoo-hou...
Abstract
Cited 4 times since 2022 (1.2 per year)
source: EuropePMC
Clinical pharmacology and therapeutics,
Volume 112, Issue 2, 18 3 2022, Pages 316-326
Model-Based Prediction of Irinotecan-Induced Grade 4 Neutropenia in Advanced Cancer Patients: Influence of Demographic and Clinical Factors.
Karas S, Mathijssen RHJ, van Schaik RHN, Forrest A, Wiltshire T, Innocenti F, Bies RR
Severe neutropenia is the major dose-liming toxicity of irinotecan-based chemotherapy. The objective was to assess to what extent a population pharmacokinetic/pharmacodynamic model including patient-specific demographic/clinical characteristics, individual pharmacokinetics, and absolute neutrophil counts (ANCs) can predict irinotecan-induced grade 4 neutropenia. A semimechanistic population pharmacokinetic/pharmacodynamic model was developed to describe neutrophil response over time in 197 patie...
Abstract
Cited 74 times since 2022 (22.8 per year)
source: EuropePMC
Journal of the American College of Cardiology,
Volume 80, Issue 8, 17 3 2022, Pages 783-800
Evolution and Prognostic Impact of Cardiac Damage After Aortic Valve Replacement.
Généreux P, Pibarot P, Redfors B, Bax JJ, Zhao Y, Makkar RR, Kapadia S, Thourani VH, Mack MJ, Nazif TM, Lindman BR, Babaliaros V, Vincent F, Russo M, McCabe JM, Gillam LD, Alu MC, Hahn RT, Webb JG, Leon MB, Cohen DJ
Background: The impact of aortic valve replacement (AVR) on progression/regression of extravalvular cardiac damage and its association with subsequent prognosis is unknown. Objectives: The purpose of this study was to describe the evolution of cardiac damage post-AVR and its association with outcomes. Methods: Patients undergoing transcatheter or surgical AVR from the PARTNER (Placement of Aortic Transcatheter Valves) 2 and 3 trials were pooled and classified by cardiac damage stage at baseline...
Abstract
Cited 3 times since 2022 (0.9 per year)
source: EuropePMC
Journal of the American Heart Association,
Volume 11, Issue 10, 16 3 2022, Pages e023313
Differences in Characteristics and Outcomes Between Patients With Hypertrophic Cardiomyopathy From Asian and European Centers.
Tjahjadi C, Butcher SC, Zegkos T, Sia CH, Hirasawa K, Kamperidis V, Ngiam JN, Wong RCC, Efthimiadis G, Bax JJ, Delgado V, Ajmone Marsan N
Abstract
Vascular,
Volume 31, Issue 6, 16 3 2022, Pages 1051-1060
What we have learned from in-vitro studies of the chimney endovascular technique for treatment of complex abdominal aortic aneurysms: A systematic review.
Meekel JP, Tran BL, van Schaik TG, Donas KP, Taneva GT, Jongkind V, Yeung KK
Background: A considerable number of patients with abdominal aortic aneurysms (AAA) is not eligible for standard endovascular repair. These complex cases require alternative surgical approaches including the readily available chimney graft endovascular aneurysm repair (Ch-EVAR) or sealing (Ch-EVAS). The optimal configuration for Ch-EVAR or Ch-EVAS is important for success but not yet known. Objective: The aim of the present study was to analyze current data of the outcomes of in-vitro chimney gr...
Abstract
Cited 2 times since 2022 (0.6 per year)
source: EuropePMC
European urology focus,
Volume 8, Issue 6, 14 2 2022, Pages 1627-1634
T1G1 Bladder Cancer: Prognosis for this Rare Pathological Diagnosis Within the Non-muscle-invasive Bladder Cancer Spectrum.
Beijert IJ, Hentschel AE, Bründl J, Compérat EM, Plass K, Rodríguez O, Subiela Henríquez JD, Hernández V, de la Peña E, Alemany I, Turturica D, Pisano F, Soria F, Čapoun O, Bauerová L, Pešl M, Maxim Bruins H, Runneboom W, Herdegen S, Breyer J, Brisuda A, Calatrava A, Rubio-Briones J, Seles M, Mannweiler S, Bosschieter J, Kusuma VRM, Ashabere D, Huebner N, Cotte J, Mertens LS, Masson-Lecomte A, Liedberg F, Cohen D, Lunelli L, Cussenot O, El Sheikh S, Volanis D, Côté JF, Rouprêt M, Haitel A, Shariat SF, Mostafid AH, Nieuwenhuijzen JA, Zigeuner R, Dominguez-Escrig JL, Hacek J, Zlotta AR, Burger M, Evert M, Hulsbergen-van de Kaa CA, van der Heijden AG, A L M Kiemeney L, Soukup V, Molinaro L, Gontero P, Llorente C, Algaba F, Palou J, N'Dow J, Ribal MJ, van der Kwast TH, Babjuk M, Sylvester RJ, van Rhijn BWG
Background: The pathological existence and clinical consequence of stage T1 grade 1 (T1G1) bladder cancer are the subject of debate. Even though the diagnosis of T1G1 is controversial, several reports have consistently found a prevalence of 2-6% G1 in their T1 series. However, it remains unclear if T1G1 carcinomas have added value as a separate category to predict prognosis within the non-muscle-invasive bladder cancer (NMIBC) spectrum. Objective: To evaluate the prognostic value of T1G1 carcino...
Abstract
Cited 6 times since 2022 (1.8 per year)
source: EuropePMC
Cardiovascular drugs and therapy,
Volume 37, Issue 5, 14 2 2022, Pages 941-953
Implications of ACC/AHA Versus ESC/EAS LDL-C Recommendations for Residual Risk Reduction in ASCVD: A Simulation Study From DA VINCI.
Vallejo-Vaz AJ, Bray S, Villa G, Brandts J, Kiru G, Murphy J, Banach M, De Servi S, Gaita D, Gouni-Berthold I, Kees Hovingh G, Jozwiak JJ, Jukema JW, Gabor Kiss R, Kownator S, Iversen HK, Maher V, Masana L, Parkhomenko A, Peeters A, Clifford P, Raslova K, Siostrzonek P, Romeo S, Tousoulis D, Vlachopoulos C, Vrablik M, Catapano AL, Poulter NR, Ray KK, DA VINCI Study Investigators
Purpose: Low-density lipoprotein cholesterol (LDL-C) recommendations differ between the 2018 American College of Cardiology/American Heart Association (ACC/AHA) and 2019 European Society of Cardiology/European Atherosclerosis Society (ESC/EAS) guidelines for patients with atherosclerotic cardiovascular disease (ASCVD) (
Abstract
Cited 8 times since 2022 (2.5 per year)
source: EuropePMC
Langmuir : the ACS journal of surfaces and colloids,
Volume 38, Issue 20, 13 2 2022, Pages 6281-6294
Discrimination of Receptor-Mediated Endocytosis by Surface-Enhanced Raman Scattering.
Yılmaz D, Culha M
Cellular energy required for the maintenance of cellular life is stored in the form of adenosine triphosphate (ATP). Understanding cellular mechanisms, including ATP-dependent metabolisms, is crucial for disease diagnosis and treatment, including drug development and investigation of new therapeutic systems. As an ATP-dependent metabolism, endocytosis plays a key role not only in the internalization of molecules but also in processes including cell growth, differentiation, and signaling. To unde...
Abstract
Cited 1 times since 2022 (0.3 per year)
source: EuropePMC
Journal of applied physiology (Bethesda, Md. : 1985),
Volume 133, Issue 1, 12 2 2022, Pages 20-26
Graded lower body negative pressure induces intraventricular negative pressures and incremental diastolic suction: a pressure-volume study in a porcine model.
Berboth L, Zirngast B, Manninger M, Steendijk P, Tschöpe C, Scherr D, Hinghofer-Szalkay HG, Goswami N, Petersen LG, Mächler H, Alogna A
Lower body negative pressure (LBNP) is a tool to study compensatory mechanisms to central hypovolemia for decades. However, the underlying hemodynamic mechanisms were mostly assessed noninvasively and remain unclear. We hypothesized that incremental LBNP reduces diastolic filling and thereby affects left ventricular (LV) diastolic suction (DS). Here, we investigated the impact of graded LBNP at three different levels of seal as well as during β-adrenergic stimulation by invasive pressure-volume...
Abstract
Cited 456 times since 2022 (139.6 per year)
source: EuropePMC
Nature genetics,
Volume 54, Issue 5, 12 2 2022, Pages 560-572
Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation.
Mahajan A, Spracklen CN, Zhang W, Ng MCY, Petty LE, Kitajima H, Yu GZ, Rüeger S, Speidel L, Kim YJ, Horikoshi M, Mercader JM, Taliun D, Moon S, Kwak SH, Robertson NR, Rayner NW, Loh M, Kim BJ, Chiou J, Miguel-Escalada I, Della Briotta Parolo P, Lin K, Bragg F, Preuss MH, Takeuchi F, Nano J, Guo X, Lamri A, Nakatochi M, Scott RA, Lee JJ, Huerta-Chagoya A, Graff M, Chai JF, Parra EJ, Yao J, Bielak LF, Tabara Y, Hai Y, Steinthorsdottir V, Cook JP, Kals M, Grarup N, Schmidt EM, Pan I, Sofer T, Wuttke M, Sarnowski C, Gieger C, Nousome D, Trompet S, Long J, Sun M, Tong L, Chen WM, Ahmad M, Noordam R, Lim VJY, Tam CHT, Joo YY, Chen CH, Raffield LM, Lecoeur C, Prins BP, Nicolas A, Yanek LR, Chen G, Jensen RA, Tajuddin S, Kabagambe EK, An P, Xiang AH, Choi HS, Cade BE, Tan J, Flanagan J, Abaitua F, Adair LS, Adeyemo A, Aguilar-Salinas CA, Akiyama M, Anand SS, Bertoni A, Bian Z, Bork-Jensen J, Brandslund I, Brody JA, Brummett CM, Buchanan TA, Canouil M, Chan JCN, Chang LC, Chee ML, Chen J, Chen SH, Chen YT, Chen Z, Chu
We assembled an ancestrally diverse collection of genome-wide association studies (GWAS) of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls (48.9% non-European descent) through the Diabetes Meta-Analysis of Trans-Ethnic association studies (DIAMANTE) Consortium. Multi-ancestry GWAS meta-analysis identified 237 loci attaining stringent genome-wide significance (P 50% posterior probability. This improved fine-mapping enabled systematic assessment of candidate causal ge...
Abstract
Cited 3 times since 2022 (0.9 per year)
source: EuropePMC
Royal Society open science,
Volume 9, Issue 5, 11 2 2022, Pages 220011
Martingales and the fixation time of evolutionary graphs with arbitrary dimensionality.
Monk T, van Schaik A
Evolutionary graph theory (EGT) investigates the Moran birth-death process constrained by graphs. Its two principal goals are to find the fixation probability and time for some initial population of mutants on the graph. The fixation probability of graphs has received considerable attention. Less is known about the distribution of fixation time. We derive clean, exact expressions for the full conditional characteristic functions (CCFs) of a close proxy to fixation and extinction times. That prox...
Abstract
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology,
Volume 30, Issue 1, 10 2 2022, Pages 83-84
<sup>18</sup>F-FDG PET/CT for the diagnosis of aortic inflammation in COVID-19.
van der Bijl P, Stassen J, Bax JJ
Abstract
Cited 4 times since 2022 (1.2 per year)
source: EuropePMC
Frontiers in cardiovascular medicine,
Volume 9, 10 2 2022, Pages 870459
Atrioventricular Block Necessitating Chronic Ventricular Pacing After Tricuspid Valve Surgery in Patients With a Systemic Right Ventricle: Long-Term Follow-Up.
Nederend M, Jongbloed MRM, Kiès P, Vliegen HW, Bouma BJ, Regeer MV, Koolbergen DR, Hazekamp MG, Schalij MJ, Egorova AD
Background: Patients with transposition of the great arteries (TGA) after an atrial switch or congenitally corrected TGA (ccTGA) are prone to systemic right ventricular (sRV) failure. Tricuspid valve (TV) regurgitation aggravates sRV dysfunction. Timely TV surgery stabilizes sRV function, yet the development of atrioventricular (AV)-conduction disturbances in the course of sRV failure can contribute to sRV dysfunction through pacing-induced dyssynchrony. This study aims to explore the incidence,...
Abstract
Cited 1 times since 2022 (0.3 per year)
source: EuropePMC
The international journal of cardiovascular imaging,
Volume 38, Issue 7, 9 2 2022, Pages 1639-1650
Atherosclerotic plaque characteristics on quantitative coronary computed tomography angiography associated with ischemia on positron emission tomography in diabetic patients.
Kamperidis V, de Graaf MA, Uusitalo V, Saraste A, Kuneman JH, van den Hoogen IJ, Knuuti J, Bax JJ
Patients with diabetes mellitus (DM) may show diffuse coronary artery atherosclerosis on coronary computed tomography angiography (CTA). The present study aimed at quantification of atherosclerotic plaque with CTA and its association with myocardial ischemia on positron emission tomography (PET) in DM patients. Of 922 symptomatic outpatients without previously known coronary artery disease who underwent CTA, 115 with DM (mean age 65 ± 8 years, 58% male) who had coronary atherosclerosis and under...
Abstract
Cancers,
Volume 14, Issue 9, 8 2 2022, Pages 2329
Impaired Global Longitudinal Strain Is Associated with Cardiovascular Events in Hodgkin Lymphoma Survivors.
Polomski EAS, Heemelaar JC, Krol ADG, Louwerens M, Beeres SLMA, Holman ER, Jukema JW, Schalij MJ, Antoni ML
Background: Treatment with thoracic irradiation for classic Hodgkin lymphoma (CHL) leads to improved survival but also increases the risk of cardiovascular events. Left ventricular (LV) dysfunction is usually assessed by echocardiographic left ventricular ejection fraction (LVEF), whereas global longitudinal strain (GLS) can detect early subclinical LV dysfunction. The purpose of this study was to evaluate if conventional echocardiographic parameters and GLS are associated with cardiovascular ev...
Abstract
Cited 11 times since 2022 (3.4 per year)
source: EuropePMC
American heart journal,
Volume 250, 7 1 2022, Pages 45-56
COMPARE LAAO: Rationale and design of the randomized controlled trial "COMPARing Effectiveness and safety of Left Atrial Appendage Occlusion to standard of care for atrial fibrillation patients at high stroke risk and ineligible to use oral anticoagulation therapy".
Huijboom M, Maarse M, Aarnink E, van Dijk V, Swaans M, van der Heijden J, IJsselmuiden S, Folkeringa R, Blaauw Y, Elvan A, Stevenhagen J, Vlachojannis G, van der Voort P, Westra S, Chaldoupi M, Khan M, de Groot J, van der Kley F, van Mieghem N, van Dijk E, Dijkgraaf M, Tijssen J, Boersma L
Background: Left atrial appendage occlusion (LAAO) provides an alternative to oral anticoagulation (OAC) for stroke prevention in patients with atrial fibrillation (AF). In patients with a long-term or permanent contraindication for OAC randomized controlled trial (RCT) data is lacking. Study objectives: To assess the efficacy and safety of LAAO in AF patients who are ineligible to use OAC. The co-primary efficacy endpoint is (1) time to first occurrence of stroke (ischemic, hemorrhagic, or unde...
Abstract
