Research

Publications

Below you can find a list of our published research.

9618 results

Cited 44 times since 2022 (13.3 per year) source: EuropePMC

Current opinion in microbiology, Volume 68, 28 4 2022, Pages 102150 Antibiotic resistance in the commensal human gut microbiota. Lamberte LE, van Schaik W

Antibiotic-resistant infections are a major threat to global public health and there is an urgent need to develop new drugs and interventions to treat and prevent infections caused by antibiotic-resistant bacteria. The human gut microbiota harbours both commensals and opportunistic pathogens which can acquire resistance to antibiotics through mutation and horizontal gene transfer. The powerful combination of modern high-throughput DNA sequencing and microbiological culture methods is providing n... Abstract

Cited 8 times since 2022 (2.4 per year) source: EuropePMC

Structural heart : the journal of the Heart Team, Volume 6, Issue 1, 26 4 2022, Pages 100027 Computed Tomography Aortic Valve Calcium Scoring in Patients With Bicuspid Aortic Valve Stenosis. Shen M, Oh JK, Guzzetti E, Singh GK, Pawade T, Tastet L, Clavel MA, Delgado V, Bax JJ, Dweck MR, Abbas AE, Mando R, Falconi ML, Perez de Arenaza D, Poh KK, Kong W, Tay E, Pressman G, Brito D, Song JK, Pibarot P

Background: Sex-specific thresholds of computed tomography (CT)-derived aortic valve calcification (AVC) or AVC density (AVCd) to identify severe aortic stenosis (AS) have been established in populations that consisted mainly of Caucasians with a tricuspid aortic valve. The objective of this study was to evaluate the accuracy (i.e., sensitivity and specificity) of previously established thresholds to identify severe AS in patients with bicuspid aortic valve (BAV) and according to ethnicity: Cauc... Abstract

Cited 8 times since 2022 (2.4 per year) source: EuropePMC

Journal of medical Internet research, Volume 24, Issue 4, 25 4 2022, Pages e30236 The Box-eHealth in the Outpatient Clinic Follow-up of Patients With Acute Myocardial Infarction: Cost-Utility Analysis. Treskes RW, van den Akker-van Marle ME, van Winden L, van Keulen N, van der Velde ET, Beeres S, Atsma D, Schalij MJ

Background: Smartphone compatible wearables have been released on the consumers market, enabling remote monitoring. Remote monitoring is often named as a tool to reduce the cost of care. Objective: The primary purpose of this paper is to describe a cost-utility analysis of an eHealth intervention compared to regular follow-up in patients with acute myocardial infarction (AMI). Methods: In this trial, of which clinical results have been published previously, patients with an AMI were randomized i... Abstract

Cited 4 times since 2022 (1.2 per year) source: EuropePMC

Journal of clinical orthopaedics and trauma, Volume 29, 22 4 2022, Pages 101873 Orthopaedic surgeons' perspective on the implementation of outpatient hip and knee arthroplasty - Results of a nationwide survey. Keulen MHF, Most J, Schotanus MGM, van Haaren EH, Heyligers IC, Boonen B

Background: Outpatient joint arthroplasty (OJA) for the hip and knee is gaining popularity among orthopaedic surgeons worldwide. The purposes of this study were to (1) assess the proportion of Dutch orthopaedic surgeons who perform OJA; (2) identify surgeons' willingness to implement OJA in the future; (3) identify reasons and barriers to implement OJA; and (4) gather surgeon's perspective on the implementation of OJA. Methods: A 20-item survey was developed and administered by email t... Abstract

Cited 4 times since 2022 (1.2 per year) source: EuropePMC

The international journal of cardiovascular imaging, Volume 38, Issue 9, 21 3 2022, Pages 1973-1985 Interaction between sex and left ventricular reverse remodeling and its association with outcomes after transcatheter aortic valve implantation. Kuneman JH, Butcher SC, Stassen J, Singh GK, Pio SM, van der Kley F, Ajmone Marsan N, Knuuti J, Bax JJ, Delgado V

Women with severe aortic stenosis (AS) have better long-term prognosis after transcatheter aortic valve implantation (TAVI) compared to men. Whether this is caused by sex-related differences in left ventricular (LV) reverse remodeling after TAVI is unknown. Patients with severe AS who underwent transfemoral TAVI between 2007 and 2018 were selected. LV dimensions, volumes, and ejection fraction (LVEF) were assessed by transthoracic echocardiography before TAVI and at 6 and 12 months follow-up aft... Abstract

Cited 3 times since 2022 (0.9 per year) source: EuropePMC

Acta diabetologica, Volume 59, Issue 7, 21 3 2022, Pages 949-957 The transferability and validity of a population-level simulation model for the economic evaluation of interventions in diabetes: the MICADO model. Emamipour S, Pagano E, Di Cuonzo D, Konings SRA, van der Heijden AA, Elders P, Beulens JWJ, Leal J, Feenstra TL

Aims: Valid health economic models are essential to inform the adoption and reimbursement of therapies for diabetes mellitus. Often existing health economic models are applied in other countries and settings than those where they were developed. This practice requires assessing the transferability of a model developed from one setting to another. We evaluate the transferability of the MICADO model, developed for the Dutch 2007 setting, in two different settings using a range of adjustment steps.... Abstract

Cited 1 times since 2022 (0.3 per year) source: EuropePMC

Journal of diabetes and its complications, Volume 36, Issue 6, 21 3 2022, Pages 108202 Confirmatory factor analysis including MRI-derived adipose tissues quantification improves associations of metabolic dysregulation to diastolic dysfunction. Klarenberg H, Dekkers IA, Peeters CFW, de Mutsert R, Jukema JW, Rosendaal FR, Leiner T, Gosselink M, Froeling M, Strijkers GJ, Boekholdt SM, Lamb HJ

Aims: To quantify metabolic impairment via a one-factor approach with confirmatory factor analysis (CFA) including MRI-derived visceral and subcutaneous adipose tissues and to associate it with diastolic dysfunction. Methods: In this cross-sectional analysis, 916 participants (53% female, mean age (SD): 56 (6)) underwent abdominal and cardiovascular MRI. With CFA a metabolic-load factor of metabolic-syndrome variables and visceral and subcutaneous adipose tissues was constructed. A piecewise str... Abstract

Cited 5 times since 2022 (1.5 per year) source: EuropePMC

BMC medical education, Volume 22, Issue 1, 21 3 2022, Pages 301 From ideal to real: a qualitative study of the implementation of in situ interprofessional simulation-based education. Ju M, Bochatay N, Robertson K, Frank J, O'Brien B, van Schaik S

Background: Despite the widespread adoption of interprofessional simulation-based education (IPSE) in healthcare as a means to optimize interprofessional teamwork, data suggest that IPSE may not achieve these intended goals due to a gap between the ideals and the realities of implementation. Methods: We conducted a qualitative case study that used the framework method to understand what and how core principles from guidelines for interprofessional education (IPE) and simulation-based education (... Abstract

Cited 2 times since 2022 (0.6 per year) source: EuropePMC

Frontiers in veterinary science, Volume 9, 20 3 2022, Pages 902559 Corrigendum: Overview of Cattle Diseases Listed Under Category C, D or E in the Animal Health Law for Which Control Programmes Are in Place Within Europe. Hodnik JJ, Acinger-Rogić Ž, Alishani M, Autio T, Balseiro A, Berezowski J, Carmo LP, Chaligiannis I, Conrady B, Costa L, Cvetkovikj I, Davidov I, Dispas M, Djadjovski I, Duarte EL, Faverjon C, Fourichon C, Frössling J, Gerilovych A, Gethmann J, Gomes J, Graham D, Guelbenzu M, Gunn GJ, Henry MK, Hopp P, Houe H, Irimia E, Ježek J, Juste RA, Kalaitzakis E, Kaler J, Kaplan S, Kostoulas P, Kovalenko K, Kneževič N, Knific T, Koleci X, Madouasse A, Malakauskas A, Mandelik R, Meletis E, Mincu M, Mõtus K, Muñoz-Gómez V, Niculae M, Nikitović J, Ocepek M, Tangen-Opsal M, Ózsvári L, Papadopoulos D, Papadopoulos T, Pelkonen S, Polak MP, Pozzato N, Rapaliuté E, Ribbens S, Niza-Ribeiro J, Roch FF, Rosenbaum Nielsen L, Saez JL, Nielsen SS, van Schaik G, Schwan E, Sekovska B, Starič J, Strain S, Šatran P, Šerić-Haračić S, Tamminen LM, Thulke HH, Toplak I, Tuunainen E, Verner S, Vilček Š, Yildiz R, Santman-Berends IMGA

[This corrects the article DOI: 10.3389/fvets.2021.688078.]. Abstract

Cited 6 times since 2022 (1.8 per year) source: EuropePMC

European journal of drug metabolism and pharmacokinetics, Volume 47, Issue 4, 20 3 2022, Pages 523-535 A Population Pharmacokinetic Model of Whole-Blood and Intracellular Tacrolimus in Kidney Transplant Recipients. Franken LG, Francke MI, Andrews LM, van Schaik RHN, Li Y, de Wit LEA, Baan CC, Hesselink DA, de Winter BCM

Background and objective: The tacrolimus concentration within peripheral blood mononuclear cells may correlate better with clinical outcomes after transplantation compared to concentrations measured in whole blood. However, intracellular tacrolimus measurements are not easily implemented in clinical practice. The prediction of intracellular concentrations based on whole-blood concentrations would be a solution for this. Therefore, the aim of this study was to describe the relationship between in... Abstract

Cited 8 times since 2022 (2.4 per year) source: EuropePMC

European journal of nuclear medicine and molecular imaging, Volume 49, Issue 10, 18 3 2022, Pages 3452-3469 FDG-PET/CT in indeterminate thyroid nodules: cost-utility analysis alongside a randomised controlled trial. de Koster EJ, Vriens D, van Aken MO, Dijkhorst-Oei LT, Oyen WJG, Peeters RP, Schepers A, de Geus-Oei LF, van den Hout WB, EfFECTS trial study group

Purpose: To evaluate cost-effectiveness of an [18F]FDG-PET/CT-driven diagnostic workup as compared to diagnostic surgery, for thyroid nodules with Bethesda III/IV cytology. [18F]FDG-PET/CT avoids 40% of futile diagnostic surgeries for benign Bethesda III/IV nodules. Methods: Lifelong societal costs and quality-adjusted life years (QALYs) were assessed for 132 patients participating in a randomised controlled multicentre trial comparing [18F]FDG-PET/CT to diagnostic surgery. The observed 1-year t... Abstract

Cited 8 times since 2022 (2.4 per year) source: EuropePMC

European journal of heart failure, Volume 24, Issue 6, 18 3 2022, Pages 976-984 Comparing and contrasting risk factors for heart failure in patients with and without history of myocardial infarction: data from HOMAGE and the UK Biobank. Rastogi T, Ho FK, Rossignol P, Merkling T, Butler J, Clark A, Collier T, Delles C, Jukema JW, Heymans S, Latini R, Mebazaa A, Pellicori P, Sever P, Staessen JA, Thijs L, Cleland JG, Sattar N, Zannad F, Girerd N

Aims: Myocardial infarction (MI) is among the commonest attributable risk factors for heart failure (HF). We compared clinical characteristics associated with the progression to HF in patients with or without a history of MI in the HOMAGE cohort and validated our results in UK Biobank. Methods and results: During a follow-up of 5.2 (3.5-5.9) years, 177 (2.4%) patients with prior MI and 370 (1.92%) patients without prior MI experienced HF onset in the HOMAGE cohort (n = 26 478, history of MI: n =... Abstract

Cited 12 times since 2022 (3.6 per year) source: EuropePMC

Campbell systematic reviews, Volume 18, Issue 2, 16 3 2022, Pages e1233 Evidence-informed practice versus evidence-based practice educational interventions for improving knowledge, attitudes, understanding, and behavior toward the application of evidence into practice: A comprehensive systematic review of UG student. Kumah EA, McSherry R, Bettany-Saltikov J, van Schaik P, Hamilton S, Hogg J, Whittaker V

Background: To produce graduates with strong knowledge and skills in the application of evidence into healthcare practice, it is imperative that all undergraduate health and social care students are taught, in an efficient manner, the processes involved in applying evidence into practice. The two main concepts that are linked to the application of evidence into practice are "evidence-based practice" and "evidence-informed practice." Globally, evidence-based practice is regard... Abstract

The international journal of cardiovascular imaging, Volume 38, Issue 9, 16 3 2022, Pages 1951-1960 Myocardial function in COVID-19 patients after hospital discharge: a descriptive study comparing the first and second 'wave' patients. Elffers TW, de Graaf MA, Regeer MV, Omara S, Schalij MJ, Groeneveld GH, Roukens AHE, Geelhoed JJM, Antoni ML

In hospitalized COVID-19 patients, myocardial injury and echocardiographic abnormalities have been described. The present study investigates cardiac function in COVID-19 patients 6 weeks post-discharge and evaluates its relation to New York Heart Association (NYHA) class. Furthermore cardiac function post-discharge between the first and second wave COVID-19 patients was compared. We evaluated 146 patients at the outpatient clinic of the Leiden University Medical Centre. NYHA class of II or highe... Abstract

Cited 1 times since 2022 (0.3 per year) source: EuropePMC

American heart journal, Volume 249, 15 3 2022, Pages 66-75 Computed tomography follow-up after elective proximal aortic surgery: Less is more? de Oliveira Marreiros DJ, Tomšič A, van Brakel TJ, Hamming JF, Scholte AJHA, Hjortnaes J, Klautz RJM

Study objective: The added value of computed tomography (CT) follow-up after elective proximal aortic surgery is unclear. We evaluated the benefit of CT follow-up by assessing the incidence of aorta-related complications and reinterventions detected during routine CT follow-up. Methods: Data on 314 patients undergoing first time elective proximal aortic surgery between 2000 and 2015 were collected. The primary study end points were aorta-related complications and reinterventions, detected during... Abstract

Cited 11 times since 2022 (3.3 per year) source: EuropePMC

Cells, Volume 11, Issue 8, 14 2 2022, Pages 1341 FK506-Binding Protein 11 Is a Novel Plasma Cell-Specific Antibody Folding Catalyst with Increased Expression in Idiopathic Pulmonary Fibrosis. Preisendörfer S, Ishikawa Y, Hennen E, Winklmeier S, Schupp JC, Knüppel L, Fernandez IE, Binzenhöfer L, Flatley A, Juan-Guardela BM, Ruppert C, Guenther A, Frankenberger M, Hatz RA, Kneidinger N, Behr J, Feederle R, Schepers A, Hilgendorff A, Kaminski N, Meinl E, Bächinger HP, Eickelberg O, Staab-Weijnitz CA

Antibodies are central effectors of the adaptive immune response, widespread used therapeutics, but also potentially disease-causing biomolecules. Antibody folding catalysts in the plasma cell are incompletely defined. Idiopathic pulmonary fibrosis (IPF) is a fatal chronic lung disease with increasingly recognized autoimmune features. We found elevated expression of FK506-binding protein 11 (FKBP11) in IPF lungs where FKBP11 specifically localized to antibody-producing plasma cells. Suggesting a... Abstract

Cited 1 times since 2022 (0.3 per year) source: EuropePMC

Cardiology and cardiovascular medicine, Volume 6, Issue 2, 14 2 2022, Pages 171-188 Development of Central Venous Stenosis Upon ICD Implantation in Dialysis Patients: A Non-Negligible Issue. Timal RJ, Karalis I, Cabezas JMM, Rotmans JI, Hensen LCR, Buiten MS, de Bie MK, van Erven L, Putter H, Schalij MJ, Rabelink TJ, Jukema JW

Background: In hemodialysis patients, implantable cardioverter-defibrillator (ICD) implantation may result in central venous stenosis (CVS) with associated symptoms, such as pain, edema of the ipsilateral arm, facial edema, and loss of dialysis access. However, literature concerning CVS in dialysis patients with a cardiac implantable electronic device is scarce. Methods: We conducted a prospective cohort study in which we investigated the incidence of CVS in end-stage renal disease patients on c... Abstract

Cited 23 times since 2022 (6.9 per year) source: EuropePMC

JACC. Cardiovascular imaging, Volume 15, Issue 6, 13 2 2022, Pages 1063-1074 Relationship Between Coronary Artery Calcium and Atherosclerosis Progression Among Patients With Suspected Coronary Artery Disease. Hollenberg EJ, Lin F, Blaha MJ, Budoff MJ, van den Hoogen IJ, Gianni U, Lu Y, Bax AM, van Rosendael AR, Tantawy SW, Andreini D, Cademartiri F, Chinnaiyan K, Choi JH, Conte E, de Araújo Gonçalves P, Hadamitzky M, Maffei E, Pontone G, Shin S, Kim YJ, Lee BK, Chun EJ, Sung JM, Gimelli A, Lee SE, Bax JJ, Berman DS, Sellers SL, Leipsic JA, Blankstein R, Narula J, Chang HJ, Shaw LJ

Background: Among symptomatic patients, it remains unclear whether a coronary artery calcium (CAC) score alone is sufficient or misses a sizeable burden and progressive risk associated with obstructive and nonobstructive atherosclerotic plaque. Objectives: Among patients with low to high CAC scores, our aims were to quantify co-occurring obstructive and nonobstructive noncalcified plaque and serial progression of atherosclerotic plaque volume. Methods: A total of 698 symptomatic patients with su... Abstract

Cited 5 times since 2022 (1.5 per year) source: EuropePMC

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, Volume 30, Issue 7, 13 2 2022, Pages 6093-6102 Body mass index at diagnosis of a childhood brain tumor; a reflection of hypothalamic-pituitary dysfunction or lifestyle? van Roessel IMAA, van Schaik J, Meeteren AYNS, Boot AM, der Grinten HLC, Clement SC, van Iersel L, Han KS, van Trotsenburg ASP, Vandertop WP, Kremer LCM, van Santen HM

Purpose: Childhood brain tumor survivors (CBTS) are at risk of becoming overweight, which has been shown to be associated with hypothalamic-pituitary (HP) dysfunction during follow-up. Body mass index (BMI) at diagnosis is related to BMI at follow-up. It is uncertain, however, whether aberrant BMI at brain tumor diagnosis reflects early hypothalamic dysfunction or rather reflects genetic and sociodemographic characteristics. We aimed to examine whether BMI at childhood brain tumor diagnosis is a... Abstract

Cited 2 times since 2022 (0.6 per year) source: EuropePMC

Biomedicines, Volume 10, Issue 4, 13 2 2022, Pages 896 Influence of Receptor Polymorphisms on the Response to α-Adrenergic Receptor Blockers in Pheochromocytoma Patients. Berends AMA, Bolhuis MS, Nolte IM, Buitenwerf E, Links TP, Timmers HJLM, Feelders RA, Eekhoff EMW, Corssmit EPM, Bisschop PH, Haak HR, van Schaik RHN, El Bouazzaoui S, Wilffert B, Kerstens MN

Background: Presurgical treatment with an α-adrenergic receptor blocker is recommended to antagonize the catecholamine-induced α-adrenergic receptor mediated vasoconstriction in patients with pheochromocytoma or sympathetic paraganglioma (PPGL). There is, however, a considerable interindividual variation in the dose-response relationship regarding the magnitude of blood pressure reduction or the occurrence of side effects. We hypothesized that genetically determined differences in α-adrenergic r... Abstract