Research

Publications

Below you can find a list of our published research.

9618 results

Cited 22 times since 2022 (6.6 per year) source: EuropePMC

JACC. Cardiovascular interventions, Volume 15, Issue 9, 13 2 2022, Pages 935-945 Prognostic Value of Increased Mitral Valve Gradient After Transcatheter Edge-to-Edge Repair for Primary Mitral Regurgitation. Yoon SH, Makar M, Kar S, Chakravarty T, Oakley L, Sekhon N, Koseki K, Enta Y, Nakamura M, Hamilton M, Patel JK, Singh S, Skaf S, Siegel RJ, Bax JJ, Makkar RR

Objectives: This study sought to evaluate the prognostic value of an increased mean mitral valve pressure gradient (MVG) in patients with primary mitral regurgitation (MR) after transcatheter edge-to-edge repair (TEER). Background: Conflicting data exist regarding impact of increased mean MVG on outcomes after TEER. Methods: This study included 419 patients with primary MR (mean age 80.6 ± 10.4 years; 40.6% female) who underwent TEER. Patients were divided into quartiles (Qs) based on discharge... Abstract

Cited 1 times since 2022 (0.3 per year) source: EuropePMC

International journal of cardiology. Congenital heart disease, Volume 9, 12 2 2022, Pages 100373 Strategies for low-molecular-weight heparin management in pregnant women with mechanical prosthetic heart valves: A nationwide survey of Dutch practice. Voortman M, Roos JW, Slomp J, van Dijk APJ, Bouma BJ, Sieswerda GTJ, Kiès P, Boer A, Waskowsky WM, von Birgelen C, Wagenaar LJ

Background: In this study we investigated current Dutch practice of low molecular weight heparin (LMWH) treatment in pregnant women with mechanical prosthetic heart valves (MPHV) in order to evaluate how management can be optimized. Methods: Between December 2020 and February 2021, we conducted a survey among Dutch congenital cardiologists of tertiary centers in the Netherlands. We collected and analyzed written, unstructured, open questionnaires that were send to all 8 specialized pregnancy hea... Abstract

Cited 5 times since 2022 (1.5 per year) source: EuropePMC

JACC. Asia, Volume 2, Issue 3, 12 2 2022, Pages 311-319 Longitudinal Quantitative Assessment of Coronary Atherosclerotic Plaque Burden Related to Serum Hemoglobin Levels. Won KB, Lee BK, Heo R, Park HB, Lin FY, Hadamitzky M, Kim YJ, Sung JM, Conte E, Andreini D, Pontone G, Budoff MJ, Gottlieb I, Chun EJ, Cademartiri F, Maffei E, Marques H, de Araújo Gonçalves P, Leipsic JA, Lee SE, Shin S, Choi JH, Virmani R, Samady H, Chinnaiyan K, Berman DS, Narula J, Bax JJ, Min JK, Chang HJ

Background: Despite a potential role of hemoglobin in atherosclerosis, data on coronary plaque volume changes (PVC) related to serum hemoglobin levels are limited. Objectives: The authors sought to evaluate coronary atherosclerotic plaque burden changes related to serum hemoglobin levels using serial coronary computed tomographic angiography (CCTA). Methods: A total of 830 subjects (age 61 ± 10 years, 51.9% male) who underwent serial CCTA were analyzed. The median interscan period was 3.2 (IQR:... Abstract

Cited 11 times since 2022 (3.3 per year) source: EuropePMC

Clinical anatomy (New York, N.Y.), Volume 35, Issue 6, 9 2 2022, Pages 701-710 The lymphatic system throughout history: From hieroglyphic translations to state of the art radiological techniques. van Schaik CJ, Boer LL, Draaisma JMT, van der Vleuten CJM, Janssen JJ, Fütterer JJ, Schultze Kool LJ, Klein WM

A comprehensive lymphatic system is indispensable for a well-functioning body; it is integral to the immune system and is also interrelated with the digestive system and fluid homeostasis. The main difficulty in examining the lymphatic system is its fine-meshed structure. This remains a challenge, leaving patients with uninterpreted symptoms and a dearth of potential therapies. We review the history of the lymphatic system up to the present with the aim of improving current knowledge. Several fi... Abstract

Cited 8 times since 2022 (2.4 per year) source: EuropePMC

Journal of ultrasound, Volume 25, Issue 4, 8 2 2022, Pages 957-963 The role of sonographic optic nerve sheath diameter measurements in pediatric head trauma. Şık N, Ulusoy E, Çitlenbik H, Öztürk A, Er A, Yılmaz D, Duman M

Purpose: To determine the accuracy of bedside sonographic measurements of optic nerve sheath diameter (ONSD) and ONSD/eyeball transverse (ETD) diameter ratios to predict space-occupying lesions (SOLs) or elevated intracranial pressure (ICP) in pediatric head trauma. Methods: Children who presented to the emergency department with head trauma and underwent cranial computed tomography (CT) were enrolled and examined by ocular ultrasonography (US), and the ONSD was measured at 3 mm posterior to the... Abstract

Cited 14 times since 2022 (4.2 per year) source: EuropePMC

Developmental science, Volume 26, Issue 1, 7 1 2022, Pages e13259 How infant-directed actions enhance infants' attention, learning, and exploration: Evidence from EEG and computational modeling. Meyer M, van Schaik JE, Poli F, Hunnius S

When teaching infants new actions, parents tend to modify their movements. Infants prefer these infant-directed actions (IDAs) over adult-directed actions and learn well from them. Yet, it remains unclear how parents' action modulations capture infants' attention. Typically, making movements larger than usual is thought to draw attention. Recent findings, however, suggest that parents might exploit movement variability to highlight actions. We hypothesized that variability in movement... Abstract

Nature communications, Volume 13, Issue 1, 6 1 2022, Pages 1962 Publisher Correction: Elucidating mechanisms of genetic cross-disease associations at the PROCR vascular disease locus. Stacey D, Chen L, Stanczyk PJ, Howson JMM, Mason AM, Burgess S, MacDonald S, Langdown J, McKinney H, Downes K, Farahi N, Peters JE, Basu S, Pankow JS, Tang W, Pankratz N, Sabater-Lleal M, de Vries PS, Smith NL, CHARGE Hemostasis Working Group, Gelinas AD, Schneider DJ, Janjic N, Samani NJ, Ye S, Summers C, Chilvers ER, Danesh J, Paul DS

Abstract

Cited 14 times since 2022 (4.2 per year) source: EuropePMC

Bone research, Volume 10, Issue 1, 6 1 2022, Pages 33 Inhibition of Cdk5 increases osteoblast differentiation and bone mass and improves fracture healing. Ahmad M, Krüger BT, Kroll T, Vettorazzi S, Dorn AK, Mengele F, Lee S, Nandi S, Yilmaz D, Stolz M, Tangudu NK, Vázquez DC, Pachmayr J, Cirstea IC, Spasic MV, Ploubidou A, Ignatius A, Tuckermann J

Identification of regulators of osteoblastogenesis that can be pharmacologically targeted is a major goal in combating osteoporosis, a common disease of the elderly population. Here, unbiased kinome RNAi screening in primary murine osteoblasts identified cyclin-dependent kinase 5 (Cdk5) as a suppressor of osteoblast differentiation in both murine and human preosteoblastic cells. Cdk5 knockdown by siRNA, genetic deletion using the Cre-loxP system, or inhibition with the small molecule roscovitine... Abstract

Cited 4 times since 2022 (1.2 per year) source: EuropePMC

European stroke journal, Volume 7, Issue 2, 6 1 2022, Pages 180-187 Prevalence, risk factors, and long-term outcomes of cerebral ischemia in hospitalized COVID-19 patients - study rationale and protocol of the CORONIS study: A multicentre prospective cohort study. van Lith TJ, Sluis WM, Wijers NT, Meijer FJ, Kamphuis-van Ulzen K, de Bresser J, Dankbaar JW, van den Heuvel FM, Antoni ML, Mulders-Manders CM, de Mast Q, van de Veerdonk FL, Klok FA, Tuladhar AM, Cannegieter SC, Wermer MJ, van der Worp HB, Huisman MV, de Leeuw FE

Background: COVID-19 is often complicated by thrombo-embolic events including ischemic stroke. The underlying mechanisms of COVID-19-associated ischemic stroke, the incidence and risk factors of silent cerebral ischemia, and the long-term functional outcome in these patients are currently unknown. Patients and methods: CORONavirus and Ischemic Stroke (CORONIS) is a multicentre prospective cohort study investigating the prevalence, risk factors and long-term incidence of (silent) cerebral ischemi... Abstract

Cited 7 times since 2022 (2.1 per year) source: EuropePMC

Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy, Volume 62, 5 1 2022, Pages 100832 Clinical implications of germline variations for treatment outcome and drug resistance for small molecule kinase inhibitors in patients with non-small cell lung cancer. Heersche N, Veerman GDM, de With M, Bins S, Assaraf YG, Dingemans AC, van Schaik RHN, Mathijssen RHJ, Jansman FGA

Small-molecule kinase inhibitors (SMKIs) represent the cornerstone in the treatment of non-small cell lung cancer (NSCLC) patients harboring genetic driver mutations. Because of the introduction of SMKIs in the last decades, treatment outcomes have drastically improved. Their treatment efficacy, the development of drug resistance as well as untoward toxicity, all suffer from large patient variability. This variability can be explained, at least in part, by their oral route of administration, whi... Abstract

Cited 6 times since 2022 (1.8 per year) source: EuropePMC

Philosophical transactions of the Royal Society of London. Series B, Biological sciences, Volume 377, Issue 1851, 4 1 2022, Pages 20210150 Male services during between-group conflict: the 'hired gun' hypothesis revisited. Bshary R, Richter XL, van Schaik C

In many group-living mammals, philopatric females form the stable core of the group and defend food or shelter against other groups of females. Where males are larger, their participation could give their female group the edge. How can females secure the contribution of males that are neither the father of current infants, nor the dominant male expecting to sire the next generation of infants? It has been proposed that females recruit these males as 'hired guns', receiving social suppo... Abstract

Cited 11 times since 2022 (3.3 per year) source: EuropePMC

Antimicrobial resistance and infection control, Volume 11, Issue 1, 4 1 2022, Pages 55 Routes of transmission of VIM-positive Pseudomonas aeruginosa in the adult intensive care unit-analysis of 9 years of surveillance at a university hospital using a mathematical model. Pham TM, Büchler AC, Voor In 't Holt AF, Severin JA, Bootsma MCJ, Gommers D, Kretzschmar ME, Vos MC

Background: Hospital outbreaks of multidrug resistant Pseudomonas aeruginosa are often caused by Pseudomonas aeruginosa clones which produce metallo-β-lactamases, such as Verona Integron-encoded Metallo-β-lactamase (VIM). Although different sources have been identified, the exact transmission routes often remain unknown. However, quantifying the role of different transmission routes of VIM-PA is important for tailoring infection prevention and control measures. The aim of this study is to quanti... Abstract

Cited 4 times since 2022 (1.2 per year) source: EuropePMC

Proceedings of the National Academy of Sciences of the United States of America, Volume 119, Issue 14, 1 1 2022, Pages e2112886119 Phenotype-Based Threat Assessment. Yang J, Eslami M, Chen YP, Das M, Zhang D, Chen S, Roberts AJ, Weston M, Volkova A, Faghihi K, Moore RK, Alaniz RC, Wattam AR, Dickerman A, Cucinell C, Kendziorski J, Coburn S, Paterson H, Obanor O, Maples J, Servetas S, Dootz J, Qin QM, Samuel JE, Han A, van Schaik EJ, de Figueiredo P

Bacterial pathogen identification, which is critical for human health, has historically relied on culturing organisms from clinical specimens. More recently, the application of machine learning (ML) to whole-genome sequences (WGSs) has facilitated pathogen identification. However, relying solely on genetic information to identify emerging or new pathogens is fundamentally constrained, especially if novel virulence factors exist. In addition, even WGSs with ML pipelines are unable to discern phen... Abstract

European heart journal. Cardiovascular Imaging, Volume 23, Issue 5, 1 1 2022, Pages 590-597 EACVI survey on hypertrophic cardiomyopathy. Podlesnikar T, Cardim N, Ajmone Marsan N, D'Andrea A, Cameli M, Popescu BA, Schulz-Menger J, Stankovic I, Toplisek J, Maurer G, Haugaa KH, Dweck MR

Aims: The European Association of Cardiovascular Imaging (EACVI) Scientific Initiatives Committee performed a global survey to evaluate current practice for the assessment and management of patients with hypertrophic cardiomyopathy (HCM). Methods and results: A total of 213 centres from 38 different countries (87% European) responded to the survey. One hundred twenty-one (57%) centres followed HCM patients in a general cardiology outpatient clinic and 85 (40%) centres in a specialized HCM/cardio... Abstract

Diabetes care, Volume 45, Issue 4, 1 1 2022, Pages e82-e83 Response to Comment on Dawed et al. Genome-Wide Meta-analysis Identifies Genetic Variants Associated With Glycemic Response to Sulfonylureas. Diabetes Care 2021;44:2673-2682. Dawed AY, Yee SW, Zhou K, van Leeuwen N, Zhang Y, Siddiqui MK, Etheridge A, Innocenti F, Xu F, Li JH, Beulens JW, van der Heijden AA, Slieker RC, Chang YC, Mercader JM, Kaur V, Witte JS, Lee MTM, Kamatani Y, Momozawa Y, Kubo M, Palmer CNA, Florez JC, Hedderson MM, 't Hart LM, Giacomini KM, Pearson ER, for MetGen Plus, for the DIRECT Consortium

Abstract

Cited 27 times since 2022 (8 per year) source: EuropePMC

The lancet. Diabetes & endocrinology, Volume 10, Issue 5, 1 1 2022, Pages 330-340 Metabolic risk factors and effect of alirocumab on cardiovascular events after acute coronary syndrome: a post-hoc analysis of the ODYSSEY OUTCOMES randomised controlled trial. Ostadal P, Steg PG, Poulouin Y, Bhatt DL, Bittner VA, Chua T, Diaz R, Goodman SG, Huo Y, Jukema JW, Karpov Y, Pordy R, Scemama M, Szarek M, White HD, Schwartz GG, ODYSSEY OUTCOMES Investigators

Background: Many patients with acute coronary syndrome have concurrent metabolic risk factors that affect risk of major adverse cardiovascular events (MACE). We aimed to assess the effects of the PCSK9 inhibitor alirocumab compared with placebo on MACE according to baseline metabolic risk factors. Methods: We performed a post-hoc analysis of the ODYSSEY OUTCOMES trial, which was a multicentre, double-blind, randomised controlled trial done in 1315 hospitals and outpatient clinics in 57 countries... Abstract

Cited 9 times since 2022 (2.7 per year) source: EuropePMC

European heart journal. Cardiovascular Imaging, Volume 23, Issue 5, 1 1 2022, Pages 699-707 Prognostic implications of left ventricular myocardial work index in patients with ST-segment elevation myocardial infarction and reduced left ventricular ejection fraction. Butcher SC, Lustosa RP, Abou R, Marsan NA, Bax JJ, Delgado V

Aims: This study aimed to determine whether lower values of left ventricular (LV) global work index (GWI) at baseline were associated with a reduction in LV functional recovery and poorer long-term prognosis in patients with reduced LV ejection fraction (LVEF ≤40%) following ST-segment elevation myocardial infarction (STEMI). Methods and results: A total of 197 individuals (62 ± 12 years, 75% male) with STEMI treated with primary percutaneous coronary intervention and reduced LVEF were evaluated... Abstract

Cited 2 times since 2022 (0.6 per year) source: EuropePMC

The American journal of cardiology, Volume 173, 1 1 2022, Pages 48-55 Meta-Analysis of Bilateral Versus Single Internal Thoracic Artery Grafting in Patients ≥70 Years of Age. Mulder BS, Candura D, Schoones JW, Etnel JRG, Schouten GN, de Weger A, Tomšič A, Klautz RJM

The optimal choice of graft material in patients ≥70 years of age undergoing coronary artery bypass grafting remains unknown. A systematic review of literature was conducted by searching PubMed, Embase, Web of Science, and Cochrane Library databases for original publications that compared bilateral internal thoracic artery (BITA) grafting with single internal thoracic artery grafting in patients ≥70 years of age. Data were extracted by 2 independent investigators and meta-analyzed with the use o... Abstract

Cited 19 times since 2022 (5.6 per year) source: EuropePMC

The American journal of cardiology, Volume 173, 1 1 2022, Pages 120-127 Prognostic Implications of Right Ventricular Systolic Dysfunction in Cardiac Amyloidosis. Tjahjadi C, Fortuni F, Stassen J, Debonnaire P, Lustosa RP, Marsan NA, Delgado V, Bax JJ

Left ventricular (LV) systolic dysfunction in cardiac amyloidosis (CA) is associated with poor prognosis. This study aimed to investigate the prognostic implications of right ventricular (RV) systolic dysfunction in CA. A total of 93 patients diagnosed with CA who underwent standard and speckle-tracking echocardiography were included. During a median follow-up of 17 (5 to 38) months, 42 patients (45%) died. Nonsurvivors were more likely to present with immunoglobulin light-chain amyloidosis and... Abstract

Cited 2 times since 2022 (0.6 per year) source: EuropePMC

JACC. Cardiovascular interventions, Volume 15, Issue 8, 1 1 2022, Pages 901 The Ratio Fallacy of Prosthesis-Patient Mismatch. Velders BJJ, Vriesendorp MD, Herrmann HC, Klautz RJM

Abstract