9618 results
Cited 5 times since 2022 (1.5 per year)
source: EuropePMC
Infection and immunity,
Volume 90, Issue 5, 22 4 2022, Pages e0057921
A Resourceful Race: Bacterial Scavenging of Host Sulfur Metabolism during Colonization.
Kies PJ, Hammer ND
Sulfur is a requirement for life. Therefore, both the host and colonizing bacteria must regulate sulfur metabolism in a coordinated fashion to meet cellular demands. The host environment is a rich source of organic and inorganic sulfur metabolites that are utilized in critical physiological processes such as redox homeostasis and cellular signaling. As such, modulating enzymes dedicated to sulfur metabolite biosynthesis plays a vital role in host fitness. This is exemplified from a molecular sta...
Abstract
Nederlands tijdschrift voor geneeskunde,
Volume 166, 21 3 2022, Pages D6190
[Disorders of the central lymphatic system].
van Schaik CJ, Janssen JJ, van der Vleuten CJM, Te Loo MWM, Schultze Kool LJ, Klein WM
The central lymphatic system consists of the thoracic duct, cisterna chyli and the retroperitoneal lymphatics through which lymph and chyle flows. Disorders of the central lymphatic system can for instance lead to leakage (chylothorax), accumulation of fluid (lymphedema) and retrograde flow (protein losing enteropathy). Abnormalities in the central lymphatic system were overlooked for years, followed by lack of diagnostic and therapeutic options. This has changed, as the technique of intranodal...
Abstract
Cited 6 times since 2022 (1.8 per year)
source: EuropePMC
Transplant international : official journal of the European Society for Organ Transplantation,
Volume 35, 21 3 2022, Pages 10122
Donor-Derived Cell-Free DNA for the Detection of Heart Allograft Injury: The Impact of the Timing of the Liquid Biopsy.
Verhoeven JGHP, Hesselink DA, Peeters AMA, de Jonge E, von der Thüsen JH, van Schaik RHN, Matic M, Baan CC, Manintveld OC, Boer K
Background: In heart transplant recipients, donor-derived cell-free DNA (ddcfDNA) is a potential biomarker for acute rejection (AR), in that increased values may indicate rejection. For the assessment of ddcfDNA as new biomarker for rejection, blood plasma sampling around the endomyocardial biopsy (EMB) seems a practical approach. To evaluate the effect of the EMB procedure on ddcfDNA values, ddcfDNA values before the EMB were pairwise compared to ddcfDNA values after the EMB. We aimed at evalua...
Abstract
Cited 7 times since 2022 (2.1 per year)
source: EuropePMC
Clinical oral investigations,
Volume 26, Issue 7, 21 3 2022, Pages 4897-4904
Salivary levels of hBDs in children and adolescents with type 1 diabetes mellitus and gingivitis.
Yilmaz D, Yilmaz N, Polat R, Nissilä V, Aydın EG, Rautava J, Gürsoy M, Gürsoy UK
Objectives: Type 1 diabetes mellitus (T1DM), a chronic autoimmune disease characterized by insulin deficiency, is related to periodontal diseases in children and adolescents. Our aim was to profile salivary human beta-defensin (hBD)-2 and hBD-3 concentrations in relation to periodontal and T1DM status in children and adolescent populations. Material and methods: Unstimulated saliva samples were collected from 66 participants including periodontally healthy T1DM patients (T1DM + C; n = 18), T1DM...
Abstract
Cited 2 times since 2022 (0.6 per year)
source: EuropePMC
Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists,
Volume 30, Issue 3, 21 3 2022, Pages 419-432
Nationwide Outcomes of Octogenarians Following Open or Endovascular Management After Ruptured Abdominal Aortic Aneurysms.
Alberga AJ, de Bruin JL, Bastos Gonçalves F, Karthaus EG, Wilschut JA, van Herwaarden JA, Wever JJ, Verhagen HJM, Collaboration With the Dutch Society of Vascular Surgery*, the Steering Committee of the Dutch Surgical Aneurysm Audit and the Dutch Institute for Clinical Auditing
Purpose: Octogenarians are known to have less-favorable outcomes following ruptured abdominal aortic aneurysm (rAAA) repair compared with their younger counterparts. Accurate information regarding perioperative outcomes following rAAA-repair is important to evaluate current treatment practice. The aim of this study was to evaluate perioperative outcomes of octogenarians and to identify factors associated with mortality and major complications after open surgical repair (OSR) or endovascular aneu...
Abstract
Cited 4 times since 2022 (1.2 per year)
source: EuropePMC
The American journal of cardiology,
Volume 172, 19 3 2022, Pages 54-61
The Quantity of Epicardial Adipose Tissue in Patients Having Ablation for Atrial Fibrillation With and Without Heart Failure.
Wang X, Butcher SC, Kuneman JH, Lustosa RP, Fortuni F, Ajmone Marsan N, Knuuti J, Bax JJ, Delgado V
The distribution of epicardial adipose tissue (EAT) across the spectrum of heart failure (HF) has yet to be fully elucidated. The present study investigated the distribution of EAT in an HF spectrum and its association with clinical and echocardiographic parameters. A total of 326 patients who underwent contrast-enhanced computed tomography before transcatheter atrial fibrillation ablation with and without HF symptoms, and a wide range of left ventricular (LV) ejection fractions (LVEF) were incl...
Abstract
Cited 7 times since 2022 (2 per year)
source: EuropePMC
Molecular therapy. Nucleic acids,
Volume 28, 19 3 2022, Pages 307-327
Extracellular vesicles enriched with an endothelial cell pro-survival microRNA affects skin tissue regeneration.
Fernandes H, Zonnari A, Abreu R, Aday S, Barão M, Albino I, Lino M, Branco A, Seabra C, Barata T, Leal EC, Tralhão JG, Gonçalves L, de Jong A, Peters HAB, de Vries MR, da Costa Martins P, Quax PHA, Ferreira L
Endothelial cell (EC) activity is essential for tissue regeneration in several (patho)physiological contexts. However, our capacity to deliver in vivo biomolecules capable of controlling EC fate is relatively limited. Here, we screened a library of microRNA (miR) mimics and identified 25 miRs capable of enhancing the survival of ECs exposed to ischemia-mimicking conditions. In vitro, we showed that miR-425-5p, one of the hits, was able to enhance EC survival and migration. In vivo, using a mouse...
Abstract
Cited 40 times since 2022 (11.7 per year)
source: EuropePMC
BMJ quality & safety,
Volume 31, Issue 5, 18 3 2022, Pages 402-408
The problem with making Safety-II work in healthcare.
Verhagen MJ, de Vos MS, Sujan M, Hamming JF
Abstract
Cited 151 times since 2022 (44.2 per year)
source: EuropePMC
Cell metabolism,
Volume 34, Issue 4, 18 3 2022, Pages 533-548.e12
Ejection of damaged mitochondria and their removal by macrophages ensure efficient thermogenesis in brown adipose tissue.
Rosina M, Ceci V, Turchi R, Chuan L, Borcherding N, Sciarretta F, Sánchez-Díaz M, Tortolici F, Karlinsey K, Chiurchiù V, Fuoco C, Giwa R, Field RL, Audano M, Arena S, Palma A, Riccio F, Shamsi F, Renzone G, Verri M, Crescenzi A, Rizza S, Faienza F, Filomeni G, Kooijman S, Rufini S, de Vries AAF, Scaloni A, Mitro N, Tseng YH, Hidalgo A, Zhou B, Brestoff JR, Aquilano K, Lettieri-Barbato D
Recent findings have demonstrated that mitochondria can be transferred between cells to control metabolic homeostasis. Although the mitochondria of brown adipocytes comprise a large component of the cell volume and undergo reorganization to sustain thermogenesis, it remains unclear whether an intercellular mitochondrial transfer occurs in brown adipose tissue (BAT) and regulates adaptive thermogenesis. Herein, we demonstrated that thermogenically stressed brown adipocytes release extracellular v...
Abstract
Cited 17 times since 2022 (5 per year)
source: EuropePMC
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology,
Volume 52, Issue 6, 18 3 2022, Pages 801-805
Ocular surface disease is common in moderate-to-severe atopic dermatitis patients.
Achten RE, Bakker DS, van Luijk CM, van der Wal M, de Graaf M, van Wijk F, Zuithoff NPA, van der Rijst LP, Boesjes CM, Thijs JL, de Boer JH, de Bruin-Weller MS
Abstract
Cited 12 times since 2022 (3.5 per year)
source: EuropePMC
Life (Basel, Switzerland),
Volume 12, Issue 3, 17 3 2022, Pages 446
Near-Infrared Fluorescence Tumor-Targeted Imaging in Lung Cancer: A Systematic Review.
Neijenhuis LKA, de Myunck LDAN, Bijlstra OD, Kuppen PJK, Hilling DE, Borm FJ, Cohen D, Mieog JSD, Steup WH, Braun J, Burggraaf J, Vahrmeijer AL, Hutteman M
Lung cancer is the most common cancer type worldwide, with non-small cell lung cancer (NSCLC) being the most common subtype. Non-disseminated NSCLC is mainly treated with surgical resection. The intraoperative detection of lung cancer can be challenging, since small and deeply located pulmonary nodules can be invisible under white light. Due to the increasing use of minimally invasive surgical techniques, tactile information is often reduced. Therefore, several intraoperative imaging techniques...
Abstract
Cited 11 times since 2022 (3.2 per year)
source: EuropePMC
Frontiers in cardiovascular medicine,
Volume 9, 17 3 2022, Pages 845359
The Prognostic Value of Right Atrial and Right Ventricular Functional Parameters in Systemic Sclerosis.
Vos JL, Butcher SC, Fortuni F, Galloo X, Rodwell L, Vonk MC, Bax JJ, van Leuven SI, de Vries-Bouwstra JK, Snoeren M, El Messaoudi S, Marsan NA, Nijveldt R
Introduction: Right ventricular (RV) function is of particular importance in systemic sclerosis (SSc), since common SSc complications, such as interstitial lung disease and pulmonary hypertension may affect RV afterload. Cardiovascular magnetic resonance (CMR) is the gold standard for measuring RV function. CMR-derived RV and right atrial (RA) strain is a promising tool to detect subtle changes in RV function, and might have incremental value, however, prognostic data is lacking. Therefore, the...
Abstract
Cited 1 times since 2022 (0.3 per year)
source: EuropePMC
Therapeutic advances in medical oncology,
Volume 14, 17 3 2022, Pages 17588359221081075
Influence of probenecid on endoxifen systemic exposure in breast cancer patients on adjuvant tamoxifen treatment.
Buck SAJ, Braal CL, Hofman MM, Oomen-de Hoop E, de Bruijn P, Ghobadi Moghaddam-Helmantel IM, Hussaarts KGAM, Vastbinder MB, van Rossum-Schornagel QC, van Schaik RHN, Jager A, Koolen SLW, Mathijssen RHJ
Introduction: In breast cancer patients treated with the anti-estrogen tamoxifen, low concentrations of the active metabolite endoxifen are associated with more disease recurrence. We hypothesized that we could increase endoxifen concentrations by induction of its formation and inhibition of its metabolism by co-administration of probenecid. Methods: We conducted a crossover study and measured endoxifen concentrations in patients on steady-state tamoxifen monotherapy and after 14 days of combina...
Abstract
Preventive veterinary medicine,
Volume 202, 16 3 2022, Pages 105611
SVEPM 2021 - Research sharing and networking in times of pandemic: The online Annual Conference of the Society for Veterinary Epidemiology and Preventive Medicine.
Dórea FC, Vergne T, van Schaik G, Barrett D, Carmo LP, Robinson PA, Brodbelt DC, McIntyre KM
Abstract
Cited 13 times since 2022 (3.8 per year)
source: EuropePMC
Advanced drug delivery reviews,
Volume 184, 16 3 2022, Pages 114184
Pharmaceutical applications of a nanospectroscopic technique: Surface-enhanced Raman spectroscopy.
Yilmaz H, Yilmaz D, Taskin IC, Culha M
Surface-enhanced Raman spectroscopy (SERS) is a very sensitive technique offering unique opportunities for detection and identification of molecules and molecular structures at extremely low concentrations even in complex sample matrixes. Since a nanostructured noble metal surface is required for the enhancement of Raman scattering, the acquired spectral information naturally originates from nanometer size domains making it a nanospectroscopic technique by breaking the diffraction limit of light...
Abstract
Cited 2 times since 2022 (0.6 per year)
source: EuropePMC
Frontiers in cardiovascular medicine,
Volume 8, 15 3 2022, Pages 779075
Continuum of Care: Positioning of the Virtual Hospital.
van der Lande ACMH, Treskes RW, Beeres SLMA, Schalij MJ
Introduction: Patients with multiple chronic diseases suffer from reduced life expectancy. Care for these patients is often divided over multiple healthcare professionals. eHealth might help to integrate care for these patients and create a continuum. It is the primary purpose of this paper to describe an intervention that integrates first, second, and third line care in patients with multiple chronic conditions using remote monitoring, remote therapy and data automatization, all integrated in a...
Abstract
Cited 19 times since 2022 (5.5 per year)
source: EuropePMC
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography,
Volume 35, Issue 8, 15 3 2022, Pages 791-800.e4
Left Ventricular Global Longitudinal Strain in Patients with Moderate Aortic Stenosis.
Stassen J, Pio SM, Ewe SH, Singh GK, Hirasawa K, Butcher SC, Cohen DJ, Généreux P, Leon MB, Marsan NA, Delgado V, Bax JJ
Moderate aortic stenosis (AS) is associated with an increased risk for adverse events. Although reduced left ventricular (LV) global longitudinal strain (GLS) is associated with worse outcomes in patients with severe AS, its prognostic value in patients with moderate AS is unknown. The aim of this study was to investigate the prognostic implications of LV GLS in patients with moderate AS. Methods: LV GLS was evaluated using speckle-tracking echocardiography in patients with moderate AS (aortic v...
Abstract
Cited 2 times since 2022 (0.6 per year)
source: EuropePMC
Medical sciences (Basel, Switzerland),
Volume 10, Issue 1, 15 3 2022, Pages 19
Parathyroid Allotransplantation: A Systematic Review.
Zhang JLH, Appelman-Dijkstra NM, Schepers A
Background: To date, there is no satisfactory treatment for patients with calcium and vitamin D supplementation refractive hypoparathyroidism. Parathyroid allotransplantation by design is a one-time cure through its restoration of the parathyroid function and, therefore, could be the solution. A systematic literature review is conducted in the present paper, with the aim of outlining the possibilities of parathyroid allotransplantation and to calculate its efficacy. Additionally, various transpl...
Abstract
Cited 10 times since 2022 (2.9 per year)
source: EuropePMC
Cancers,
Volume 14, Issue 6, 15 3 2022, Pages 1494
Impact of <i>BRCA</i> Status on Reproductive Decision-Making and Self-Concept: A Mixed-Methods Study Informing the Development of Tailored Interventions.
Hesse-Biber S, Seven M, Jiang J, Schaik SV, Dwyer AA
This mixed-methods study sought to deepen our understanding of self-concept and experiences in balancing cancer risk/reproductive decisions after learning of BRCA+ status. First, a quantitative survey of BRCA+ women (n = 505) examined the childbearing status, risk-reducing surgery, and self-concept. At the time of testing, 307/505 (60.8%) women were of reproductive age (
Abstract
Cited 4 times since 2022 (1.2 per year)
source: EuropePMC
Journal of the peripheral nervous system : JPNS,
Volume 27, Issue 2, 15 3 2022, Pages 159-165
Analysis of relapse by inflammatory Rasch-built overall disability scale status in the PATH study of subcutaneous immunoglobulin in chronic inflammatory demyelinating polyneuropathy.
Merkies ISJ, van Schaik IN, Bril V, Hartung HP, Lewis RA, Sobue G, Lawo JP, Mielke O, Cornblath DR, PATH study group
Clinical trials in chronic inflammatory demyelinating polyneuropathy (CIDP) often assess efficacy using the ordinal Inflammatory Neuropathy Cause and Treatment (INCAT) disability score. Here, data from the PATH study was reanalyzed using change in Inflammatory Rasch-built Overall Disability Scale (I-RODS) to define CIDP relapse instead of INCAT. The PATH study comprised an intravenous immunoglobulin (IVIG) dependency period and an IVIG (IgPro10 [Privigen]) restabilization period; subjects were t...
Abstract
