Research

Publications

Below you can find a list of our published research.

9618 results

Cited 2 times since 2022 (0.6 per year) source: EuropePMC

The American journal of medicine, Volume 135, Issue 7, 14 2 2022, Pages 915-918 Effect of Alirocumab on Incidence of Atrial Fibrillation After Acute Coronary Syndromes: Insights from the ODYSSEY OUTCOMES Trial. Lopes RD, Guimarães PO, Schwartz GG, Bhatt DL, Bittner VA, Budaj A, Dalby AJ, Diaz R, Goodman SG, Harrington RA, Jukema JW, Kiss RG, Loy M, Pordy R, Poulouin Y, Szarek M, White HD, Steg PG, ODYSSEY OUTCOMES Investigators

Background: Using data from the ODYSSEY OUTCOMES trial (NCT01663402), we sought to identify factors associated with the development of incident atrial fibrillation in patients with recent acute coronary syndrome without prior atrial fibrillation and to determine whether alirocumab treatment influenced risk of incident atrial fibrillation. Methods: ODYSSEY OUTCOMES compared alirocumab treatment with placebo in 18,924 patients with recent acute coronary syndrome and dyslipidemia despite high-inten... Abstract

Cited 1 times since 2022 (0.3 per year) source: EuropePMC

European journal of nutrition, Volume 61, Issue 5, 14 2 2022, Pages 2761-2773 Adherence to the Dutch healthy diet index and change in glycemic control and cardiometabolic markers in people with type 2 diabetes. Bartels ECM, den Braver NR, Borgonjen-van den Berg KJ, Rutters F, van der Heijden A, Beulens JWJ

Purpose: To investigate whether adherence to the Dutch Healthy Diet index 2015 (DHD15-index) is associated with change in glycemic control and cardio-metabolic markers over two-year follow-up in people with type 2 diabetes (T2D). Methods: This prospective cohort study included 1202 individuals with T2D (mean age 68.7 ± 9.0 years; 62.5% male; mean HbA1c 53.8 ± 11.7 mmol/mol) from the Diabetes Care System cohort. Baseline dietary intake was assessed using a validated food frequency questionnaire,... Abstract

Cited 3 times since 2022 (0.9 per year) source: EuropePMC

PLoS computational biology, Volume 18, Issue 3, 14 2 2022, Pages e1009875 Does plasmid-based beta-lactam resistance increase E. coli infections: Modelling addition and replacement mechanisms. Godijk NG, Bootsma MCJ, van Werkhoven HC, Schweitzer VA, de Greeff SC, Schoffelen AF, Bonten MJM

Infections caused by antibiotic-resistant bacteria have become more prevalent during past decades. Yet, it is unknown whether such infections occur in addition to infections with antibiotic-susceptible bacteria, thereby increasing the incidence of infections, or whether they replace such infections, leaving the total incidence unaffected. Observational longitudinal studies cannot separate both mechanisms. Using plasmid-based beta-lactam resistant E. coli as example we applied mathematical modell... Abstract

Cited 22 times since 2022 (6.4 per year) source: EuropePMC

Frontiers in cardiovascular medicine, Volume 9, 11 2 2022, Pages 854314 Pirfenidone Has Anti-fibrotic Effects in a Tissue-Engineered Model of Human Cardiac Fibrosis. Bracco Gartner TCL, Crnko S, Leiteris L, van Adrichem I, van Laake LW, Bouten CVC, Goumans MJ, Suyker WJL, Sluijter JPG, Hjortnaes J

A fundamental process in the development and progression of heart failure is fibrotic remodeling, characterized by excessive deposition of extracellular matrix proteins in response to injury. Currently, therapies that effectively target and reverse cardiac fibrosis are lacking, warranting novel therapeutic strategies and reliable methods to study their effect. Using a gelatin methacryloyl hydrogel, human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) and human fetal cardiac fibr... Abstract

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 30, Issue 9, 11 2 2022, Pages 431-435 Emergency Heart failure Mortality Risk Grade may help to reduce heart failure admissions. van Hattem NE, Beeres SLMA, Mertens BJA, Antoni ML, Atsma DE, Schalij MJ, den Haan MC

Introduction: Hospital admissions for heart failure (HF) are frequent and pose a heavy burden on health care resources. Currently, the decision to hospitalise is based on clinical judgement rather than on prognostic risk stratification. The Emergency Heart failure Mortality Risk Grade (EHMRG) was recently developed to identify high-risk HF patients in the emergency department (ED). Objective: To assess the ability of the EHMRG to predict 30-day mortality in Dutch HF patients visiting the ED and... Abstract

Cited 13 times since 2022 (3.8 per year) source: EuropePMC

Acta dermato-venereologica, Volume 102, 11 2 2022, Pages adv00666 Identification of Risk Factors for Dupilumab-associated Ocular Surface Disease in Patients with Atopic Dermatitis. Achten RE, Van Luijk C, Van der Rijst L, Bakker D, Spekhorst L, Zuithoff N, Schuttelaar M, Romeijn G, Voorberg A, Kamsteeg M, Haeck I, De Graaf M, Thijs J, De Boer J, De Bruin-Weller M

This study identified risk factors for the development of dupilumab-associated ocular surface disease in patients with moderate-to-severe atopic dermatitis in a large prospective daily practice cohort. Data from the Dutch BioDay Registry were used to assess the risk of developing dupilumab-associated ocular surface disease, by performing univariate and multivariate logistic regression analyses. A total of 469 patients were included, of which 152/469 (32.4%) developed dupilumab-associated ocular... Abstract

Cited 3 times since 2022 (0.9 per year) source: EuropePMC

Journal of child and adolescent psychiatric nursing : official publication of the Association of Child and Adolescent Psychiatric Nurses, Inc, Volume 35, Issue 3, 10 2 2022, Pages 267-276 The relationship between posttraumatic stress disorder, posttraumatic growth, and rumination in adolescents after earthquake: A systematic review. Turan N, Yılmaz DY, Ertekin K

Purpose: This systematic review aims to examine, from an interdisciplinary perspective, the relationship between posttraumatic stress disorder (PTSD), posttraumatic growth (PTG), and rumination in adolescents after an earthquake. The aim of the review is to provide high-quality, evidence-based recommendations that contribute to the roles of psychiatric nurses and the development of psychosocial support systems. Design and methods: This study has been conducted in line with the Centres for Review... Abstract

Cited 4 times since 2022 (1.2 per year) source: EuropePMC

Journal of lipid research, Volume 63, Issue 5, 10 2 2022, Pages 100193 Apolipoprotein A-V is a potential target for treating coronary artery disease: evidence from genetic and metabolomic analyses. Ibi D, Boot M, Dollé MET, Jukema JW, Rosendaal FR, Christodoulides C, Neville MJ, Koivula R, Rensen PCN, Karpe F, Noordam R, Willems van Dijk K

Triglyceride (TG)-lowering LPL variants in combination with genetic LDL-C-lowering variants are associated with reduced risk of coronary artery disease (CAD). Genetic variation in the APOA5 gene encoding apolipoprotein A-V also strongly affects TG levels, but the potential clinical impact and underlying mechanisms are yet to be resolved. Here, we aimed to study the effects of APOA5 genetic variation on CAD risk and plasma lipoproteins through factorial genetic association analyses. Using data fr... Abstract

Cited 14 times since 2022 (4.1 per year) source: EuropePMC

Frontiers in endocrinology, Volume 13, 9 2 2022, Pages 845937 Dextroamphetamine Treatment in Children With Hypothalamic Obesity. van Schaik J, Welling MS, de Groot CJ, van Eck JP, Juriaans A, Burghard M, Oude Ophuis SBJ, Bakker B, Tissing WJE, Schouten-van Meeteren AYN, van den Akker ELT, van Santen HM

Introduction: Hypothalamic obesity (HO) in children has severe health consequences. Lifestyle interventions are mostly insufficient and currently no drug treatment is approved for children with HO. Amphetamines are known for their stimulant side-effect on resting energy expenditure (REE) and suppressing of appetite. Earlier case series have shown positive effects of amphetamines on weight in children with acquired HO. We present our experiences with dextroamphetamine treatment in the, up to now,... Abstract

Cited 14 times since 2022 (4.1 per year) source: EuropePMC

Diagnostics (Basel, Switzerland), Volume 12, Issue 3, 9 2 2022, Pages 669 Sclerodermic Cardiomyopathy-A State-of-the-Art Review. Giucă A, Gegenava T, Mihai CM, Jurcuţ C, Săftoiu A, Gȋrniţă DM, Popescu BA, Ajmone Marsan N, Jurcuț R

Systemic sclerosis (SSc) is a chronic autoimmune disorder with unknown triggering factors, and complex pathophysiologic links which lead to fibrosis of skin and internal organs, including the heart, lungs, and gut. However, more than 100 years after the first description of cardiac disease in SSc, sclerodermic cardiomyopathy (SScCmp) is an underrecognized, occult disease with important adverse long-term prognosis. Laboratory tests, electrocardiography (ECG) and cardiovascular multimodality imagi... Abstract

Cited 7 times since 2022 (2 per year) source: EuropePMC

Emergent materials, Volume 5, Issue 1, 9 2 2022, Pages 105-132 Nanotechnology in food and water security: on-site detection of agricultural pollutants through surface-enhanced Raman spectroscopy. Yılmaz D, Günaydın BN, Yüce M

Agricultural pollutants are harmful components threatening human health, wildlife, the environment, and the ecosystem. To avoid their exposure, developing prevention and detection systems with high sensitivity and selectivity is required. Most conventional methods, including molecular and chromatographic techniques, cannot be adopted for outdoor on-site detection even though they can provide sensitive and selective detection. Thus, detection platforms that can provide on-site detection via minia... Abstract

Cited 10 times since 2022 (2.9 per year) source: EuropePMC

Nature communications, Volume 13, Issue 1, 9 2 2022, Pages 1222 Elucidating mechanisms of genetic cross-disease associations at the PROCR vascular disease locus. Stacey D, Chen L, Stanczyk PJ, Howson JMM, Mason AM, Burgess S, MacDonald S, Langdown J, McKinney H, Downes K, Farahi N, Peters JE, Basu S, Pankow JS, Tang W, Pankratz N, Sabater-Lleal M, de Vries PS, Smith NL, CHARGE Hemostasis Working Group, Gelinas AD, Schneider DJ, Janjic N, Samani NJ, Ye S, Summers C, Chilvers ER, Danesh J, Paul DS

Many individual genetic risk loci have been associated with multiple common human diseases. However, the molecular basis of this pleiotropy often remains unclear. We present an integrative approach to reveal the molecular mechanism underlying the PROCR locus, associated with lower coronary artery disease (CAD) risk but higher venous thromboembolism (VTE) risk. We identify PROCR-p.Ser219Gly as the likely causal variant at the locus and protein C as a causal factor. Using genetic analyses, human r... Abstract

Cited 14 times since 2022 (4.1 per year) source: EuropePMC

ESC heart failure, Volume 9, Issue 3, 9 2 2022, Pages 1597-1607 Right ventricular-pulmonary artery coupling in cardiac resynchronization therapy: evolution and prognosis. Stassen J, Galloo X, Hirasawa K, Chimed S, Marsan NA, Delgado V, van der Bijl P, Bax JJ

Aims: Chronic pressure overload and right ventricular (RV) dysfunction can lead to RV-pulmonary artery (PA) uncoupling in patients with heart failure. The evolution and prognostic values of RV-PA coupling assessed by echocardiography in patients undergoing cardiac resynchronization therapy (CRT) have not been thoroughly investigated. The aim of this study was to evaluate the evolution and prognostic value of tricuspid annular plane systolic excursion (TAPSE)/pulmonary artery systolic pressure (P... Abstract

Cited 4 times since 2022 (1.2 per year) source: EuropePMC

Frontiers in cardiovascular medicine, Volume 9, 7 1 2022, Pages 870390 Corrigendum: Robotic Cardiac Surgery in Europe: Status 2020. Cerny S, Oosterlinck W, Onan B, Singh S, Segers P, Bolcal C, Alhan C, Navarra E, Pettinari M, Van Praet F, De Praetere H, Vojacek J, Cebotaru T, Modi P, Doguet F, Franke U, Ouda A, Melly L, Malapert G, Labrousse L, Gianoli M, Agnino A, Philipsen T, Jansens JL, Folliguet T, Palmen M, Pereda D, Musumeci F, Suwalski P, Cathenis K, Van den Eynde J, Bonatti J

[This corrects the article DOI: 10.3389/fcvm.2021.827515.]. Abstract

Cited 47 times since 2022 (13.6 per year) source: EuropePMC

BMC geriatrics, Volume 22, Issue 1, 5 1 2022, Pages 184 Age is the main determinant of COVID-19 related in-hospital mortality with minimal impact of pre-existing comorbidities, a retrospective cohort study. Henkens MTHM, Raafs AG, Verdonschot JAJ, Linschoten M, van Smeden M, Wang P, van der Hooft BHM, Tieleman R, Janssen MLF, Ter Bekke RMA, Hazebroek MR, van der Horst ICC, Asselbergs FW, Magdelijns FJH, Heymans SRB, CAPACITY-COVID collaborative consortium

Background: Age and comorbidities increase COVID-19 related in-hospital mortality risk, but the extent by which comorbidities mediate the impact of age remains unknown. Methods: In this multicenter retrospective cohort study with data from 45 Dutch hospitals, 4806 proven COVID-19 patients hospitalized in Dutch hospitals (between February and July 2020) from the CAPACITY-COVID registry were included (age 69[58-77]years, 64% men). The primary outcome was defined as a combination of in-hospital mor... Abstract

Cited 4 times since 2022 (1.2 per year) source: EuropePMC

Drug discovery today, Volume 27, Issue 6, 4 1 2022, Pages 1716-1723 Advanced molecular imaging for the characterisation of complex medicines. Yilmaz D, Sharp PS, Main MJ, Simpson PB

A growing number and diversity of complex medicines is in development and reaching the market, with many of these medicines utilising innovative delivery technology to achieve appropriate biodistribution and exposure. Accurate assessment of biodistribution, cell penetration, internalised form, cargo release and efficacy are essential for the development of these medicines. Advanced imaging technologies, deploying different labelling techniques that allow the assessment of both carrier and cargo,... Abstract

Cited 13 times since 2022 (3.8 per year) source: EuropePMC

ESMO open, Volume 7, Issue 2, 3 1 2022, Pages 100416 Circulating tumour cells to drive the use of neoadjuvant chemotherapy in patients with muscle-invasive bladder cancer. Beije N, de Kruijff IE, de Jong JJ, Klaver SO, de Vries P, Jacobs RAL, Somford DM, Te Slaa E, van der Heijden AG, Alfred Witjes J, Fossion LMCL, Boevé ER, van der Hoeven J, van Melick HHE, Wijburg CJ, Bickerstaffe H, Martens JWM, de Wit R, Kraan J, Sleijfer S, Boormans JL

Background: Guidelines recommend neoadjuvant chemotherapy (NAC) for the treatment of nonmetastatic muscle-invasive bladder cancer (MIBC). NAC is, however, underutilized in practice because of its associated limited overall survival (OS) benefit and significant treatment-related toxicity. We hypothesized that the absence of circulating tumour cells (CTCs) identifies MIBC patients with such a favourable prognosis that NAC may be withheld. Patients and methods: The CirGuidance study was an open-lab... Abstract

Cited 12 times since 2022 (3.5 per year) source: EuropePMC

Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists, Volume 30, Issue 3, 3 1 2022, Pages 364-371 Normalization of Time-Intensity Curves for Quantification of Foot Perfusion Using Near-Infrared Fluorescence Imaging With Indocyanine Green. Van Den Hoven P, Tange F, Van Der Valk J, Nerup N, Putter H, Van Rijswijk C, Van Schaik J, Schepers A, Vahrmeijer A, Hamming J, Van Der Vorst J

Purpose: Near-infrared (NIR) fluorescence imaging using indocyanine green (ICG) is gaining popularity for the quantification of tissue perfusion, including foot perfusion in patients with lower extremity arterial disease (LEAD). However, the absolute fluorescence intensity is influenced by patient-and system-related factors limiting reliable and valid quantification. To enhance the quality of quantitative perfusion assessment using ICG NIR fluorescence imaging, normalization of the measured time... Abstract

Cited 7 times since 2022 (2 per year) source: EuropePMC

Seminars in nuclear medicine, Volume 52, Issue 5, 2 1 2022, Pages 597-610 Nuclear medicine imaging methods of radiation-induced cardiotoxicity. Polomski ES, Antoni ML, Jukema JW, Kroep JR, Dibbets-Schneider P, Sattler MGA, de Geus-Oei LF

Breast cancer survival is significantly improved over the past decades due to major improvements in anti-tumor therapies and the implementation of regular screening, which leads to early detection of breast cancer. Therefore, it is of utmost importance to prevent patients from long-term side effects, including radiotherapy-induced cardiotoxicity. Radiotherapy may contribute to damage of myocardial structures on the cellular level, which eventually could result in various types of cardiovascular... Abstract

Cited 10 times since 2022 (2.9 per year) source: EuropePMC

Vascular and endovascular surgery, Volume 56, Issue 5, 2 1 2022, Pages 472-479 Doppler Ultrasonography Derived Maximal Systolic Acceleration: Value Determination With Artificially Induced Stenosis. Brouwers JJWM, van Doorn LP, Pronk L, van Wissen RC, Putter H, Schepers A, Hamming JF

BackgroundIn diagnosing peripheral arterial disease (PAD), medial arterial calcification (MAC) hampers arterial compression and could lead to unreliable ankle brachial index (ABI), toe brachial index (TBI) and toe pressure (TP). Doppler ultrasonography (DUS) derived maximal systolic acceleration (ACCmax) might be more accurate to diagnose PAD. In an in vitro study, a strong correlation between ACCmax and the severity of stenotic disease was determined. The aim of this study was to investigate th... Abstract