Research

Publications

Below you can find a list of our published research.

9618 results

Cited 41 times since 2022 (11.8 per year) source: EuropePMC

JACC. Cardiovascular interventions, Volume 15, Issue 5, 1 1 2022, Pages 523-532 The PARTNER 3 Bicuspid Registry for Transcatheter Aortic Valve Replacement in Low-Surgical-Risk Patients. Williams MR, Jilaihawi H, Makkar R, O'Neill WW, Guyton R, Malaisrie SC, Brown DL, Blanke P, Leipsic JA, Pibarot P, Hahn RT, Leon MB, Cohen DJ, Bax JJ, Kodali SK, Mack MJ, Lu M, Webb JG

Objectives: The study compared 1-year outcomes between transcatheter aortic valve replacement (TAVR) patients with bicuspid aortic valve (BAV) morphology and clinically similar patients having tricuspid aortic valve (TAV) morphology. Background: There are limited prospective data on TAVR using the SAPIEN 3 device in low-surgical-risk patients with severe, symptomatic aortic stenosis and bicuspid anatomy. Methods: Low-risk, severe aortic stenosis patients with BAV were candidates for the PARTNER... Abstract

Cited 8 times since 2022 (2.3 per year) source: EuropePMC

European journal of anaesthesiology, Volume 39, Issue 3, 1 1 2022, Pages 210-218 Association between benzodiazepine premedication and 30-day mortality rate: A propensity-score weighted analysis of the Peri-interventional Outcome Study in the Elderly (POSE). Kowark A, Berger M, Rossaint R, Schmid M, Coburn M, POSE-Study group

Background: Recent guidelines suggest that benzodiazepine premedication should be avoided in elderly patients, though with limited supporting evidence. Objective: We conducted a secondary analysis of the POSE data to explore the association of premedication in patients aged 80 years or older with 30-day mortality. Design: We used propensity score methods to perform a confounder-adjusted time-to-event analysis of the association between benzodiazepine premedication and 30-day mortality of the POS... Abstract

Cited 12 times since 2022 (3.5 per year) source: EuropePMC

British journal of nursing (Mark Allen Publishing), Volume 31, Issue 6, 1 1 2022, Pages 322-330 Evidence-informed practice: simplifying and applying the concept for nursing students and academics. Kumah EA, McSherry R, Bettany-Saltikov J, van Schaik P

Background: Nurses' ability to apply evidence effectively in practice is a critical factor in delivering high-quality patient care. Evidence-based practice (EBP) is recognised as the gold standard for the delivery of safe and effective person-centred care. However, decades following its inception, nurses continue to encounter difficulties in implementing EBP and, although models for its implementation offer stepwise approaches, factors, such as the context of care and its mechanistic nature... Abstract

Cited 28 times since 2022 (8.1 per year) source: EuropePMC

Journal of hypertension, Volume 40, Issue 3, 1 1 2022, Pages 606-614 A low aldosterone/renin ratio and high soluble ACE2 associate with COVID-19 severity. Akin S, Schriek P, van Nieuwkoop C, Neuman RI, Meynaar I, van Helden EJ, Bouazzaoui HE, Baak R, Veuger M, Mairuhu RATA, van den Berg L, van Driel V, Visser LE, de Jonge E, Garrelds IM, Duynstee JFAB, van Rooden JK, Ludikhuize J, Verdonk K, Caliskan K, Jansen T, van Schaik RHN, Danser AHJ

Background: The severity of COVID-19 after SARS-CoV-2 infection is unpredictable. Angiotensin-converting enzyme-2 (ACE2) is the receptor responsible for coronavirus binding, while subsequent cell entry relies on priming by the serine protease TMPRSS2 (transmembrane protease, serine 2). Although renin-angiotensin-aldosterone-system (RAAS) blockers have been suggested to upregulate ACE2, their use in COVID-19 patients is now considered well tolerated. The aim of our study was to investigate parame... Abstract

Cited 19 times since 2022 (5.5 per year) source: EuropePMC

European journal of anaesthesiology, Volume 39, Issue 3, 1 1 2022, Pages 198-209 Peri-interventional outcome study in the elderly in Europe: A 30-day prospective cohort study. POSE-Study group

Objectives: The aim of this study was to describe the 30-day mortality rate of patients aged 80 years and older undergoing surgical and nonsurgical procedures under anaesthesia in Europe and to identify risk factors associated with mortality. Design: A prospective cohort study. Setting: European multicentre study, performed from October 2017 to December 2018. Centres committed to a 30-day recruitment period within the study period. Patients: Nine thousand four hundred and ninety-seven consecutiv... Abstract

Cited 3 times since 2022 (0.9 per year) source: EuropePMC

European heart journal, Volume 43, Issue 13, 1 1 2022, Pages 1288-1295 The year in cardiovascular medicine 2021: imaging. Bucciarelli-Ducci C, Ajmone-Marsan N, Di Carli M, Nicol E

This article reviews the most relevant literature published in 2021 on the role of cardiovascular imaging in cardiovascular medicine. Coronavirus disease 2019 (COVID-19) continued to impact the healthcare landscape, resulting in reduced access to hospital-based cardiovascular care including reduced routine diagnostic cardiovascular testing. However, imaging has also facilitated the understanding of the presence and extent of myocardial damage caused by the coronavirus infection. What has dominat... Abstract

Cited 9 times since 2022 (2.6 per year) source: EuropePMC

European heart journal. Cardiovascular Imaging, Volume 23, Issue 4, 1 1 2022, Pages 578-585 Prognostic implications of cardiac damage classification based on computed tomography in severe aortic stenosis. Hirasawa K, vanRosendael PJ, Fortuni F, Singh GK, Kuneman JH, Vollema EM, Ajmone Marsan N, Knuuti J, Bax JJ, Delgado V

Aims: An echocardiographic staging system of severe aortic stenosis (AS) based on additional extra-valvular cardiac damage has been associated with prognosis after transcatheter aortic valve implantation (TAVI). Multidetector row computed tomography (MDCT) is key in the evaluation of AS patients undergoing TAVI and can potentially detect extra-valvular cardiac damage. This study aimed at evaluating the prognostic implications of an MDCT staging system of severe AS in patients undergoing TAVI. Me... Abstract

Cited 5 times since 2022 (1.4 per year) source: EuropePMC

The British journal of surgery, Volume 109, Issue 4, 1 1 2022, Pages 340-345 Mortality following elective abdominal aortic aneurysm repair in women. Tedjawirja VN, Alberga AJ, Hof MHP, Vahl AC, Koelemay MJW, Balm R, Dutch Society of Vascular Surgery

Background: Previous studies have focused on patient-related risk factors to explain the higher mortality risk in women undergoing elective abdominal aortic aneurysm (AAA) repair. The aim of this study was to evaluate whether hospital-related factors influence outcomes following AAA repair in women. Methods: Patients undergoing elective AAA repair in 61 hospitals in the Netherlands were identified from the Dutch Surgical Aneurysm Audit registry (2013-2018). A mixed-effects logistic regression an... Abstract

Cited 2 times since 2022 (0.6 per year) source: EuropePMC

European journal of cardiovascular nursing, Volume 21, Issue 2, 1 1 2022, Pages 169-173 Implantable cardioverter-defibrillators and the older patient: the Dutch clinical practice. Yilmaz D, Egorova AD, Schalij MJ, van Erven L

Background and objective: Balance between benefit and burden of implantable cardioverter-defibrillator (ICD) therapy is more debatable in older patients, compared to younger patients. Of around 6000 yearly implanted ICDs in the Netherlands, 1:4 is received by patients ≥75 years. We aimed to evaluate the current clinical practice in the Netherlands for ICD implants and generator replacements, with a special focus on the older ICD patients. Research design and methods: Cardiologists from all Dutch... Abstract

Cited 6 times since 2022 (1.7 per year) source: EuropePMC

European heart journal. Cardiovascular Imaging, Volume 23, Issue 4, 1 1 2022, Pages 447-449 How to do lung ultrasound. Stassen J, Bax JJ

Abstract

Cited 41 times since 2022 (11.8 per year) source: EuropePMC

European heart journal, Volume 43, Issue 11, 1 1 2022, Pages 1104-1120 Clinical presentation, disease course, and outcome of COVID-19 in hospitalized patients with and without pre-existing cardiac disease: a cohort study across 18 countries. CAPACITY-COVID Collaborative Consortium and LEOSS Study Group

Aims: Patients with cardiac disease are considered high risk for poor outcomes following hospitalization with COVID-19. The primary aim of this study was to evaluate heterogeneity in associations between various heart disease subtypes and in-hospital mortality. Methods and results: We used data from the CAPACITY-COVID registry and LEOSS study. Multivariable Poisson regression models were fitted to assess the association between different types of pre-existing heart disease and in-hospital mortal... Abstract

Cited 49 times since 2022 (14.1 per year) source: EuropePMC

Diabetes care, Volume 45, Issue 3, 1 1 2022, Pages 674-683 Type 2 Diabetes Partitioned Polygenic Scores Associate With Disease Outcomes in 454,193 Individuals Across 13 Cohorts. DiCorpo D, LeClair J, Cole JB, Sarnowski C, Ahmadizar F, Bielak LF, Blokstra A, Bottinger EP, Chaker L, Chen YI, Chen Y, de Vries PS, Faquih T, Ghanbari M, Gudmundsdottir V, Guo X, Hasbani NR, Ibi D, Ikram MA, Kavousi M, Leonard HL, Leong A, Mercader JM, Morrison AC, Nadkarni GN, Nalls MA, Noordam R, Preuss M, Smith JA, Trompet S, Vissink P, Yao J, Zhao W, Boerwinkle E, Goodarzi MO, Gudnason V, Jukema JW, Kardia SLR, Loos RJF, Liu CT, Manning AK, Mook-Kanamori D, Pankow JS, Picavet HSJ, Sattar N, Simonsick EM, Verschuren WMM, Willems van Dijk K, Florez JC, Rotter JI, Meigs JB, Dupuis J, Udler MS

Objective: Type 2 diabetes (T2D) has heterogeneous patient clinical characteristics and outcomes. In previous work, we investigated the genetic basis of this heterogeneity by clustering 94 T2D genetic loci using their associations with 47 diabetes-related traits and identified five clusters, termed β-cell, proinsulin, obesity, lipodystrophy, and liver/lipid. The relationship between these clusters and individual-level metabolic disease outcomes has not been assessed. Research design and methods:... Abstract

Cited 12 times since 2022 (3.5 per year) source: EuropePMC

European heart journal. Cardiovascular Imaging, Volume 23, Issue 4, 1 1 2022, Pages 515-523 Orientation of the right superior pulmonary vein affects outcome after pulmonary vein isolation. Szegedi N, Vecsey-Nagy M, Simon J, Szilveszter B, Herczeg S, Kolossváry M, Idelbi H, Osztheimer I, Klaudia Nagy V, Tahin T, Széplaki G, Delgado V, Bax JJ, Maurovich-Horvat P, Merkely B, Gellér L

Aims: Controversial results have been published regarding the influence of pulmonary vein (PV) anatomical variations on outcomes after pulmonary vein isolation (PVI). However, no data are available on the impact of PV orientation on the long-term success rates of point-by-point PVI. We sought to determine the impact of PV anatomy and orientation on atrial fibrillation (AF)-free survival in patients undergoing PVI using the radiofrequency point-by-point technique. Methods and results: We retrospe... Abstract

Cited 8 times since 2022 (2.3 per year) source: EuropePMC

American journal of epidemiology, Volume 191, Issue 5, 1 1 2022, Pages 886-899 Evaluation of the Value of Waist Circumference and Metabolomics in the Estimation of Visceral Adipose Tissue. Boone SC, van Smeden M, Rosendaal FR, le Cessie S, Groenwold RHH, Jukema JW, van Dijk KW, Lamb HJ, Greenland P, Neeland IJ, Allison MA, Criqui MH, Budoff MJ, Lind LL, Kullberg J, Ahlström H, Mook-Kanamori DO, de Mutsert R

Visceral adipose tissue (VAT) is a strong prognostic factor for cardiovascular disease and a potential target for cardiovascular risk stratification. Because VAT is difficult to measure in clinical practice, we estimated prediction models with predictors routinely measured in general practice and VAT as outcome using ridge regression in 2,501 middle-aged participants from the Netherlands Epidemiology of Obesity study, 2008-2012. Adding waist circumference and other anthropometric measurements on... Abstract

Cited 4 times since 2022 (1.2 per year) source: EuropePMC

The Journal of cardiovascular nursing, Volume 37, Issue 2, 1 1 2022, Pages 192-196 Type D Personality Associated With Increased Risk for Mortality in Adults With Congenital Heart Disease. Kauw D, Schoormans D, Sieswerda GT, Van Melle JP, Vliegen HW, Van Dijk APJ, Hulsbergen-Zwarts MS, Post MC, Ansink TJ, Mulder BJM, Bouma BJ, Schuuring MJ

Background: Type D personality has been previously shown to increase the risk for mortality in patients with acquired heart disease. Objective: We aimed to compare mortality in adult patients with congenital heart disease (CHD) with and without type D. Methods: Survival was assessed using prospective data from the Dutch national Congenital Corvitia registry for adults with CHD. Patients were randomly selected from the registry and characterized at inclusion in 2009 for the presence of type D usi... Abstract

Cited 24 times since 2022 (6.9 per year) source: EuropePMC

JAMA cardiology, Volume 7, Issue 3, 1 1 2022, Pages 309-319 Association of Plaque Location and Vessel Geometry Determined by Coronary Computed Tomographic Angiography With Future Acute Coronary Syndrome-Causing Culprit Lesions. Han D, Lin A, Kuronuma K, Tzolos E, Kwan AC, Klein E, Andreini D, Bax JJ, Cademartiri F, Chinnaiyan K, Chow BJW, Conte E, Cury RC, Feuchtner G, Hadamitzky M, Kim YJ, Leipsic JA, Maffei E, Marques H, Plank F, Pontone G, Villines TC, Al-Mallah MH, de Araújo Gonçalves P, Danad I, Gransar H, Lu Y, Lee JH, Lee SE, Baskaran L, Al'Aref SJ, Yoon YE, Van Rosendael A, Budoff MJ, Samady H, Stone PH, Virmani R, Achenbach S, Narula J, Chang HJ, Min JK, Lin FY, Shaw LJ, Slomka PJ, Dey D, Berman DS

Importance: Distinct plaque locations and vessel geometric features predispose to altered coronary flow hemodynamics. The association between these lesion-level characteristics assessed by coronary computed tomographic angiography (CCTA) and risk of future acute coronary syndrome (ACS) is unknown. Objective: To examine whether CCTA-derived adverse geometric characteristics (AGCs) of coronary lesions describing location and vessel geometry add to plaque morphology and burden for identifying culpr... Abstract

Cited 16 times since 2022 (4.6 per year) source: EuropePMC

Human molecular genetics, Volume 31, Issue 7, 1 1 2022, Pages 1051-1066 C/D box snoRNA SNORD113-6/AF357425 plays a dual role in integrin signalling and arterial fibroblast function via pre-mRNA processing and 2'O-ribose methylation. van Ingen E, van den Homberg DAL, van der Bent ML, Mei H, Papac-Milicevic N, Kremer V, Boon RA, Quax PHA, Wojta J, Nossent AY

We have previously shown that C/D box small nucleolar RNAs (snoRNAs) transcribed from the DLK1-DIO3 locus on human chromosome 14 (14q32) are associated with cardiovascular disease. DLK1-DIO3 snoRNAs are 'orphan snoRNAs' that have no known targets. We aimed to identify RNA targets and elucidate the mechanism-of-action of human SNORD113-6 (AF357425 in mice). As AF357425-knockout cells were non-viable, we induced overexpression or inhibition of AF357425 in primary murine fibroblasts and p... Abstract

Cited 15 times since 2022 (4.3 per year) source: EuropePMC

Microbiology spectrum, Volume 10, Issue 2, 28 4 2022, Pages e0213421 Phenotypic and Genotypic Characterization of a Hypervirulent Carbapenem-Resistant Klebsiella pneumoniae ST17-KL38 Clinical Isolate Harboring the Carbapenemase IMP-4. He J, Du X, Zeng X, Moran RA, van Schaik W, Zou Q, Yu Y, Zhang J, Hua X

Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) is a threat to global public health. We characterized a sequence type 17 (ST17) K. pneumoniae clinical isolate that was resistant to carbapenems and belonged to serotype KL38/O2. Its complete genome is comprised of a 5.1-Mb chromosome and two conjugative plasmids. The 52,578-bp N-type plasmid pXH210-IMP contains the blaIMP-4 carbapenemase gene and the quinolone resistance gene qnrS1. The 272,742-bp FII(K)-9:FIB(K)-10 plasmid pXH2... Abstract

Cited 10 times since 2022 (2.9 per year) source: EuropePMC

The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland, Volume 21, Issue 1, 28 4 2022, Pages 1-7 Exploring the surgical personality. Sier VQ, Schmitz RF, Schepers A, van der Vorst JR

Surgery is a demanding field, requiring determination and emotional stability. This review explores the surgical personality, addressing international personality differences between surgical and non-surgical specialties. Across the globe, surgically-interested individuals (i.e., medical students, residents, surgeons) generally scored higher on conscientiousness, open mindedness, and extraversion, and lower on neuroticism compared to non-surgically-interested contemporaries. Extraversion was inv... Abstract

Cited 2 times since 2022 (0.6 per year) source: EuropePMC

Biomedicines, Volume 10, Issue 3, 28 4 2022, Pages 565 Blood M2-like Monocyte Polarization Is Associated with Calcific Plaque Phenotype in Stable Coronary Artery Disease: A Sub-Study of SMARTool Clinical Trial. Sbrana S, Cecchettini A, Bastiani L, Di Giorgi N, Mazzone A, Ceccherini E, Vozzi F, Caselli C, Neglia D, Clemente A, Scholte AJHA, Parodi O, Pelosi G, Rocchiccioli S

Background: Atherosclerosis is a chronic inflammatory disease. The balance between pro- and anti-inflammatory factors, acting on the arterial wall, promotes less or more coronary plaque macro-calcification, respectively. We investigated the association between monocyte phenotypic polarization and CTCA-assessed plaque dense-calcium volume (DCV) in patients with stable coronary artery disease (CAD). Methods: In 55 patients, individual DCV component was assessed by quantitative CTCA and normalized... Abstract