9618 results
Cited 11 times since 2022 (3.1 per year)
source: EuropePMC
Scientific reports,
Volume 12, Issue 1, 10 2 2022, Pages 2283
Metabolic profile in endothelial cells of chronic thromboembolic pulmonary hypertension and pulmonary arterial hypertension.
Smolders VFED, Rodríguez C, Blanco I, Szulcek R, Timens W, Piccari L, Roger Y, Hu X, Morén C, Bonjoch C, Sebastián L, Castellà M, Osorio J, Peinado VI, Bogaard HJ, Quax PHA, Cascante M, Barberà JA, Tura-Ceide O
Chronic thromboembolic pulmonary hypertension (CTEPH) and pulmonary arterial hypertension (PAH) are two forms of pulmonary hypertension (PH) characterized by obstructive vasculopathy. Endothelial dysfunction along with metabolic changes towards increased glycolysis are important in PAH pathophysiology. Less is known about such abnormalities in endothelial cells (ECs) from CTEPH patients. This study provides a systematic metabolic comparison of ECs derived from CTEPH and PAH patients. Metabolic g...
Abstract
Cited 15 times since 2022 (4.3 per year)
source: EuropePMC
Annals of the rheumatic diseases,
Volume 81, Issue 5, 10 2 2022, Pages 644-652
Proteogenomic analysis of the autoreactive B cell repertoire in blood and tissues of patients with Sjögren's syndrome.
Broeren MGA, Wang JJ, Balzaretti G, Groenen PJTA, van Schaik BDC, Chataway T, Kaffa C, Bervoets S, Hebeda KM, Bounova G, Pruijn GJM, Gordon TP, De Vries N, Thurlings RM
Objective: To comparatively analyse the aberrant affinity maturation of the antinuclear and rheumatoid factor (RF) B cell repertoires in blood and tissues of patients with Sjögren's syndrome (SjS) using an integrated omics workflow. Methods: Peptide sequencing of anti-Ro60, anti-Ro52, anti-La and RF was combined with B cell repertoire analysis at the DNA, RNA and single cell level in blood B cell subsets, affected salivary gland and extranodal marginal zone lymphomas of mucosa-associated ly...
Abstract
Cited 1 times since 2022 (0.3 per year)
source: EuropePMC
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery,
Volume 63, Issue 5, 10 2 2022, Pages 773-774
Hypothesis of the High Mortality of Female Patients Following Elective Open Abdominal Aortic Aneurysm Repair.
Bulder RMA, Tedjawirja VN, Hamming JF, Koelemay MJ, Balm R, Lindeman JHN, study group collaborators
Abstract
BMC research notes,
Volume 15, Issue 1, 8 2 2022, Pages 28
The effect of estrogen on brown adipose tissue activity in male rats.
Sievers W, Kettle C, Green RA, Van Schaik L, Hale MW, Irving HR, Whelan DR, Rathner JA
Objective: Centrally administered estrogen can increase sympathetic nerve activity to brown adipose tissue, resulting in thermogenesis. The central thermogenic effects of estrogen have not been investigated in males. Therefore, this study sought to investigate the effects of peripherally and centrally administered estrogen on thermogenesis, heart rate and mean arterial pressure in male rats. Thermogenesis was assessed by monitoring brown adipose tissue temperature. Results: Peripherally administ...
Abstract
Cited 48 times since 2022 (13.6 per year)
source: EuropePMC
Water research,
Volume 214, 5 1 2022, Pages 118162
Prevalence and circulation patterns of SARS-CoV-2 variants in European sewage mirror clinical data of 54 European cities.
Agrawal S, Orschler L, Schubert S, Zachmann K, Heijnen L, Tavazzi S, Gawlik BM, de Graaf M, Medema G, Lackner S
For community-level monitoring, the European Commission under the EU Sewage Sentinel System recommends wastewater-based SARS-CoV-2 surveillance. Tracking SARS-CoV-2 variants in a community is pivotal for appropriate public health response. Genome sequencing of SARS-CoV-2 in wastewater samples for tracking variants is challenging, often resulting in low coverage genome sequences, thereby impeding the detection of the SARS-CoV-2 mutations. Therefore, we aimed at high-coverage SARS-CoV-2 genome seq...
Abstract
Cited 9 times since 2022 (2.5 per year)
source: EuropePMC
Frontiers in cardiovascular medicine,
Volume 8, 3 1 2022, Pages 784980
Interfering in the ALK1 Pathway Results in Macrophage-Driven Outward Remodeling of Murine Vein Grafts.
de Jong A, Sier VQ, Peters HAB, Schilder NKM, Jukema JW, Goumans MJTH, Quax PHA, de Vries MR
Aims: Vein grafts are frequently used to bypass coronary artery occlusions. Unfortunately, vein graft disease (VGD) causes impaired patency rates. ALK1 mediates signaling by TGF-β via TGFβR2 or BMP9/10 via BMPR2, which is an important pathway in fibrotic, inflammatory, and angiogenic processes in vascular diseases. The role of the TGF-β pathway in VGD is previously reported, however, the contribution of ALK1 signaling is not known. Therefore, we investigated ALK1 signaling in VGD in a mouse mode...
Abstract
Cited 5 times since 2022 (1.4 per year)
source: EuropePMC
Journal of interprofessional care,
2 1 2022, Pages 1-9
Exploring the role of power during debriefing of interprofessional simulations.
Robertson K, Ju M, O'Brien BC, van Schaik SM, Bochatay N
Interprofessional simulation aims to improve teamwork and patient care by bringing participants from multiple professions together to practice simulated patient care scenarios. Yet, power dynamics may influence interprofessional learning during simulation, which typically occurs during the debriefing. This issue has received limited attention to date but may explain why communication breakdowns and conflicts among healthcare teams persist despite widespread adoption of interprofessional simulati...
Abstract
Cited 33 times since 2022 (9.3 per year)
source: EuropePMC
Cancer treatment reviews,
Volume 104, 1 1 2022, Pages 102340
Treatment-driven tumour heterogeneity and drug resistance: Lessons from solid tumours.
Crucitta S, Cucchiara F, Mathijssen R, Mateo J, Jager A, Joosse A, Passaro A, Attili I, Petrini I, van Schaik R, Danesi R, Del Re M
Molecular heterogeneity characterizes tumours' evolution and adaptation and, because of its dynamics and continuous changes under external pressure, it is one of the major causes of drug resistance, contributing to therapy failure. Several studies reported evidence of molecular events occuring in individual tumours, including monoclonal or polyclonal resistance, and primary or secondary resistance mechanisms. While primary resistance is a phenomenon already present at the diagnosis of a tum...
Abstract
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology,
Volume 29, Issue 1, 1 1 2022, Pages 4
Correction to: The Role of Editors.
Iskandrian AE, Bax JJ
Abstract
Cited 16 times since 2022 (4.5 per year)
source: EuropePMC
European heart journal. Cardiovascular Imaging,
Volume 23, Issue 3, 1 1 2022, Pages 412-422
The Leiden Convention coronary coding system: translation from the surgical to the universal view.
Koppel CJ, Vliegen HW, Bökenkamp R, Ten Harkel ADJ, Kiès P, Egorova AD, Jukema JW, Hazekamp MG, Schalij MJ, Gittenberger-de Groot AC, Jongbloed MRM
Aims: The Leiden Convention coronary coding system structures the large variety of coronary anatomical patterns; isolated and in congenital heart disease. It is widely used by surgeons but not by cardiologists as the system uses a surgeons' cranial view. Since thoracic surgeons and cardiologists work closely together, a coronary coding system practical for both disciplines is mandatory. To this purpose, the 'surgical' coronary coding system was adapted to an 'imaging' sy...
Abstract
Cited 1 times since 2022 (0.3 per year)
source: EuropePMC
JAMA surgery,
Volume 157, Issue 2, 1 1 2022, Pages 176
Generalizability of the Results and Concerns About Leakage Rates of the ICAN Trial.
de Steur WO, Hutteman M, Hartgrink HH
Abstract
Cited 5 times since 2022 (1.4 per year)
source: EuropePMC
Journal of cardiovascular computed tomography,
Volume 16, Issue 4, 1 1 2022, Pages 319-326
Coronary volume to left ventricular mass ratio in patients with diabetes mellitus.
Kuneman JH, El Mahdiui M, van Rosendael AR, van den Hoogen IJ, Patel MR, Nørgaard BL, Fairbairn TA, Nieman K, Akasaka T, Berman DS, Hurwitz Koweek LM, Pontone G, Kawasaki T, Rønnow Sand NP, Jensen JM, Amano T, Poon M, Øvrehus KA, Sonck J, Rabbat MG, De Bruyne B, Rogers C, Matsuo H, Bax JJ, Leipsic JA, Knuuti J
Background: Diabetes mellitus is a major risk factor for coronary artery disease (CAD) and may provoke structural and functional changes in coronary vasculature. The coronary volume to left ventricular mass (V/M) ratio is a new anatomical parameter capable of revealing a potential physiological imbalance between coronary vasculature and myocardial mass. The aim of this study was to examine the V/M derived from coronary computed tomography angiography (CCTA) in patients with diabetes. Methods: Pa...
Abstract
Cited 6 times since 2022 (1.7 per year)
source: EuropePMC
Journal of tissue viability,
Volume 31, Issue 2, 1 1 2022, Pages 358-364
Translation and validation of the ELPO for Turkish population: Risk assessment scale for the development of pressure injuries due to surgical positioning.
Sengul T, Gul A, Yilmaz D, Gokduman T
Aim of the study: This study was conducted to translate the ELPO risk assessment scale for the development of pressure injuries due to surgical positioning to Turkish and to test its validity and reliability in the Turkish Population. Materials and methods: The data were collected using the patient identification form, the risk assessment scale for the prevention of injuries due to surgical positioning, and the Braden Scale. This scale consisted of a total of seven items, each of which contained...
Abstract
Cited 1 times since 2022 (0.3 per year)
source: EuropePMC
Acta clinica Croatica,
Volume 60, Issue 3, 1 1 2022, Pages 361-366
SYNTHETIC CANNABINOID BONZAI RELATED CREATINE KINASE ENZYME ELEVATION: A TURKISH CENTER STUDY.
Erismis B, Yilmaz D, Polat O, Deniz H, Yucel MH, Hursitoglu M
Synthetic cannabinoid (locally named 'Bonzai' in Turkey) use is increasing worldwide (especially among people with low income). One of its harmful adverse effects is an increase in serum levels of muscle enzymes (i.e., creatine kinase [CK]). The aim of this study was to determine the prevalence of Bonzai use in patients admitted with elevated CK levels and to compare the 1-month survival status of Bonzai users with that of non-Bonzai users. This retrospective study was conducted on a t...
Abstract
Cited 1 times since 2022 (0.3 per year)
source: EuropePMC
Pediatric emergency care,
Volume 38, Issue 2, 1 1 2022, Pages e871-e875
Evaluation of Pediatric Maxillofacial Injury: Who Is Critical?
Ulusoy E, Armağan C, Çağlar A, Er A, Akgül F, Çitlenbik H, Yilmaz D, Duman M
Objective: Isolated facial injuries are less common among pediatric trauma patients. The literature has focused on, especially, fractures in facial injuries. There is a limited number of studies evaluating all facial injuries in childhood. The study aims to evaluate the clinical characteristics of maxillofacial injuries and to identify patients who require further intervention. Methods: The data from pediatric patients with maxillofacial injury (
Abstract
Cited 32 times since 2022 (9 per year)
source: EuropePMC
JAMA cardiology,
Volume 7, Issue 2, 1 1 2022, Pages 175-183
Outcomes Associated With Catheter Ablation of Ventricular Tachycardia in Patients With Cardiac Sarcoidosis.
Siontis KC, Santangeli P, Muser D, Marchlinski FE, Zeppenfeld K, Hoogendoorn JC, Narasimhan C, Sauer WH, Zipse MM, Kapa S, Vedantham V, Rosenthal DG, Robinson MR, Patton KK, Murgatroyd F, Chicos AB, Soejima K, Roukoz H, Sacher F, Bhan A, Appelbaum J, Dickfeld T, Mankad P, Ellenbogen KA, Kron J, Kim HM, Froehlich J, Eagle KA, Bogun FM, Crawford TC
Importance: Ventricular tachycardia (VT) is associated with high mortality in patients with cardiac sarcoidosis (CS), and medical management of CS-associated VT is limited by high failure rates. The role of catheter ablation has been investigated in small, single-center studies. Objective: To investigate outcomes associated with VT ablation in patients with CS. Design, setting, and participants: This cohort study from the Cardiac Sarcoidosis Consortium registry (2003-2019) included 16 tertiary r...
Abstract
Cited 10 times since 2022 (2.8 per year)
source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology,
Volume 24, Issue 2, 1 1 2022, Pages 296-305
Comparing clinical performance of current implantable cardioverter-defibrillator implantation recommendations in arrhythmogenic right ventricular cardiomyopathy.
Bosman LP, Bosman LP, Nielsen Gerlach CL, Cadrin-Tourigny J, Orgeron G, Tichnell C, Murray B, Bourfiss M, van der Heijden JF, Yap SC, Zeppenfeld K, van den Berg MP, Wilde AAM, Asselbergs FW, Tandri H, Calkins H, van Tintelen JP, James CA, Te Riele ASJM
Aims: Arrhythmogenic right ventricular cardiomyopathy (ARVC) patients have an increased risk of ventricular arrhythmias (VA). Four implantable cardioverter-defibrillator (ICD) recommendation algorithms are available The International Task Force Consensus ('ITFC'), an ITFC modification by Orgeron et al. ('mITFC'), the AHA/HRS/ACC guideline for VA management ('AHA'), and the HRS expert consensus statement ('HRS'). This study aims to validate and compare the...
Abstract
Cited 3 times since 2022 (0.8 per year)
source: EuropePMC
Frontiers in genetics,
Volume 12, 31 5 2022, Pages 785947
Protocol: A Multiplexed Reporter Assay to Study Effects of Chromatin Context on DNA Double-Strand Break Repair.
Schep R, Leemans C, Brinkman EK, van Schaik T, van Steensel B
DNA double-strand breaks (DSBs) can be repaired through various pathways. Understanding how these pathways are regulated is of great interest for cancer research and optimization of gene editing. The local chromatin environment can affect the balance between repair pathways, but this is still poorly understood. Here we provide a detailed protocol for DSB-TRIP, a technique that utilizes the specific DNA scars left by DSB repair pathways to study pathway usage throughout the genome. DSB-TRIP rando...
Abstract
Cited 11 times since 2022 (3.1 per year)
source: EuropePMC
JACC. Clinical electrophysiology,
Volume 8, Issue 4, 31 5 2022, Pages 437-449
Multielectrode Unipolar Voltage Mapping and Electrogram Morphology to Identify Post-Infarct Scar Geometry: Validation by Histology.
Glashan CA, Tofig BJ, Beukers H, Tao Q, Blom SA, Villadsen PR, Lassen TR, de Riva M, Kristiansen SB, Zeppenfeld K
Objectives: This study sought to evaluate the ability of uni- and bipolar electrograms collected with a multielectrode catheter with smaller electrodes to: 1) delineate scar; and 2) determine local scar complexity. Background: Early reperfusion results in variable endocardial scar, often overlaid with surviving viable myocardium. Although bipolar voltage (BV) mapping is considered the pillar of substrate-based ablation, the role of unipolar voltage (UV) mapping has not been sufficiently explored...
Abstract
Cited 1 times since 2022 (0.3 per year)
source: EuropePMC
Frontiers in cardiovascular medicine,
Volume 9, 31 5 2022, Pages 793972
Hybrid CMR- and FDG-PET-Imaging Gives New Insights Into the Relationship of Myocardial Metabolic Activity and Fibrosis in Patients With Becker Muscular Dystrophy.
Vehof V, Büther F, Florian A, Drakos S, Chamling B, Kies P, Stegger L, Yilmaz A
Background: Cardiac involvement in patients with Becker muscular dystrophy (BMD) is an important predictor of mortality. The cardiac phenotype of BMD patients is characterized by slowly progressive myocardial fibrosis that starts in the left ventricular (LV) free wall segments and extends into the septal wall during the disease course. Purpose: Since the reason for this characteristic cardiac phenotype is unknown and comprehensive approaches using e.g. hybrid imaging combining cardiovascular mag...
Abstract
