9618 results
Cited 4 times since 2022 (1.1 per year)
source: EuropePMC
Scientific reports,
Volume 12, Issue 1, 31 5 2022, Pages 1628
Chemotherapy response prediction with diffuser elapser network.
Koyuncu B, Melek A, Yilmaz D, Tuzer M, Unlu MB
In solid tumors, elevated fluid pressure and inadequate blood perfusion resulting from unbalanced angiogenesis are the prominent reasons for the ineffective drug delivery inside tumors. To normalize the heterogeneous and tortuous tumor vessel structure, antiangiogenic treatment is an effective approach. Additionally, the combined therapy of antiangiogenic agents and chemotherapy drugs has shown promising effects on enhanced drug delivery. However, the need to find the appropriate scheduling and...
Abstract
Cited 7 times since 2022 (2 per year)
source: EuropePMC
BMC health services research,
Volume 22, Issue 1, 30 5 2022, Pages 129
Clarifying responsibility: professional digital health in the doctor-patient relationship, recommendations for physicians based on a multi-stakeholder dialogue in the Netherlands.
Silven AV, van Peet PG, Boers SN, Tabak M, de Groot A, Hendriks D, van Os HJA, Bonten TN, Atsma DE, de Graaf TJ, Sombroek MP, Chavannes NH, Villalobos-Quesada M
Background: Implementation of digital health (eHealth) generally involves adapting pre-established and carefully considered processes or routines, and still raises multiple ethical and legal dilemmas. This study aimed to identify challenges regarding responsibility and liability when prescribing digital health in clinical practice. This was part of an overarching project aiming to explore the most pressing ethical and legal obstacles regarding the implementation and adoption of digital health in...
Abstract
Cited 4 times since 2022 (1.1 per year)
source: EuropePMC
BMC ecology and evolution,
Volume 22, Issue 1, 28 4 2022, Pages 7
Long-term individualized monitoring of sympatric bat species reveals distinct species- and demographic differences in hibernation phenology.
Meier F, Grosche L, Reusch C, Runkel V, van Schaik J, Kerth G
Background: Hibernation allows species to conserve energy and thereby bridge unfavorable environmental conditions. At the same time, hibernation imposes substantial ecological and physiological costs. Understanding how hibernation timing differs within and between species can provide insights into the underlying drivers of this trade-off. However, this requires individualized long-term data that are often unavailable. Here, we used automatic monitoring techniques and a reproducible analysis pipe...
Abstract
Cited 6 times since 2022 (1.7 per year)
source: EuropePMC
Journal of perinatal medicine,
Volume 50, Issue 4, 28 4 2022, Pages 467-475
Effects of music on sleep quality and comfort levels of pregnant women.
Sanlı Y, Goke Arslan G, Aypar Akbag NN, Canbulat Sahiner N, Yılmaz D, Yucel SC
Objectives: This pilot randomized controlled experimental study was conducted to investigate effects of music on sleep quality and comfort levels of pregnant women. Methods: The sample of the study consisted of 70 pregnant women who met the inclusion criteria and agreed to participate in the study. The pregnant women were assigned to the music (n=35) and control groups (n=35). In the study, the musical pieces composed in Uşşak mode were played for the participants in the music group. The pregnan...
Abstract
Cited 7 times since 2022 (2 per year)
source: EuropePMC
Circulation. Arrhythmia and electrophysiology,
Volume 15, Issue 2, 28 4 2022, Pages e009979
Nonsustained Ventricular Tachycardia Is Independently Associated With Sustained Ventricular Arrhythmias in Nonischemic Dilated Cardiomyopathy.
Piers SR, Androulakis AF, Yim KS, van Rein N, Venlet J, Kapel GF, Siebelink HM, Lamb HJ, Cannegieter SC, Man SC, Zeppenfeld K
Background: Spontaneous nonsustained ventricular tachycardia (NSVT) on Holter, VT inducibility during electrophysiology study, and late gadolinium enhancement (LGE) on cardiac magnetic resonance (CMR) have been associated with sustained ventricular arrhythmias (SVAs) in nonischemic dilated cardiomyopathy (DCM). This study aimed to analyze whether these parameters carry independent prognostic value for spontaneous SVA in DCM. Methods: Between 2011 and 2018, patients with the DCM clinical spectrum...
Abstract
Cited 5 times since 2022 (1.4 per year)
source: EuropePMC
Journal of cardiovascular development and disease,
Volume 9, Issue 2, 27 4 2022, Pages 43
Sarcomere Disassembly and Transfection Efficiency in Proliferating Human iPSC-Derived Cardiomyocytes.
Yuan Q, Maas RGC, Brouwer ECJ, Pei J, Blok CS, Popovic MA, Paauw NJ, Bovenschen N, Hjortnaes J, Harakalova M, Doevendans PA, Sluijter JPG, van der Velden J, Buikema JW
Contractility of the adult heart relates to the architectural degree of sarcomeres in individual cardiomyocytes (CMs) and appears to be inversely correlated with the ability to regenerate. In this study we utilized multiple imaging techniques to follow the sequence of sarcomere disassembly during mitosis resulting in cellular or nuclear division in a source of proliferating human pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). We observed that both mono- and binuclear hiPSC-CMs give ri...
Abstract
Cited 19 times since 2022 (5.3 per year)
source: EuropePMC
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography,
Volume 35, Issue 7, 26 4 2022, Pages 703-711.e3
Noninvasive Left Ventricular Myocardial Work in Patients with Chronic Aortic Regurgitation and Preserved Left Ventricular Ejection Fraction.
Meucci MC, Butcher SC, Galloo X, van der Velde ET, Marsan NA, Bax JJ, Delgado V
Background: Left ventricular (LV) global longitudinal strain (GLS) has been proposed as a sensitive marker of myocardial damage in patients with chronic severe aortic regurgitation (AR) and preserved LV ejection fraction (LVEF). However, LV GLS does not take into account the afterload. Noninvasive LV myocardial work is a novel parameter of LV myocardial performance, which integrates measurements of myocardial deformation and noninvasive blood pressure (afterload). The aims of this study were (1)...
Abstract
Cited 2 times since 2022 (0.6 per year)
source: EuropePMC
Preventive veterinary medicine,
Volume 200, 25 4 2022, Pages 105582
Capacity of a Bayesian model to detect infected herds using disease dynamics and risk factor information from surveillance programmes: A simulation study.
Mercat M, van Roon AM, Santman-Berends I, van Schaik G, Nielen M, Graham D, More SJ, Guelbenzu-Gonzalo M, Fourichon C, Madouasse A
Control programmes against non-regulated infectious diseases of farm animals are widely implemented. Different control programmes have different definitions of "freedom from infection" which can lead to difficulties when trading animals between countries. When a disease is still present, in order to identify herds that are safe to trade with, estimating herd-level probabilities of being infected when classified "free from infection" using field data is of major interest. Our...
Abstract
Nederlands tijdschrift voor geneeskunde,
Volume 166, 24 4 2022, Pages D6172
[Genotype-guided antithrombotic therapy].
van den Broek WWA, Azzahhafi J, van Schaik RHN, Ten Berg JM
Although current literature indicates both a clinical and a cost-effective benefit of routine genotype-guided treatment of patients treated with clopidogrel, this strategy is not recommended in guidelines. In cardiology, but also in neurology and vascular surgery, the current scientific evidence for this is still insufficient. Nevertheless, the role of pharmacogenetics will gain importance in today's medical world, where the demand for personalised medicine is on the rise. The implementatio...
Abstract
Cited 15 times since 2022 (4.2 per year)
source: EuropePMC
eLife,
Volume 11, 24 4 2022, Pages e74387
Dynamics and nanoscale organization of the postsynaptic endocytic zone at excitatory synapses.
Catsburg LA, Westra M, van Schaik AM, MacGillavry HD
At postsynaptic sites of neurons, a prominent clathrin-coated structure, the endocytic zone (EZ), controls the trafficking of glutamate receptors and is essential for synaptic plasticity. Despite its importance, little is known about how this clathrin structure is organized to mediate endocytosis. We used live-cell and super-resolution microscopy to reveal the dynamic organization of this poorly understood clathrin structure in rat hippocampal neurons. We found that a subset of endocytic protein...
Abstract
Cited 35 times since 2022 (9.8 per year)
source: EuropePMC
Neurology,
Volume 98, Issue 4, 24 4 2022, Pages e343-e351
Cardiovascular Risk Factors and MRI Markers of Cerebral Small Vessel Disease: A Mendelian Randomization Study.
Taylor-Bateman V, Gill D, Georgakis MK, Malik R, Munroe P, Traylor M, International Consortium of Blood Pressure (ICBP)
Background and objectives: Cardiovascular risk factors have been implicated in the etiology of cerebral small vessel disease (CSVD); however, whether the associations are causal remains unclear in part due to the susceptibility of observational studies to reverse causation and confounding. Here, we use mendelian randomization (MR) to determine which cardiovascular risk factors are likely to be involved in the etiology of CSVD. Methods: We used data from large-scale genome-wide association studie...
Abstract
The American journal of cardiology,
Volume 169, 23 4 2022, Pages 93-99
Long-Term Impact of Preventive Tricuspid Valve Annuloplasty on Right Ventricular Remodeling.
Dietz MF, van Wijngaarden AL, Mack MJ, Braun J, Ajmone Marsan N, Delgado V, Klautz R, Bax JJ
In patients with primary mitral regurgitation (MR), concomitant tricuspid valve (TV) annuloplasty at the time of left-sided valve surgery is indicated in case of a dilated TV annulus ≥40 mm independent of the presence or severity of tricuspid regurgitation (TR). However, the long-term impact on right ventricular (RV) adverse remodeling is less well established and the benefit of preventive TV annuloplasty remains controversial. The aim of the study was to assess differences in long-term RV adver...
Abstract
Cited 13 times since 2022 (3.6 per year)
source: EuropePMC
ESC heart failure,
Volume 9, Issue 2, 22 4 2022, Pages 912-924
Functional classification of left ventricular remodelling: prognostic relevance in myocardial infarction.
Chimed S, van der Bijl P, Lustosa R, Fortuni F, Montero-Cabezas JM, Ajmone Marsan N, Gersh BJ, Delgado V, Bax JJ
Aims: The current definition of post ST-segment elevation myocardial infarction (STEMI) left ventricular (LV) remodelling is purely structural (LV dilatation) and does not consider LV function (ejection fraction, EF), even though it is known to be a predictor of long-term post-STEMI outcome. This study aimed to reclassify LV remodelling after STEMI by integrating LV dilatation and function (LVEF) and to investigate the prognostic implications. Methods and results: Data from an ongoing registry o...
Abstract
Cited 24 times since 2022 (6.7 per year)
source: EuropePMC
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography,
Volume 35, Issue 5, 21 3 2022, Pages 477-485.e3
Left Atrial Reservoir Function and Outcomes in Secondary Mitral Regurgitation.
Stassen J, Namazi F, van der Bijl P, van Wijngaarden SE, Kamperidis V, Marsan NA, Delgado V, Bax JJ
Background: Left atrial (LA) size is a marker of disease severity and is related to worse outcomes in secondary mitral regurgitation (MR). The prognostic value of LA function assessed by LA reservoir strain (LARS), however, remains unknown. The aim of this study was to investigate the prognostic implications of LARS in patients with significant secondary MR. Methods: LARS was evaluated using speckle-tracking echocardiography in patients with more than mild (grade ≥ 2) secondary MR. The populatio...
Abstract
Cited 2 times since 2022 (0.6 per year)
source: EuropePMC
Life (Basel, Switzerland),
Volume 12, Issue 2, 21 3 2022, Pages 154
Near-Infrared Fluorescence with Indocyanine Green to Assess Bone Perfusion: A Systematic Review.
Michi M, Madu M, Winters HAH, de Bruin DM, van der Vorst JR, Driessen C
Background: Adequate perfusion of a bone flap is essential for successful reconstruction of osseous defects. Unfortunately, complications related to inadequate bone perfusion are common. Near-infrared fluorescence (NIRF) imaging enables intraoperative visualization of perfusion. NIRF has been investigated in reconstructive surgery to aid the surgeon in clinical perioperative assessment of soft tissue perfusion. However, little is known on the beneficial use of NIRF to assess bone perfusion. Ther...
Abstract
Cited 7 times since 2022 (2 per year)
source: EuropePMC
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract,
Volume 26, Issue 5, 20 3 2022, Pages 1063-1069
In-hospital Delay of Appendectomy in Acute, Complicated Appendicitis.
Bolmers MDM, de Jonge J, Bom WJ, van Rossem CC, van Geloven AAW, Bemelman WA, Snapshot Appendicitis Collaborative Study group
Background: Present theory is that uncomplicated and complicated appendicitis are different entities. Recent studies suggest it is safe to delay surgery in patients with uncomplicated appendicitis. We hypothesize that patients with complicated appendicitis are at higher risk for postoperative complications when surgery is delayed. Methods: Data was used from the multicenter, prospective SNAPSHOT appendicitis study of 1975 patients undergoing surgery for suspected appendicitis. Adult patients (≥ ...
Abstract
Cited 4 times since 2022 (1.1 per year)
source: EuropePMC
The Annals of thoracic surgery,
Volume 116, Issue 3, 20 3 2022, Pages 483-490
Outcomes of Surgical Bioprosthetic Aortic Valve Replacement in Patients Aged ≤65 and >65 Years.
Kiaii BB, Moront MG, Patel HJ, Ruel M, Bensari FN, Kress DC, Liu F, Klautz RJM, Sabik JF
Background: Implantation of a bioprosthetic valve is a reasonable choice for patients aged > 65 years. For middle-aged patients there is less certainty about whether a mechanical or bioprosthetic valve is best. Methods: The Pericardial Surgical Aortic Valve Replacement (PERIGON) Pivotal Trial is evaluating the safety and efficacy of the Avalus bioprosthesis (Medtronic). We evaluated clinical and echocardiographic outcomes through 5 years of follow-up, stratified by age ≤ 65 and >65 years....
Abstract
Cited 40 times since 2022 (11.2 per year)
source: EuropePMC
Frontiers in cardiovascular medicine,
Volume 8, 20 3 2022, Pages 827515
Robotic Cardiac Surgery in Europe: Status 2020.
Cerny S, Oosterlinck W, Onan B, Singh S, Segers P, Bolcal C, Alhan C, Navarra E, Pettinari M, Van Praet F, De Praetere H, Vojacek J, Cebotaru T, Modi P, Doguet F, Franke U, Ouda A, Melly L, Malapert G, Labrousse L, Gianoli M, Agnino A, Philipsen T, Jansens JL, Folliguet T, Palmen M, Pereda D, Musumeci F, Suwalski P, Cathenis K, Van den Eynde J, Bonatti J
Background: European surgeons were the first worldwide to use robotic techniques in cardiac surgery and major steps in procedure development were taken in Europe. After a hype in the early 2000s case numbers decreased but due to technological improvements renewed interest can be noted. We assessed the current activities and outcomes in robotically assisted cardiac surgery on the European continent. Methods: Data were collected in an international anonymized registry of 26 European centers with a...
Abstract
Cited 25 times since 2022 (7 per year)
source: EuropePMC
International journal of molecular sciences,
Volume 23, Issue 3, 19 3 2022, Pages 1057
N-6-Methyladenosine in Vasoactive microRNAs during Hypoxia; A Novel Role for METTL4.
van den Homberg DAL, van der Kwast RVCT, Quax PHA, Nossent AY
N-6-methyladenosine (m6A) is the most prevalent post-transcriptional RNA modification in eukaryotic cells. The modification is reversible and can be dynamically regulated by writer and eraser enzymes. Alteration in the levels of these enzymes can lead to changes in mRNA stability, alternative splicing or microRNA processing, depending on the m6A-binding proteins. Dynamic regulation of mRNA m6A methylation after ischemia and hypoxia influences mRNA stability, alternative splicing and translation,...
Abstract
Cited 2 times since 2022 (0.6 per year)
source: EuropePMC
The American journal of cardiology,
Volume 171, 19 3 2022, Pages 151-158
Prognostic Implications of Right Ventricular Free Wall Strain in Recipients of Cardiac Resynchronization Therapy.
Stassen J, van der Bijl P, Galloo X, Hirasawa K, Prihadi EA, Marsan NA, Bax JJ
Right ventricular (RV) function is an important prognostic marker in cardiac resynchronization therapy (CRT) recipients. Measuring RV systolic function with echocardiography, however, remains challenging due to the complexity of right heart morphology. Evaluation of RV function with RV free wall strain (FWS) may improve risk stratification in recipients of CRT compared with conventional RV function parameters. In 871 recipients of CRT (mean age 65 ± 11 years, 75% were men), RV function was asses...
Abstract
