9618 results
Cited 24 times since 2022 (6.7 per year)
source: EuropePMC
The Journal of biological chemistry,
Volume 298, Issue 3, 14 2 2022, Pages 101589
Immunosuppressive calcineurin inhibitor cyclosporine A induces proapoptotic endoplasmic reticulum stress in renal tubular cells.
Yilmaz DE, Kirschner K, Demirci H, Himmerkus N, Bachmann S, Mutig K
Current immunosuppressive strategies in organ transplantation rely on calcineurin inhibitors cyclosporine A (CsA) or tacrolimus (Tac). Both drugs are nephrotoxic, but CsA has been associated with greater renal damage than Tac. CsA inhibits calcineurin by forming complexes with cyclophilins, whose chaperone function is essential for proteostasis. We hypothesized that stronger toxicity of CsA may be related to suppression of cyclophilins with ensuing endoplasmic reticulum (ER) stress and unfolded...
Abstract
Cited 8 times since 2022 (2.2 per year)
source: EuropePMC
Journal of plastic, reconstructive & aesthetic surgery : JPRAS,
Volume 75, Issue 6, 14 2 2022, Pages 1820-1825
Quantification of near-infrared fluorescence imaging with indocyanine green in free flap breast reconstruction.
Van Den Hoven P, Verduijn PS, Van Capelle L, Tange FP, Michi M, Corion LUM, Sibinga Mulder BG, Mureau MAM, Vahrmeijer AL, Van Der Vorst JR
Background: One of the complications of free flap breast reconstruction is the occurrence of skin and fat necrosis. Intra-operative use of near-infrared (NIR) fluorescence imaging with Indocyanine Green (ICG) has the potential to predict these complications. In this study, the quantification of the fluorescence intensity measured in free flap breast reconstruction was performed to gain insight into the perfusion patterns observed with ICG NIR fluorescence imaging. Methods: ICG NIR fluorescence i...
Abstract
Cited 1 times since 2022 (0.3 per year)
source: EuropePMC
Frontiers in robotics and AI,
Volume 8, 13 2 2022, Pages 781985
Who Wants to Grant Robots Rights?
De Graaf MMA, Hindriks FA, Hindriks KV
The robot rights debate has thus far proceeded without any reliable data concerning the public opinion about robots and the rights they should have. We have administered an online survey (n = 439) that investigates layman's attitudes toward granting particular rights to robots. Furthermore, we have asked them the reasons for their willingness to grant them those rights. Finally, we have administered general perceptions of robots regarding appearance, capacities, and traits. Results show tha...
Abstract
Cited 25 times since 2022 (6.9 per year)
source: EuropePMC
JACC. Cardiovascular imaging,
Volume 15, Issue 6, 12 2 2022, Pages 961-970
Prognostic Impact of Extra-Mitral Valve Cardiac Involvement in Patients With Primary Mitral Regurgitation.
van Wijngaarden AL, Mantegazza V, Hiemstra YL, Volpato V, van der Bijl P, Pepi M, Palmen M, Delgado V, Ajmone Marsan N, Tamborini G, Bax JJ
Background: In patients with severe primary mitral regurgitation (MR), the indication for surgery is currently based on the presence of symptoms, left ventricular dilatation and dysfunction, atrial fibrillation, and pulmonary hypertension. Objectives: The aim of this study was to evaluate the prognostic impact of the presence of extra-mitral valve cardiac involvement (including known risk factors but also severe left atrial [LA] dilatation and right ventricular [RV] dysfunction) in a large multi...
Abstract
Cited 2 times since 2022 (0.6 per year)
source: EuropePMC
JACC. Cardiovascular imaging,
Volume 15, Issue 2, 12 2 2022, Pages 221-223
Apical Rocking and Septal Flash: Predictors of Secondary Mitral Regurgitation Improvement After Cardiac Resynchronization Therapy.
Bax JJ, van der Bijl P
Abstract
Cited 4 times since 2022 (1.1 per year)
source: EuropePMC
JACC. Cardiovascular imaging,
Volume 15, Issue 5, 12 2 2022, Pages 745-746
Etiology and Outcomes of Isolated Tricuspid Regurgitation.
Bax JJ, van der Bijl P
Abstract
Cited 31 times since 2022 (8.6 per year)
source: EuropePMC
Communications medicine,
Volume 2, 11 2 2022, Pages 6
Resisting disinfectants.
van Dijk HFG, Verbrugh HA, Ad hoc advisory committee on disinfectants of the Health Council of the Netherlands
Although often overlooked, the use of disinfectants can lead to antimicrobial resistance and this may exacerbate resistance to antibiotics. Here, we explain why all antimicrobial agents, including disinfectants, should be used prudently in a way that is guided by evidence.
Abstract
Cited 14 times since 2022 (3.9 per year)
source: EuropePMC
The Cochrane database of systematic reviews,
Volume 1, 11 2 2022, Pages CD004429
Immunoglobulin for multifocal motor neuropathy.
Keddie S, Eftimov F, van den Berg LH, Brassington R, de Haan RJ, van Schaik IN
Background: Multifocal motor neuropathy (MMN) is a rare, probably immune-mediated disorder characterised by slowly progressive, asymmetric, distal weakness of one or more limbs with no objective loss of sensation. It may cause prolonged periods of disability. Treatment options for MMN are few. People with MMN do not usually respond to steroids or plasma exchange. Uncontrolled studies have suggested a beneficial effect of intravenous immunoglobulin (IVIg). This is an update of a Cochrane Review f...
Abstract
Cited 6 times since 2022 (1.7 per year)
source: EuropePMC
Cardiovascular revascularization medicine : including molecular interventions,
Volume 40, 11 2 2022, Pages 189-194
Bailout Intravascular Lithotripsy for the Treatment of Acutely Underexpanded Stents in Heavily Calcified Coronary Lesions: A Case Series.
Mousa MAA, Bingen BO, Amri IA, Digiacomo S, Karalis I, Jukema JW, Montero-Cabezas JM
Stent underexpansion is a common problem in heavily calcified coronary lesions treated with percutaneous coronary intervention, and has been associated with in-stent restenosis, stent thrombosis and, subsequently, poor clinical outcomes. Adequate preparation of heavily calcified coronary lesions (e.g. using non-compliant balloons, cutting/scoring balloons, rotational/orbital atherectomy or intravascular lithotripsy) prior to stent implantation is essential in preventing stent underexpansion. How...
Abstract
Cited 6 times since 2022 (1.7 per year)
source: EuropePMC
Ultrastructural pathology,
Volume 46, Issue 1, 11 2 2022, Pages 63-79
Distribution of Aquaporin-4 channels in hippocampus and prefrontal cortex in mk-801-treated balb/c mice.
Ericek OB, Akillioglu K, Saker D, Cevik I, Donmez Kutlu M, Kara S, Yilmaz DM
Functional disorders of the glymphatic system and Aquaporin-4 (AQP-4) channels take part in the pathophysiology of neurodegenerative disease. The aim of this study was to describe the distribution of AQP-4 channels in the prefrontal cortex and hippocampus in a mouse model of NMDA receptor blocking agent-induced schizophrenia-like behavior model. NMDA receptor antagonist MK-801 was used to produce the experimental schizophrenia model. MK-801 injections were administered for eleven days to Balb/c...
Abstract
Cited 6 times since 2022 (1.7 per year)
source: EuropePMC
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery,
Volume 63, Issue 2, 10 2 2022, Pages 275-283
Treatment Outcome Trends for Non-Ruptured Abdominal Aortic Aneurysms: A Nationwide Prospective Cohort Study.
Alberga AJ, Karthaus EG, Wilschut JA, de Bruin JL, Akkersdijk GP, Geelkerken RH, Hamming JF, Wever JJ, Verhagen HJM, Dutch Society of Vascular Surgery, Steering Committee of the Dutch Surgical Aneurysm Audit, and the Dutch Institute for Clinical Auditing
Objective: The Dutch Surgical Aneurysm Audit (DSAA) initiative was established in 2013 to monitor and improve nationwide outcomes of aortic aneurysm surgery. The objective of this study was to examine whether outcomes of surgery for intact abdominal aortic aneurysms (iAAA) have improved over time. Methods: Patients who underwent primary repair of an iAAA by standard endovascular (EVAR) or open surgical repair (OSR) between 2014 and 2019 were selected from the DSAA for inclusion. The primary outc...
Abstract
Non-coding RNA,
Volume 8, Issue 1, 10 2 2022, Pages 2
Circulating miRNAs and Vascular Injury Markers Associate with Cardiovascular Function in Older Patients Reaching End-Stage Kidney Disease.
Zhao Q, Nooren SJL, Zijlstra LE, Westenberg JJM, Kroft LJM, Jukema JW, Berkhout-Byrne NC, Rabelink TJ, van Zonneveld AJ, van Buren M, Mooijaart SP, Bijkerk R
The prevalence of end-stage kidney disease (ESKD) is rapidly increasing and mostly occurring in patients aged 65 years or older. The main cause of death in these patients is cardiovascular disease (CVD). Novel markers of vascular integrity may thus be of clinical value for identifying patients at high risk for CVD. Here we associated the levels of selected circulating angiogenic miRNAs, angiopoietin-2 (Ang-2) and asymmetric dimethylarginine (ADMA) with cardiovascular structure and function (as d...
Abstract
Cited 7 times since 2022 (1.9 per year)
source: EuropePMC
European radiology,
Volume 32, Issue 5, 8 2 2022, Pages 3408-3422
Utilizing (serial) coronary computed tomography angiography (CCTA) to predict plaque progression and major adverse cardiac events (MACE): results, merits and challenges.
van Driest FY, Bijns CM, van der Geest RJ, Broersen A, Dijkstra J, Scholte AJHA, Jukema JW
Objectives: To present an overview of studies using serial coronary computed tomography angiography (CCTA) as a tool for finding both quantitative (changes) and qualitative plaque characteristics as well as epicardial adipose tissue (EAT) volume changes as predictors of plaque progression and/or major adverse cardiac events (MACE) and outline the challenges and advantages of using a serial non-invasive imaging approach for assessing cardiovascular prognosis. Methods: A literature search was perf...
Abstract
Cited 5 times since 2022 (1.4 per year)
source: EuropePMC
Brain and behavior,
Volume 12, Issue 2, 7 1 2022, Pages e2407
A neural signature for combined action observation and motor imagery? An fNIRS study into prefrontal activation, automatic imitation, and self-other perceptions.
Emerson JR, Scott MW, van Schaik P, Butcher N, Kenny RPW, Eaves DL
Introduction: Research indicates that both observed and imagined actions can be represented in the brain as two parallel sensorimotor representations. One proposal is that higher order cognitive processes would align these two hypothetical action simulations. Methods: We investigated this hypothesis using an automatic imitation paradigm, with functional near-infrared spectroscopy recordings over the prefrontal cortex during different motor simulation states. On each trial, participants (n = 14)...
Abstract
Cited 7 times since 2022 (1.9 per year)
source: EuropePMC
PloS one,
Volume 17, Issue 1, 7 1 2022, Pages e0261826
Association of cognitive function with increased risk of cancer death and all-cause mortality: Longitudinal analysis, systematic review, and meta-analysis of prospective observational studies.
Rostamian S, le Cessie S, Marijt KA, Jukema JW, Mooijaart SP, van Buchem MA, van Hall T, Gussekloo J, Trompet S
Background: Disturbed cognitive function is associated with several causes of mortality; however, the association between cognitive function and the risk of cancer death has not been extensively investigated yet. We aimed to evaluate the association of cognitive function with the risk of cancer death and all-cause mortality in the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER) and Leiden 85-plus Study. Additionally, a systematic review and meta-analysis of longitudinal studies...
Abstract
Cited 3 times since 2022 (0.8 per year)
source: EuropePMC
Archives of physical medicine and rehabilitation,
Volume 103, Issue 8, 6 1 2022, Pages 1582-1591
Reducing the Number of Test Items of the Action Research Arm Test Poststroke: A Decision Tree Analysis<sup>✰</sup>.
Zonjee VJ, Selles RW, Roorda LD, Nijland RH, van der Oest MJW, Bosomworth HJ, van Wijck F, Meskers CGM, van Schaik SM, Van den Berg-Vos RM, Kwakkel G
Objective: The present study aimed to create a shorter version of the Action Research Arm Test (ARAT) without compromising its measurement properties. Design: Secondary analysis of stroke recovery cohorts that used the ARAT to measure upper limb impairment. Setting: Rehabilitation centers. Participants: Patients with stroke from 5 different stroke recovery cohorts (N=1425). Interventions: Not applicable. Main outcome measures: A decision tree version of the ARAT (ARAT-DT) was developed using chi...
Abstract
Cited 11 times since 2022 (3 per year)
source: EuropePMC
Frontiers in microbiology,
Volume 12, 6 1 2022, Pages 765492
Temperature-Regulated IncX3 Plasmid Characteristics and the Role of Plasmid-Encoded H-NS in Thermoregulation.
Baomo L, Lili S, Moran RA, van Schaik W, Chao Z
Carbapenem-resistant Enterobacteriaceae (CRE) are a critical public health problem worldwide. Globally, IncX3-type plasmids have emerged as the predominant vehicles carrying the metallo-β-lactamase gene bla NDM. Although bla NDM-bearing IncX3 plasmids have been found in various hosts from diverse environments, whether their transfer and persistence properties vary under different conditions and what factors influence any variation is unknown. By observing the effects of different temperatures on...
Abstract
Cited 21 times since 2022 (5.8 per year)
source: EuropePMC
Nature biomedical engineering,
Volume 6, Issue 4, 6 1 2022, Pages 389-402
Conditional immortalization of human atrial myocytes for the generation of in vitro models of atrial fibrillation.
Harlaar N, Dekker SO, Zhang J, Snabel RR, Veldkamp MW, Verkerk AO, Fabres CC, Schwach V, Lerink LJS, Rivaud MR, Mulder AA, Corver WE, Goumans MJTH, Dobrev D, Klautz RJM, Schalij MJ, Veenstra GJC, Passier R, van Brakel TJ, Pijnappels DA, de Vries AAF
The lack of a scalable and robust source of well-differentiated human atrial myocytes constrains the development of in vitro models of atrial fibrillation (AF). Here we show that fully functional atrial myocytes can be generated and expanded one-quadrillion-fold via a conditional cell-immortalization method relying on lentiviral vectors and the doxycycline-controlled expression of a recombinant viral oncogene in human foetal atrial myocytes, and that the immortalized cells can be used to generat...
Abstract
Cited 3 times since 2022 (0.8 per year)
source: EuropePMC
Surgical endoscopy,
Volume 36, Issue 8, 6 1 2022, Pages 6214-6222
Does livestreaming surgical education have the future? Development and participant evaluation of a national COVID-19 livestreaming initiative.
Feenstra TM, van Felius LP, Vriens MR, Stassen LPS, van Acker GJD, van Dijkum EJMN, Schijven MP, Bonjer HJ, NVvH Livestream Collaborative Group
Backgrounds: COVID-19 related reduction of surgical procedures jeopardizes learning on the job of surgical residents. Many educators resorted to digital resources in the search for alternatives. However, these resources are often limited to the extent they offer resident-surgeon interaction like a joint surgical performance does. Here we present a roadmap of livestreaming surgical procedures, and evaluate how surgical livestreams on human cadavers address the unmet educational needs of surgical...
Abstract
Cited 31 times since 2022 (8.6 per year)
source: EuropePMC
European journal of cancer (Oxford, England : 1990),
Volume 162, 5 1 2022, Pages 148-157
UGT1A1 genotype-guided dosing of irinotecan: A prospective safety and cost analysis in poor metaboliser patients.
Hulshof EC, de With M, de Man FM, Creemers GJ, Deiman BALM, Swen JJ, Houterman S, Koolen SLW, Bins S, Thijs AMJ, Laven MMJ, Hövels AM, Luelmo SAC, Houtsma D, Shulman K, McLeod HL, van Schaik RHN, Guchelaar HJ, Mathijssen RHJ, Gelderblom H, Deenen MJ
Aim: To determine the safety, feasibility, pharmacokinetics, and cost of UGT1A1 genotype-guided dosing of irinotecan. Patients and methods: In this prospective, multicentre, non-randomised study, patients intended for treatment with irinotecan were pre-therapeutically genotyped for UGT1A1∗28 and UGT1A1∗93. Homozygous variant carriers (UGT1A1 poor metabolisers; PMs) received an initial 30% dose reduction. The primary endpoint was incidence of febrile neutropenia in the first two cycles of treatme...
Abstract
