7827 results
Cited 8 times since 2019 (1.4 per year)
source: EuropePMC
Journal of clinical psychopharmacology,
Volume 39, Issue 6, 1 1 2019, Pages 583-590
Effects of Pharmacogenetic Screening for CYP2D6 Among Elderly Starting Therapy With Nortriptyline or Venlafaxine: A Pragmatic Randomized Controlled Trial (CYSCE Trial).
van der Schans J, Hak E, Postma M, Breuning L, Brouwers JRBJ, Ditters K, Jansen PAF, Kok RM, Maring JG, van Marum R, Mulder H, Nanninga J, Oude Voshaar RC, Risselada AJ, Vleugel L, Stek M, van Schaik RHN, Berm EJJ, Wilffert B
Purpose/background: The duration of untreated depression is a predictor for poor future prognosis, making rapid dose finding essential. Genetic variation of the CYP2D6 isoenzyme can influence the optimal dosage needed for individual patients. The aim of this study was to determine the effectiveness of CYP2D6 pharmacogenetic screening to accelerate drug dosing in older patients with depression initiating nortriptyline or venlafaxine. Methods/procedures: In this randomized controlled trial, patien...
Abstract
Cited 14 times since 2019 (2.5 per year)
source: EuropePMC
American journal of hypertension,
Volume 32, Issue 12, 1 1 2019, Pages 1146-1153
Genome-Wide Association Study of Apparent Treatment-Resistant Hypertension in the CHARGE Consortium: The CHARGE Pharmacogenetics Working Group.
Irvin MR, Sitlani CM, Floyd JS, Psaty BM, Bis JC, Wiggins KL, Whitsel EA, Sturmer T, Stewart J, Raffield L, Sun F, Liu CT, Xu H, Cupples AL, Tanner RM, Rossing P, Smith A, Zilhão NR, Launer LJ, Noordam R, Rotter JI, Yao J, Li X, Guo X, Limdi N, Sundaresan A, Lange L, Correa A, Stott DJ, Ford I, Jukema JW, Gudnason V, Mook-Kanamori DO, Trompet S, Palmas W, Warren HR, Hellwege JN, Giri A, O'donnell C, Hung AM, Edwards TL, Ahluwalia TS, Arnett DK, Avery CL
Background: Only a handful of genetic discovery efforts in apparent treatment-resistant hypertension (aTRH) have been described. Methods: We conducted a case-control genome-wide association study of aTRH among persons treated for hypertension, using data from 10 cohorts of European ancestry (EA) and 5 cohorts of African ancestry (AA). Cases were treated with 3 different antihypertensive medication classes and had blood pressure (BP) above goal (systolic BP ≥ 140 mm Hg and/or diastolic BP ≥ 90 mm...
Abstract
Cited 56 times since 2019 (9.9 per year)
source: EuropePMC
JAMA,
Volume 322, Issue 20, 1 1 2019, Pages 1977-1986
Association Between Levothyroxine Treatment and Thyroid-Related Symptoms Among Adults Aged 80 Years and Older With Subclinical Hypothyroidism.
Mooijaart SP, Du Puy RS, Stott DJ, Kearney PM, Rodondi N, Westendorp RGJ, den Elzen WPJ, Postmus I, Poortvliet RKE, van Heemst D, van Munster BC, Peeters RP, Ford I, Kean S, Messow CM, Blum MR, Collet TH, Watt T, Dekkers OM, Jukema JW, Smit JWA, Langhorne P, Gussekloo J
Importance: It is unclear whether levothyroxine treatment provides clinically important benefits in adults aged 80 years and older with subclinical hypothyroidism. Objective: To determine the association of levothyroxine treatment for subclinical hypothyroidism with thyroid-related quality of life in adults aged 80 years and older. Design, setting, and participants: Prospectively planned combined analysis of data involving community-dwelling adults aged 80 years and older with subclinical hypoth...
Abstract
Cited 56 times since 2019 (9.9 per year)
source: EuropePMC
Epidemiology (Cambridge, Mass.),
Volume 30, Issue 6, 1 1 2019, Pages 813-816
Survival Bias in Mendelian Randomization Studies: A Threat to Causal Inference.
Smit RAJ, Trompet S, Dekkers OM, Jukema JW, le Cessie S
It has been argued that survival bias may distort results in Mendelian randomization studies in older populations. Through simulations of a simple causal structure we investigate the degree to which instrumental variable (IV)-estimators may become biased in the context of exposures that affect survival. We observed that selecting on survival decreased instrument strength and, for exposures with directionally concordant effects on survival (and outcome), introduced downward bias of the IV-estimat...
Abstract
Cited 38 times since 2019 (6.7 per year)
source: EuropePMC
Annals of oncology : official journal of the European Society for Medical Oncology,
Volume 30, Issue 11, 1 1 2019, Pages 1697-1727
EAU-ESMO consensus statements on the management of advanced and variant bladder cancer-an international collaborative multi-stakeholder effort: under the auspices of the EAU and ESMO Guidelines Committees†.
Horwich A, Babjuk M, Bellmunt J, Bruins HM, De Reijke TM, De Santis M, Gillessen S, James N, Maclennan S, Palou J, Powles T, Ribal MJ, Shariat SF, Van Der Kwast T, Xylinas E, Agarwal N, Arends T, Bamias A, Birtle A, Black PC, Bochner BH, Bolla M, Boormans JL, Bossi A, Briganti A, Brummelhuis I, Burger M, Castellano D, Cathomas R, Chiti A, Choudhury A, Compérat E, Crabb S, Culine S, De Bari B, DeBlok W, De Visschere PJL, Decaestecker K, Dimitropoulos K, Dominguez-Escrig JL, Fanti S, Fonteyne V, Frydenberg M, Futterer JJ, Gakis G, Geavlete B, Gontero P, Grubmüller B, Hafeez S, Hansel DE, Hartmann A, Hayne D, Henry AM, Hernandez V, Herr H, Herrmann K, Hoskin P, Huguet J, Jereczek-Fossa BA, Jones R, Kamat AM, Khoo V, Kiltie AE, Krege S, Ladoire S, Lara PC, Leliveld A, Linares-Espinós E, Løgager V, Lorch A, Loriot Y, Meijer R, Carmen Mir M, Moschini M, Mostafid H, Müller AC, Müller CR, N'Dow J, Necchi A, Neuzillet Y, Oddens JR, Oldenburg J, Osanto S, Oyen WJG, Pacheco-Figueiredo L, Pappot H, Patel MI, Pieters BR,
Background: Although guidelines exist for advanced and variant bladder cancer management, evidence is limited/conflicting in some areas and the optimal approach remains controversial. Objective: To bring together a large multidisciplinary group of experts to develop consensus statements on controversial topics in bladder cancer management. Design: A steering committee compiled proposed statements regarding advanced and variant bladder cancer management which were assessed by 113 experts in a Del...
Abstract
Cited 28 times since 2019 (4.9 per year)
source: EuropePMC
European heart journal. Cardiovascular Imaging,
Volume 20, Issue 11, 1 1 2019, Pages 1187-1197
Imaging in ESC clinical guidelines: chronic coronary syndromes.
Saraste A, Barbato E, Capodanno D, Edvardsen T, Prescott E, Achenbach S, Bax JJ, Wijns W, Knuuti J
The European Society of Cardiology (ESC) has recently published new guidelines on the diagnosis and management of chronic coronary syndromes (CCS). The 2019 guideline identified six common clinical scenarios of CCS defined by the different evolutionary phases of coronary artery disease (CAD), excluding the situations in which an acute coronary event, often with coronary thrombus formation, dominates the clinical presentation. This review aims at providing a summary of novel or revised concepts i...
Abstract
Cited 8 times since 2019 (1.4 per year)
source: EuropePMC
European heart journal. Cardiovascular Imaging,
Volume 20, Issue 11, 1 1 2019, Pages 1279-1286
Long-term prognostic utility of computed tomography coronary angiography in older populations.
Gnanenthiran SR, Naoum C, Leipsic JA, Achenbach S, Al-Mallah MH, Andreini D, Bax JJ, Berman DS, Budoff MJ, Cademartiri F, Callister TQ, Chang HJ, Chinnaiyan K, Chow BJW, Cury RC, DeLago A, Feuchtner G, Hadamitzky M, Hausleiter J, Kaufman PA, Kim YJ, Maffei E, Marques H, de Araújo Gonçalves P, Pontone G, Raff GL, Rubinshtein R, Shaw LJ, Villines TC, Gransar H, Lu Y, Jones EC, Peña JM, Lin FY, Kritharides L, Min JK
Aims: The long-term prognostic value of coronary computed tomography angiography (CCTA)-identified coronary artery disease (CAD) has not been evaluated in elderly patients (≥70 years). We compared the ability of coronary CCTA to predict 5-year mortality in older vs. younger populations. Methods and results: From the prospective CONFIRM (COronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter) registry, we analysed CCTA results according to age 50%); (ii) segment in...
Abstract
Cited 6 times since 2019 (1.1 per year)
source: EuropePMC
European heart journal,
Volume 40, Issue 41, 1 1 2019, Pages e20-e22
Assessment of coronary artery plaque with non-contrast and T1-weighted magnetic resonance: promise for clinical use?
Schindler TH, Bax JJ
Abstract
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 27, Issue 11, 1 1 2019, Pages 550-558
Myocardial infarction patients referred to the primary care physician after 1‑year treatment according to a guideline-based protocol have a good prognosis.
Bodde MC, van Hattem NE, Abou R, Mertens BJA, van Duijn HJ, Numans ME, Bax JJ, Schalij MJ, Jukema JW
Introduction: Identifying ST-elevation myocardial infarction (STEMI) patients who can be referred back to the general practitioner (GP) can improve patient-tailored care. However, the long-term prognosis of patients who are returned to the care of their GP is unknown. Therefore, the aim of this study was to assess the long-term prognosis of patients referred back to the GP after treatment in accordance with a 1-year institutional guideline-based protocol. Methods: All consecutive patients treate...
Abstract
Cited 90 times since 2019 (15.9 per year)
source: EuropePMC
European heart journal. Cardiovascular Imaging,
Volume 20, Issue 11, 1 1 2019, Pages 1198-1207
Impact of a decreasing pre-test probability on the performance of diagnostic tests for coronary artery disease.
Juarez-Orozco LE, Saraste A, Capodanno D, Prescott E, Ballo H, Bax JJ, Wijns W, Knuuti J
Aims: To provide a pooled estimation of contemporary pre-test probabilities (PTPs) of significant coronary artery disease (CAD) across clinical patient categories, re-evaluate the utility of the application of diagnostic techniques according to such estimates, and propose a comprehensive diagnostic technique selection tool for suspected CAD. Methods and results: Estimates of significant CAD prevalence across sex, age, and type of chest pain categories from three large-scale studies were pooled (...
Abstract
European heart journal. Cardiovascular Imaging,
Volume 20, Issue 11, 1 1 2019, Pages 1296-1297
Diagnostic value of hybrid imaging with computed tomography coronary angiogram and stress positron emission tomography in patients with coronary artery bypass grafting.
Ng ACT, Bax JJ
Abstract
Cited 48 times since 2019 (8.5 per year)
source: EuropePMC
European heart journal. Cardiovascular Imaging,
Volume 20, Issue 11, 1 1 2019, Pages 1307-1314
Differential association between the progression of coronary artery calcium score and coronary plaque volume progression according to statins: the Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography Imaging (PARADIGM) study.
Lee SE, Sung JM, Andreini D, Budoff MJ, Cademartiri F, Chinnaiyan K, Choi JH, Chun EJ, Conte E, Gottlieb I, Hadamitzky M, Kim YJ, Kumar A, Lee BK, Leipsic JA, Maffei E, Marques H, Pontone G, Raff G, Shin S, Stone PH, Samady H, Virmani R, Narula J, Berman DS, Shaw LJ, Bax JJ, Lin FY, Min JK, Chang HJ
Aims: Coronary artery calcium score (CACS) is a strong predictor of major adverse cardiac events (MACE). Conversely, statins, which markedly reduce MACE risk, increase CACS. We explored whether CACS progression represents compositional plaque volume (PV) progression differently according to statin use. Methods and results: From a prospective multinational registry of consecutive patients (n = 2252) who underwent serial coronary computed tomography angiography (CCTA) at a ≥ 2-year interval, 654 p...
Abstract
Cited 22 times since 2019 (3.9 per year)
source: EuropePMC
Journal of the American Heart Association,
Volume 8, Issue 21, 1 1 2019, Pages e011194
Clinical Predictors and Prognostic Impact of Recovery of Wall Motion Abnormalities in Takotsubo Syndrome: Results From the International Takotsubo Registry.
Jurisic S, Gili S, Cammann VL, Kato K, Szawan KA, D'Ascenzo F, Jaguszewski M, Bossone E, Citro R, Sarcon A, Napp LC, Franke J, Noutsias M, Knorr M, Heiner S, Burgdorf C, Koenig W, Pott A, Kherad B, Rajan L, Michels G, Pfister R, Cuneo A, Jacobshagen C, Karakas M, Meyer P, Arroja JD, Banning A, Cuculi F, Kobza R, Fischer TA, Vasankari T, Airaksinen KEJ, Dworakowski R, Kaiser C, Osswald S, Galiuto L, Dichtl W, Chan C, Bridgman P, Beug D, Delmas C, Lairez O, Kozel M, Tousek P, Winchester DE, Gilyarova E, Shilova A, Gilyarov M, El-Battrawy I, Akin I, Galuszka J, Ukena C, Poglajen G, Paolini C, Bilato C, Carrilho-Ferreira P, Pinto FJ, Opolski G, MacCarthy P, Kobayashi Y, Prasad A, Rihal CS, Widimský P, Horowitz JD, Di Mario C, Crea F, Tschöpe C, Pieske BM, Hasenfuß G, Rottbauer W, Braun-Dullaeus RC, Felix SB, Borggrefe M, Thiele H, Bauersachs J, Katus HA, Schunkert H, Münzel T, Böhm M, Bax JJ, Lüscher TF, Ruschitzka F, Ghadri JR, Templin C
Background Left ventricular (LV) recovery in takotsubo syndrome (TTS) occurs over a wide-ranging interval, varying from hours to weeks. We sought to investigate the clinical predictors and prognostic impact of recovery time for TTS patients. Methods and Results TTS patients from the International Takotsubo Registry were included in this study. Cut-off for early LV recovery was determined to be 10 days after the acute event. Multivariable logistic regression was used to assess factors associated...
Abstract
Cited 22 times since 2019 (3.9 per year)
source: EuropePMC
Annals of surgery,
Volume 270, Issue 5, 1 1 2019, Pages 852-858
Saccular Abdominal Aortic Aneurysms: Patient Characteristics, Clinical Presentation, Treatment, and Outcomes in the Netherlands.
Karthaus EG, Tong TML, Vahl A, Hamming JF, Dutch Society of Vascular Surgery, the Steering Committee of the Dutch Surgical Aneurysm Audit and the Dutch Institute for Clinical Auditing
Objective: The aim of this was to analyze differences between saccular-shaped abdominal aortic aneurysms (SaAAAs) and fusiform abdominal aortic aneurysms (FuAAAs) regarding patient characteristics, treatment, and outcome, to advise a threshold for intervention for SaAAAs. Background: Based on the assumption that SaAAAs are more prone to rupture, guidelines suggest early elective treatment. However, little is known about the natural history of SaAAAs and the threshold for intervention is not subs...
Abstract
Cited 4 times since 2019 (0.7 per year)
source: EuropePMC
Annals of surgery,
Volume 270, Issue 5, 1 1 2019, Pages 930-936
Objective Assessment of Fitness to Perform (FTOP) After Surgical Night Shifts in the Netherlands: An Observational Study Using the Validated FTOP Self-test in Daily Surgical Practice.
Tummers FHMP, Huizinga CRH, Stockmann HBAC, Hamming JF, Cohen AF, van der Bogt KEA, FTOP Collaborators*
Background: Surgical skills and decision making are influenced by alertness, reaction time, eye-hand coordination, and concentration. Night shift might impair these functions but it is unclear to what extent. The aim of this study was to investigate whether a night shift routinely impairs the surgeon's fitness to perform and whether this reaches a critical limit as compared to relevant frames of reference. Methods: Consultants (n = 59) and residents (n = 103) conducted fitness to perform me...
Abstract
Cited 11 times since 2019 (1.9 per year)
source: EuropePMC
Annals of surgery,
Volume 270, Issue 5, 1 1 2019, Pages 727-734
Procedural Surgical RCTs in Daily Practice: Do Surgeons Adopt Or Is It Just a Waste of Time?
Oberkofler CE, Hamming JF, Staiger RD, Brosi P, Biondo S, Farges O, Legemate DA, Morino M, Pinna AD, Pinto-Marques H, Reynolds JV, Campos RR, Rogiers X, Soreide K, Puhan MA, Clavien PA, Rinkes IB
Objective: To assess the adoption of recommendation from randomized clinical trials (RCTs) and investigate factors favoring or preventing adoption. Background: RCT are considered to be the cornerstone of evidence-based medicine by representing the highest level of evidence. As such, we expect RCT's recommendations to be followed rigorously in daily surgical practice. Methods: We performed a structured search for RCTs published in the medical and surgical literature from 2009 to 2013, allowi...
Abstract
Cited 16 times since 2019 (2.8 per year)
source: EuropePMC
Physical review letters,
Volume 123, Issue 18, 1 1 2019, Pages 188102
Lateral Subunit Coupling Determines Intermediate Filament Mechanics.
Lorenz C, Forsting J, Schepers AV, Kraxner J, Bauch S, Witt H, Klumpp S, Köster S
The cytoskeleton is a composite network of three types of protein filaments, among which intermediate filaments (IFs) are the most extensible ones. Two very important IFs are keratin and vimentin, which have similar molecular architectures but different mechanical behaviors. Here we compare the mechanical response of single keratin and vimentin filaments using optical tweezers. We show that the mechanics of vimentin strongly depends on the ionic strength of the buffer and that its force-strain c...
Abstract
Cited 13 times since 2019 (2.3 per year)
source: EuropePMC
European heart journal. Cardiovascular Imaging,
Volume 20, Issue 11, 1 1 2019, Pages 1231-1238
Referral of patients for fractional flow reserve using quantitative flow ratio.
Smit JM, Koning G, van Rosendael AR, El Mahdiui M, Mertens BJ, Schalij MJ, Jukema JW, Delgado V, Reiber JHC, Bax JJ, Scholte AJ
Aims: Quantitative flow ratio (QFR) is a recently developed technique to calculate fractional flow reserve (FFR) based on 3D quantitative coronary angiography and computational fluid dynamics, obviating the need for a pressure-wire and hyperaemia induction. QFR might be used to guide patient selection for FFR and subsequent percutaneous coronary intervention (PCI) referral in hospitals not capable to perform FFR and PCI. We aimed to investigate the feasibility to use QFR to appropriately select...
Abstract
JACC. Cardiovascular imaging,
Volume 12, Issue 11 Pt 1, 1 1 2019, Pages 2282
Is Older Age Truly a Predictor of SVD?
Vriesendorp MD, de Lind van Wijngaarden RAF, Klautz RJM
Abstract
Cited 8 times since 2019 (1.4 per year)
source: EuropePMC
Academic medicine : journal of the Association of American Medical Colleges,
Volume 94, Issue 11, 1 1 2019, Pages 1728-1732
Jump-Starting Faculty Development in Quality Improvement and Patient Safety Education: A Team-Based Approach.
van Schaik SM, Chang A, Fogh S, Haehn M, Lyndon A, O'Brien B, O'Sullivan P, Ranji S, Rosenbluth G, Sehgal N, Tabas J, Baron RB
Problem: Quality improvement (QI) and patient safety (PS) are cornerstones of health care delivery. Accreditation organizations increasingly require that learners engage in QIPS. For many faculty, these are new domains. Additional faculty development is needed for them to teach and mentor trainees. Existing programs, such as the Association of American Medical Colleges Teaching for Quality (Te4Q) program, target individual faculty and thus accommodate only limited participants at a time, which i...
Abstract
