Research

Publications

Below you can find a list of our published research.

6125 results

European journal of heart failure, Volume 26, Issue 10, 27 4 2024, Pages 2173-2182 Heart failure risk assessment in patients with hypertrophic cardiomyopathy based on the H2FPEF score. Laenens D, Zegkos T, Kamperidis V, Wong RCC, Li TY, Sia CH, Kong WKF, Efthimiadis G, Poh KK, Ziakas A, Bax JJ, Ajmone Marsan N

Aims: The aim of this study was to investigate whether the H2FPEF score, which was developed to improve the diagnosis of heart failure (HF) with preserved ejection fraction, is associated with HF outcomes in patients with hypertrophic cardiomyopathy (HCM). Methods and results: Patients with HCM and preserved left ventricular ejection fraction (LVEF ≥50%) were included from a multicentre registry and the H2FPEF score was calculated. Patients were divided into three groups: low (0-1), intermediate... Abstract

British journal of cancer, Volume 131, Issue 7, 24 4 2024, Pages 1224-1236 IMPRESS: Improved methylation profiling using restriction enzymes and smMIP sequencing, combined with a new biomarker panel, creating a multi-cancer detection assay. Vandenhoeck J, Neefs I, Vanpoucke T, Ibrahim J, Suls A, Peeters D, Schepers A, Hoischen A, Fransen E, Peeters M, Van Camp G, Op de Beeck K

Background: Despite the worldwide progress in cancer diagnostics, more sensitive diagnostic biomarkers are needed. The methylome has been extensively investigated in the last decades, but a low-cost, bisulfite-free detection method for multiplex analysis is still lacking. Methods: We developed a methylation detection technique called IMPRESS, which combines methylation-sensitive restriction enzymes and single-molecule Molecular Inversion Probes. We used this technique for the development of a mu... Abstract

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 23 4 2024, Pages euae214 Patient selection, ventricular tachycardia substrate delineation and data transfer for stereotactic arrhythmia radioablation. A Clinical Consensus Statement of the European Heart Rhythm Association (EHRA) of the ESC and the Heart Rhythm Society (HRS). Zeppenfeld K, Rademaker R, Al-Ahmad A, Carbucicchio C, De Chillou C, Ebert M, Stevenson WG, Ho G, Kautzner J, Sramko M, Lambiase P, Lloyd M, Merino JL, Pruvot E, Sapp J, Schiappacasse L, Zei PC

Stereotactic arrythmia radioablation (STAR) is a novel, non-invasive and promising treatment option for ventricular arrythmias (VA). It has been applied in highly selected patients mainly as bail-out procedure, when (multiple) catheter-ablations, together with anti-arrhythmic drugs, were unable to control the VAs. Despite the increasing clinical use there is still limited knowledge of the acute and long-term response of normal and diseased myocardium to STAR. Acute toxicity appeared to be reason... Abstract

JACC. Clinical electrophysiology, Volume 10, Issue 11, 21 3 2024, Pages 2303-2311 Excellent Outcomes After First-Line Ablation in Post-MI Patients With Tolerated VT and LVEF >35. Rademaker R, de Riva M, Piers SRD, Wijnmaalen AP, Zeppenfeld K

Background: Post-myocardial infarction (MI) patients with ventricular tachycardia (VT) are considered at risk for VT recurrence and sudden cardiac death (SCD). Recent guidelines indicate that in selected patients catheter ablation should be considered instead of an implantable cardioverter-defibrillator (ICD). Objectives: This study aimed to analyze outcomes of patients referred for VT ablation according to left ventricular ejection fraction (LVEF), tolerance of VT, and acute ablation outcome. M... Abstract

Microbiology spectrum, Volume 12, Issue 10, 20 3 2024, Pages e0420823 An interlaboratory proficiency test using metagenomic sequencing as a diagnostic tool for the detection of RNA viruses in swine fecal material. Liu L, Hakhverdyan M, Wallgren P, Vanneste K, Fu Q, Lucas P, Blanchard Y, de Graaf M, Oude Munnink BB, van Boheemen S, Bossers A, Hulst M, Van Borm S

Metagenomic shotgun sequencing (mNGS) can serve as a generic molecular diagnostic tool. An mNGS proficiency test (PT) was performed in six European veterinary and public health laboratories to detect porcine astroviruses in fecal material and the extracted RNA. While different mNGS workflows for the generation of mNGS data were used in the different laboratories, the bioinformatic analysis was standardized using a metagenomic read classifier as well as read mapping to selected astroviral referen... Abstract

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 32, Issue 10, 19 3 2024, Pages 356-362 Trends in adoption of extravascular cardiac implantable electronic devices: the Dutch cohort. Breeman KTN, Knops RE, van der Stoel MD, Boersma LVA, Yap SC, van Erven L, van Dijk VF, Maass AH, Wilde AAM, Tjong FVY, Device Registration Committee of the Netherlands Heart Registration

Introduction: Conventional implantable cardioverter-defibrillators (ICDs) and pacemakers carry a risk of pocket- and lead-related complications in particular. To avoid these complications, extravascular devices (EVDs) have been developed, such as the subcutaneous ICD (S-ICD) and leadless pacemaker (LP). However, data on patient or centre characteristics related to the actual adoption of EVDs are lacking. Objective: To assess real-world nationwide trends in EVD adoption in the Netherlands. Method... Abstract

Cited 1 times since 2024 (1.9 per year) source: EuropePMC

The lancet. Gastroenterology & hepatology, Volume 9, Issue 10, 13 2 2024, Pages 924-934 Indocyanine green near-infrared fluorescence bowel perfusion assessment to prevent anastomotic leakage in minimally invasive colorectal surgery (AVOID): a multicentre, randomised, controlled, phase 3 trial. Faber RA, Meijer RPJ, Droogh DHM, Jongbloed JJ, Bijlstra OD, Boersma F, Braak JPBM, Meershoek-Klein Kranenbarg E, Putter H, Holman FA, Mieog JSD, Neijenhuis PA, van Staveren E, Bloemen JG, Burger JWA, Aukema TS, Brouwers MAM, Marinelli AWKS, Westerterp M, Doornebosch PG, van der Weijde A, Bosscha K, Handgraaf HJM, Consten ECJ, Sikkenk DJ, Burggraaf J, Keereweer S, van der Vorst JR, Hutteman M, Peeters KCMJ, Vahrmeijer AL, Hilling DE

Background: Anastomotic leakage is a severe postoperative complication in colorectal surgery and compromised bowel perfusion is considered a major contributing factor. Conventional methods to assess bowel perfusion have a low predictive value for anastomotic leakage. We therefore aimed to evaluate the efficacy of real-time assessment with near-infrared (NIR) fluorescence imaging with indocyanine green (ICG) in the prevention of anastomotic leakage. Methods: This multicentre, randomised, controll... Abstract

Cited 1 times since 2024 (1.9 per year) source: EuropePMC

Antimicrobial agents and chemotherapy, Volume 68, Issue 9, 13 2 2024, Pages e0065024 Bacteriophage therapy reduces Staphylococcus aureus in a porcine and human ex vivo burn wound infection model. Molendijk MM, Boekema BKHL, Lattwein KR, Vlig M, Bode LGM, Koopmans MPG, Verbon A, de Graaf M, van Wamel WJB

Burn wounds are a major burden, with high mortality rates due to infections. Staphylococcus aureus is a major causative agent of burn wound infections, which can be difficult to treat because of antibiotic resistance and biofilm formation. An alternative to antibiotics is the use of bacteriophages, viruses that infect and kill bacteria. We investigated the efficacy of bacteriophage therapy for burn wound infections, in both a porcine and a newly developed human ex vivo skin model. In both models... Abstract

Journal of thoracic disease, Volume 16, Issue 8, 13 2 2024, Pages 4914-4923 Deep learning to predict long-term mortality from plain chest X-ray in patients referred for suspected coronary artery disease. D'Ancona G, Savardi M, Massussi M, Van Der Valk V, Scherptong RWC, Signoroni A, Farina D, Murero M, Ince H, Benussi S, Curello S, Arslan F

Background: The hypothesis that a deep learning (DL) model can produce long-term prognostic information from chest X-ray (CXR) has already been confirmed within cancer screening programs. We summarize our experience with DL prediction of long-term mortality, from plain CXR, in patients referred for angina and coronary angiography. Methods: Data of patients referred to an Italian academic hospital were analyzed retrospectively. We designed a deep convolutional neural network (DCNN) that, from CXR... Abstract

Cited 1 times since 2024 (1.8 per year) source: EuropePMC

Journal of cardiovascular electrophysiology, Volume 35, Issue 10, 8 2 2024, Pages 1972-1980 Characterization of atrial arrhythmias following mitral valve repair: Incidence and risk factors. El Mathari S, Tomšič A, Kharbanda RK, Zappala P, Wijnmaalen AP, Klautz RJM, Silva MR, Palmen M

Objectives: This study aims to investigate the occurrence, type and correlation of early and late atrial arrhythmias following mitral valve repair in patients with no preoperative history of atrial arrhythmias. Methods: Patients undergoing mitral valve (MV) repair for degenerative disease were included. Early and late postoperative electrocardiograms were evaluated for the incidence and type of atrial arrhythmia (atrial fibrillation [AF] or atrial tachycardia [AT]). Results: The 192 patients wer... Abstract

Future oncology (London, England), Volume 20, Issue 27, 5 1 2024, Pages 2015-2022 Expression of integrin αvβ3 in medullary thyroid carcinoma. de Vries LH, Lodewijk L, Pijnappel EW, van Diest PJ, Schepers A, Bonenkamp HJ, van Engen-van Grunsven IA, Kruijff S, van Hemel BM, Links TP, Nieveen van Dijkum EJ, van Eeden S, van Leeuwaarde RS, Valk GD, de Keizer B, Borel Rinkes IH, Vriens MR

Aim: Tumor markers often remain elevated after intended curative resection of medullary thyroid carcinoma (MTC). The aim of this study was to determine the expression of αvβ3, a promising theranostics target, in MTC and its metastases.Materials & methods: Avβ3 expression was analyzed in 104 patients using a tissue microarray and correlated with clinicopathological variables and survival.Results: Cytoplasmic αvβ3 positivity was seen in 70 patients and was associated with lymph node metastases... Abstract

Journal of electrocardiology, Volume 86, 5 1 2024, Pages 153768 Rationale and design of the artificial intelligence scalable solution for acute myocardial infarction (ASSIST) study. Domingo-Gardeta T, Montero-Cabezas JM, Jurado-Román A, Sabaté M, Aboal J, Baranchuk A, Carrillo X, García-Zamora S, Dores H, van der Valk V, Scherptong RWC, Andrés-Cordón JF, Vidal P, Moreno-Martínez D, Toribio-Fernández R, Lillo-Castellano JM, Cruz R, De Guio F, Marina-Breysse M, Martínez-Sellés M

Background: Acute coronary syndrome (ACS), specifically ST-segment elevation myocardial infarction is a major cause of morbidity and mortality throughout Europe. Diagnosis in the acute setting is mainly based on clinical symptoms and physician's interpretation of an electrocardiogram (ECG), which may be subject to errors. ST-segment elevation is the leading criteria to activate urgent reperfusion therapy, but a clear ST-elevation pattern might not be present in patients with coronary occlus... Abstract

International journal of cardiology, Volume 415, 3 1 2024, Pages 132421 CIED-based remote monitoring in heart failure using the HeartLogic™ algorithm: Which patients benefit most? van der Lande ACMH, Feijen M, Egorova AD, Beles M, van Bockstal K, Phagu AAS, Schalij MJ, Heggermont WA, Beeres SLMA

Background & aims: Early identification of worsening HF enables timely adjustments to prevent hospitalization. Recent studies show the HeartLogic™ algorithm detects congestion and reduces HF events. However, it is unclear which patients benefit most. Therefore, this study aims to identify and characterize HF patients who benefit most from CIED-based remote monitoring with HeartLogic™. Methods: In this multicenter retrospective study, patients with a CIED and HeartLogic™ algorithm under struc... Abstract

International journal of cardiology, Volume 414, 3 1 2024, Pages 132414 The prognostic value of changes in pulmonary vein flow patterns after surgical repair for primary mitral regurgitation. Yedidya I, Stassen J, Butcher S, van Wijngaarden AL, Wu Y, van der Bijl P, Marsan NA, Delgado V, Bax J

Background: The pulmonary vein (PV) flow pattern is influenced by the presence of mitral regurgitation (MR). After a successful reduction in MR severity, the pattern is expected to be changed. We aimed to evaluate the prognostic value of a change in the PV flow pattern in patients with primary MR undergoing mitral valve repair (MVR). Methods: The PV flow pattern was assessed with transthoracic echocardiography in 216 patients (age 65 [IQR 56-72] years, 70% male) with primary MR before and after... Abstract

European heart journal. Cardiovascular Imaging, Volume 25, Issue 9, 1 1 2024, Pages 1296-1305 Structural and functional abnormalities of left-sided cardiac chambers in Barlow's disease without significant mitral regurgitation. Meucci MC, Mantegazza V, Wu HW, van Wijngaarden AL, Garlaschè A, Tamborini G, Pepi M, Bax JJ, Ajmone Marsan N

Aims: This study aims to explore the presence of left ventricular (LV) and left atrial (LA) morphological and functional abnormalities in patients with Barlow's disease (BD) without significant mitral regurgitation (MR) and to investigate whether these abnormalities may predict MR progression. Methods and results: Consecutive patients with BD were retrospectively identified from two tertiary centres; those with MR graded from trivial to mild-to-moderate were selected and matched with health... Abstract

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, Volume 35, Issue 8, 1 1 2024, Pages e14222 Reply to Sujoy Khan. van der Rijst LP, de Winter-de Groot KM, de Bruin-Weller MS, de Graaf M

Abstract

Cited 1 times since 2024 (1.8 per year) source: EuropePMC

European journal of preventive cardiology, Volume 31, Issue 10, 1 1 2024, Pages e75-e78 Comparison of change in lipoprotein(a) mass and molar concentrations by alirocumab and risk of subsequent cardiovascular events in ODYSSEY OUTCOMES. Szarek M, Reijnders E, Steg PG, Jukema JW, Schwertfeger M, Bhatt DL, Bittner VA, Diaz R, Fazio S, Garon G, Goodman SG, Harrington RA, White HD, Zeiher AM, Cobbaert C, Schwartz GG

Abstract

Heart rhythm, Volume 22, Issue 2, 31 5 2024, Pages 536-543 ECTOPIC trial: The efficacy of flEcainide Compared To metOprolol in reducing Premature ventrIcular Contractions: A randomized open-label crossover study in pediatric patients. Bertels RA, Kammeraad JAE, van Geloven N, Filippini LH, van der Palen RLF, Tak RO, Frerich S, Vanagt W, Rehbock JJB, Knobbe I, Kuipers IM, de Riva M, Zeppenfeld K, Blom NA

Background: Frequent premature ventricular contractions (PVCs) in children are usually considered benign. Symptoms and left ventricular dysfunction are indications for treatment with antiarrhythmic drugs. Objective: This study aimed to evaluate the efficacy of flecainide vs metoprolol in reducing PVCs in children. Methods: A randomized open-label crossover trial was conducted of children with a PVC burden of >15% on Holter monitoring successively treated with metoprolol and flecainide, or vic... Abstract

International archives of allergy and immunology, Volume 185, Issue 11, 30 5 2024, Pages 1074-1082 Dog Allergy in Children: A Single-Centered Study. Büyük Yaytokgil Ş, Alim Aydın S, Yilmaz D, Şengül Emeksiz Z, Gülseren SC, Toyran M, Civelek E, Dibek Misirlioğlu E

Introduction: Dogs are among the most commonly allergenic pets for children. Data on risk factors for the development of dog allergy are scarce. This study aimed to evaluate the characteristics of children with dog allergy and identify predictors of symptom development with dog exposure. Methods: The study included children with dog allergen sensitization demonstrated by skin prick test (SPT) between September 1, 2019, and December 1, 2022. Demographic, clinical, and laboratory data were collect... Abstract

Cited 1 times since 2024 (1.7 per year) source: EuropePMC

FEBS open bio, Volume 14, Issue 10, 28 4 2024, Pages 1668-1681 Daily rhythms in metabolic and locomotor behaviour of prematurely ageing PolgA mice. Singh A, Yilmaz D, Wehrle E, Kuhn GA, Müller R

Ageing is an inherent and intricate biological process that takes place in living organisms as time progresses. It involves the decline of multiple physiological functions, leading to body structure and overall performance modifications. The ageing process differs among individuals and is influenced by various factors, including lifestyle, environment and genetic makeup. Metabolic changes and reduced locomotor activity are common hallmarks of ageing. Our study focuses on exploring these phenomen... Abstract