6177 results
Cited 83 times since 2020 (16.3 per year)
source: EuropePMC
Circulation,
Volume 141, Issue 20, 29 5 2020, Pages 1608-1617
Peripheral Artery Disease and Venous Thromboembolic Events After Acute Coronary Syndrome: Role of Lipoprotein(a) and Modification by Alirocumab: Prespecified Analysis of the ODYSSEY OUTCOMES Randomized Clinical Trial.
Schwartz GG, Steg PG, Szarek M, Bittner VA, Diaz R, Goodman SG, Kim YU, Jukema JW, Pordy R, Roe MT, White HD, Bhatt DL, ODYSSEY OUTCOMES Committees and Investigators*
Background: Patients with acute coronary syndrome are at risk for peripheral artery disease (PAD) events and venous thromboembolism (VTE). PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitors reduce lipoprotein(a) and low-density lipoprotein cholesterol (LDL-C) levels. Our objective was to ascertain whether PCSK9 inhibition reduces the risk of PAD events or VTE after acute coronary syndrome, and if such effects are related to levels of lipoprotein(a) or LDL-C. Methods: This was a pre...
Abstract
Cited 1 times since 2020 (0.2 per year)
source: EuropePMC
JACC. Clinical electrophysiology,
Volume 6, Issue 4, 29 5 2020, Pages 461-462
Whole Heart Histology: A Method for the Direct Integration of Histology With Electrophysiological and Imaging Data.
Glashan CA, Tofig BJ, Tao Q, Blom SA, Sørensen JCH, Zeppenfeld K, Kristiansen SB
Abstract
Cited 9 times since 2020 (1.8 per year)
source: EuropePMC
Cells,
Volume 9, Issue 4, 29 5 2020, Pages E824
Loss of Endothelial Glycocalyx Hyaluronan Impairs Endothelial Stability and Adaptive Vascular Remodeling After Arterial Ischemia.
Wang G, de Vries MR, Sol WMPJ, van Oeveren-Rietdijk AM, de Boer HC, van Zonneveld AJ, Quax PHA, Rabelink TJ, van den Berg BM
We recently reported that loss of hyaluronan (HA) from the endothelial glycocalyx leads to loss of vessel stability in specific microcirculatory vascular beds. Here we hypothesized that such derangements in the glycocalyx may also impair the adaptive response to vascular ischemia. Endothelial specific conditional hyaluronan synthase 2-KO (Has2-cKO) mice revealed reduced endothelial HA expression and lower hindlimb perfusion at baseline compared to control mice. After a single ligation of the com...
Abstract
Cited 147 times since 2020 (28.9 per year)
source: EuropePMC
The New England journal of medicine,
Volume 382, Issue 18, 29 5 2020, Pages 1696-1707
Anticoagulation with or without Clopidogrel after Transcatheter Aortic-Valve Implantation.
Nijenhuis VJ, Brouwer J, Delewi R, Hermanides RS, Holvoet W, Dubois CLF, Frambach P, De Bruyne B, van Houwelingen GK, Van Der Heyden JAS, Toušek P, van der Kley F, Buysschaert I, Schotborgh CE, Ferdinande B, van der Harst P, Roosen J, Peper J, Thielen FWF, Veenstra L, Chan Pin Yin DRPP, Swaans MJ, Rensing BJWM, van 't Hof AWJ, Timmers L, Kelder JC, Stella PR, Baan J, Ten Berg JM
Background: The roles of anticoagulation alone or with an antiplatelet agent after transcatheter aortic-valve implantation (TAVI) have not been well studied. Methods: We performed a randomized trial of clopidogrel in patients undergoing TAVI who were receiving oral anticoagulation for appropriate indications. Patients were assigned before TAVI in a 1:1 ratio not to receive clopidogrel or to receive clopidogrel for 3 months. The two primary outcomes were all bleeding and non-procedure-related ble...
Abstract
Cited 7 times since 2020 (1.4 per year)
source: EuropePMC
Journal of clinical medicine,
Volume 9, Issue 4, 26 4 2020, Pages E911
Ventricular Repolarization is Associated with Cognitive Function, but Not with Cognitive Decline and Brain Magnetic Resonance Imaging (MRI) Measurements in Older Adults.
Zonneveld MH, Noordam R, Grond JV, Sabayan B, Mooijaart SP, Mcfarlane PW, Jukema JW, Trompet S
We aimed to investigate the cross-sectional and longitudinal associations of electrocardiogram (ECG)-based QT, QTc, JT, JTc, and QRS intervals with cognitive function and brain magnetic resonance imaging (MRI) measurements in a cohort of older individuals at increased risk for cardiovascular disease, but free of known arrhythmias. We studied 4627 participants (54% female, mean age 75 years) enrolled in the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER). Ten-second ECGs were co...
Abstract
Cited 20 times since 2020 (3.9 per year)
source: EuropePMC
Current opinion in cell biology,
Volume 64, 26 4 2020, Pages 58-66
How to maintain the genome in nuclear space.
Mitrentsi I, Yilmaz D, Soutoglou E
Genomic instability can be life-threatening. The fine balance between error-free and mutagenic DNA repair pathways is essential for maintaining genome integrity. Recent advances in DNA double-strand break induction and detection techniques have allowed the investigation of DNA damage and repair in the context of the highly complex nuclear structure. These studies have revealed that the 3D genome folding, nuclear compartmentalization and cytoskeletal components control the spatial distribution of...
Abstract
Cited 14 times since 2020 (2.8 per year)
source: EuropePMC
Journal of clinical medicine,
Volume 9, Issue 4, 26 4 2020, Pages E908
The Development of the Ascending Aortic Wall in Tricuspid and Bicuspid Aortic Valve: A Process from Maturation to Degeneration.
Grewal N, Gittenberger-de Groot AC, Thusen JV, Wisse LJ, Bartelings MM, DeRuiter MC, Klautz RJM, Poelmann RE
Background: Patients with a bicuspid aortic valve (BAV) have an increased risk for aortic dilation and dissection. In this study, we provide a histological stratification of the developing aorta in the tricuspid aortic valve (TAV) and the BAV populations as a reference for future studies on aortopathy and related syndromes. Methods: Non-dilated TAV and BAV ascending aortic wall samples were collected, including 60 TAV (embryonic-70 years) and 32 BAV specimens (fetal-72 years, categorized in eigh...
Abstract
Cited 8 times since 2020 (1.6 per year)
source: EuropePMC
JACC. Basic to translational science,
Volume 5, Issue 4, 25 4 2020, Pages 360-373
Therapeutic Antibody Against Phosphorylcholine Preserves Coronary Function and Attenuates Vascular <sup>18</sup>F-FDG Uptake in Atherosclerotic Mice.
Ståhle M, Silvola JMU, Hellberg S, de Vries M, Quax PHA, Kroon J, Rinne P, de Jong A, Liljenbäck H, Savisto N, Wickman A, Stroes ESG, Ylä-Herttuala S, Saukko P, Abrahamsson T, Pettersson K, Knuuti J, Roivainen A, Saraste A
This study showed that treatment with a therapeutic monoclonal immunoglobulin-G1 antibody against phosphorylcholine on oxidized phospholipids preserves coronary flow reserve and attenuates atherosclerotic inflammation as determined by the uptake of 18F-fluorodeoxyglucose in atherosclerotic mice. The noninvasive imaging techniques represent translational tools to assess the efficacy of phosphorylcholine-targeted therapy on coronary artery function and atherosclerosis in clinical studies.
Abstract
Cited 12 times since 2020 (2.3 per year)
source: EuropePMC
Oral surgery, oral medicine, oral pathology and oral radiology,
Volume 130, Issue 2, 18 3 2020, Pages 209-216
Evaluation of a metal artifact reduction algorithm and an optimization filter in the estimation of peri-implant dehiscence defects by using cone beam computed tomography: an in-vitro study.
Bayrak S, Orhan K, Kursun Çakmak ES, Görürgöz C, Odabaşı O, Yilmaz D, Atakan C
Objectives: The aim of this study was to assess the effect of a metal artifact reduction (MAR) algorithm and the adaptive image noise optimizer (AINO) optimization filter in the detection of peri-implant dehiscences with cone beam computed tomography (CBCT). Study design: Nine implants (3 zirconium, 3 titanium, and 3 zirconium-titanium) were placed in 3 sheep heads. Dehiscences were created on the buccal and lingual/palatal surfaces. A total of 9 defects and 9 controls with no defects were evalu...
Abstract
Cited 3 times since 2020 (0.6 per year)
source: EuropePMC
JACC. Cardiovascular imaging,
Volume 13, Issue 5, 18 3 2020, Pages 1133-1134
Individualized Patient Risk Stratification Using Machine Learning and Topological Data Analysis.
Ng ACT, Delgado V, Bax JJ
Abstract
Cited 5 times since 2020 (1 per year)
source: EuropePMC
International journal of cardiology. Heart & vasculature,
Volume 27, 17 3 2020, Pages 100499
Multifocal cardiovascular calcification in patients with established cardiovascular disease; prevalence, risk factors, and relation with recurrent cardiovascular disease.
van 't Klooster CC, Nathoe HM, Hjortnaes J, Bots ML, Isgum I, Lessmann N, van der Graaf Y, Leiner T, Visseren FLJ, UCC-SMART-study group
Aims: The aim is to investigate (multifocal) cardiovascular calcification in patients with established cardiovascular disease (CVD), regarding prevalence, risk factors, and relation with recurrent CVD or vascular interventions. Coronary artery calcification (CAC), thoracic aortic calcification (TAC) (including ascending aorta, aortic arch, descending aorta), mitral annular calcification (MAC), and aortic valve calcification (AVC) are studied. Methods: The study concerned 568 patients with establ...
Abstract
Cited 10 times since 2020 (2 per year)
source: EuropePMC
The Journal of thoracic and cardiovascular surgery,
Volume 162, Issue 6, 12 2 2020, Pages 1684-1695
Comparison of microstructural alterations in the proximal aorta between aortic stenosis and regurgitation.
Sequeira Gross TM, Lindner D, Ojeda FM, Neumann J, Grewal N, Kuntze T, Blankenberg S, Reichenspurner H, Westermann D, Girdauskas E
Objective: We aimed to analyze the association among flow patterns, gene expression, and histologic alterations of the proximal aorta in patients with aortic valve disease. Methods: A total of 131 patients referred for aortic valve replacement were grouped by valve dysfunction (aortic stenosis vs aortic regurgitation) and valve morphology (bicuspid vs tricuspid). On the basis of magnetic resonance imaging, aortic tissue from outer and inner curvature was collected for gene expression and histolo...
Abstract
Cited 40 times since 2020 (7.8 per year)
source: EuropePMC
Circulation. Cardiovascular imaging,
Volume 13, Issue 3, 12 2 2020, Pages e009750
Impact of Clinical Characteristics and Statins on Coronary Plaque Progression by Serial Computed Tomography Angiography.
Smit JM, van Rosendael AR, El Mahdiui M, Neglia D, Knuuti J, Saraste A, Buechel RR, Teresinska A, Pizzi MN, Roque A, Poddighe R, Mertens BJ, Caselli C, Rocchiccioli S, Parodi O, Pelosi G, Scholte AJ
Background Progression of coronary artery disease using serial coronary computed tomography angiography (CTA) is of clinical interest. Our primary aim was to prospectively assess the impact of clinical characteristics and statin use on quantitatively assessed coronary plaque progression in a low-risk study population during long-term follow-up. Methods Patients who previously underwent coronary CTA for suspected coronary artery disease were prospectively included to undergo follow-up coronary CT...
Abstract
Cited 15 times since 2020 (2.9 per year)
source: EuropePMC
Cells,
Volume 9, Issue 3, 12 2 2020, Pages E701
Local Mast Cell Activation Promotes Neovascularization.
Bot I, Velden DV, Bouwman M, Kröner MJ, Kuiper J, Quax PHA, de Vries MR
Mast cells have been associated with arteriogenesis and collateral formation. In advanced human atherosclerotic plaques, mast cells have been shown to colocalize with plaque neovessels, and mast cells have also been associated with tumor vascularization. Based on these associations, we hypothesize that mast cells promote angiogenesis during ischemia. In human ischemic muscle tissue from patients with end-stage peripheral artery disease, we observed activated mast cells, predominantly located aro...
Abstract
Cited 9 times since 2020 (1.8 per year)
source: EuropePMC
European journal of nuclear medicine and molecular imaging,
Volume 47, Issue 6, 9 2 2020, Pages 1518-1526
Prevalence of hyperfunctioning thyroid nodules among those in need of fine needle aspiration cytology according to ATA 2015, EU-TIRADS, and ACR-TIRADS.
Noto B, Eveslage M, Pixberg M, Gonzalez Carvalho JM, Schäfers M, Riemann B, Kies P
Purpose: Given the large number of patients with thyroid nodules, improvement of the specificity of current ultrasound-based thyroid nodule classification systems (ATA, EU-TIRADS, and ACR-TIRADS) is warranted to reduce the number of diagnostic thyroidectomies. Thyroid scintigraphy has been shown to demonstrate hyperfunctional nodules, associated with a low malignancy risk, in euthyroid patients. However, it is not known if thyroid scintigraphy could improve specificity of current classification...
Abstract
Cited 5 times since 2020 (1 per year)
source: EuropePMC
European journal of obstetrics, gynecology, and reproductive biology,
Volume 248, 6 1 2020, Pages 150-155
Evaluation of mode of birth in pregnant women with heart disease.
Petrus AHJ, Jongert BL, Kiès P, Sueters M, Jongbloed MRM, Vliegen HW, Schalij MJ, van Lith J, van den Akker T
Objective: Maternal heart disease (HD) complicates 1-4 % of pregnancies and is associated with adverse maternal and fetal outcomes. Although vaginal birth is generally recommended in the guidelines, cesarean section (CS) rates in women with HD are often high. Aim of the present study was to evaluate mode of birth and pregnancy outcomes in women with HD in a tertiary care hospital in the Netherlands. Study design: The study population consisted of 128 consecutive pregnancies in 99 women with HD,...
Abstract
Cited 12 times since 2020 (2.3 per year)
source: EuropePMC
BMC nephrology,
Volume 21, Issue 1, 5 1 2020, Pages 81
The association of kidney function and cognitive decline in older patients at risk of cardiovascular disease: a longitudinal data analysis.
Zijlstra LE, Trompet S, Mooijaart SP, van Buren M, Sattar N, Stott DJ, Jukema JW
Background: Chronic kidney disease (CKD) has been identified as a significant direct marker for cognitive decline, but controversy exists regarding the magnitude of the association of kidney function with cognitive decline across the different CKD stages. Therefore, the aim of this study was to investigate the association of kidney function with cognitive decline in older patients at high risk of cardiovascular disease, using data from the PROspective Study of Pravastatin in the Elderly at Risk...
Abstract
Cited 34 times since 2020 (6.6 per year)
source: EuropePMC
The journal of allergy and clinical immunology. In practice,
Volume 8, Issue 6, 3 1 2020, Pages 1972-1979.e8
Effectiveness of myAirCoach: A mHealth Self-Management System in Asthma.
Khusial RJ, Honkoop PJ, Usmani O, Soares M, Simpson A, Biddiscombe M, Meah S, Bonini M, Lalas A, Polychronidou E, Koopmans JG, Moustakas K, Snoeck-Stroband JB, Ortmann S, Votis K, Tzovaras D, Chung KF, Fowler S, Sont JK, myAirCoach study group
Background: Self-management programs have beneficial effects on asthma control, but their implementation in clinical practice is poor. Mobile health (mHealth) could play an important role in enhancing self-management. Objective: To assess the clinical effectiveness and technology acceptance of myAirCoach-supported self-management on top of usual care in patients with asthma using inhalation medication. Methods: Patients were recruited in 2 separate studies. The myAirCoach system consisted of an...
Abstract
European heart journal. Cardiovascular Imaging,
Volume 21, Issue 3, 1 1 2020, Pages 299-306
Exercise haemodynamics after restrictive mitral annuloplasty for functional mitral regurgitation.
Petrus AHJ, Tops LF, Holman ER, Marsan NA, Bax JJ, Schalij MJ, Steendijk P, Klautz RJM, Braun J
Aims: Restrictive mitral annuloplasty (RMA) can provide a durable solution for functional mitral regurgitation (MR), but might result in obstruction to antegrade mitral flow. Aim of this study was to assess the magnitude of change in mitral valve area (MVA) during exercise after RMA, to relate the change in MVA to left ventricular (LV) geometry and function, and to assess its haemodynamic and clinical impact. Methods and results: Bicycle exercise echocardiography was performed in 32 patients aft...
Abstract
Cited 70 times since 2020 (13.6 per year)
source: EuropePMC
JAMA cardiology,
Volume 5, Issue 3, 1 1 2020, Pages 282-290
Association of High-Density Calcified 1K Plaque With Risk of Acute Coronary Syndrome.
van Rosendael AR, Narula J, Lin FY, van den Hoogen IJ, Gianni U, Al Hussein Alawamlh O, Dunham PC, Peña JM, Lee SE, Andreini D, Cademartiri F, Chinnaiyan K, Chow BJW, Conte E, Cury RC, Feuchtner G, Hadamitzky M, Kim YJ, Leipsic J, Maffei E, Marques H, de Araújo Gonçalves P, Plank F, Pontone G, Raff GL, Villines TC, Weirich HG, Al'Aref SJ, Baskaran L, Cho I, Danad I, Han D, Heo R, Lee JH, Rivzi A, Stuijfzand WJ, Gransar H, Lu Y, Sung JM, Park HB, Samady H, Stone PH, Virmani R, Budoff MJ, Berman DS, Chang HJ, Bax JJ, Min JK, Shaw LJ
Importance: Plaque morphologic measures on coronary computed tomography angiography (CCTA) have been associated with future acute coronary syndrome (ACS). However, the evolution of calcified coronary plaques by noninvasive imaging is not known. Objective: To ascertain whether the increasing density in calcified coronary plaque is associated with risk for ACS. Design, setting, and participants: This multicenter case-control cohort study included individuals enrolled in ICONIC (Incident Coronary S...
Abstract
