Research

Publications

Below you can find a list of our published research.

7435 results

Revista espanola de cardiologia (English ed.), Volume 69, Issue 4, 23 4 2016, Pages 460-461 Could Descending Septal Artery Be Another Variant of the Dual Left Anterior Descending Artery? Response. Montero-Cabezas JM, Delgado V, Karalis I, Schalij MJ

Abstract

Cited 9 times since 2016 (1 per year) source: EuropePMC

Journal of internal medicine, Volume 279, Issue 6, 23 4 2016, Pages 592-605 Heat-killed Staphylococcus aureus reduces atherosclerosis by inducing anti-inflammatory macrophages. Frodermann V, van Duijn J, van Puijvelde GH, van Santbrink PJ, Lagraauw HM, de Vries MR, Quax PH, Bot I, Foks AC, de Jager SC, Kuiper J

Background: Staphylococcus aureus cell wall components can induce IL-10 responses by immune cells, which may be atheroprotective. Therefore, in this study, we investigated whether heat-killed S. aureus (HK-SA) could inhibit the development of atherosclerosis. Methods: Atherosclerosis-susceptible LDL receptor-deficient mice were administered intraperitoneal HK-SA twice weekly and fed a Western-type diet for 6 weeks. Results: HK-SA administration resulted in a 1.6-fold increase in IL-10 production... Abstract

Cited 91 times since 2016 (10 per year) source: EuropePMC

Cardiovascular research, Volume 110, Issue 1, 23 4 2016, Pages 6-22 The multifactorial nature of microRNAs in vascular remodelling. Welten SM, Goossens EA, Quax PH, Nossent AY

Vascular remodelling is a multifactorial process that involves both adaptive and maladaptive changes of the vessel wall through, among others, cell proliferation and migration, but also apoptosis and necrosis of the various cell types in the vessel wall. Vascular remodelling can be beneficial, e.g. during neovascularization after ischaemia, as well as pathological, e.g. during atherosclerosis and aneurysm formation. In recent years, it has become clear that microRNAs are able to target many gene... Abstract

Cited 22 times since 2016 (2.4 per year) source: EuropePMC

European heart journal, Volume 37, Issue 47, 22 4 2016, Pages 3536-3543 The 200th anniversary of the stethoscope: Can this low-tech device survive in the high-tech 21st century? Bank I, Vliegen HW, Bruschke AV

In 1816, Laennec discovered that auscultation of the heart and lungs could effectively be performed by placing a hollow cylinder (initially made of a roll of paper) between the chest of the patient and the ear of the examiner. This was the first step in the development of the stethoscope, which was a breakthrough in the diagnosis and management of cardiac and pulmonary patients. Technical improvements of the stethoscope followed and in cardiac patients auscultation soon became a major diagnostic... Abstract

Cited 8 times since 2016 (0.9 per year) source: EuropePMC

Nutrition, metabolism, and cardiovascular diseases : NMCD, Volume 26, Issue 8, 19 3 2016, Pages 697-705 HDL functionality in South Asians as compared to white Caucasians. Bakker LE, Boon MR, Annema W, Dikkers A, van Eyk HJ, Verhoeven A, Mayboroda OA, Jukema JW, Havekes LM, Meinders AE, Willems van Dijk K, Jazet IM, Tietge UJ, Rensen PC

Background and aims: South Asians have an exceptionally high risk of developing cardiovascular disease compared to white Caucasians. A contributing factor might be dysfunction of high density lipoprotein (HDL). We aimed to compare HDL function in different age groups of both ethnicities. Methods and results: HDL functionality with respect to cholesterol efflux, anti-oxidation and anti-inflammation was determined using fasting, apoB-depleted, plasma samples from South Asian and white Caucasian ne... Abstract

Cited 35 times since 2016 (3.9 per year) source: EuropePMC

Neurology, Volume 86, Issue 12, 17 3 2016, Pages 1120-1127 10-Second heart rate variability and cognitive function in old age. Mahinrad S, Jukema JW, van Heemst D, Macfarlane PW, Clark EN, de Craen AJ, Sabayan B

Objective: To investigate the cross-sectional and longitudinal associations of 10-second heart rate variability (HRV) with various domains of cognitive function in older participants at risk of cardiovascular disease. Methods: We studied 3,583 participants, mean age of 75.0 years, who were enrolled in the Prospective Study of Pravastatin in the Elderly at Risk. From baseline 10-second ECGs, standard deviation of normal-to-normal intervals was calculated as the index of HRV. Four cognitive domain... Abstract

Cited 13 times since 2016 (1.4 per year) source: EuropePMC

European journal of preventive cardiology, Volume 23, Issue 13, 16 3 2016, Pages 1383-1392 High-sensitivity cardiac troponin T is associated with cognitive decline in older adults at high cardiovascular risk. Wijsman LW, de Craen AJ, Trompet S, Sabayan B, Muller M, Stott DJ, Ford I, Welsh P, Westendorp RG, Jukema JW, Sattar N, Mooijaart SP

Aims: Cardiac troponin T (cTnT), measured with a high-sensitivity (hs) assay, is associated with cognitive decline, but the underlying mechanism is unknown. We investigated the association of hs-cTnT with cognitive function and decline, and studied whether this association was independent of cardiovascular diseases or risk factors, and N-terminal pro-brain natriuretic peptide (NT-proBNP). Methods and results: We studied 5407 participants (mean age 75.31 years) from the PROspective Study of Prava... Abstract

Cited 7 times since 2016 (0.8 per year) source: EuropePMC

BMJ case reports, Volume 2016, 15 3 2016, Pages bcr2015213106 Multiple carpometacarpal dislocations and an associated fracture of the hamate: an uncommon injury. Brinkman JN, Hartholt KA, de Vries MR

Dislocation of the four ulnar carpometacarpal (CMC) joints with a concurrent fracture of the hamate is a rare injury, with a paucity of published cases. A great force is required to dislocate a CMC joint. Diagnosis can easily be missed, due to other serious associated injuries. Appropriate treatment of CMC joint dislocations usually leads to excellent outcomes. We present a case of dorsal dislocation of the four ulnar CMC joints after punching a wall. The injury was treated with a closed reducti... Abstract

Cited 31 times since 2016 (3.4 per year) source: EuropePMC

Arteriosclerosis, thrombosis, and vascular biology, Volume 36, Issue 4, 11 2 2016, Pages 757-764 Effect of Coronary Atherosclerosis and Myocardial Ischemia on Plasma Levels of High-Sensitivity Troponin T and NT-proBNP in Patients With Stable Angina. Caselli C, Prontera C, Liga R, De Graaf MA, Gaemperli O, Lorenzoni V, Ragusa R, Marinelli M, Del Ry S, Rovai D, Giannessi D, Aguade-Bruix S, Clemente A, Bax JJ, Lombardi M, Sicari R, Zamorano J, Scholte AJ, Kaufmann PA, Knuuti J, Underwood SR, Clerico A, Neglia D

Objective: Circulating levels of high-sensitivity cardiac troponin T (hs-cTnT) and N terminal pro brain natriuretic peptide (NT-proBNP) are predictors of prognosis in patients with coronary artery disease (CAD). We aimed at evaluating the effect of coronary atherosclerosis and myocardial ischemia on cardiac release of hs-cTnT and NT-proBNP in patients with suspected CAD. Approach and results: Hs-cTnT and NT-proBNP were measured in 378 patients (60.1±0.5 years, 229 males) with stable angina and u... Abstract

Cited 12 times since 2016 (1.3 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 102, Issue 12, 10 2 2016, Pages 943-949 Coronary anatomy as related to bicuspid aortic valve morphology. Koenraadt WM, Tokmaji G, DeRuiter MC, Vliegen HW, Scholte AJ, Siebelink HM, Gittenberger-de Groot AC, de Graaf MA, Wolterbeek R, Mulder BJ, Bouma BJ, Schalij MJ, Jongbloed MR

Objective: Variable coronary anatomy has been described in patients with bicuspid aortic valves (BAVs). This was never specified to BAV morphology, and prognostic relevance of coronary vessel dominance in this patient group is unclear. The purpose of this study was to evaluate valve morphology in relation to coronary artery anatomy and outcome in patients with isolated BAV and with associated aortic coarctation (CoA). Methods: Coronary anatomy was evaluated in 186 patients with BAV (141 men (79%... Abstract

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 50, Issue 1, 9 2 2016, Pages 190 Reply to Mannacio et al. Gielen CL, Bruggemans EF, Brand A, Klautz RJ

Abstract

Cited 10 times since 2016 (1.1 per year) source: EuropePMC

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, Volume 24, Issue 4, 9 2 2016, Pages 1253-1262 Relation between quantitative coronary CTA and myocardial ischemia by adenosine stress myocardial CT perfusion. van Rosendael AR, Kroft LJ, Broersen A, Dijkstra J, van den Hoogen IJ, van Zwet EW, Bax JJ, de Graaf MA, Scholte AJ

Background: Coronary-computed tomography angiography (CTA) has limited accuracy to predict myocardial ischemia. Besides luminal area stenosis, other coronary plaque morphology and composition parameters may help to assess ischemia. With the integration of coronary CTA and adenosine stress CT myocardial perfusion (CTP), reliable information regarding coronary anatomy and function can be derived in one procedure. This analysis aimed to investigate the association between coronary stenosis severity... Abstract

Cited 50 times since 2016 (5.5 per year) source: EuropePMC

The Annals of thoracic surgery, Volume 101, Issue 5, 6 1 2016, Pages 1684-1689 Bentall Procedure: A Systematic Review and Meta-Analysis. Mookhoek A, Korteland NM, Arabkhani B, Di Centa I, Lansac E, Bekkers JA, Bogers AJ, Takkenberg JJ

Background: The Bentall procedure is considered the gold standard in the treatment of patients requiring aortic root replacement. An up-to-date overview of outcomes after the Bentall procedure is lacking. Methods: We conducted a systematic review and meta-analysis of characteristics of and long-term outcome after the Bentall procedure with a mechanical valve prosthesis. Pooling was performed using the inverse variance method within a random-effects model. Outcome events are reported as linearize... Abstract

Cited 5 times since 2016 (0.5 per year) source: EuropePMC

Differentiation; research in biological diversity, Volume 91, Issue 4-5, 5 1 2016, Pages 90-103 The avian embryo to study development of the cardiac conduction system. Kelder TP, Vicente-Steijn R, Poelmann RE, Mummery CL, DeRuiter MC, Jongbloed MR

The avian embryo has long been a popular model system in developmental biology. The easy accessibility of the embryo makes it particularly suitable for in ovo microsurgery and manipulation. Re-incubation of the embryo allows long-term follow-up of these procedures. The current review focuses on the variety of techniques available to study development of the cardiac conduction system in avian embryos. Based on the large amount of relevant data arising from experiments in avian embryos, we conclud... Abstract

Cited 13 times since 2016 (1.4 per year) source: EuropePMC

Journal of visualized experiments : JoVE, Issue 108, 3 1 2016, Pages e53294 A Novel Murine Model of Arteriovenous Fistula Failure: The Surgical Procedure in Detail. Wong CY, de Vries MR, Wang Y, van der Vorst JR, Vahrmeijer AL, van Zonneveld AJ, Hamming JF, Roy-Chaudhury P, Rabelink TJ, Quax PH, Rotmans JI

The arteriovenous fistula (AVF) still suffers from a high number of failures caused by insufficient remodeling and intimal hyperplasia from which the exact pathophysiology remains unknown. In order to unravel the pathophysiology a murine model of AVF-failure was developed in which the configuration of the anastomosis resembles the preferred situation in the clinical setting. A model was described in which an AVF is created by connecting the venous end of the branch of the external jugular vein t... Abstract

The American journal of cardiology, Volume 117, Issue 7, 2 1 2016, Pages 1167-1172 Comparison of Left Ventricular Volume and Ejection Fraction and Frequency and Extent of Aortic Regurgitation After Operative Repair of Type A Aortic Dissection Among Three Different Surgical Techniques. Regeer MV, Versteegh MI, Klautz RJ, Schalij MJ, Bax JJ, Marsan NA, Delgado V

Differences in recurrence rate of aortic regurgitation (AR) and extent of left ventricular (LV) remodeling across the different surgical options in patients operated for type A aortic dissection remain unknown. The present evaluation compared the AR recurrence rate and changes in LV volumes and systolic function in valve-sparing aorta replacement (VSAR), supracoronary ascending aorta replacement (SCAR), and aortic valve and aorta replacement (AVAR). A total of 97 patients (58 ± 12 years, 62% men... Abstract

Cited 13 times since 2016 (1.4 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 24, Issue 2, 1 1 2016, Pages 127-133 The extent of the raphe in bicuspid aortic valves is associated with aortic regurgitation and aortic root dilatation. Koenraadt WM, Grewal N, Gaidoukevitch OY, DeRuiter MC, Gittenberger-de Groot AC, Bartelings MM, Holman ER, Klautz RJ, Schalij MJ, Jongbloed MR

Background: The clinical course of bicuspid aortic valves (BAVs) is variable. Data on predictors of aortopathy and valvular dysfunction mainly focus on valve morphology. Aim: To determine whether the presence and extent of the raphe (fusion site of valve leaflets) is associated with the degree of aortopathy and valvular dysfunction in patients with isolated BAV and associated aortic coarctation (CoA). Methods: Valve morphology and aortic dimensions of 255 BAV patients were evaluated retrospectiv... Abstract

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 24, Issue 2, 1 1 2016, Pages 154-155 An anomalous left coronary artery with a malignant course: coronary angiography and myocardial perfusion imaging with computed tomography. de Graaf MA, van Rosendael AR, Kroft LJ, Vliegen HW, Hazekamp MG, Bax JJ, Scholte AJ

Abstract

Cited 6 times since 2016 (0.7 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 24, Issue 2, 1 1 2016, Pages 143-151 Outcome of stand-alone thoracoscopic epicardial left atrial posterior box isolation with bipolar radiofrequency energy for longstanding persistent atrial fibrillation. Compier MG, Braun J, Tjon A, Zeppenfeld K, Klautz RJ, Schalij MJ, Trines SA

Introduction: Catheter ablation of longstanding (> 1 year) persistent atrial fibrillation (AF) is associated with poor outcome. This might be due to remodelling and fibrosis formation, mainly located in the posterior left atrial (LA) wall. Therefore, we adopted a thoracoscopic epicardial box isolation of the posterior left atrium using bipolar RF energy with intraoperative testing of conduction block. Methods and results: Bilateral thoracoscopic box isolation was performed with a bipolar RF c... Abstract

Cited 103 times since 2016 (11.3 per year) source: EuropePMC

Nature communications, Volume 7, 1 1 2016, Pages 10494 Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels. Kilpeläinen TO, Carli JF, Skowronski AA, Sun Q, Kriebel J, Feitosa MF, Hedman ÅK, Drong AW, Hayes JE, Zhao J, Pers TH, Schick U, Grarup N, Kutalik Z, Trompet S, Mangino M, Kristiansson K, Beekman M, Lyytikäinen LP, Eriksson J, Henneman P, Lahti J, Tanaka T, Luan J, Del Greco M F, Pasko D, Renström F, Willems SM, Mahajan A, Rose LM, Guo X, Liu Y, Kleber ME, Pérusse L, Gaunt T, Ahluwalia TS, Ju Sung Y, Ramos YF, Amin N, Amuzu A, Barroso I, Bellis C, Blangero J, Buckley BM, Böhringer S, I Chen YD, de Craen AJ, Crosslin DR, Dale CE, Dastani Z, Day FR, Deelen J, Delgado GE, Demirkan A, Finucane FM, Ford I, Garcia ME, Gieger C, Gustafsson S, Hallmans G, Hankinson SE, Havulinna AS, Herder C, Hernandez D, Hicks AA, Hunter DJ, Illig T, Ingelsson E, Ioan-Facsinay A, Jansson JO, Jenny NS, Jørgensen ME, Jørgensen T, Karlsson M, Koenig W, Kraft P, Kwekkeboom J, Laatikainen T, Ladwig KH, LeDuc CA, Lowe G, Lu Y, Marques-Vidal P, Meisinger C, Menni C, Morris AP, Myers RH, Männistö S, Nalls MA, Paternoster L, Peters A, Pradha

Leptin is an adipocyte-secreted hormone, the circulating levels of which correlate closely with overall adiposity. Although rare mutations in the leptin (LEP) gene are well known to cause leptin deficiency and severe obesity, no common loci regulating circulating leptin levels have been uncovered. Therefore, we performed a genome-wide association study (GWAS) of circulating leptin levels from 32,161 individuals and followed up loci reaching P Abstract