Research

Publications

Below you can find a list of our published research.

6196 results

Cited 49 times since 2006 (2.6 per year) source: EuropePMC

Heart rhythm, Volume 3, Issue 9, 15 3 2006, Pages 1092-1099 Elucidation of the spatial ventricular gradient and its link with dispersion of repolarization. Draisma HH, Schalij MJ, van der Wall EE, Swenne CA

The ventricular gradient, a notion conceived by Wilson et al during the 1930s, has contributed considerably to a better understanding of the ECG manifestations of the cardiac repolarization process. The power of the ventricular gradient is its ability to assess the primary factors that contribute to the T wave (i.e., heterogeneity of action potential morphology throughout the ventricles) in the presence of secondary factors contributing to the T wave (i.e., heterogeneity in ventricular depolariz... Abstract

Cited 194 times since 2006 (10.3 per year) source: EuropePMC

Microbes and infection, Volume 8, Issue 8, 13 2 2006, Pages 2052-2060 Human T-cell responses to 25 novel antigens encoded by genes of the dormancy regulon of Mycobacterium tuberculosis. Leyten EM, Lin MY, Franken KL, Friggen AH, Prins C, van Meijgaarden KE, Voskuil MI, Weldingh K, Andersen P, Schoolnik GK, Arend SM, Ottenhoff TH, Klein MR

The dormancy (DosR) regulon of Mycobacterium tuberculosis is expressed in vitro during hypoxia and low-dose nitric oxide stimulation. Tubercle bacilli are thought to encounter these conditions in humans during latent infection. In this study, immune responses were evaluated to 25 most strongly induced DosR-regulon-encoded proteins, referred to as latency antigens. Proliferation assays were performed using M. tuberculosis-specific T-cell lines and peripheral blood mononuclear cells (PBMC) from tu... Abstract

Cited 10 times since 2006 (0.5 per year) source: EuropePMC

European journal of nuclear medicine and molecular imaging, Volume 33, Issue 10, 9 2 2006, Pages 1157-1161 Prognostic value of stress 99mTc-tetrofosmin myocardial perfusion imaging in predicting all-cause mortality: a 6-year follow-up study. Elhendy A, Schinkel AF, van Domburg RT, Bax JJ, Valkema R, Biagini E, Poldermans D

Purpose: The aim of this study was to ascertain whether stress myocardial perfusion imaging can independently predict long-term mortality. Methods: We studied 1,386 patients with known or suspected coronary artery disease by means of stress 99mTc-tetrofosmin myocardial perfusion tomography. The end point during follow-up was death from any cause. Mortality rates were compared with that in a reference population using calculated age- and gender-specific data in the general population. Results: Me... Abstract

Cited 8 times since 2006 (0.4 per year) source: EuropePMC

The American journal of cardiology, Volume 98, Issue 3, 6 1 2006, Pages 309-313 Role of calcified spots detected by intravascular ultrasound in patients with ST-segment elevation acute myocardial infarction. van der Hoeven BL, Liem SS, Oemrawsingh PV, Dijkstra J, Jukema JW, Putter H, Atsma DE, van der Wall EE, Bax JJ, Reiber JC, Schalij MJ

Electron beam computed tomographic studies have demonstrated that the extent of intracoronary calcium is related to risk of coronary events. This study was performed to gain further insight into the distribution of focal calcifications and their relation to the site of plaque rupture within the culprit artery in consecutive patients (n = 60) with acute myocardial infarction (AMI) using intravascular ultrasound imaging. Calcifications in the culprit lesion and adjacent segments were classified an... Abstract

Cited 625 times since 2006 (33 per year) source: EuropePMC

Circulation, Volume 113, Issue 23, 5 1 2006, Pages 2744-2753 Atherosclerotic lesion size and vulnerability are determined by patterns of fluid shear stress. Cheng C, Tempel D, van Haperen R, van der Baan A, Grosveld F, Daemen MJ, Krams R, de Crom R

Background: Atherosclerotic lesions are predominantly observed in curved arteries and near side branches, where low or oscillatory shear stress patterns occur, suggesting a causal connection. However, the effect of shear stress on plaque vulnerability is unknown because the lack of an appropriate in vivo model precludes cause-effect studies. Methods and results: We developed a perivascular shear stress modifier that induces regions of lowered, increased, and lowered/oscillatory (ie, with vortice... Abstract

Cited 10 times since 2006 (0.5 per year) source: EuropePMC

The American journal of cardiology, Volume 98, Issue 2, 5 1 2006, Pages 262-266 Pregnancy after biventricular repair for pulmonary atresia with ventricular septal defect. Drenthen W, Pieper PG, Zoon N, Roos-Hesselink JW, Voors AA, Mulder BJ, van Dijk AP, Sollie KM, Vliegen HW, Ebels T, van Veldhuisen DJ, ZAHARA Investigators

Information on pregnancy and delivery in women with biventricular repair for isolated noncomplex pulmonary atresia with a ventricular septal defect (PAVSD) is limited. Using a nationwide congenital heart disease registry (CONgenital CORvitia [CONCOR]), 9 women with biventricular repair for PAVSD (aged 21 to 38 years) were identified. Ten pregnancies were observed in 5 different women with PAVSD, including 3 spontaneous miscarriages. Clinically significant (non)cardiac complications were document... Abstract

Cited 5 times since 2006 (0.3 per year) source: EuropePMC

The American journal of cardiology, Volume 98, Issue 2, 5 1 2006, Pages 259-261 Fertility, pregnancy, and delivery after biventricular repair for pulmonary atresia with an intact ventricular septum. Drenthen W, Pieper PG, Roos-Hesselink JW, Zoon N, Voors AA, Mulder BJ, van Dijk AP, Vliegen HW, Sollie KM, Ebels T, van Veldhuisen DJ, ZAHARA Investigators

The objective of the present study to investigate fertility, pregnancy, and delivery in women with biventricular repair for pulmonary atresia with an intact ventricular septum (PAIVS). Using a nationwide registry (CONCOR), 37 patients with pulmonary atresia were identified, 6 of whom (aged 21 to 34 years) had biventricular repair for PAIVS. Three PAIVS patients had a total of 5 pregnancies, including 1 abortion and 1 ectopic pregnancy. Besides minor noncardiac complications, the 3 live-birth pre... Abstract

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 14, Issue 6, 1 1 2006, Pages 207-208 Pulmonary arterial hypertension associated with congenital heart disease: the efficacy of drug treatment in symptomatic patients. Henkens IR, Vliegen HW

Abstract

Cited 22 times since 2006 (1.2 per year) source: EuropePMC

Acta cardiologica, Volume 61, Issue 3, 1 1 2006, Pages 327-331 Apolipoprotein-E polymorphism and response to pravastatin in men with coronary artery disease (REGRESS). Maitland-van der Zee AH, Jukema JW, Zwinderman AH, Hallman DM, De Boer A, Kastelein JJ, De Knijff P

Objective: [corrected] The influence ofApoE polymorphism on the efficacy of statins in lowering plasma lipids and lipoproteins and improving angiographic parameters was assessed. Methods: ApoE genotypes were studied in a group (n = 815) of well-characterised male coronary artery disease (CAD) patients who participated in the lipid-lowering regression study 'Regression Growth Evaluation Statin Study (REGRESS)'. Results: There was a significant interaction between treatment (placebo/prav... Abstract

Cited 20 times since 2006 (1.1 per year) source: EuropePMC

Journal of cardiovascular electrophysiology, Volume 17, Issue 6, 1 1 2006, Pages 586-593 Serial reevaluation for ARVD/C is indicated in patients presenting with left bundle branch block ventricular tachycardia and minor ECG abnormalities. Kiès P, Bootsma M, Bax JJ, Zeppenfeld K, van Erven L, Wijffels MC, van der Wall EE, Schalij MJ

Introduction: Diagnosis of arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is based on a set of criteria proposed by the International Task Force (TF) for Cardiomyopathies in 1994. To fulfill these criteria, presence of both electrocardiographic and anatomical abnormalities must be assessed with ECG and imaging techniques, respectively. This may be difficult in patients with early/mild forms of the disease as detectable structural abnormalities may still be absent. We evaluate... Abstract

Cited 16 times since 2006 (0.8 per year) source: EuropePMC

Current drug discovery technologies, Volume 3, Issue 2, 1 1 2006, Pages 135-144 Selective targeting of liposomes to macrophages using a ligand with high affinity for the macrophage scavenger receptor class A. Rensen PC, Gras JC, Lindfors EK, van Dijk KW, Jukema JW, van Berkel TJ, Biessen EA

Macrophages play an important role in inflammatory processes and are crucially involved in the onset and progression of atherosclerosis and tumorigenesis. Therefore, macrophages are regarded as an excellent target for therapeutic intervention. Since the scavenger receptor class A (SRA) is highly expressed on macrophages, we developed in the present study an SRA-specific particulate drug carrier by providing phosphatidylcholine liposomes with a targeting ligand for SRA. To enable firm association... Abstract

Cited 36 times since 2006 (1.9 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 92, Issue 12, 1 1 2006, Pages 1779-1783 Comprehensive cardiac assessment with multislice computed tomography: evaluation of left ventricular function and perfusion in addition to coronary anatomy in patients with previous myocardial infarction. Henneman MM, Schuijf JD, Jukema JW, Lamb HJ, de Roos A, Dibbets P, Stokkel MP, van der Wall EE, Bax JJ

Objective: To evaluate a comprehensive multislice computed tomography (MSCT) protocol in patients with previous infarction, including assessment of coronary artery stenoses, left ventricular (LV) function and perfusion. Patients and methods: 16-slice MSCT was performed in 21 patients with previous infarction; from the MSCT data, coronary artery stenoses, (regional and global) LV function and perfusion were assessed. Invasive coronary angiography and gated single-photon emission computed tomograp... Abstract

Cited 24 times since 2006 (1.3 per year) source: EuropePMC

American heart journal, Volume 151, Issue 6, 1 1 2006, Pages 1323.e7-12 The impact of hypertension on systolic and diastolic left ventricular function. A tissue Doppler echocardiographic study. Bountioukos M, Schinkel AF, Bax JJ, Lampropoulos S, Poldermans D

Background: The purpose of this study is to assess the impact of hypertension on systolic function and diastolic function using 2-dimensional echocardiography, conventional Doppler imaging of the transmitral inflow, and tissue Doppler imaging (TDI) of the mitral annulus. Methods: From an outpatient clinic population, 414 consecutive patients underwent 2-dimensional echocardiography, conventional Doppler imaging of the transmitral inflow, and TDI of the septal, lateral, inferior, and posterior wa... Abstract

Nature clinical practice. Cardiovascular medicine, Volume 3, Issue 6, 1 1 2006, Pages 304-305 Can dobutamine stress echocardiography predict patient outcome after acute myocardial infarction? Bax JJ, Poldermans D

Abstract

Cited 30 times since 2006 (1.6 per year) source: EuropePMC

AJR. American journal of roentgenology, Volume 186, Issue 6 Suppl 2, 1 1 2006, Pages S366-70 MDCT assessment of right ventricular systolic function. Doğan H, Kroft LJ, Bax JJ, Schuijf JD, van der Geest RJ, Doornbos J, de Roos A

Objective: The objective of our study was to validate using MDCT for the assessment of right ventricular (RV) function. MDCT with retrospective ECG gating was performed in 15 patients being evaluated for suspected cardiovascular disease. Echocardiography was performed for comparison. The MDCT images were reconstructed at 20 phase points over the cardiac cycle. The end-diastolic and end-systolic volumes of both ventricles were measured. Stroke volumes and ejection fractions were calculated from t... Abstract

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 14, Issue 6, 1 1 2006, Pages 232-238 From the waste paper basket: total AV block? Wijnmaalen AP, van den Berg TM, Delemarre BJ

Abstract

Cited 187 times since 2006 (9.9 per year) source: EuropePMC

Human gene therapy, Volume 17, Issue 6, 1 1 2006, Pages 683-691 Treatment with intramuscular vascular endothelial growth factor gene compared with placebo for patients with diabetes mellitus and critical limb ischemia: a double-blind randomized trial. Kusumanto YH, van Weel V, Mulder NH, Smit AJ, van den Dungen JJ, Hooymans JM, Sluiter WJ, Tio RA, Quax PH, Gans RO, Dullaart RP, Hospers GA

Despite advances in revascularization techniques, limb salvage and relief of pain cannot be achieved in many diabetic patients with diffuse peripheral vascular disease. Our objective was to determine the effect of intramuscular administration of phVEGF165 (vascular endothelial growth factor gene-carrying plasmid) on critical limb ischemia (CLI) compared with placebo (0.9% NaCl). A double-blind, placebo-controlled study was performed in 54 adult diabetic patients with CLI. The primary end point w... Abstract

Cited 49 times since 2006 (2.6 per year) source: EuropePMC

The American journal of pathology, Volume 168, Issue 6, 1 1 2006, Pages 2027-2035 TR3 nuclear orphan receptor prevents cyclic stretch-induced proliferation of venous smooth muscle cells. de Waard V, Arkenbout EK, Vos M, Mocking AI, Niessen HW, Stooker W, de Mol BA, Quax PH, Bakker EN, VanBavel E, Pannekoek H, de Vries CJ

In coronary artery bypass surgery, the patency of arterial grafts is higher than that of venous grafts because of vein-graft disease, which involves excessive proliferation of venous smooth muscle cells (SMCs) and subsequent accelerated atherosclerosis. We studied the function of TR3 nuclear orphan receptor (TR3) in the early response of SMCs to mechanical strain, a major initiator of vein-graft disease. We demonstrate that TR3 expression is induced in human saphenous vein segments exposed ex vi... Abstract

Cited 107 times since 2006 (5.6 per year) source: EuropePMC

American journal of physiology. Heart and circulatory physiology, Volume 291, Issue 5, 26 4 2006, Pages H2424-30 Characterization of right ventricular function after monocrotaline-induced pulmonary hypertension in the intact rat. Hessel MH, Steendijk P, den Adel B, Schutte CI, van der Laarse A

We characterized hemodynamics and systolic and diastolic right ventricular (RV) function in relation to structural changes in the rat model of monocrotaline (MCT)-induced pulmonary hypertension. Rats were treated with MCT at 30 mg/kg body wt (MCT30, n = 15) and 80 mg/kg body wt (MCT80, n = 16) to induce compensated RV hypertrophy and RV failure, respectively. Saline-treated rats served as control (Cont, n = 13). After 4 wk, a pressure-conductance catheter was introduced into the RV to assess pre... Abstract

Cited 2 times since 2006 (0.1 per year) source: EuropePMC

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 30, Issue 1, 26 4 2006, Pages 33-34 A mechanical prosthesis for pulmonary valve replacement? Hazekamp MG

Abstract