6136 results
Cited 308 times since 2016 (34.1 per year)
source: EuropePMC
Science (New York, N.Y.),
Volume 351, Issue 6278, 1 1 2016, Pages 1166-1171
Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease.
Zanoni P, Khetarpal SA, Larach DB, Hancock-Cerutti WF, Millar JS, Cuchel M, DerOhannessian S, Kontush A, Surendran P, Saleheen D, Trompet S, Jukema JW, De Craen A, Deloukas P, Sattar N, Ford I, Packard C, Majumder Aa, Alam DS, Di Angelantonio E, Abecasis G, Chowdhury R, Erdmann J, Nordestgaard BG, Nielsen SF, Tybjærg-Hansen A, Schmidt RF, Kuulasmaa K, Liu DJ, Perola M, Blankenberg S, Salomaa V, Männistö S, Amouyel P, Arveiler D, Ferrieres J, Müller-Nurasyid M, Ferrario M, Kee F, Willer CJ, Samani N, Schunkert H, Butterworth AS, Howson JM, Peloso GM, Stitziel NO, Danesh J, Kathiresan S, Rader DJ, CHD Exome+ Consortium, CARDIoGRAM Exome Consortium, Global Lipids Genetics Consortium
Scavenger receptor BI (SR-BI) is the major receptor for high-density lipoprotein (HDL) cholesterol (HDL-C). In humans, high amounts of HDL-C in plasma are associated with a lower risk of coronary heart disease (CHD). Mice that have depleted Scarb1 (SR-BI knockout mice) have markedly elevated HDL-C levels but, paradoxically, increased atherosclerosis. The impact of SR-BI on HDL metabolism and CHD risk in humans remains unclear. Through targeted sequencing of coding regions of lipid-modifying gene...
Abstract
Cited 3 times since 2016 (0.3 per year)
source: EuropePMC
Journal of atrial fibrillation,
Volume 8, Issue 5, 29 5 2016, Pages 1362
Cardiac Resynchronization Therapy in Non-Ischemic Cardiomyopathy.
Shanks M, Delgado V, Bax JJ
Cardiac resynchronization therapy (CRT) is an established therapy for heart failure patients who remain symptomatic despite optimal medical therapy, have reduced left ventricular ejection fraction (120 ms), preferably with left bundle branch block morphology. The response to CRT depends on the cardiac substrate: presence of correctable left ventricular mechanical dyssynchrony, presence of myocardial fibrosis (scar) and position of the left ventricular pacing lead. Patients with non-ischemic card...
Abstract
Revista espanola de cardiologia (English ed.),
Volume 69, Issue 4, 23 4 2016, Pages 460-461
Could Descending Septal Artery Be Another Variant of the Dual Left Anterior Descending Artery? Response.
Montero-Cabezas JM, Delgado V, Karalis I, Schalij MJ
Abstract
Cited 9 times since 2016 (1 per year)
source: EuropePMC
Journal of internal medicine,
Volume 279, Issue 6, 23 4 2016, Pages 592-605
Heat-killed Staphylococcus aureus reduces atherosclerosis by inducing anti-inflammatory macrophages.
Frodermann V, van Duijn J, van Puijvelde GH, van Santbrink PJ, Lagraauw HM, de Vries MR, Quax PH, Bot I, Foks AC, de Jager SC, Kuiper J
Background: Staphylococcus aureus cell wall components can induce IL-10 responses by immune cells, which may be atheroprotective. Therefore, in this study, we investigated whether heat-killed S. aureus (HK-SA) could inhibit the development of atherosclerosis. Methods: Atherosclerosis-susceptible LDL receptor-deficient mice were administered intraperitoneal HK-SA twice weekly and fed a Western-type diet for 6 weeks. Results: HK-SA administration resulted in a 1.6-fold increase in IL-10 production...
Abstract
Cited 91 times since 2016 (10.1 per year)
source: EuropePMC
Cardiovascular research,
Volume 110, Issue 1, 23 4 2016, Pages 6-22
The multifactorial nature of microRNAs in vascular remodelling.
Welten SM, Goossens EA, Quax PH, Nossent AY
Vascular remodelling is a multifactorial process that involves both adaptive and maladaptive changes of the vessel wall through, among others, cell proliferation and migration, but also apoptosis and necrosis of the various cell types in the vessel wall. Vascular remodelling can be beneficial, e.g. during neovascularization after ischaemia, as well as pathological, e.g. during atherosclerosis and aneurysm formation. In recent years, it has become clear that microRNAs are able to target many gene...
Abstract
Cited 22 times since 2016 (2.4 per year)
source: EuropePMC
European heart journal,
Volume 37, Issue 47, 22 4 2016, Pages 3536-3543
The 200th anniversary of the stethoscope: Can this low-tech device survive in the high-tech 21st century?
Bank I, Vliegen HW, Bruschke AV
In 1816, Laennec discovered that auscultation of the heart and lungs could effectively be performed by placing a hollow cylinder (initially made of a roll of paper) between the chest of the patient and the ear of the examiner. This was the first step in the development of the stethoscope, which was a breakthrough in the diagnosis and management of cardiac and pulmonary patients. Technical improvements of the stethoscope followed and in cardiac patients auscultation soon became a major diagnostic...
Abstract
Cited 8 times since 2016 (0.9 per year)
source: EuropePMC
Nutrition, metabolism, and cardiovascular diseases : NMCD,
Volume 26, Issue 8, 19 3 2016, Pages 697-705
HDL functionality in South Asians as compared to white Caucasians.
Bakker LE, Boon MR, Annema W, Dikkers A, van Eyk HJ, Verhoeven A, Mayboroda OA, Jukema JW, Havekes LM, Meinders AE, Willems van Dijk K, Jazet IM, Tietge UJ, Rensen PC
Background and aims: South Asians have an exceptionally high risk of developing cardiovascular disease compared to white Caucasians. A contributing factor might be dysfunction of high density lipoprotein (HDL). We aimed to compare HDL function in different age groups of both ethnicities. Methods and results: HDL functionality with respect to cholesterol efflux, anti-oxidation and anti-inflammation was determined using fasting, apoB-depleted, plasma samples from South Asian and white Caucasian ne...
Abstract
Cited 35 times since 2016 (3.9 per year)
source: EuropePMC
Neurology,
Volume 86, Issue 12, 17 3 2016, Pages 1120-1127
10-Second heart rate variability and cognitive function in old age.
Mahinrad S, Jukema JW, van Heemst D, Macfarlane PW, Clark EN, de Craen AJ, Sabayan B
Objective: To investigate the cross-sectional and longitudinal associations of 10-second heart rate variability (HRV) with various domains of cognitive function in older participants at risk of cardiovascular disease. Methods: We studied 3,583 participants, mean age of 75.0 years, who were enrolled in the Prospective Study of Pravastatin in the Elderly at Risk. From baseline 10-second ECGs, standard deviation of normal-to-normal intervals was calculated as the index of HRV. Four cognitive domain...
Abstract
Cited 13 times since 2016 (1.4 per year)
source: EuropePMC
European journal of preventive cardiology,
Volume 23, Issue 13, 16 3 2016, Pages 1383-1392
High-sensitivity cardiac troponin T is associated with cognitive decline in older adults at high cardiovascular risk.
Wijsman LW, de Craen AJ, Trompet S, Sabayan B, Muller M, Stott DJ, Ford I, Welsh P, Westendorp RG, Jukema JW, Sattar N, Mooijaart SP
Aims: Cardiac troponin T (cTnT), measured with a high-sensitivity (hs) assay, is associated with cognitive decline, but the underlying mechanism is unknown. We investigated the association of hs-cTnT with cognitive function and decline, and studied whether this association was independent of cardiovascular diseases or risk factors, and N-terminal pro-brain natriuretic peptide (NT-proBNP). Methods and results: We studied 5407 participants (mean age 75.31 years) from the PROspective Study of Prava...
Abstract
Cited 7 times since 2016 (0.8 per year)
source: EuropePMC
BMJ case reports,
Volume 2016, 15 3 2016, Pages bcr2015213106
Multiple carpometacarpal dislocations and an associated fracture of the hamate: an uncommon injury.
Brinkman JN, Hartholt KA, de Vries MR
Dislocation of the four ulnar carpometacarpal (CMC) joints with a concurrent fracture of the hamate is a rare injury, with a paucity of published cases. A great force is required to dislocate a CMC joint. Diagnosis can easily be missed, due to other serious associated injuries. Appropriate treatment of CMC joint dislocations usually leads to excellent outcomes. We present a case of dorsal dislocation of the four ulnar CMC joints after punching a wall. The injury was treated with a closed reducti...
Abstract
Cited 31 times since 2016 (3.4 per year)
source: EuropePMC
Arteriosclerosis, thrombosis, and vascular biology,
Volume 36, Issue 4, 11 2 2016, Pages 757-764
Effect of Coronary Atherosclerosis and Myocardial Ischemia on Plasma Levels of High-Sensitivity Troponin T and NT-proBNP in Patients With Stable Angina.
Caselli C, Prontera C, Liga R, De Graaf MA, Gaemperli O, Lorenzoni V, Ragusa R, Marinelli M, Del Ry S, Rovai D, Giannessi D, Aguade-Bruix S, Clemente A, Bax JJ, Lombardi M, Sicari R, Zamorano J, Scholte AJ, Kaufmann PA, Knuuti J, Underwood SR, Clerico A, Neglia D
Objective: Circulating levels of high-sensitivity cardiac troponin T (hs-cTnT) and N terminal pro brain natriuretic peptide (NT-proBNP) are predictors of prognosis in patients with coronary artery disease (CAD). We aimed at evaluating the effect of coronary atherosclerosis and myocardial ischemia on cardiac release of hs-cTnT and NT-proBNP in patients with suspected CAD. Approach and results: Hs-cTnT and NT-proBNP were measured in 378 patients (60.1±0.5 years, 229 males) with stable angina and u...
Abstract
Cited 12 times since 2016 (1.3 per year)
source: EuropePMC
Heart (British Cardiac Society),
Volume 102, Issue 12, 10 2 2016, Pages 943-949
Coronary anatomy as related to bicuspid aortic valve morphology.
Koenraadt WM, Tokmaji G, DeRuiter MC, Vliegen HW, Scholte AJ, Siebelink HM, Gittenberger-de Groot AC, de Graaf MA, Wolterbeek R, Mulder BJ, Bouma BJ, Schalij MJ, Jongbloed MR
Objective: Variable coronary anatomy has been described in patients with bicuspid aortic valves (BAVs). This was never specified to BAV morphology, and prognostic relevance of coronary vessel dominance in this patient group is unclear. The purpose of this study was to evaluate valve morphology in relation to coronary artery anatomy and outcome in patients with isolated BAV and with associated aortic coarctation (CoA). Methods: Coronary anatomy was evaluated in 186 patients with BAV (141 men (79%...
Abstract
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
Volume 50, Issue 1, 9 2 2016, Pages 190
Reply to Mannacio et al.
Gielen CL, Bruggemans EF, Brand A, Klautz RJ
Abstract
Cited 10 times since 2016 (1.1 per year)
source: EuropePMC
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology,
Volume 24, Issue 4, 9 2 2016, Pages 1253-1262
Relation between quantitative coronary CTA and myocardial ischemia by adenosine stress myocardial CT perfusion.
van Rosendael AR, Kroft LJ, Broersen A, Dijkstra J, van den Hoogen IJ, van Zwet EW, Bax JJ, de Graaf MA, Scholte AJ
Background: Coronary-computed tomography angiography (CTA) has limited accuracy to predict myocardial ischemia. Besides luminal area stenosis, other coronary plaque morphology and composition parameters may help to assess ischemia. With the integration of coronary CTA and adenosine stress CT myocardial perfusion (CTP), reliable information regarding coronary anatomy and function can be derived in one procedure. This analysis aimed to investigate the association between coronary stenosis severity...
Abstract
Cited 50 times since 2016 (5.5 per year)
source: EuropePMC
The Annals of thoracic surgery,
Volume 101, Issue 5, 6 1 2016, Pages 1684-1689
Bentall Procedure: A Systematic Review and Meta-Analysis.
Mookhoek A, Korteland NM, Arabkhani B, Di Centa I, Lansac E, Bekkers JA, Bogers AJ, Takkenberg JJ
Background: The Bentall procedure is considered the gold standard in the treatment of patients requiring aortic root replacement. An up-to-date overview of outcomes after the Bentall procedure is lacking. Methods: We conducted a systematic review and meta-analysis of characteristics of and long-term outcome after the Bentall procedure with a mechanical valve prosthesis. Pooling was performed using the inverse variance method within a random-effects model. Outcome events are reported as linearize...
Abstract
Cited 5 times since 2016 (0.5 per year)
source: EuropePMC
Differentiation; research in biological diversity,
Volume 91, Issue 4-5, 5 1 2016, Pages 90-103
The avian embryo to study development of the cardiac conduction system.
Kelder TP, Vicente-Steijn R, Poelmann RE, Mummery CL, DeRuiter MC, Jongbloed MR
The avian embryo has long been a popular model system in developmental biology. The easy accessibility of the embryo makes it particularly suitable for in ovo microsurgery and manipulation. Re-incubation of the embryo allows long-term follow-up of these procedures. The current review focuses on the variety of techniques available to study development of the cardiac conduction system in avian embryos. Based on the large amount of relevant data arising from experiments in avian embryos, we conclud...
Abstract
Cited 13 times since 2016 (1.4 per year)
source: EuropePMC
Journal of visualized experiments : JoVE,
Issue 108, 3 1 2016, Pages e53294
A Novel Murine Model of Arteriovenous Fistula Failure: The Surgical Procedure in Detail.
Wong CY, de Vries MR, Wang Y, van der Vorst JR, Vahrmeijer AL, van Zonneveld AJ, Hamming JF, Roy-Chaudhury P, Rabelink TJ, Quax PH, Rotmans JI
The arteriovenous fistula (AVF) still suffers from a high number of failures caused by insufficient remodeling and intimal hyperplasia from which the exact pathophysiology remains unknown. In order to unravel the pathophysiology a murine model of AVF-failure was developed in which the configuration of the anastomosis resembles the preferred situation in the clinical setting. A model was described in which an AVF is created by connecting the venous end of the branch of the external jugular vein t...
Abstract
The American journal of cardiology,
Volume 117, Issue 7, 2 1 2016, Pages 1167-1172
Comparison of Left Ventricular Volume and Ejection Fraction and Frequency and Extent of Aortic Regurgitation After Operative Repair of Type A Aortic Dissection Among Three Different Surgical Techniques.
Regeer MV, Versteegh MI, Klautz RJ, Schalij MJ, Bax JJ, Marsan NA, Delgado V
Differences in recurrence rate of aortic regurgitation (AR) and extent of left ventricular (LV) remodeling across the different surgical options in patients operated for type A aortic dissection remain unknown. The present evaluation compared the AR recurrence rate and changes in LV volumes and systolic function in valve-sparing aorta replacement (VSAR), supracoronary ascending aorta replacement (SCAR), and aortic valve and aorta replacement (AVAR). A total of 97 patients (58 ± 12 years, 62% men...
Abstract
Cited 13 times since 2016 (1.4 per year)
source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 24, Issue 2, 1 1 2016, Pages 127-133
The extent of the raphe in bicuspid aortic valves is associated with aortic regurgitation and aortic root dilatation.
Koenraadt WM, Grewal N, Gaidoukevitch OY, DeRuiter MC, Gittenberger-de Groot AC, Bartelings MM, Holman ER, Klautz RJ, Schalij MJ, Jongbloed MR
Background: The clinical course of bicuspid aortic valves (BAVs) is variable. Data on predictors of aortopathy and valvular dysfunction mainly focus on valve morphology. Aim: To determine whether the presence and extent of the raphe (fusion site of valve leaflets) is associated with the degree of aortopathy and valvular dysfunction in patients with isolated BAV and associated aortic coarctation (CoA). Methods: Valve morphology and aortic dimensions of 255 BAV patients were evaluated retrospectiv...
Abstract
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 24, Issue 2, 1 1 2016, Pages 154-155
An anomalous left coronary artery with a malignant course: coronary angiography and myocardial perfusion imaging with computed tomography.
de Graaf MA, van Rosendael AR, Kroft LJ, Vliegen HW, Hazekamp MG, Bax JJ, Scholte AJ
Abstract
