Research

Publications

Below you can find a list of our published research.

6139 results

Cited 88 times since 2013 (7.4 per year) source: EuropePMC

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, Volume 28, Issue 5, 29 5 2013, Pages 1085-1092 Arteriovenous access failure: more than just intimal hyperplasia? Rothuizen TC, Wong C, Quax PH, van Zonneveld AJ, Rabelink TJ, Rotmans JI

Haemodialysis vascular access patency is severely compromised by fistula non-maturation and access stenosis. Intimal hyperplasia (IH) is considered the culprit lesion in failed fistulas, resulting in luminal narrowing and stenosis. This review focuses on the biology and pathophysiology of fistula failure and highlights not only the classically associated IH but also some relatively neglected but potentially important contributors such as inadequate outward remodelling. In addition, the complex p... Abstract

Cited 33 times since 2013 (2.8 per year) source: EuropePMC

American heart journal, Volume 165, Issue 5, 27 4 2013, Pages 793-99, 799.e1 Contrast-induced acute kidney injury and clinical outcomes after intra-arterial and intravenous contrast administration: risk comparison adjusted for patient characteristics by design. Kooiman J, Le Haen PA, Gezgin G, de Vries JP, Boersma D, Brulez HF, Sijpkens YW, van der Molen AJ, Cannegieter SC, Hamming JF, Huisman MV

Background: Direct comparisons between risk of contrast induced acute kidney injury (CI-AKI) after intra-arterial versus intravenous contrast administration are scarce. We estimated and compared the risk of CI-AKI and its clinical course after both modes of contrast administration in patients who underwent both. Methods: One hundred seventy patients who received both intra-arterial and intravenous contrast injections within one year between 2001 and 2010 were included. Primary outcome was occurr... Abstract

Cited 73 times since 2013 (6.1 per year) source: Scopus

Antioxidants & redox signaling, Volume 19, Issue 6, 26 4 2013, Pages 535-545 Oxidative damage in clinical ischemia/reperfusion injury: a reappraisal. de Vries DK, Kortekaas KA, Tsikas D, Wijermars LG, van Noorden CJ, Suchy MT, Cobbaert CM, Klautz RJ, Schaapherder AF, Lindeman JH

Aims: Ischemia/reperfusion (I/R) injury is a common clinical problem. Although the pathophysiological mechanisms underlying I/R injury are unclear, oxidative damage is considered a key factor in the initiation of I/R injury. Findings from preclinical studies consistently show that quenching reactive oxygen and nitrogen species (RONS), thus limiting oxidative damage, alleviates I/R injury. Results from clinical intervention studies on the other hand are largely inconclusive. In this study, we sys... Abstract

Cited 100 times since 2013 (8.3 per year) source: Scopus

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 44, Issue 1, 25 4 2013, Pages e8-15 Transcatheter valve-in-ring implantation after failure of surgical mitral repair. Descoutures F, Himbert D, Maisano F, Casselman F, de Weger A, Bodea O, Van der Kley F, Colombo A, Giannini C, Rein KA, De Bruyne B, Petronio AS, Dahle G, Alfieri O, Vahanian A

Objectives: Redo surgery after failed mitral valve repair may be high risk, or contraindicated in patients with comorbidities. Because of this high risk, other interventional possibilities like transcatheter valve implantation might be of benefit. We report our experience with transcatheter mitral valve-in-ring implantation (TVIR) in high-risk patients after failure of surgical ring annuloplasty. Methods: From January 2010 to February 2012, following a multidisciplinary discussion, 17 high-risk... Abstract

Cited 36 times since 2013 (3 per year) source: EuropePMC

European journal of cardiovascular nursing, Volume 13, Issue 1, 22 4 2013, Pages 86-94 Illness perceptions of adults with congenital heart disease and their predictive value for quality of life two years later. Schoormans D, Mulder BJ, van Melle JP, Pieper PG, van Dijk AP, Sieswerda GT, Hulsbergen-Zwarts MS, Plokker TH, Brunninkhuis LG, Vliegen HW, Sprangers MA

Background: To improve patients' quality of life (QoL) we need to identify modifiable determinants, such as illness perceptions. Patients' illness perceptions are known to regulate emotional responses and health-behaviour. Illness perceptions comprise several components: consequences, control, coherence, changeability and emotional representations. Aims: To examine (a) the relation between patient characteristics and illness perceptions, and (b) the independent predictive value of illn... Abstract

Cited 30 times since 2013 (2.5 per year) source: EuropePMC

PloS one, Volume 8, Issue 3, 12 2 2013, Pages e59199 Subclinical thyroid dysfunction and cognitive decline in old age. Wijsman LW, de Craen AJ, Trompet S, Gussekloo J, Stott DJ, Rodondi N, Welsh P, Jukema JW, Westendorp RG, Mooijaart SP

Background: Subclinical thyroid dysfunction has been implicated as a risk factor for cognitive decline in old age, but results are inconsistent. We investigated the association between subclinical thyroid dysfunction and cognitive decline in the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER). Methods: Prospective longitudinal study of men and women aged 70-82 years with pre-existing vascular disease or more than one risk factor to develop this condition (N = 5,154). Participan... Abstract

Cited 60 times since 2013 (5 per year) source: EuropePMC

Journal of internal medicine, Volume 274, Issue 1, 11 2 2013, Pages 77-85 Circulating interleukin-6 concentration and cognitive decline in old age: the PROSPER study. Mooijaart SP, Sattar N, Trompet S, Lucke J, Stott DJ, Ford I, Jukema JW, Westendorp RG, de Craen AJ, PROSPER Study Group

Background: Inflammation is involved in the pathogenesis of cardiovascular disease and cognitive decline. Interleukin-6 (IL-6) has a role in cardiovascular disease, but the association of IL-6 concentration and the functional IL-6 -174 polymorphism with cognitive decline has not been demonstrated unequivocally. The objective of this study was to investigate the associations between both high concentration of IL-6 and the -174 promoter polymorphism, and increased cognitive decline in old age. Met... Abstract

Cited 16 times since 2013 (1.3 per year) source: EuropePMC

PloS one, Volume 8, Issue 3, 6 1 2013, Pages e58572 Small hydrophobic protein of human metapneumovirus does not affect virus replication and host gene expression in vitro. de Graaf M, Herfst S, Aarbiou J, Burgers PC, Zaaraoui-Boutahar F, Bijl M, van Ijcken W, Schrauwen EJ, Osterhaus AD, Luider TM, Scholte BJ, Fouchier RA, Andeweg AC

Human metapneumovirus (HMPV) encodes a small hydrophobic (SH) protein of unknown function. HMPV from which the SH open reading frame was deleted (HMPVΔSH) was viable and displayed similar replication kinetics, cytopathic effect and plaque size compared with wild type HMPV in several cell-lines. In addition, no differences were observed in infection efficiency or cell-to-cell spreading in human primary bronchial epithelial cells (HPBEC) cultured at an air-liquid interphase. Host gene expression w... Abstract

Cited 4 times since 2013 (0.3 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 99, Issue 8, 6 1 2013, Pages 556-561 Association between discharge heart rate and left ventricular adverse remodelling in ST segment elevation myocardial infarction patients treated with primary percutaneous coronary intervention. Joyce E, Hoogslag GE, Leong DP, Fox K, Schalij MJ, Marsan NA, Bax JJ, Delgado V

Objective: Left ventricular (LV) adverse remodelling is an important determinant of mortality after ST segment elevation myocardial infarction (STEMI). Recently, discharge heart rate (DHR) has been associated with long-term outcomes after STEMI. Whether DHR is related to the development of LV remodelling after STEMI remains unknown. The present study evaluated the association between DHR after STEMI and the occurrence of LV remodelling at 6 months. DESIGN, SETTING, PATIENTS AND INTERVENTIONS: In... Abstract

Cited 22 times since 2013 (1.8 per year) source: EuropePMC

The pharmacogenomics journal, Volume 14, Issue 1, 5 1 2013, Pages 6-13 Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval. Avery CL, Sitlani CM, Arking DE, Arnett DK, Bis JC, Boerwinkle E, Buckley BM, Ida Chen YD, de Craen AJ, Eijgelsheim M, Enquobahrie D, Evans DS, Ford I, Garcia ME, Gudnason V, Harris TB, Heckbert SR, Hochner H, Hofman A, Hsueh WC, Isaacs A, Jukema JW, Knekt P, Kors JA, Krijthe BP, Kristiansson K, Laaksonen M, Liu Y, Li X, Macfarlane PW, Newton-Cheh C, Nieminen MS, Oostra BA, Peloso GM, Porthan K, Rice K, Rivadeneira FF, Rotter JI, Salomaa V, Sattar N, Siscovick DS, Slagboom PE, Smith AV, Sotoodehnia N, Stott DJ, Stricker BH, Stürmer T, Trompet S, Uitterlinden AG, van Duijn C, Westendorp RG, Witteman JC, Whitsel EA, Psaty BM

Variability in response to drug use is common and heritable, suggesting that genome-wide pharmacogenomics studies may help explain the 'missing heritability' of complex traits. Here, we describe four independent analyses in 33 781 participants of European ancestry from 10 cohorts that were designed to identify genetic variants modifying the effects of drugs on QT interval duration (QT). Each analysis cross-sectionally examined four therapeutic classes: thiazide diuretics (prevalence of... Abstract

Cited 113 times since 2013 (9.4 per year) source: EuropePMC

Annals of neurology, Volume 73, Issue 3, 4 1 2013, Pages 397-407 Autoantibodies to cytosolic 5'-nucleotidase 1A in inclusion body myositis. Pluk H, van Hoeve BJ, van Dooren SH, Stammen-Vogelzangs J, van der Heijden A, Schelhaas HJ, Verbeek MM, Badrising UA, Arnardottir S, Gheorghe K, Lundberg IE, Boelens WC, van Engelen BG, Pruijn GJ

Objective: Sporadic inclusion body myositis (sIBM) is an inflammatory myopathy characterized by both degenerative and autoimmune features. In contrast to other inflammatory myopathies, myositis-specific autoantibodies had not been found in sIBM patients until recently. We used human skeletal muscle extracts as a source of antigens to detect autoantibodies in sIBM and to characterize the corresponding antigen. Methods: Autoantibodies to skeletal muscle antigens were detected by immunoblotting. Th... Abstract

Cited 17 times since 2013 (1.4 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 21, Issue 3, 1 1 2013, Pages 113-117 Ebstein's anomaly may be caused by mutations in the sarcomere protein gene MYH7. van Engelen K, Postma AV, van de Meerakker JB, Roos-Hesselink JW, Helderman-van den Enden AT, Vliegen HW, Rahman T, Baars MJ, Sels JW, Bauer U, Pickardt T, Sperling SR, Moorman AF, Keavney B, Goodship J, Klaassen S, Mulder BJ

Ebstein's anomaly is a rare congenital heart malformation characterised by adherence of the septal and posterior leaflets of the tricuspid valve to the underlying myocardium. Associated abnormalities of left ventricular morphology and function including left ventricular noncompaction (LVNC) have been observed. An association between Ebstein's anomaly with LVNC and mutations in the sarcomeric protein gene MYH7, encoding β-myosin heavy chain, has been shown by recent studies. This might... Abstract

Cited 8 times since 2013 (0.7 per year) source: EuropePMC

Circulation, Volume 127, Issue 12, 1 1 2013, Pages 1340-1341 Compression of the left main coronary artery by a giant pulmonary artery aneurysm. Jurado-Román A, Hernández-Hernández F, Ruíz-Cano MJ, Velázquez-Martín MT, Medina JM, Pérez-López I, Barrios-Garrido-Lestache E, Montero-Cabezas JM, Escribano-Subías P

Abstract

Cited 72 times since 2013 (6 per year) source: EuropePMC

The Journal of urology, Volume 190, Issue 2, 1 1 2013, Pages 574-579 Intraoperative near infrared fluorescence guided identification of the ureters using low dose methylene blue: a first in human experience. Verbeek FP, van der Vorst JR, Schaafsma BE, Swijnenburg RJ, Gaarenstroom KN, Elzevier HW, van de Velde CJ, Frangioni JV, Vahrmeijer AL

Purpose: Near infrared fluorescence imaging is a promising technique that offers real-time visual information during surgery. In this study we report the first clinical results to our knowledge of ureteral imaging using near infrared fluorescence after a simple peripheral infusion of methylene blue. Furthermore, we assessed the optimal timing and dose of methylene blue. Materials and methods: A total of 12 patients who underwent lower abdominal surgery were included in this prospective feasibili... Abstract

Cited 34 times since 2013 (2.8 per year) source: EuropePMC

BJOG : an international journal of obstetrics and gynaecology, Volume 120, Issue 6, 19 3 2013, Pages 758-764 Near-infrared fluorescence sentinel lymph node biopsy in vulvar cancer: a randomised comparison of lymphatic tracers. Schaafsma BE, Verbeek FP, Peters AA, van der Vorst JR, de Kroon CD, van Poelgeest MI, Trimbos JB, van de Velde CJ, Frangioni JV, Vahrmeijer AL, Gaarenstroom KN

This study aims to confirm the feasibility of near-infrared (NIR) fluorescence imaging for sentinel lymph node (SLN) biopsy in vulvar cancer and to compare the tracer indocyanine green (ICG) bound to human serum albumin (HSA) versus ICG alone. Women received 99mTc-nanocolloid and patent blue for SLN detection. Subsequently, women randomly received ICG:HSA or ICG alone. In 24 women, 35 SLNs were intraoperatively detected. All SLNs detected were radioactive and NIR fluorescent and 27 (77%) were bl... Abstract

Cited 26 times since 2013 (2.2 per year) source: EuropePMC

Circulation. Arrhythmia and electrophysiology, Volume 6, Issue 2, 18 3 2013, Pages 380-391 Engraftment patterns of human adult mesenchymal stem cells expose electrotonic and paracrine proarrhythmic mechanisms in myocardial cell cultures. Askar SF, Ramkisoensing AA, Atsma DE, Schalij MJ, de Vries AA, Pijnappels DA

Background: After intramyocardial injection, mesenchymal stem cells (MSCs) may engraft and influence host myocardium. However, engraftment rate and pattern of distribution are difficult to control in vivo, hampering assessment of potential adverse effects. In this study, the role of the engraftment patterns of MSCs on arrhythmicity in controllable in vitro models is investigated. Methods and results: Cocultures of 4×10(5) neonatal rat cardiomyocytes and 7% or 28% adult human MSCs (hMSCs) in diff... Abstract

Cited 98 times since 2013 (8.1 per year) source: EuropePMC

The international journal of cardiovascular imaging, Volume 29, Issue 5, 16 3 2013, Pages 1177-1190 Automatic quantification and characterization of coronary atherosclerosis with computed tomography coronary angiography: cross-correlation with intravascular ultrasound virtual histology. de Graaf MA, Broersen A, Kitslaar PH, Roos CJ, Dijkstra J, Lelieveldt BP, Jukema JW, Schalij MJ, Delgado V, Bax JJ, Reiber JH, Scholte AJ

Plaque constitution on computed tomography coronary angiography (CTA) is associated with prognosis. At present only visual assessment of plaque constitution is possible. An accurate automatic, quantitative approach for CTA plaque constitution assessment would improve reproducibility and allows higher accuracy. The present study assessed the feasibility of a fully automatic and quantitative analysis of atherosclerosis on CTA. Clinically derived CTA and intravascular ultrasound virtual histology (... Abstract

Cited 12 times since 2013 (1 per year) source: EuropePMC

PloS one, Volume 8, Issue 2, 15 3 2013, Pages e56262 Non-homologous end-joining pathway associated with occurrence of myocardial infarction: gene set analysis of genome-wide association study data. Verschuren JJ, Trompet S, Deelen J, Stott DJ, Sattar N, Buckley BM, Ford I, Heijmans BT, Guchelaar HJ, Houwing-Duistermaat JJ, Slagboom PE, Jukema JW

Purpose: DNA repair deficiencies have been postulated to play a role in the development and progression of cardiovascular disease (CVD). The hypothesis is that DNA damage accumulating with age may induce cell death, which promotes formation of unstable plaques. Defects in DNA repair mechanisms may therefore increase the risk of CVD events. We examined whether the joints effect of common genetic variants in 5 DNA repair pathways may influence the risk of CVD events. Methods: The PLINK set-based t... Abstract

Cited 15 times since 2013 (1.2 per year) source: EuropePMC

Systematic reviews, Volume 2, 15 3 2013, Pages 13 Individual patient data meta-analysis for the clinical assessment of coronary computed tomography angiography: protocol of the Collaborative Meta-Analysis of Cardiac CT (CoMe-CCT). Schuetz GM, Schlattmann P, Achenbach S, Budoff M, Garcia MJ, Roehle R, Pontone G, Meijboom WB, Andreini D, Alkadhi H, Honoris L, Bettencourt N, Hausleiter J, Leschka S, Gerber BL, Meijs MF, Shabestari AA, Sato A, Zimmermann E, Schoepf UJ, Diederichsen A, Halon DA, Mendoza-Rodriguez V, Hamdan A, Nørgaard BL, Brodoefel H, Ovrehus KA, Jenkins SM, Halvorsen BA, Rixe J, Sheikh M, Langer C, Martuscelli E, Romagnoli A, Scholte AJ, Marcus RP, Ulimoen GR, Nieman K, Mickley H, Nikolaou K, Tardif JC, Johnson TR, Muraglia S, Chow BJ, Maintz D, Laule M, Dewey M

Unlabelled: Background: Coronary computed tomography angiography has become the foremost noninvasive imaging modality of the coronary arteries and is used as an alternative to the reference standard, conventional coronary angiography, for direct visualization and detection of coronary artery stenoses in patients with suspected coronary artery disease. Nevertheless, there is considerable debate regarding the optimal target population to maximize clinical performance and patient benefit. The most... Abstract

Cited 22 times since 2013 (1.8 per year) source: EuropePMC

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 44, Issue 2, 13 2 2013, Pages 269-274 Disparity in right vs left ventricular recovery during follow-up after ventricular septal defect correction in children. Klitsie LM, Kuipers IM, Roest AA, Van der Hulst AE, Stijnen T, Hazekamp MG, Blom NA, Ten Harkel AD

Objectives: Long-term prognosis after ventricular septal defect (VSD) correction in childhood is excellent. Nevertheless, decreased biventricular systolic performance has been described immediately following VSD surgery in children. In an effort to better understand this decrease and its time-course, we characterized biventricular systolic performance following VSD closure in paediatric patients up to 20 months postoperatively. Methods: Thirty-nine children undergoing VSD surgery and 22 age-matc... Abstract