6139 results
Cited 40 times since 2013 (3.3 per year)
source: EuropePMC
Journal of lipid research,
Volume 54, Issue 5, 10 2 2013, Pages 1265-1274
Lysophosphatidic acid triggers mast cell-driven atherosclerotic plaque destabilization by increasing vascular inflammation.
Bot M, de Jager SC, MacAleese L, Lagraauw HM, van Berkel TJ, Quax PH, Kuiper J, Heeren RM, Biessen EA, Bot I
Lysophosphatidic acid (LPA), a bioactive lysophospholipid, accumulates in the atherosclerotic plaque. It has the capacity to activate mast cells, which potentially exacerbates plaque progression. In this study, we thus aimed to investigate whether LPA contributes to plaque destabilization by modulating mast cell function. We here show by an imaging mass spectrometry approach that several LPA species are present in atherosclerotic plaques. Subsequently, we demonstrate that LPA is a potent mast ce...
Abstract
Cited 41 times since 2013 (3.4 per year)
source: EuropePMC
Clinical research in cardiology : official journal of the German Cardiac Society,
Volume 102, Issue 5, 8 2 2013, Pages 329-336
Discussing sexual function in the cardiology practice.
Nicolai MP, Both S, Liem SS, Pelger RC, Putter H, Schalij MJ, Elzevier HW
Background: In patients with cardiovascular disease, sexual dysfunction is frequently encountered. Erectile dysfunction shares the same modifiable risk factors as coronary artery disease and the fear of triggering cardiovascular events can create stress and anxiety impacting the sexual lives of patients and their partners. To optimise healthcare, knowledge of cardiologists' attitude and practice patterns regarding the discussion about sexual function is essential. Methods: A 31-itemed anony...
Abstract
Cited 144 times since 2013 (11.9 per year)
source: EuropePMC
PLoS genetics,
Volume 9, Issue 2, 7 1 2013, Pages e1003266
A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function.
Porcu E, Medici M, Pistis G, Volpato CB, Wilson SG, Cappola AR, Bos SD, Deelen J, den Heijer M, Freathy RM, Lahti J, Liu C, Lopez LM, Nolte IM, O'Connell JR, Tanaka T, Trompet S, Arnold A, Bandinelli S, Beekman M, Böhringer S, Brown SJ, Buckley BM, Camaschella C, de Craen AJ, Davies G, de Visser MC, Ford I, Forsen T, Frayling TM, Fugazzola L, Gögele M, Hattersley AT, Hermus AR, Hofman A, Houwing-Duistermaat JJ, Jensen RA, Kajantie E, Kloppenburg M, Lim EM, Masciullo C, Mariotti S, Minelli C, Mitchell BD, Nagaraja R, Netea-Maier RT, Palotie A, Persani L, Piras MG, Psaty BM, Räikkönen K, Richards JB, Rivadeneira F, Sala C, Sabra MM, Sattar N, Shields BM, Soranzo N, Starr JM, Stott DJ, Sweep FC, Usala G, van der Klauw MM, van Heemst D, van Mullem A, Vermeulen SH, Visser WE, Walsh JP, Westendorp RG, Widen E, Zhai G, Cucca F, Deary IJ, Eriksson JG, Ferrucci L, Fox CS, Jukema JW, Kiemeney LA, Pramstaller PP, Schlessinger D, Shuldiner AR, Slagboom EP, Uitterlinden AG, Vaidya B, Visser TJ, Wolffenbuttel BH, Meulenbel
Thyroid hormone is essential for normal metabolism and development, and overt abnormalities in thyroid function lead to common endocrine disorders affecting approximately 10% of individuals over their life span. In addition, even mild alterations in thyroid function are associated with weight changes, atrial fibrillation, osteoporosis, and psychiatric disorders. To identify novel variants underlying thyroid function, we performed a large meta-analysis of genome-wide association studies for serum...
Abstract
Cardiovascular research,
Volume 98, Issue 1, 7 1 2013, Pages 156-157
Prolongation of minimal action potential duration in sustained fibrillation decreases complexity by transient destabilization: reply.
Bingen BO, Askar SF, Schalij MJ, de Vries AA, Pijnappels DA
Abstract
Cited 2 times since 2013 (0.2 per year)
source: EuropePMC
European heart journal,
Volume 34, Issue 17, 7 1 2013, Pages 1278
The invisible made visible: multi-modality imaging in the evaluation of cardiac sarcoidosis.
Joyce E, Delgado V, Ninaber MK, Marsan NA
Abstract
Cited 8 times since 2013 (0.7 per year)
source: EuropePMC
The Journal of cardiovascular surgery,
Volume 54, Issue 1 Suppl 1, 1 1 2013, Pages 47-53
Ruptured AAA: state of the art management.
Eefting D, Ultee KH, Von Meijenfeldt GC, Hoeks SE, ten Raa S, Hendriks JM, Bastos Goncalves F, Verhagen HJ
Since its introduction more than two decades ago, endovascular aneurysm repair (EVAR) has become the primary choice for elective treatment of abdominal aortic aneurysms (AAA) in many medical centers. The (dis)advantages, including 30-day mortality and long-term survival, of both open and endovascular elective AAA repair have been studied extensively, including four randomized trials. On the contrary, the survival benefit of EVAR for ruptured AAAs is not as well established as in elective situati...
Abstract
Cited 35 times since 2013 (2.9 per year)
source: EuropePMC
Journal of lipid research,
Volume 54, Issue 2, 1 1 2013, Pages 561-566
PCSK9 SNP rs11591147 is associated with low cholesterol levels but not with cognitive performance or noncardiovascular clinical events in an elderly population.
Postmus I, Trompet S, de Craen AJ, Buckley BM, Ford I, Stott DJ, Sattar N, Slagboom PE, Westendorp RG, Jukema JW
Proprotein convertase subtilisin-like/kexin type 9 (PCSK9) is a protein involved in LDL-cholesterol metabolism. The single-nucleotide polymorphism (SNP) rs11591147 has been associated with lower LDL-cholesterol and a lower risk of coronary heart disease. Because PCSK9 has high affinity to the LDL receptor, inhibiting PCSK9 is a testable therapeutic target for lipid-lowering therapy. Currently, several approaches to inhibit PCSK9 are under development, but it is unknown what the effects of those...
Abstract
Cited 3 times since 2013 (0.2 per year)
source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 21, Issue 2, 1 1 2013, Pages 101-105
Ten-year mortality risk of patients undergoing elective PCI: long-term follow-up of the GENetic Determinants of Restenosis (GENDER) study : No increased mortality risk by restenosis, only by coronary artery disease itself.
Verschuren JJ, Trompet S, Tio RA, de Winter RJ, Doevendans PA, Jukema JW
Abstract
Cited 3 times since 2013 (0.2 per year)
source: EuropePMC
Heart (British Cardiac Society),
Volume 99, Issue 4, 1 1 2013, Pages 279-284
Thrombus management in the catheterisation laboratory in the setting of primary percutaneous coronary intervention: what is the current evidence?
Dharma S, Kedev S, Jukema JW
Abstract
Cited 22 times since 2013 (1.8 per year)
source: EuropePMC
Differentiation; research in biological diversity,
Volume 85, Issue 3, 1 1 2013, Pages 101-109
Polycistronic lentivirus induced pluripotent stem cells from skin biopsies after long term storage, blood outgrowth endothelial cells and cells from milk teeth.
Dambrot C, van de Pas S, van Zijl L, Brändl B, Wang JW, Schalij MJ, Hoeben RC, Atsma DE, Mikkers HM, Mummery CL, Freund C
The generation of human induced pluripotent stem cells (hiPSCs) requires the collection of donor tissue, but clinical circumstances in which the interests of patients have highest priority may compromise the quality and availability of cells that are eventually used for reprogramming. Here we compared (i) skin biopsies stored in standard physiological salt solution for up to two weeks (ii) blood outgrowth endothelial cells (BOECs) isolated from fresh peripheral blood and (iii) children's mi...
Abstract
Cited 11 times since 2013 (0.9 per year)
source: EuropePMC
EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology,
Volume 8, Issue 10, 1 1 2013, Pages 1199-1206
Long-term outcome of second-generation everolimus-eluting stents and Endeavor zotarolimus-eluting stents in a prospective registry of ST-elevation myocardial infarction patients.
Velders MA, Boden H, van der Hoeven BL, Liem SS, Atary JZ, van der Wall EE, Jukema JW, Schalij MJ
Aims: The optimal drug-eluting stent (DES) in ST-elevation myocardial infarction (STEMI) patients remains unclear. We sought to compare the long-term performance of everolimus-eluting stents (EES) and Endeavor zotarolimus-eluting stents (E-ZES) in STEMI. Methods and results: The current analysis of a prospective registry included consecutive patients treated with EES or E-ZES for STEMI. Adjustment for measured confounders was done using Cox regression. In total, 931 patients met the inclusion cr...
Abstract
Cited 53 times since 2013 (4.4 per year)
source: EuropePMC
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer,
Volume 8, Issue 2, 1 1 2013, Pages 214-221
A randomized controlled trial of postthoracotomy pulmonary rehabilitation in patients with resectable lung cancer.
Stigt JA, Uil SM, van Riesen SJ, Simons FJ, Denekamp M, Shahin GM, Groen HJ
Introduction: Little is known about the effects of rehabilitation for patients with lung cancer after thoracotomy. The primary objective of this study was to evaluate the effect of a multidisciplinary rehabilitation program on quality of life (QOL) and secondary objectives were to determine its effects on pain and exercise capacity and the feasibility of combining rehabilitation with adjuvant chemotherapy. Methods: Patients who had undergone a thoracotomy for lung cancer were randomized between...
Abstract
Cited 201 times since 2013 (16.6 per year)
source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology,
Volume 15, Issue 5, 30 5 2013, Pages 742-749
Heart rate variability and first cardiovascular event in populations without known cardiovascular disease: meta-analysis and dose-response meta-regression.
Hillebrand S, Gast KB, de Mutsert R, Swenne CA, Jukema JW, Middeldorp S, Rosendaal FR, Dekkers OM
Aims: Heart rate variability (HRV) is associated with cardiovascular disease (CVD) in individuals with known CVD. It is less clear whether HRV is associated with a first cardiovascular event. Therefore, we performed a meta-analysis to study the association between HRV and incident cardiovascular events in populations without known CVD. Methods and results: We performed a meta-analysis and dose-response meta-regression of studies assessing the association between HRV and CVD. We searched Pubmed,...
Abstract
Cited 66 times since 2013 (5.4 per year)
source: EuropePMC
European journal of heart failure,
Volume 15, Issue 6, 29 5 2013, Pages 690-698
Impact of bosentan on exercise capacity in adults after the Fontan procedure: a randomized controlled trial.
Schuuring MJ, Vis JC, van Dijk AP, van Melle JP, Vliegen HW, Pieper PG, Sieswerda GT, de Bruin-Bon RH, Mulder BJ, Bouma BJ
Aims: An endothelin-1 receptor blocker, shown to be effective in patients with pulmonary arterial hypertension, might decrease pulmonary vascular resistance to increase cardiac filling and consequently improve exercise capacity in Fontan patients. Methods and results: This was a prospective, multicentre randomized open label trial in Fontan patients. One group received bosentan for 6 months. The other group did not receive study medication for the first 3 months, followed by bosentan for 6 month...
Abstract
Cited 21 times since 2013 (1.7 per year)
source: EuropePMC
Biomaterials,
Volume 34, Issue 12, 29 5 2013, Pages 3053-3063
A small molecule approach to engineering vascularized tissue.
Doorn J, Fernandes HA, Le BQ, van de Peppel J, van Leeuwen JP, De Vries MR, Aref Z, Quax PH, Myklebost O, Saris DB, van Blitterswijk CA, de Boer J
The repertoire of growth factors determines the biological engagement of human mesenchymal stromal cells (hMSCs) in processes such as immunomodulation and tissue repair. Hypoxia is a strong modulator of the secretome and well known stimuli to increase the secretion of pro-angiogenic molecules. In this manuscript, we employed a high throughput screening assay on an hMSCs cell line in order to identify small molecules that mimic hypoxia. Importantly, we show that the effect of these small molecule...
Abstract
Case reports in pediatrics,
Volume 2013, 28 4 2013, Pages 426923
Volumetric Computed Tomography Angiography in the Evaluation of Mediastinal Fluid Collections following Congenital Cardiac Surgery.
Roest AA, Roelofs J, Hazekamp MG, Rijlaarsdam ME, Geleijns J, Kroft LJ
We present 3 patients with 4 causes of mediastinal fluid collection after congenital cardiac surgery in this extended case report. Volumetric computed tomography played an essential role in diagnosing causes and extent, relevant to subsequent management. Recent advances in volumetric computed tomography allow fast and accurate imaging of cardiovascular and extravascular structures in children with acceptable radiation dose, providing a powerful imaging tool for the evaluation of complications af...
Abstract
Cited 16 times since 2013 (1.3 per year)
source: EuropePMC
The Journal of surgical research,
Volume 183, Issue 1, 25 4 2013, Pages 253-257
Ex vivo sentinel node mapping in colon cancer combining blue dye staining and fluorescence imaging.
Schaafsma BE, Verbeek FP, van der Vorst JR, Hutteman M, Kuppen PJ, Frangioni JV, van de Velde CJ, Vahrmeijer AL
Background: The sentinel lymph node procedure has been proposed to improve nodal staging in colon cancer patients. The aim of this study was to assess the added value of near-infrared (NIR) fluorescence imaging to conventional blue dye staining for ex vivo sentinel lymph node mapping. Materials and methods: We included 22 consecutive patients undergoing surgery for colon cancer. After tumor resection, we submucosally injected a premixed cocktail of the near-infrared lymphatic tracer HSA800 and b...
Abstract
Cited 80 times since 2013 (6.6 per year)
source: EuropePMC
International journal of cardiology,
Volume 168, Issue 3, 23 4 2013, Pages 1965-1974
T-cell co-stimulation by CD28-CD80/86 and its negative regulator CTLA-4 strongly influence accelerated atherosclerosis development.
Ewing MM, Karper JC, Abdul S, de Jong RC, Peters HA, de Vries MR, Redeker A, Kuiper J, Toes RE, Arens R, Jukema JW, Quax PH
Objective: T-cells are central to the immune response responsible for native atherosclerosis. The objective of this study is to investigate T-cell contribution to post-interventional accelerated atherosclerosis development, as well as the role of the CD28-CD80/86 co-stimulatory and Cytotoxic T-Lymphocyte Antigen (CTLA)-4 co-inhibitory pathways controlling T-cell activation status in this process. Methods and results: The role of T-cells and the CD28-CD80/86 co-stimulatory and CTLA-4 co-inhibitor...
Abstract
Cited 8 times since 2013 (0.7 per year)
source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology,
Volume 15, Issue 5, 22 4 2013, Pages 690-696
Duty-cycled bipolar/unipolar radiofrequency ablation for symptomatic atrial fibrillation induces significant pulmonary vein narrowing at long-term follow-up.
Compier MG, Leong DP, Marsan NA, Delgado V, Zeppenfeld K, Schalij MJ, Trines SA
Aims: A novel duty-cycled bipolar/unipolar ablation catheter pulmonary vein ablation catheter (PVAC) has been developed to achieve pulmonary vein (PV) isolation in patients with atrial fibrillation (AF). Ablation with PVAC was recently found to induce PV narrowing at 3 months follow-up. The long-term effects of this catheter on PV dimensions are however unknown and were evaluated with this study. Methods and results: Patients (n = 62, 71% male, age 60 ± 7 years) with drug-refractory AF scheduled...
Abstract
Cited 36 times since 2013 (3 per year)
source: EuropePMC
Journal of behavioral medicine,
Volume 37, Issue 2, 19 3 2013, Pages 308-321
A self-regulation lifestyle program for post-cardiac rehabilitation patients has long-term effects on exercise adherence.
Janssen V, De Gucht V, van Exel H, Maes S
As maintenance of lifestyle change and risk factor modification following completion of cardiac rehabilitation has been shown to be notoriously difficult, we developed a brief self-regulation lifestyle program for post-cardiac rehabilitation patients. Randomized-controlled trial. Following completion of cardiac rehabilitation 210 patients were randomized to receive either a lifestyle maintenance program (n = 112) or standard care (n = 98). The program was based on self-regulation principles and...
Abstract
