Research

Publications

Below you can find a list of our published research.

6139 results

Cited 4 times since 2011 (0.3 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 97, Issue 7, 30 5 2011, Pages 574-578 Diverse patterns of longitudinal and radial dyssynchrony in patients with advanced systolic heart failure. Zhang Q, van Bommel RJ, Chan YS, Delgado V, Liang Y, Schalij MJ, Bax JJ, Fang F, Wai-Kwok Yip G, Yu CM

Background: Little is known about the impact of QRS duration and aetiology of heart failure on the pattern of left ventricular long- and short-axis dyssynchrony. Objective: To investigate the impact of QRS duration and aetiology of heart failure on the pattern of left ventricular long- and short-axis dyssynchrony using tissue Doppler imaging (TDI) and two-dimensional (2D) speckle tracking imaging. Methods: 448 patients with heart failure (aged 65 ± 12 years, 75% men) with ejection fraction ≤ 35%... Abstract

Cited 248 times since 2011 (17.5 per year) source: EuropePMC

Stem cell research, Volume 6, Issue 3, 28 4 2011, Pages 206-214 Human mesenchymal stem cell-conditioned medium improves cardiac function following myocardial infarction. Timmers L, Lim SK, Hoefer IE, Arslan F, Lai RC, van Oorschot AA, Goumans MJ, Strijder C, Sze SK, Choo A, Piek JJ, Doevendans PA, Pasterkamp G, de Kleijn DP

Recent studies suggest that the therapeutic effects of stem cell transplantation following myocardial infarction (MI) are mediated by paracrine factors. One of the main goals in the treatment of ischemic heart disease is to stimulate vascular repair mechanisms. Here, we sought to explore the therapeutic angiogenic potential of mesenchymal stem cell (MSC) secretions. Human MSC secretions were collected as conditioned medium (MSC-CM) using a clinically compliant protocol. Based on proteomic and pa... Abstract

Cited 26 times since 2011 (1.8 per year) source: EuropePMC

Molecular therapy : the journal of the American Society of Gene Therapy, Volume 19, Issue 7, 25 4 2011, Pages 1331-1341 Transcription factor rational design improves directed differentiation of human mesenchymal stem cells into skeletal myocytes. Gonçalves MA, Janssen JM, Nguyen QG, Athanasopoulos T, Hauschka SD, Dickson G, de Vries AA

There is great interest in transdifferentiating cells from one lineage into those of another and in dedifferentiating mature cells back into a stem/progenitor cell state by deploying naturally occurring transcription factors (TFs). Often, however, steering cellular differentiation pathways in a predictable and efficient manner remains challenging. Here, we investigated the principle of combining domains from different lineage-specific TFs to improve directed cellular differentiation. As proof-of... Abstract

Cited 56 times since 2011 (4 per year) source: EuropePMC

PloS one, Volume 6, Issue 1, 24 4 2011, Pages e16118 A sensitive assay for virus discovery in respiratory clinical samples. de Vries M, Deijs M, Canuti M, van Schaik BD, Faria NR, van de Garde MD, Jachimowski LC, Jebbink MF, Jakobs M, Luyf AC, Coenjaerts FE, Claas EC, Molenkamp R, Koekkoek SM, Lammens C, Leus F, Goossens H, Ieven M, Baas F, van der Hoek L

In 5-40% of respiratory infections in children, the diagnostics remain negative, suggesting that the patients might be infected with a yet unknown pathogen. Virus discovery cDNA-AFLP (VIDISCA) is a virus discovery method based on recognition of restriction enzyme cleavage sites, ligation of adaptors and subsequent amplification by PCR. However, direct discovery of unknown pathogens in nasopharyngeal swabs is difficult due to the high concentration of ribosomal RNA (rRNA) that acts as competitor.... Abstract

Cited 6 times since 2011 (0.4 per year) source: EuropePMC

Rheumatology international, Volume 32, Issue 2, 23 4 2011, Pages 529-533 Polyarteritis nodosa and Henoch-Schönlein purpura nephritis in a child with familial Mediterranean fever: a case report. Girisgen I, Sonmez F, Koseoglu K, Erisen S, Yilmaz D

Familial Mediterranean fever is an autosomal recessive disease characterized by recurrent self-limited attacks of fever accompanied by peritonitis, pleuritis, and arthritis. Approximately 5% of individuals with familial Mediterranean fever have been reported to have Henoch-Schonlein purpura and about 1% to have polyarteritis nodosa. A 7-year-old girl presenting with complaints of purpuric rash, abdominal pain, arthritis, hematuria, and proteinuria and having IgA depositions on renal biopsy was d... Abstract

Cited 81 times since 2011 (5.7 per year) source: EuropePMC

Vaccine, Volume 29, Issue 11, 20 3 2011, Pages 2100-2109 Ag85B-ESAT-6 adjuvanted with IC31® promotes strong and long-lived Mycobacterium tuberculosis specific T cell responses in volunteers with previous BCG vaccination or tuberculosis infection. van Dissel JT, Soonawala D, Joosten SA, Prins C, Arend SM, Bang P, Tingskov PN, Lingnau K, Nouta J, Hoff ST, Rosenkrands I, Kromann I, Ottenhoff TH, Doherty TM, Andersen P

New TB vaccines are urgently needed because of the apparent lack of effect of the BCG vaccine on rates of adult contagious pulmonary tuberculosis and the risk of disseminated BCG disease in immunocompromised individuals. Since BCG appears to protect children, the primary target for vaccine development is a booster vaccine for adults but such vaccines ideally need to be able to efficiently prime mycobacterially naïve individuals as well as boost individuals previously vaccinated with BCG and thos... Abstract

Cited 95 times since 2011 (6.7 per year) source: EuropePMC

The pharmacogenomics journal, Volume 12, Issue 3, 18 3 2011, Pages 233-237 Differential effect of the rs4149056 variant in SLCO1B1 on myopathy associated with simvastatin and atorvastatin. Brunham LR, Lansberg PJ, Zhang L, Miao F, Carter C, Hovingh GK, Visscher H, Jukema JW, Stalenhoef AF, Ross CJ, Carleton BC, Kastelein JJ, Hayden MR

Statins reduce cardiovascular morbidity and mortality in appropriately selected patients. However, statin-associated myopathy is a significant risk associated with these agents. Recently, variation in the SLCO1B1 gene was reported to predict simvastatin-associated myopathy. The aim of this study was to replicate association of the rs4149056 variant in SLCO1B1 with severe statin-associated myopathy in a cohort of patients using a variety of statin medications and to investigate the association wi... Abstract

Cited 38 times since 2011 (2.7 per year) source: EuropePMC

American heart journal, Volume 161, Issue 2, 15 3 2011, Pages 307-313 Pregnancy in women with corrected tetralogy of Fallot: occurrence and predictors of adverse events. Balci A, Drenthen W, Mulder BJ, Roos-Hesselink JW, Voors AA, Vliegen HW, Moons P, Sollie KM, van Dijk AP, van Veldhuisen DJ, Pieper PG

Background: In women with corrected tetralogy of Fallot (ToF), pregnancy is associated with maternal cardiac, obstetric, and offspring complications. Our aim is to investigate the magnitude and determinants of pregnancy outcome in women with corrected ToF. Methods: In this retrospective international multicenter study using 2 congenital heart disease registries, 204 women with corrected ToF were identified. Within this group, 74 women had 157 pregnancies, including 30 miscarriages and 4 terminat... Abstract

Cited 53 times since 2011 (3.7 per year) source: EuropePMC

Stroke, Volume 42, Issue 3, 13 2 2011, Pages 638-644 Cerebral microbleeds are predictive of mortality in the elderly. Altmann-Schneider I, Trompet S, de Craen AJ, van Es AC, Jukema JW, Stott DJ, Sattar N, Westendorp RG, van Buchem MA, van der Grond J

Background and purpose: To investigate the prognostic value of cerebral microbleeds (CMB) regarding overall, cardiovascular-related, and stroke-related mortality and to investigate possible differences based on a cerebral amyloid angiopathy-type and nonlobar distribution of microbleeds. Methods: We included 435 subjects who were participants from the nested MRI substudy of the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER). Cox proportional hazard models were applied to estima... Abstract

Cited 1 times since 2011 (0.1 per year) source: EuropePMC

Expert opinion on emerging drugs, Volume 16, Issue 2, 13 2 2011, Pages 203-233 Emerging drugs for coronary artery disease. From past achievements and current needs to clinical promises. Ahmed TA, Karalis I, Jukema JW

Introduction: Coronary artery disease (CAD) is one of the major causes of morbidity and mortality worldwide, exerting a huge economic burden. Although drug treatment in the past decades has made large advances, significant residual risk remains. However, in the coming years, there are still a lot of great advances and major breakthroughs expected. Areas covered: New treatments are expected to provide higher efficacy with favorable safety profiles. In this review article, we provide an almost com... Abstract

Cited 26 times since 2011 (1.8 per year) source: EuropePMC

Cardiovascular research, Volume 90, Issue 2, 13 2 2011, Pages 295-304 Antiproliferative treatment of myofibroblasts prevents arrhythmias in vitro by limiting myofibroblast-induced depolarization. Askar SF, Ramkisoensing AA, Schalij MJ, Bingen BO, Swildens J, van der Laarse A, Atsma DE, de Vries AA, Ypey DL, Pijnappels DA

Aims: Cardiac fibrosis is associated with increased incidence of cardiac arrhythmias, but the underlying proarrhythmic mechanisms remain incompletely understood and antiarrhythmic therapies are still suboptimal. This study tests the hypothesis that myofibroblast (MFB) proliferation leads to tachyarrhythmias by altering the excitability of cardiomyocytes (CMCs) and that inhibition of MFB proliferation would thus lower the incidence of such arrhythmias. Methods and results: Endogenous MFBs in neon... Abstract

Cited 43 times since 2011 (3 per year) source: EuropePMC

European heart journal, Volume 32, Issue 15, 8 2 2011, Pages 1926-1934 Turning 18 with congenital heart disease: prediction of infective endocarditis based on a large population. Verheugt CL, Uiterwaal CS, van der Velde ET, Meijboom FJ, Pieper PG, Veen G, Stappers JL, Grobbee DE, Mulder BJ

Aims: The risk of infective endocarditis (IE) in adults with congenital heart disease is known to be increased, yet empirical risk estimates are lacking. We sought to predict the occurrence of IE in patients with congenital heart disease at the transition from childhood into adulthood. Methods and results: We identified patients from the CONCOR national registry for adults with congenital heart disease. Potential predictors included patient characteristics, and complications and interventions in... Abstract

Cited 15 times since 2011 (1.1 per year) source: EuropePMC

Journal of cardiovascular translational research, Volume 4, Issue 2, 7 1 2011, Pages 182-191 Bone marrow cell injection for chronic myocardial ischemia: the past and the future. van Ramshorst J, Rodrigo SF, Schalij MJ, Beeres SL, Bax JJ, Atsma DE

Intramyocardial bone marrow cell injection is currently being investigated as a new therapeutic option for the treatment of chronic myocardial ischemia. Experimental studies and early phase clinical trials established a favorable safety profile of this approach and suggested that bone marrow cell injection was associated with clinical and functional improvements. Recently, a randomized, double-blind, placebo-controlled trial demonstrated that intramyocardial bone marrow cell injection was associ... Abstract

Cited 23 times since 2011 (1.6 per year) source: EuropePMC

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, Volume 37, Issue 3, 6 1 2011, Pages 252-257 Intraoperative near-infrared fluorescence imaging of colorectal metastases targeting integrin α(v)β(3) expression in a syngeneic rat model. Hutteman M, Mieog JS, van der Vorst JR, Dijkstra J, Kuppen PJ, van der Laan AM, Tanke HJ, Kaijzel EL, Que I, van de Velde CJ, Löwik CW, Vahrmeijer AL

Aim: Near-infrared (NIR) fluorescence optical imaging is a promising technique to assess the extent of colorectal metastases during curative-intended surgery. However, NIR fluorescence imaging of liver metastases is highly challenging due to hepatic uptake and clearance of many fluorescent dyes. In the current study, the biodistribution and the ability to demarcate liver and peritoneal metastases were assessed during surgery in a syngeneic rat model of colorectal cancer using an integrin α(v)β(3... Abstract

Cited 25 times since 2011 (1.8 per year) source: EuropePMC

PloS one, Volume 6, Issue 1, 6 1 2011, Pages e14493 Exploitation of herpesvirus immune evasion strategies to modify the immunogenicity of human mesenchymal stem cell transplants. de la Garza-Rodea AS, Verweij MC, Boersma H, van der Velde-van Dijke I, de Vries AA, Hoeben RC, van Bekkum DW, Wiertz EJ, Knaän-Shanzer S

Background: Mesenchymal stem cells (MSCs) are multipotent cells residing in the connective tissue of many organs and holding great potential for tissue repair. In culture, human MSCs (hMSCs) are capable of extensive proliferation without showing chromosomal aberrations. Large numbers of hMSCs can thus be acquired from small samples of easily obtainable tissues like fat and bone marrow. MSCs can contribute to regeneration indirectly by secretion of cytokines or directly by differentiation into sp... Abstract

Cited 12 times since 2011 (0.8 per year) source: EuropePMC

Circulation. Cardiovascular imaging, Volume 4, Issue 2, 5 1 2011, Pages 122-129 Intramyocardial bone marrow-derived mononuclear cell injection for chronic myocardial ischemia: the effect on diastolic function. van Ramshorst J, Antoni ML, Beeres SL, Roes SD, Delgado V, Rodrigo SF, de Roos A, Holman ER, Fibbe WE, Lamb HJ, Zwaginga JJ, Boersma E, van der Wall EE, Schalij MJ, Atsma DE, Bax JJ

Background: The present substudy of a recently published randomized trial aimed to investigate the effect of intramyocardial bone marrow cell injection on diastolic function in patients with chronic myocardial ischemia. Methods and results: In a total of 50 patients, diastolic function was evaluated before and 3 months after bone marrow cell injection using standard echocardiography and strain analysis. In addition, MRI-derived transmitral flow measurements were obtained in a subset of 36 patien... Abstract

Cited 58 times since 2011 (4.1 per year) source: EuropePMC

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 13, Issue 3, 5 1 2011, Pages 389-394 Long-term follow-up of primary and secondary prevention implantable cardioverter defibrillator patients. van Welsenes GH, van Rees JB, Borleffs CJ, Cannegieter SC, Bax JJ, van Erven L, Schalij MJ

Aims: The beneficial effects of implantable cardioverter defibrillators (ICDs) in primary and secondary prevention patients are well established. However, data on potential differences between both groups in mortality and ICD therapy rates during long-term follow-up are scarce. The aim of the study was to assess differences in mortality and ICD therapy between secondary and primary prevention ICD recipients. Methods and results: With the exception of patients with congenital monogenetic cardiac... Abstract

Cited 17 times since 2011 (1.2 per year) source: EuropePMC

Heart rhythm, Volume 8, Issue 5, 4 1 2011, Pages 665-671 Reversed polarity of bipolar electrograms for predicting a successful ablation site in focal idiopathic right ventricular outflow tract arrhythmias. van Huls van Taxis CF, Wijnmaalen AP, den Uijl DW, Gawrysiak M, Putter H, Schalij MJ, Zeppenfeld K

Background: Radiofrequency catheter ablation (RFCA) for idiopathic right ventricular outflow tract (RVOT) arrhythmias is typically guided by local activation time (LAT) mapping and unipolar electrogram morphology (QS configuration). However, LAT mapping is limited by the large variation among patients, and the area demonstrating a QS configuration of the unipolar electrogram may be larger than the focal source. Reversed polarity has been proposed as a criterion for guiding RFCA. Objective: The p... Abstract

Cited 11 times since 2011 (0.8 per year) source: EuropePMC

Current problems in cardiology, Volume 36, Issue 1, 1 1 2011, Pages 9-47 Multimodality imaging in diabetic heart disease. Ng AC, Delgado V, Djaberi R, Schuijf JD, Boogers MJ, Auger D, Bertini M, de Roos A, van der Meer RW, Lamb HJ, Bax JJ

Diabetic heart disease is currently defined as left ventricular dysfunction that occurs independently of coronary artery disease and hypertension. Its underlying etiology is likely to be multifactorial, acting synergistically together to cause myocardial dysfunction. Multimodality cardiac imaging, such as echocardiography, nuclear, computed tomography, and magnetic resonance imaging, can provide invaluable insight into different aspects of the disease process, from imaging at the cellular level... Abstract

Cited 55 times since 2011 (3.9 per year) source: EuropePMC

The American journal of cardiology, Volume 107, Issue 2, 1 1 2011, Pages 243-249 Effect of pulmonary vein anatomy and left atrial dimensions on outcome of circumferential radiofrequency catheter ablation for atrial fibrillation. den Uijl DW, Tops LF, Delgado V, Schuijf JD, Kroft LJ, de Roos A, Boersma E, Trines SA, Zeppenfeld K, Schalij MJ, Bax JJ

Multislice computed tomography (MSCT) is commonly acquired before radiofrequency catheter ablation (RFCA) for atrial fibrillation (AF) to plan and guide the procedure. MSCT allows accurate measurement of the left atrial (LA) and pulmonary vein (PV) dimensions and classification of the PV anatomy. The aim of the present study was to investigate the effect of LA dimensions, PV dimensions, and PV anatomy on the outcome of circumferential RFCA for AF. A total of 100 consecutive patients undergoing R... Abstract