Research

Publications

Below you can find a list of our published research.

6139 results

Cited 8 times since 2010 (0.5 per year) source: EuropePMC

European journal of internal medicine, Volume 21, Issue 4, 13 2 2010, Pages 293-296 The tolerability and efficacy of low-dose simvastatin in statin-intolerant patients. Degreef LE, Opdam FL, Teepe-Twiss IM, Jukema JW, Guchelaar HJ, Tamsma JT

Background/aim: Statin intolerance is increasingly recognized as a therapy limiting factor in the primary and secondary prevention of cardiovascular disease. Since vulnerability to dose related adverse events differ between subjects treated with statins we hypothesized low-dose simvastatin would be tolerated and effective in statin-intolerant patients. Method: A single center open label prospective observational study was performed assessing tolerability and efficacy of low-dose simvastatin trea... Abstract

Cited 33 times since 2010 (2.2 per year) source: EuropePMC

The American journal of cardiology, Volume 106, Issue 1, 13 2 2010, Pages 4-12 Three-year outcome of sirolimus-eluting versus bare-metal stents for the treatment of ST-segment elevation myocardial infarction (from the MISSION! Intervention Study). Atary JZ, van der Hoeven BL, Liem SS, Jukema JW, van der Bom JG, Atsma DE, Bootsma M, Zeppenfeld K, van der Wall EE, Schalij MJ

To compare the long-term efficacy and safety of sirolimus-eluting stents (SES) to those of bare-metal stents (BMS) for ST-segment elevation myocardial infarction, outcomes were assessed in 310 patients (mean age age 59 +/- 11 years, 78% men) included in the randomized MISSION! Intervention Study: A Prospective Randomised Controlled Trial to Evaluate the Efficacy of Drug-Eluting Stents Versus Bare-Metal Stents for the Treatment of Acute Myocardial Infarction after a median follow-up period of 38... Abstract

Cited 32 times since 2010 (2.2 per year) source: EuropePMC

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 38, Issue 6, 13 2 2010, Pages 699-706 Surgery for transposition of the great arteries, ventricular septal defect and left ventricular outflow tract obstruction: European Congenital Heart Surgeons Association multicentre study. Hazekamp MG, Gomez AA, Koolbergen DR, Hraska V, Metras DR, Mattila IP, Daenen W, Berggren HE, Rubay JE, Stellin G, European Congenital Heart Surgeons Association

Objectives: Optimal surgical management for patients with transposition of the great arteries (TGA), ventricular septal defect (VSD) and left ventricular outflow obstruction (LVOTO) remains controversial. Although the Rastelli operation has been the most widely performed surgical procedure during the past decades, several studies have shown its suboptimal long-term prognosis. Other operations have been developed to improve results. This study was performed to compare the outcomes of the differen... Abstract

Cited 2 times since 2010 (0.1 per year) source: EuropePMC

The international journal of cardiovascular imaging, Volume 27, Issue 7, 8 2 2010, Pages 939-942 Stress imaging in patients with diabetes; routine practice? van der Wall EE, Scholte AJ, Holman ER, Bax JJ

Abstract

Cited 7 times since 2010 (0.5 per year) source: EuropePMC

EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, Volume 6 Suppl G, 1 1 2010, Pages G38-47 Pre-operative aortic valve implantation evaluation: multimodality imaging. Delgado V, Schuijf JD, Bax JJ

Transcatheter aortic valve implantation procedures have been one of the main therapeutic breakthroughs of the last decade providing a feasible alternative therapy to patients with severe symptomatic aortic stenosis and high operative risk. To date, more than 10,000 patients have been treated with this novel therapy and promising results, using either a transarterial or transapical approach have been reported. Accurate preprocedural evaluation of candidates for TAVI is crucial to optimise the suc... Abstract

EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, Volume 6 Suppl G, 1 1 2010, Pages G94-G100 Function and anatomy: SPECT-MPI and MSCT coronary angiography. Scholte AJ, Roos CJ, van Werkhoven JM

For the diagnosis of coronary artery disease (CAD), non-invasive cardiac imaging is indispensable. Myocardial perfusion imaging (MPI) by single photon emission computed tomography (SPECT) investigates the pathophysiological consequences of luminal obstructive CAD, while multislice computed tomography coronary angiography (CTA) indicates the presence, extent and location of coronary atherosclerosis. The integration of CTA and SPECT data may provide important information which may be useful for pa... Abstract

EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, Volume 6 Suppl G, 1 1 2010, Pages G5 On cardiovascular imaging. de Feyter P, Bax JJ

Abstract

Cited 120 times since 2010 (8.1 per year) source: EuropePMC

Anesthesiology, Volume 112, Issue 5, 1 1 2010, Pages 1105-1115 Postoperative mortality in The Netherlands: a population-based analysis of surgery-specific risk in adults. Noordzij PG, Poldermans D, Schouten O, Bax JJ, Schreiner FA, Boersma E

Background: Few data are available that systematically describe rates and trends of postoperative mortality for fairly large, unselected patient populations. Methods: This population-based study uses a registry of 3.7 million surgical procedures in 102 hospitals in The Netherlands during 1991-2005. Patients older than 20 yr who underwent an elective, nonday case, open surgical procedure were enrolled. Patient data included main (discharge) diagnosis, secondary diagnoses, dates of admission and d... Abstract

Cited 1 times since 2010 (0.1 per year) source: EuropePMC

EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, Volume 6 Suppl G, 1 1 2010, Pages G57-64 Quantification of stenosis severity on multidetector row computed tomography. Boogers MJ, Schuijf JD

A comprehensive evaluation of coronary anatomy and atherosclerosis can be provided by MDCT. Currently, several studies have used either manual or semi-automated algorithms for quantification of different plaque characteristics, in particular the degree of luminal narrowing. Although the feasibility of these quantitative algorithms has been demonstrated, further refinement of quantitative CT algorithms is currently indicated to allow a comprehensive yet fully automated analysis of plaque characte... Abstract

EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, Volume 6 Suppl G, 1 1 2010, Pages G28-37 Non-invasive imaging in percutaneous mitral valve procedures. Marsan NA, Bax JJ

Novel percutaneous techniques for the treatment of mitral valve (MV) disease have recently been developed and provide an alternative to surgery in patients with high operative risk. However, the complexity of MV anatomy and the variety of mitral regurgitation mechanisms require sophisticated procedures and accurate patient selection. Non-invasive imaging (echocardiography, multislice computed tomography) provides crucial anatomical details and exact characterisation of the mechanism underlying m... Abstract

Cited 16 times since 2010 (1.1 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 96, Issue 9, 1 1 2010, Pages 661 Edwards SAPIEN transcatheter heart valve in native pulmonary valve position. Bertels RA, Blom NA, Schalij MJ

Abstract

Cited 45 times since 2010 (3 per year) source: EuropePMC

Journal of innate immunity, Volume 2, Issue 4, 30 5 2010, Pages 307-315 Endogenous inflammatory molecules engage Toll-like receptors in cardiovascular disease. Ionita MG, Arslan F, de Kleijn DP, Pasterkamp G

Innate immunity is important in the pathogenesis and progression of cardiovascular disease. Innate immune cells express various pattern-recognition receptors, among which also Toll-like receptors (TLRs). TLRs occur in atherosclerotic lesions where they are triggered by both exogenous (bacterial and viral pathogens) and endogenous (tissue damage-associated) molecules. Several endogenous TLR activators are described in relation to atherosclerotic disease or ischemia-induced cardiac injury. Experim... Abstract

Cited 39 times since 2010 (2.6 per year) source: EuropePMC

Clinical journal of the American Society of Nephrology : CJASN, Volume 5, Issue 7, 29 5 2010, Pages 1198-1204 Temporary perioperative decline of renal function is an independent predictor for chronic kidney disease. van Kuijk JP, Flu WJ, Chonchol M, Hoeks SE, Winkel TA, Verhagen HJ, Bax JJ, Poldermans D

Background and objectives: Acute kidney injury is an independent predictor of short- and long-term survival; however, data on the relationship between reversible transitory decline of kidney function and chronic kidney disease (CKD) are lacking. We assessed the prognostic value of temporary renal function decline on the development of long-term CKD. Design, setting, participants, & measurements: The study included 1308 patients who were undergoing major vascular surgery (aortic aneurysm repa... Abstract

Cited 115 times since 2010 (7.7 per year) source: EuropePMC

European heart journal, Volume 31, Issue 13, 27 4 2010, Pages 1640-1647 Prognostic importance of strain and strain rate after acute myocardial infarction. Antoni ML, Mollema SA, Delgado V, Atary JZ, Borleffs CJ, Boersma E, Holman ER, van der Wall EE, Schalij MJ, Bax JJ

Aims: Recently, strain and strain rate have been introduced as novel parameters reflecting left ventricular (LV) function. The purpose of the current study was to assess the prognostic importance of strain and strain rate after acute myocardial infarction (AMI). Methods and results: A total of 659 patients after AMI were evaluated. Baseline echocardiography was performed to assess LV function with traditional parameters and strain and strain rate. During follow-up, 51 patients (8%) reached the p... Abstract

Cited 47 times since 2010 (3.2 per year) source: EuropePMC

Pacing and clinical electrophysiology : PACE, Volume 33, Issue 8, 27 4 2010, Pages 1013-1019 Recurrent implantable cardioverter-defibrillator replacement is associated with an increasing risk of pocket-related complications. Borleffs CJ, Thijssen J, de Bie MK, van Rees JB, van Welsenes GH, van Erven L, Bax JJ, Cannegieter SC, Schalij MJ

Background: Despite beneficial effects of implantable cardioverter-defibrillator (ICD) therapy, limited service life results in replacement within the majority of patients. Data concerning the effect of replacement procedures on the occurrence of pocket-related adverse events are scarce. In this study, the requirement for pocket-related surgical re-interventions following ICD treatment and the effect of device replacement were evaluated. Methods: From 1992 to 2008, 2,415 patients receiving an IC... Abstract

Cited 26 times since 2010 (1.7 per year) source: EuropePMC

Journal of electrocardiology, Volume 43, Issue 4, 24 4 2010, Pages 294-301 The spatial QRS-T angle in the Frank vectorcardiogram: accuracy of estimates derived from the 12-lead electrocardiogram. Schreurs CA, Algra AM, Man SC, Cannegieter SC, van der Wall EE, Schalij MJ, Kors JA, Swenne CA

Background and purpose: The spatial QRS-T angle (SA), a predictor of sudden cardiac death, is a vectorcardiographic variable. Gold standard vertorcardiograms (VCGs) are recorded by using the Frank electrode positions. However, with the commonly available 12-lead ECG, VCGs must be synthesized by matrix multiplication (inverse Dower matrix/Kors matrix). Alternatively, Rautaharju proposed a method to calculate SA directly from the 12-lead ECG. Neither spatial angles computed by using the inverse Do... Abstract

Cited 24 times since 2010 (1.6 per year) source: EuropePMC

Arteriosclerosis, thrombosis, and vascular biology, Volume 30, Issue 8, 22 4 2010, Pages 1591-1597 6-mercaptopurine inhibits atherosclerosis in apolipoprotein e*3-leiden transgenic mice through atheroprotective actions on monocytes and macrophages. Pols TW, Bonta PI, Pires NM, Otermin I, Vos M, de Vries MR, van Eijk M, Roelofsen J, Havekes LM, Quax PH, van Kuilenburg AB, de Waard V, Pannekoek H, de Vries CJ

Objective: 6-Mercaptopurine (6-MP), the active metabolite of the immunosuppressive prodrug azathioprine, is commonly used in autoimmune diseases and transplant recipients, who are at high risk for cardiovascular disease. Here, we aimed to gain knowledge on the action of 6-MP in atherosclerosis, with a focus on monocytes and macrophages. Methods and results: We demonstrate that 6-MP induces apoptosis of THP-1 monocytes, involving decreased expression of the intrinsic antiapoptotic factors B-cell... Abstract

Cited 22 times since 2010 (1.5 per year) source: EuropePMC

European journal of nuclear medicine and molecular imaging, Volume 37, Issue 9, 22 4 2010, Pages 1698-1705 Cardiac autonomic neuropathy in patients with diabetes and no symptoms of coronary artery disease: comparison of 123I-metaiodobenzylguanidine myocardial scintigraphy and heart rate variability. Scholte AJ, Schuijf JD, Delgado V, Kok JA, Bus MT, Maan AC, Stokkel MP, Kharagitsingh AV, Dibbets-Schneider P, van der Wall EE, Bax JJ

Purpose: The purpose of this study was to evaluate the prevalence of cardiac autonomic neuropathy (CAN) in a cohort of patients with type 2 diabetes, truly asymptomatic for coronary artery disease (CAD), using heart rate variability (HRV) and (123)I-metaiodobenzylguanidine ((123)I-mIBG) myocardial scintigraphy. Methods: The study group comprised 88 patients with type 2 diabetes prospectively recruited from an outpatient diabetes clinic. In all patients myocardial perfusion scintigraphy, CAN by H... Abstract

Cited 84 times since 2010 (5.6 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 96, Issue 11, 20 3 2010, Pages 872-878 The emerging burden of hospital admissions of adults with congenital heart disease. Verheugt CL, Uiterwaal CS, van der Velde ET, Meijboom FJ, Pieper PG, Sieswerda GT, Plokker HW, Grobbee DE, Mulder BJ

Objective: To assess the extent and the characteristics of hospital admissions in registered adult patients with congenital heart disease. Design: Observational cohort study. Setting: The Netherlands. Patients: 5798 adult patients with congenital heart disease from the Dutch CONCOR national registry linked to the Dutch National Medical Registration (Prismant). Main outcome measures: All hospital admissions from the years 2001 up until 2006. Results: During 28 990 patient-years, 2908 patients (50... Abstract

Cited 45 times since 2010 (3 per year) source: EuropePMC

Circulation, Volume 121, Issue 17, 19 3 2010, Pages 1887-1895 Early reperfusion during acute myocardial infarction affects ventricular tachycardia characteristics and the chronic electroanatomic and histological substrate. Wijnmaalen AP, Schalij MJ, von der Thüsen JH, Klautz RJ, Zeppenfeld K

Background: Reperfusion therapy during acute myocardial infarction results in myocardial salvage and improved ventricular function but may also influence the arrhythmogenic substrate for ventricular tachycardia (VT). This study used electroanatomic mapping and infarct histology to assess the impact of reperfusion on the substrate and on VT characteristics late after acute myocardial infarction. Methods and results: The study population consisted of 36 patients (32 men; age, 63+/-15 years) referr... Abstract