8684 results
Cited 4 times since 2016 (0.4 per year)
source: EuropePMC
The American journal of emergency medicine,
Volume 34, Issue 8, 7 1 2016, Pages 1364-1368
Comparison of near-infrared spectroscopy and head CT interpretations of the ED patients with minor head injury.
Akyol PY, Bayram B, Acerer A, Girgin MC, Yılmaz DÇ, Men S, Atilla R
Abstract
Cited 98 times since 2016 (10.7 per year)
source: EuropePMC
The Lancet. Neurology,
Volume 15, Issue 7, 7 1 2016, Pages 695-707
Identification of additional risk loci for stroke and small vessel disease: a meta-analysis of genome-wide association studies.
Neurology Working Group of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, the Stroke Genetics Network (SiGN), and the International Stroke Genetics Consortium (ISGC)
Background: Genetic determinants of stroke, the leading neurological cause of death and disability, are poorly understood and have seldom been explored in the general population. Our aim was to identify additional loci for stroke by doing a meta-analysis of genome-wide association studies. Methods: For the discovery sample, we did a genome-wide analysis of common genetic variants associated with incident stroke risk in 18 population-based cohorts comprising 84 961 participants, of whom 4348 had...
Abstract
Cited 14 times since 2016 (1.5 per year)
source: EuropePMC
Scientific reports,
Volume 6, 7 1 2016, Pages 24248
Deficiency of the TLR4 analogue RP105 aggravates vein graft disease by inducing a pro-inflammatory response.
Wezel A, de Vries MR, Maassen JM, Kip P, Peters EA, Karper JC, Kuiper J, Bot I, Quax PHA
Venous grafts are often used to bypass occlusive atherosclerotic lesions; however, poor patency leads to vein graft disease. Deficiency of TLR4, an inflammatory regulator, reduces vein graft disease. Here, we investigate the effects of the accessory molecule and TLR4 analogue RadioProtective 105 (RP105) on vein graft disease. RP105 deficiency resulted in a 90% increase in vein graft lesion area compared to controls. In a hypercholesterolemic setting (LDLr(-/-)/RP105(-/-) versus LDLr(-/-) mice),...
Abstract
Cited 5 times since 2016 (0.5 per year)
source: EuropePMC
Applied neuropsychology. Child,
Volume 6, Issue 2, 6 1 2016, Pages 145-157
Neuropsychological presentation and adaptive skills in high-functioning adolescents with visual impairment: A preliminary investigation.
Greenaway R, Pring L, Schepers A, Isaacs DP, Dale NJ
Studies in infants and young children with congenital visual impairment (VI) have indicated early developmental vulnerabilities, conversely research with older children and adults have highlighted areas of cognitive strength. A minimal amount is known, however, about the possible combination of strengths and weaknesses in adolescence, and this present study therefore aims to explore the neuropsychological presentation and adaptive behavior profile in high-functioning adolescents with congenital...
Abstract
Cited 17 times since 2016 (1.9 per year)
source: EuropePMC
Journal of experimental child psychology,
Volume 147, 6 1 2016, Pages 71-81
Little chameleons: The development of social mimicry during early childhood.
van Schaik JE, Hunnius S
Adults use behavioral mimicry to blend in with (or stand out from) their social environment. Adopting another's mannerisms and behaviors, or "mimicking", communicates liking and similarity between interaction partners and has been shown to serve as an implicit affiliation mechanism. Given this important social function, it is surprising that so little is known about the development of mimicry. In two studies, we investigated mimicry and its social sensitivity during early childhoo...
Abstract
Cited 29 times since 2016 (3.2 per year)
source: EuropePMC
PloS one,
Volume 11, Issue 4, 6 1 2016, Pages e0151870
Measuring Hair Cortisol Concentrations to Assess the Effect of Anthropogenic Impacts on Wild Chimpanzees (Pan troglodytes).
Carlitz EH, Miller R, Kirschbaum C, Gao W, Hänni DC, van Schaik CP
Non-human primates face major environmental changes due to increased human impacts all over the world. Although some species are able to survive in certain landscapes with anthropogenic impact, their long-term viability and fitness may be decreased due to chronic stress. Here we assessed long-term stress levels through cortisol analysis in chimpanzee hair obtained from sleeping nests in northwestern Uganda, in order to estimate welfare in the context of ecotourism, forest fragmentation with huma...
Abstract
Cited 6 times since 2016 (0.7 per year)
source: EuropePMC
PloS one,
Volume 11, Issue 4, 6 1 2016, Pages e0152938
Discrepant Results of Experimental Human Mesenchymal Stromal Cell Therapy after Myocardial Infarction: Are Animal Models Robust Enough?
den Haan MC, van Zuylen VL, Pluijmert NJ, Schutte CI, Fibbe WE, Schalij MJ, Roelofs H, Atsma DE
Background: Human mesenchymal stromal cells (MSCs) have been reported to preserve cardiac function in myocardial infarction (MI) models. Previously, we found a beneficial effect of intramyocardial injection of unstimulated human MSCs (uMSCs) on cardiac function after permanent coronary artery ligation. In the present study we aimed to extend this research by investigating the effect of intramyocardial injection of human MSCs pre-stimulated with the pro-inflammatory cytokine interferon-gamma (iMS...
Abstract
Cited 2 times since 2016 (0.2 per year)
source: EuropePMC
Renal failure,
Volume 38, Issue 5, 6 1 2016, Pages 781-786
Comparison of serum paraoxonase and arylesterase activities between iron deficiency anemia patients and chronic kidney disease patients with anemia.
Okuturlar Y, Akalin N, Kaptanogullari OH, Guner NT, Yilmaz D, Gedikbasi A, Soyluk O, Mert M, Serin SO, Kocoglu H, Hursitoglu M, Kumbasar A
Objective: Altered paraoxonase (PON) and arylesterase (ARE) activities have been shown in anemic chronic kidney disease (CKD) patients and in iron deficiency anemia (IDA) patients. Whether accompanying anemia alone is responsible for this diminished PON and ARE activities in CKD patients or an additive factor for this is not well studied. Therefore, we tried to clarify this issue here. Methods: A total of 82 subjects that consisted of 19 patients with IDA (group 1), 23 anemic CKD patients (group...
Abstract
Cited 5 times since 2016 (0.5 per year)
source: EuropePMC
Neurourology and urodynamics,
Volume 36, Issue 3, 6 1 2016, Pages 597-603
Effects of silodosin, a selective alpha-1A adrenoceptor antagonist, on erectile function in a rat model of partial bladder outlet obstruction.
Bastaskın T, Kaya E, Ozakca I, Yilmaz D, Bayatlı N, Akdemir AO, Gur S
Aim: We investigated the effects of silodosin (selective α1A -adrenoceptor antagonist) on erectile dysfunction (ED) in a rat model of bladder outlet obstruction. Methods: Adult male Sprague-Dawley rats (n = 32) were divided into four groups: (i) sham-operated control; (ii) silodosin-treated (sham) control (0.1 mg/kg/day); (iii) partial bladder outlet obstruction (PBOO); and (iv) silodosin-treated with PBOO. PBOO was induced by ligation of the urethra for 6 weeks. In vivo, erectile responses were...
Abstract
Cited 16 times since 2016 (1.7 per year)
source: EuropePMC
The British journal of surgery,
Volume 103, Issue 8, 5 1 2016, Pages 995-1002
Quality of life from a randomized trial of open and endovascular repair for abdominal aortic aneurysm.
de Bruin JL, Groenwold RH, Baas AF, Brownrigg JR, Prinssen M, Grobbee DE, Blankensteijn JD, DREAM Study Group
Background: Long-term survival is similar after open or endovascular repair of abdominal aortic aneurysm. Few data exist on the effect of either procedure on long-term health-related quality of life (HRQoL) and health status. Methods: Patients enrolled in a multicentre randomized clinical trial (DREAM trial; 2000-2003) in Europe of open repair versus endovascular repair (EVAR) of abdominal aortic aneurysm were asked to complete questionnaires on health status and HRQoL. HRQoL scores were assesse...
Abstract
Cited 18 times since 2016 (2 per year)
source: EuropePMC
Heart (British Cardiac Society),
Volume 102, Issue 16, 5 1 2016, Pages 1302-1308
Cardiac adaption during pregnancy in women with congenital heart disease and healthy women.
Kampman MA, Valente MA, van Melle JP, Balci A, Roos-Hesselink JW, Mulder BJ, van Dijk AP, Oudijk MA, Jongbloed MR, van Veldhuisen DJ, Pieper PG, ZAHARA II investigators
Objective: Pregnancy in women with congenital heart disease (CHD) is associated with deterioration in cardiac function. However, longitudinal data are scarce. This study describes serial changes in cardiac dimensions and function during pregnancy in women with CHD and compares these with healthy pregnant women (controls). Methods: Eight tertiary centres prospectively enrolled 125 pregnant women with CHD (pregnancy duration 0.1). Left ventricular ejection fraction (LVEF)
Abstract
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America,
Volume 62, Issue 11, 5 1 2016, Pages 1470
Reply to Leenders.
Hetem DJ, Bootsma MC, Bonten MJ
Abstract
Cited 136 times since 2016 (14.8 per year)
source: EuropePMC
Journal of the American College of Cardiology,
Volume 67, Issue 19, 2 1 2016, Pages 2263-2288
Natural History, Diagnostic Approaches, and Therapeutic Strategies for Patients With Asymptomatic Severe Aortic Stenosis.
Généreux P, Stone GW, O'Gara PT, Marquis-Gravel G, Redfors B, Giustino G, Pibarot P, Bax JJ, Bonow RO, Leon MB
Aortic stenosis (AS) is one of the most common valvular diseases encountered in clinical practice. Current guidelines recommend aortic valve replacement (AVR) when the aortic valve is severely stenotic and the patient is symptomatic; however, a substantial proportion of patients with severe AS are asymptomatic at the time of first diagnosis. Although specific morphological valve features, exercise testing, stress imaging, and biomarkers can help to identify patients with asymptomatic severe AS w...
Abstract
Cited 1 times since 2016 (0.1 per year)
source: EuropePMC
Pancreas,
Volume 45, Issue 4, 1 1 2016, Pages 541-545
A Common CCK-B Receptor Intronic Variant in Pancreatic Adenocarcinoma in a Hungarian Cohort.
Balázs A, Németh BC, Ördög B, Hegyi E, Hritz I, Czakó L, Czimmer J, Gódi S, Csiszkó A, Rakonczay Z, Párniczky A, Izbéki F, Halász A, Kahán Z, Hegyi P, Sahin-Tóth M, Hungarian Pancreatic Study Group
Objectives: Variant c.811+32C>A in intron 4 of the cholecystokinin-B receptor gene (CCKBR) was reported to correlate with higher pancreatic cancer risk and poorer survival. The variant was suggested to induce retention of intron 4, resulting in a new splice form with enhanced receptor activity. Our objective was to validate the c.811+32C>A variant as an emerging biomarker for pancreatic cancer risk and prognosis. Methods: We genotyped variant c.811+32C>A in 122 pancreatic adenocarcinoma...
Abstract
Cited 18 times since 2016 (2 per year)
source: EuropePMC
Teaching and learning in medicine,
Volume 28, Issue 2, 1 1 2016, Pages 125-134
Useful but Different: Resident Physician Perceptions of Interprofessional Feedback.
Vesel TP, O'Brien BC, Henry DM, van Schaik SM
Unlabelled: Phenomenon: Based on recently formulated interprofessional core competencies, physicians are expected to incorporate feedback from other healthcare professionals. Based on social identity theory, physicians likely differentiate between feedback from members of their own profession and others. The current study examined residents' experiences with, and perceptions of, interprofessional feedback. Approach: In 2013, Anesthesia, Obstetrics-Gynecology, Pediatrics, and Psychiatry resi...
Abstract
Cited 5 times since 2016 (0.5 per year)
source: EuropePMC
Medical education,
Volume 50, Issue 4, 1 1 2016, Pages 387-389
Context matters: groupthink and outcomes of health care teams.
Madigosky W, van Schaik S
Abstract
Cited 5 times since 2016 (0.5 per year)
source: EuropePMC
EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology,
Volume 11, Issue 13, 1 1 2016, Pages 1554-1561
Acute effect of MitraClip implantation on mitral valve geometry in patients with functional mitral regurgitation: insights from three-dimensional transoesophageal echocardiography.
Al Amri I, Debonnaire P, van der Kley F, Schalij MJ, Bax JJ, Marsan NA, Delgado V
Aims: Our aim was to evaluate the acute effects of transcatheter edge-to-edge mitral valve repair using the MitraClip device on mitral valve geometry in patients with functional mitral regurgitation (FMR). Methods and results: Forty-two patients (age 73 years [IQ range 66.1-78.0], 55% men, 62% ischaemic FMR) with moderate-to-severe and severe FMR treated with the MitraClip were included. Three-dimensional transoesophageal echocardiography was performed prior to and immediately after MitraClip im...
Abstract
Cited 9 times since 2016 (1 per year)
source: EuropePMC
EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology,
Volume 11, Issue 13, 1 1 2016, Pages 1554-1561
Acute effect of MitraClip implantation on mitral valve geometry in patients with functional mitral regurgitation: insights from three-dimensional transoesophageal echocardiography.
Al Amri I, Debonnaire P, van der Kley F, Schalij MJ, Bax JJ, Marsan NA, Delgado V
Aims: Our aim was to evaluate the acute effects of transcatheter edge-to-edge mitral valve repair using the MitraClip device on mitral valve geometry in patients with functional mitral regurgitation (FMR). Methods and results: Forty-two patients (age 73 years [IQ range 66.1-78.0], 55% men, 62% ischaemic FMR) with moderate-to-severe and severe FMR treated with the MitraClip were included. Three-dimensional transoesophageal echocardiography was performed prior to and immediately after MitraClip im...
Abstract
Cited 29 times since 2016 (3.2 per year)
source: EuropePMC
Journal of medical genetics,
Volume 53, Issue 7, 1 1 2016, Pages 441-449
Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels.
van Leeuwen EM, Sabo A, Bis JC, Huffman JE, Manichaikul A, Smith AV, Feitosa MF, Demissie S, Joshi PK, Duan Q, Marten J, van Klinken JB, Surakka I, Nolte IM, Zhang W, Mbarek H, Li-Gao R, Trompet S, Verweij N, Evangelou E, Lyytikäinen LP, Tayo BO, Deelen J, van der Most PJ, van der Laan SW, Arking DE, Morrison A, Dehghan A, Franco OH, Hofman A, Rivadeneira F, Sijbrands EJ, Uitterlinden AG, Mychaleckyj JC, Campbell A, Hocking LJ, Padmanabhan S, Brody JA, Rice KM, White CC, Harris T, Isaacs A, Campbell H, Lange LA, Rudan I, Kolcic I, Navarro P, Zemunik T, Salomaa V, LifeLines Cohort Study, Kooner AS, Kooner JS, Lehne B, Scott WR, Tan ST, de Geus EJ, Milaneschi Y, Penninx BW, Willemsen G, de Mutsert R, Ford I, Gansevoort RT, Segura-Lepe MP, Raitakari OT, Viikari JS, Nikus K, Forrester T, McKenzie CA, de Craen AJ, de Ruijter HM, CHARGE Lipids Working Group, Pasterkamp G, Snieder H, Oldehinkel AJ, Slagboom PE, Cooper RS, Kähönen M, Lehtimäki T, Elliott P, van der Harst P, Jukema JW, Mook-Kanamori DO, Boomsma DI, Ch
Background: So far, more than 170 loci have been associated with circulating lipid levels through genome-wide association studies (GWAS). These associations are largely driven by common variants, their function is often not known, and many are likely to be markers for the causal variants. In this study we aimed to identify more new rare and low-frequency functional variants associated with circulating lipid levels. Methods: We used the 1000 Genomes Project as a reference panel for the imputation...
Abstract
Cited 31 times since 2016 (3.4 per year)
source: EuropePMC
Circulation research,
Volume 118, Issue 8, 1 1 2016, Pages 1254-1263
Meta-Analyses of Human Cell-Based Cardiac Regeneration Therapies: Controversies in Meta-Analyses Results on Cardiac Cell-Based Regenerative Studies.
Gyöngyösi M, Wojakowski W, Navarese EP, Moye LÀ, ACCRUE Investigators
In contrast to multiple publication-based meta-analyses involving clinical cardiac regeneration therapy in patients with recent myocardial infarction, a recently published meta-analysis based on individual patient data reported no effect of cell therapy on left ventricular function or clinical outcome. A comprehensive review of the data collection, statistics, and the overall principles of meta-analyses provides further clarification and explanation for this controversy. The advantages and pitfa...
Abstract
