Research

Publications

Below you can find a list of our published research.

6161 results

Cited 8 times since 2007 (0.5 per year) source: EuropePMC

Annals of vascular surgery, Volume 21, Issue 6, 1 1 2007, Pages 780-789 Glycemic control, lipid-lowering treatment, and prognosis in diabetic patients with peripheral atherosclerotic disease. Feringa HH, Karagiannis SE, Vidakovic R, Elhendy A, Schouten O, Boersma E, Bax JJ, Poldermans D

Glycemic control may be an underestimated risk factor in diabetic patients with peripheral arterial disease (PAD). Chronic statin therapy may improve glycemic control and outcome in these patients. In an observational cohort study of 425 consecutive diabetic patients with PAD, chronic statin therapy was noted, the ankle-brachial index was measured, and serial glycemic hemoglobin (HbA(1c)) measurements were obtained. During follow-up (median 7 years), all-cause mortality and cardiac death occurre... Abstract

Cited 14 times since 2007 (0.8 per year) source: EuropePMC

American heart journal, Volume 154, Issue 5, 1 1 2007, Pages 954-961 Statin therapy is associated with improved outcomes in vascular surgery patients with renal impairment. Welten GM, Chonchol M, Hoeks SE, Schouten O, Dunkelgrün M, van Gestel YR, Goei D, Bax JJ, van Domburg RT, Poldermans D

Background: Little is known about the association between baseline kidney function, statin therapy, and outcome after vascular surgery in patients with and without chronic kidney disease. Methods: A total of 2126 patients underwent elective major vascular surgery and were divided into 2 categories based on baseline creatinine clearance (CrCl), calculated using the Cockcroft-Gault equation: CrCl > or = 60 mL/min (n = 1358, reference) and CrCl < 60 mL/min (n = 768). Outcome measures were 30-... Abstract

Cited 19 times since 2007 (1.1 per year) source: EuropePMC

Coronary artery disease, Volume 18, Issue 7, 1 1 2007, Pages 571-576 The prevalence and prognosis of unrecognized myocardial infarction and silent myocardial ischemia in patients undergoing major vascular surgery. Feringa HH, Karagiannis SE, Vidakovic R, Elhendy A, ten Cate FJ, Noordzij PG, van Domburg RT, Bax JJ, Poldermans D

Objective: The aim of this study is to determine the prevalence and prognosis of unrecognized myocardial infarction (MI) and silent myocardial ischemia in vascular surgery patients. Methods: In a cohort of 1092 patients undergoing preoperative dobutamine stress echocardiography and noncardiac vascular surgery, unrecognized MI was determined by rest wall motion abnormalities in the absence of a history of MI. Silent myocardial ischemia was determined by stress-induced wall motion abnormalities in... Abstract

Cited 381 times since 2007 (21.9 per year) source: EuropePMC

Stem cell research, Volume 1, Issue 2, 1 1 2007, Pages 129-137 Reduction of myocardial infarct size by human mesenchymal stem cell conditioned medium. Timmers L, Lim SK, Arslan F, Armstrong JS, Hoefer IE, Doevendans PA, Piek JJ, El Oakley RM, Choo A, Lee CN, Pasterkamp G, de Kleijn DP

Although paracrine effects of mesenchymal stem cells (MSCs) have been suggested previously, cardioprotection by human MSC secretions has never been demonstrated. Human MSC-conditioned medium (CM) was collected by following a clinically compliant protocol. In a porcine model of ischemia and reperfusion injury, intravenous and intracoronary MSC-CM treatment significantly reduced myocardial nuclear oxidative stress as determined by immunostaining for 8-hydroxy-2'-deoxyguanosine. In addition, e... Abstract

Cited 90 times since 2007 (5.2 per year) source: EuropePMC

Journal of the American Geriatrics Society, Volume 55, Issue 11, 1 1 2007, Pages 1777-1785 Association between apolipoprotein E4 and cognitive decline in elderly adults. Packard CJ, Westendorp RG, Stott DJ, Caslake MJ, Murray HM, Shepherd J, Blauw GJ, Murphy MB, Bollen EL, Buckley BM, Cobbe SM, Ford I, Gaw A, Hyland M, Jukema JW, Kamper AM, Macfarlane PW, Jolles J, Perry IJ, Sweeney BJ, Twomey C, Prospective Study of Pravastatin in the Elderly at Risk Group

Objective: To determine the influence of apolipoprotein E on cognitive decline in a cohort of elderly men and women. Design: Prospective study. Setting: Scotland, Ireland, and the Netherlands. Participants: Five thousand eight hundred four subjects aged 70 to 82 from the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER). Measurements: Subjects were assessed at baseline and over a mean 3.2-year (range 0.7-4.2) follow-up for memory (Picture-Word Recall), speed of information proces... Abstract

Cited 23 times since 2007 (1.3 per year) source: EuropePMC

International journal of cardiology, Volume 131, Issue 2, 1 1 2007, Pages 285-287 Effect of EPO administration on myocardial infarct size in patients with non-STE acute coronary syndromes; results from a pilot study. Liem A, van de Woestijne AP, Bruijns E, Roeters van Lennep HW, de Boo JA, van Halteren HK, van Es TP, Jukema JW, van der Laarse A, Zwinderman AH, van Veldhuisen DJ

A pilot study was performed to determine the effect of 40,000 IU Epo on myocardial damage in 51 patients with non-ST segment elevation acute coronary syndrome (non-STE ACS). No significant difference in myocardial damage was found, but an increased systolic blood pressure was noticed. Abstract

Cited 1 times since 2007 (0.1 per year) source: EuropePMC

Nederlands tijdschrift voor geneeskunde, Volume 151, Issue 46, 1 1 2007, Pages 2580-2585 [Percutaneous implantation of a pulmonary valve in 3 children with surgically corrected cardiac anomalies]. Bökenkamp R, Hazekamp MG, Schalij MJ, Clur SA, Ottenkamp J, Blom NA

An 11-year-old girl, a 15-year-old boy and a 12-year-old girl all underwent percutaneous implantation of a Melody pulmonary valve prosthesis to replace a stenotic and insufficient homograft in the pulmonary artery. Preoperatively, 2 of the children suffered from fatigue and dyspnoea on exertion The homografts had been implanted between the ages of 1-2, to establish surgical continuity between the right ventricle and the pulmonary artery. The anomalies were tetralogy of Fallot, pulmonary atresia... Abstract

Cited 54 times since 2007 (3.1 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 93, Issue 11, 1 1 2007, Pages 1461-1470 Multi-modality imaging to assess left atrial size, anatomy and function. Tops LF, van der Wall EE, Schalij MJ, Bax JJ

The left atrium (LA) anterior-posterior diameter was one of the first standardised echocardiographic parameters. However, the clinical importance of LA size assessment has been neglected for some time. Recent population-based studies have demonstrated the prognostic value of LA size for long-term outcome. Furthermore, with new dedicated techniques such as tissue Doppler imaging, it has become feasible to assess (regional) LA function. In addition, the introduction of catheter ablation procedures... Abstract

Cited 24 times since 2007 (1.4 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 93, Issue 11, 1 1 2007, Pages 1339-1350 Optimal use of echocardiography in cardiac resynchronisation therapy. Bleeker GB, Yu CM, Nihoyannopoulos P, de Sutter J, Van de Veire N, Holman ER, Schalij MJ, van der Wall EE, Bax JJ

Echocardiography has several roles in patients with cardiac resynchronisation therapy (CRT). First, it can optimise selection of CRT candidates by demonstration of left ventricular (LV) dyssynchrony. Second, it can be used to assess immediate response to CRT, including detection of acute LV resynchronisation. Echocardiography is also useful to evaluate long-term benefit from CRT. Finally, echocardiography is important in optimisation of pacemaker settings, including AV and VV optimisation. Abstract

Nederlands tijdschrift voor geneeskunde, Volume 151, Issue 47, 1 1 2007, Pages 2615-2619 [The endocannabinoid system, overweight, and the CB1-endocannabinoid-receptor antagonist rimonabant]. Boekholdt SM, Jukema JW, Peters RJ

--Obesity is an important healthcare issue. --Recent research has led to insights into the role of the endocannabinoid system in the regulation of body weight. --Rimonabant is a CB1-endocannabinoid-receptor antagonist. --Four trials were published recently on the efficacy and safety of rimonabant in the treatment of people with obesity. --When combined with a hypocaloric diet, rimonabant 20 mg/day was more effective than placebo in achieving and maintaining weight loss. In addition, treatment wi... Abstract

Cited 179 times since 2007 (10.3 per year) source: EuropePMC

Circulation, Volume 116, Issue 20, 29 5 2007, Pages 2241-2252 Catheter ablation of ventricular tachycardia after repair of congenital heart disease: electroanatomic identification of the critical right ventricular isthmus. Zeppenfeld K, Schalij MJ, Bartelings MM, Tedrow UB, Koplan BA, Soejima K, Stevenson WG

Background: Catheter ablation of ventricular tachycardia (VT) after repair of congenital heart disease can be difficult because of nonmappable VTs and complex anatomy. Insights into the relation between anatomic isthmuses identified by delineating unexcitable tissue using substrate mapping techniques and critical reentry circuit isthmuses might facilitate ablation. Methods and results: Sinus rhythm voltage mapping of the right ventricle was performed in 11 patients with sustained VT after repair... Abstract

Cited 26 times since 2007 (1.5 per year) source: EuropePMC

Pathology, research and practice, Volume 203, Issue 12, 29 5 2007, Pages 863-872 Activation of signaling molecules and matrix metalloproteinases in right ventricular myocardium of rats with pulmonary hypertension. Umar S, Hessel M, Steendijk P, Bax W, Schutte C, Schalij M, van der Wall E, Atsma D, van der Laarse A

Pulmonary hypertension induces right ventricular (RV) overload, which is transmitted to cardiomyocytes via integrins that activate intracellular messengers, including focal adhesion kinase (FAK) and neuronal nitric oxide synthase (NOS1). We investigated whether RV hypertrophy (RVH) and RV failure (RVF) were associated with activation of FAK, NOS1, and matrix metalloproteinases (MMPs). Rats were treated without (RVC) or with a low dose of monocrotaline (30mg/kg) to induce RVH, and with a high dos... Abstract

Cited 14 times since 2007 (0.8 per year) source: EuropePMC

The American journal of cardiology, Volume 100, Issue 12, 26 4 2007, Pages 1786-1791 Comparison with computed tomography of two ultrasound devices for diagnosis of abdominal aortic aneurysm. Vidakovic R, Feringa HH, Kuiper RJ, Karagiannis SE, Schouten O, Dunkelgrun M, Hoeks SE, Bom N, Bax JJ, Neskovic AN, Poldermans D

Screening for abdominal aortic aneurysms (AAAs) in patients at risk will become more cost effective if a simple, inexpensive, and reliable ultrasound device is available. The aim of this study was to compare a 2-dimensional, handheld ultrasound device and a newly developed ultrasound volume scanner (based on bladder scan technology) with computed tomography (CT) for diagnosing AAA. A total of 146 patients (mean age 69 +/- 10 years; 127 men) were screened for the presence of AAAs (diameter >3... Abstract

Cited 18 times since 2007 (1 per year) source: EuropePMC

Journal of thrombosis and haemostasis : JTH, Volume 6, Issue 1, 25 4 2007, Pages 151-157 Development of a new test for the global fibrinolytic capacity in whole blood. Rijken DC, Hoegee-de Nobel E, Jie AF, Atsma DE, Schalij MJ, Nieuwenhuizen W

Background: The development of global tests for the fibrinolytic capacity in blood is hampered by the low base-line fibrinolytic activity in blood, by the involvement of both plasmatic components and blood cells in the fibrinolytic system and by the loss of fibrinolytic activity as a result of the action of plasminogen activator inhibitor-1 (PAI-1). Objective: To develop a new test for the global fibrinolytic capacity (GFC) of whole blood samples. Methods and results: Collection of blood in thro... Abstract

Cited 73 times since 2007 (4.2 per year) source: EuropePMC

The American journal of cardiology, Volume 100, Issue 11, 24 4 2007, Pages 1665-1670 Usefulness of QRS duration to predict response to cardiac resynchronization therapy in patients with end-stage heart failure. Mollema SA, Bleeker GB, van der Wall EE, Schalij MJ, Bax JJ

Despite current selection criteria, 20% to 30% of patients treated with cardiac resynchronization therapy (CRT) do not benefit. It has been suggested that QRS duration may not be the optimal criterion to select patients for CRT. The objective of this study was to systematically evaluate the predictive value of QRS duration for response to CRT in a large group of consecutive patients. A total of 242 patients with heart failure scheduled for implantation of a CRT device were studied. Selection cri... Abstract

Cited 501 times since 2007 (28.7 per year) source: EuropePMC

Molecular & cellular proteomics : MCP, Volume 7, Issue 2, 21 3 2007, Pages 282-289 A versatile nanotrap for biochemical and functional studies with fluorescent fusion proteins. Rothbauer U, Zolghadr K, Muyldermans S, Schepers A, Cardoso MC, Leonhardt H

Green fluorescent proteins (GFPs) and variants thereof are widely used to study protein localization and dynamics. We engineered a specific binder for fluorescent proteins based on a 13-kDa GFP binding fragment derived from a llama single chain antibody. This GFP-binding protein (GBP) can easily be produced in bacteria and coupled to a monovalent matrix. The GBP allows a fast and efficient (one-step) isolation of GFP fusion proteins and their interacting factors for biochemical analyses includin... Abstract

Cited 1586 times since 2007 (90.8 per year) source: EuropePMC

Circulation, Volume 116, Issue 22, 19 3 2007, Pages 2634-2653 Universal definition of myocardial infarction. Thygesen K, Alpert JS, White HD, Joint ESC/ACCF/AHA/WHF Task Force for the Redefinition of Myocardial Infarction, Jaffe AS, Apple FS, Galvani M, Katus HA, Newby LK, Ravkilde J, Chaitman B, Clemmensen PM, Dellborg M, Hod H, Porela P, Underwood R, Bax JJ, Beller GA, Bonow R, Van der Wall EE, Bassand JP, Wijns W, Ferguson TB, Steg PG, Uretsky BF, Williams DO, Armstrong PW, Antman EM, Fox KA, Hamm CW, Ohman EM, Simoons ML, Poole-Wilson PA, Gurfinkel EP, Lopez-Sendon JL, Pais P, Mendis S, Zhu JR, Wallentin LC, Fernández-Avilés F, Fox KM, Parkhomenko AN, Priori SG, Tendera M, Voipio-Pulkki LM, Vahanian A, Camm AJ, De Caterina R, Dean V, Dickstein K, Filippatos G, Funck-Brentano C, Hellemans I, Kristensen SD, McGregor K, Sechtem U, Silber S, Tendera M, Widimsky P, Zamorano JL, Morais J, Brener S, Harrington R, Morrow D, Lim M, Martinez-Rios MA, Steinhubl S, Levine GN, Gibler WB, Goff D, Tubaro M, Dudek D, Al-Attar N

Abstract

Cited 19 times since 2007 (1.1 per year) source: EuropePMC

Circulation, Volume 116, Issue 18, 15 3 2007, Pages 2018-2028 Resynchronization of separated rat cardiomyocyte fields with genetically modified human ventricular scar fibroblasts. Pijnappels DA, van Tuyn J, de Vries AA, Grauss RW, van der Laarse A, Ypey DL, Atsma DE, Schalij MJ

Background: Nonresponse to cardiac resynchronization therapy is associated with the presence of slow or nonconducting scar tissue. Genetic modification of scar tissue, aimed at improving conduction, may be a novel approach to achieve effective resynchronization. Therefore, the feasibility of resynchronization with genetically modified human ventricular scar fibroblasts was studied in a coculture model. Methods and results: An in vitro model was used to study the effects of forced expression of t... Abstract

Nature clinical practice. Cardiovascular medicine, Volume 4, Issue 12, 9 2 2007, Pages 644-645 Can tissue Doppler imaging detect myocardial viability in patients with left ventricular dysfunction? Bax JJ, Poldermans D

Abstract

Cited 107 times since 2007 (6.1 per year) source: EuropePMC

Pflugers Archiv : European journal of physiology, Volume 455, Issue 6, 2 1 2007, Pages 979-986 Release of cardiac troponin I from viable cardiomyocytes is mediated by integrin stimulation. Hessel MH, Atsma DE, van der Valk EJ, Bax WH, Schalij MJ, van der Laarse A

Elevated cardiac troponin-I (cTnI) levels have been demonstrated in serum of patients without acute coronary syndromes, potentially via a stretch-related process. We hypothesize that this cTnI release from viable cardiomyocytes is mediated by stimulation of stretch-responsive integrins. Cultured cardiomyocytes were treated with (1) Gly-Arg-Gly-Asp-Ser (GRGDS, n = 22) to stimulate integrins, (2) Ser-Asp-Gly-Arg-Gly (SDGRG, n = 8) that does not stimulate integrins, or (3) phosphate-buffered saline... Abstract