9618 results
Cited 61 times since 2003 (2.8 per year)
source: Scopus
Reproduction (Cambridge, England),
Volume 126, Issue 4, 1 1 2003, Pages 469-480
Proliferation and apoptosis in bovine placentomes during pregnancy and around induced and spontaneous parturition as well as in cows retaining the fetal membranes.
Boos A, Janssen V, Mülling C
Placental growth can be achieved by either cellular proliferation or hypertrophy. Tissue regeneration and the nutrition of the fetus via embryotrophe require high rates of cellular turnover and the so-called pre-term 'maturation' of the placenta is correlated with a reduction of maternal crypt epithelial cells. Placentomes of 45 pregnant cows were collected from an abattoir to assess the role of proliferation and apoptosis in placental physiology and pathology. Placentomes were also ta...
Abstract
Cited 1 times since 2003 (0 per year)
source: EuropePMC
The international journal of cardiovascular imaging,
Volume 19, Issue 5, 1 1 2003, Pages 367-369
Congenital coronary artery anomalies angiographic classification revisited.
Vliegen HW, Bruschke AV
Abstract
Cited 86 times since 2003 (3.9 per year)
source: EuropePMC
Journal of cell science,
Volume 116, Issue Pt 19, 1 1 2003, Pages 3971-3984
Complex protein-DNA dynamics at the latent origin of DNA replication of Epstein-Barr virus.
Ritzi M, Tillack K, Gerhardt J, Ott E, Humme S, Kremmer E, Hammerschmidt W, Schepers A
The sequential binding of the origin recognition complex (ORC), Cdc6p and the minichromosome maintenance proteins (MCM2-7) mediates replication competence at eukaryotic origins of DNA replication. The latent origin of Epstein-Barr virus, oriP, is a viral origin known to recruit ORC. OriP also binds EBNA1, a virally encoded protein that lacks any activity predicted to be required for replication initiation. Here, we used chromatin immunoprecipitation and chromatin binding to compare the cell-cycl...
Abstract
Cited 21 times since 2003 (1 per year)
source: EuropePMC
Pacing and clinical electrophysiology : PACE,
Volume 26, Issue 10, 1 1 2003, Pages 2042-2044
Resynchronization therapy after congenital heart surgery to improve left ventricular function.
Roofthooft MT, Blom NA, Rijlaarsdam ME, Bökenkamp R, Ottenkamp J, Schalij MJ, Bax JJ, Hazekamp MG
This report describes the mid-term beneficial hemodynamic effect of biventricular pacing in an infant with congestive heart failure after congenital heart surgery, due to resynchronization of the left and right ventricle, optimization of the AV delay, and (partial) correction of the LV dyssynchrony.
Abstract
Cited 19 times since 2003 (0.9 per year)
source: EuropePMC
Journal of cardiovascular electrophysiology,
Volume 14, Issue 10, 1 1 2003, Pages 1110-1112
Transvenous biventricular pacing in a child after congenital heart surgery as an alternative therapy for congestive heart failure.
Blom NA, Bax JJ, Ottenkamp J, Schalij MJ
Transvenous Biventricular Pacing in Children. Cardiac resynchronization therapy improves short-term and long-term hemodynamics in adult patients with congestive heart failure and left bundle branch block. We describe the feasibility of transvenous biventricular pacemaker implantation in a 6-year-old child with heart failure and wide QRS complex after congenital heart surgery. Myocardial tissue Doppler imaging was used to demonstrate intraventricular dyssynchrony and resynchronization after cardi...
Abstract
Cited 33 times since 2003 (1.5 per year)
source: EuropePMC
The Journal of thoracic and cardiovascular surgery,
Volume 126, Issue 4, 1 1 2003, Pages 1053-1060
Pulmonary artery remodeling in transposition of the great arteries: relevance for neoaortic root dilatation.
Lalezari S, Hazekamp MG, Bartelings MM, Schoof PH, Gittenberger-De Groot AC
Objective: Transposition of the great arteries is currently treated by performing the arterial switch operation. Dilatation of the neoaortic root is a late complication with unknown cause. Samples of patients with untreated transposition of the great arteries and patients with normally related great arteries were compared to investigate a possible role for vascular remodeling in the dilatation process. Methods: Aortic and pulmonary artery vessel wall and sinus samples were taken from 20 untreate...
Abstract
Cited 63 times since 2003 (2.9 per year)
source: EuropePMC
Circulation,
Volume 108, Issue 17, 29 5 2003, Pages 2099-2106
Voltage and activation mapping: how the recording technique affects the outcome of catheter ablation procedures in patients with congenital heart disease.
de Groot NM, Schalij MJ, Zeppenfeld K, Blom NA, Van der Velde ET, Van der Wall EE
Background: Endocardial mapping is mandatory before radiofrequency catheter ablation (RFCA). Mapping can be performed with either unipolar or bipolar recordings. Impact of the recording technique used was studied in patients with and without structural heart disease using the 3D electroanatomic CARTO mapping system. Methods and results: Patients (n=44; 16 males; age 43+/-16 years) referred for RFCA of atrial flutter (AFL, n=18), focal atrial tachycardia (FAT, n=4), AV nodal reentrant tachycardia...
Abstract
Cited 4 times since 2003 (0.2 per year)
source: EuropePMC
Radiology,
Volume 228, Issue 3, 1 1 2003, Pages 834-841
Vein graft function improvement after percutaneous intervention: evaluation with MR flow mapping.
Langerak SE, Vliegen HW, Jukema JW, Zwinderman AH, Lamb HJ, de Roos A, van der Wall EE
Purpose: To provide functional reference values in single and sequential vein grafts by using magnetic resonance (MR) flow mapping and to examine the effect of percutaneous intervention (PCI) on coronary artery bypass graft function. Materials and methods: Fast MR flow mapping at baseline and during adenosine-induced stress was performed in 39 nonstenotic single vein grafts and 20 nonstenotic sequential vein grafts, as well as in 15 stenotic vein grafts before and 7.3 weeks +/- 1.5 after success...
Abstract
Cited 4 times since 2003 (0.2 per year)
source: EuropePMC
Current opinion in urology,
Volume 13, Issue 5, 1 1 2003, Pages 389-395
Future strategies in the diagnosis, staging and treatment of bladder cancer.
van der Heijden AG, Witjes JA
Purpose of review: In this review new modalities in the diagnosis, staging and treatment of superficial and invasive bladder cancer are reviewed. Recent findings: Urinary markers still cannot replace cystoscopy in diagnosing bladder cancer. However, DNA micro-array has shown promise for diagnosis. In the treatment of superficial bladder cancer, valrubicin, pirarubicin and gemcitabine are novelties. Furthermore, a combination therapy of hyperthermia and mitomycin-C as well as photodynamic therapy...
Abstract
Cited 38 times since 2003 (1.7 per year)
source: EuropePMC
Circulation,
Volume 108 Suppl 1, 1 1 2003, Pages II39-42
Early versus delayed revascularization in patients with ischemic cardiomyopathy and substantial viability: impact on outcome.
Bax JJ, Schinkel AF, Boersma E, Rizzello V, Elhendy A, Maat A, Roelandt JR, van der Wall EE, Poldermans D
Background: Patients with ischemic cardiomyopathy and viable myocardium may improve in function and prognosis following revascularization. Delayed revascularization may result in less favorable outcome, and therefore the impact of timing of revascularization on long-term outcome was evaluated. Methods and results: Patients (n=85) with ischemic cardiomyopathy and substantial viability (>or=25% of the left ventricle) on dobutamine stress echocardiography underwent surgical revascularization. Ba...
Abstract
Cited 11 times since 2003 (0.5 per year)
source: EuropePMC
The American journal of cardiology,
Volume 92, Issue 5, 1 1 2003, Pages 613-616
Effect of atorvastatin on myocardial contractile reserve assessed by tissue Doppler imaging in moderately hypercholesterolemic patients without heart disease.
Bountioukos M, Rizzello V, Krenning BJ, Bax JJ, Kertai MD, Vourvouri EC, Schinkel AF, Biagini E, Boersma E, Roelandt JR, Poldermans D
An improvement in myocardial longitudinal systolic velocities, assessed by pulsed-wave tissue Doppler imaging during low-dose dobutamine infusion, was observed at 6-month follow-up after 6 months of treatment with atorvastatin. Our findings indicate a favorable effect of atorvastatin on contractile reserve, possibly through an enhancement of flow-dependent coronary dilatation during stress.
Abstract
Cited 4 times since 2003 (0.2 per year)
source: EuropePMC
European heart journal,
Volume 24, Issue 17, 1 1 2003, Pages 1541-1542
Dobutamine echocardiography: a diagnostic tool comes of age.
Poldermans D, Bax JJ
Abstract
Cited 8 times since 2003 (0.4 per year)
source: EuropePMC
The American journal of cardiology,
Volume 92, Issue 6, 1 1 2003, Pages 712-715
Relation between QT dispersion and myocardial viability in ischemic cardiomyopathy.
Schinkel AF, Bountioukos M, Poldermans D, Elhendy A, Valkema R, Vourvouri EC, Biagini E, Rizzello V, Kertai MD, Krenning B, Krenning EP, Roelandt JR, Bax JJ
The aim of this study was to evaluate the relation between QT dispersion and myocardial viability as assessed by single-photon emission computed tomography. The study population included 97 consecutive patients with severely impaired left ventricular function secondary to chronic coronary artery disease. Patients with a low QT dispersion had a substantial amount of viable myocardium, whereas patients with a high QT dispersion had predominantly nonviable scar tissue.
Abstract
Cited 50 times since 2003 (2.3 per year)
source: EuropePMC
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology,
Volume 10, Issue 5, 1 1 2003, Pages 543-556
PET myocardial glucose metabolism and perfusion imaging: Part 1-Guidelines for data acquisition and patient preparation.
Bacharach SL, Bax JJ, Case J, Delbeke D, Kurdziel KA, Martin WH, Patterson RE
Abstract
Cited 480 times since 2003 (21.8 per year)
source: EuropePMC
Clinical pharmacology and therapeutics,
Volume 74, Issue 3, 1 1 2003, Pages 245-254
Genetic polymorphisms of the CYP3A4, CYP3A5, and MDR-1 genes and pharmacokinetics of the calcineurin inhibitors cyclosporine and tacrolimus.
Hesselink DA, van Schaik RH, van der Heiden IP, van der Werf M, Gregoor PJ, Lindemans J, Weimar W, van Gelder T
Background: The calcineurin inhibitors cyclosporine (INN, cyclosporin) and tacrolimus have a narrow therapeutic index and show considerable interindividual variability in their pharmacokinetics. The low oral bioavailability of calcineurin inhibitors is thought to result from the actions of the metabolizing enzymes cytochrome P450 (CYP) 3A4 and CYP3A5 and the multidrug efflux pump P-glycoprotein, encoded by MDR-1. Objective: Our objective was to determine the role of genetic polymorphisms in CYP3...
Abstract
Cited 23 times since 2003 (1 per year)
source: EuropePMC
Preventive veterinary medicine,
Volume 60, Issue 4, 1 1 2003, Pages 281-295
Prevalence estimates for paratuberculosis adjusted for test variability using Bayesian analysis.
van Schaik G, Schukken YH, Crainiceanu C, Muskens J, VanLeeuwen JA
The ELISA tests that are available to detect an infection with Mycobacterium avium subsp. paratuberculosis (MAP) have a limited validity expressed as the sensitivity (Se) and specificity (Sp). In many studies, the Se and Sp of the tests are treated as constants and this will result in an underestimation of the variability of the true prevalence (TP). Bayesian inference provided a natural framework for using information on the test variability (i.e., the uncertainty) in the estimates of test Se a...
Abstract
Cited 171 times since 2003 (7.8 per year)
source: EuropePMC
Arthritis and rheumatism,
Volume 48, Issue 9, 1 1 2003, Pages 2489-2500
Citrullination of synovial proteins in murine models of rheumatoid arthritis.
Vossenaar ER, Nijenhuis S, Helsen MM, van der Heijden A, Senshu T, van den Berg WB, van Venrooij WJ, Joosten LA
Objective: Antibodies directed to citrulline-containing proteins are highly specific for rheumatoid arthritis (RA) and can be detected in up to 80% of patients with RA. Citrulline is a nonstandard amino acid that can be incorporated into proteins only by posttranslational modification of arginine by peptidylarginine deiminase (PAD) enzymes. The objective of this study was to investigate the presence of anticitrulline antibodies, PAD enzymes, and citrullinated antigens in mouse models of both acu...
Abstract
Cited 138 times since 2003 (6.3 per year)
source: EuropePMC
Proceedings of the National Academy of Sciences of the United States of America,
Volume 100, Issue 19, 28 4 2003, Pages 10989-10994
The EBV nuclear antigen 1 (EBNA1) enhances B cell immortalization several thousandfold.
Humme S, Reisbach G, Feederle R, Delecluse HJ, Bousset K, Hammerschmidt W, Schepers A
The Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA1) is one of the earliest viral proteins expressed after infection and is the only latent protein consistently expressed in viral-associated tumors. EBNA1's crucial role in viral DNA replication, episomal maintenance, and partitioning is well examined whereas its importance for the immortalization process and the tumorgenicity of EBV is unclear. To address these open questions, we generated, based on the maxi-EBV system, an EBNA1-deficient...
Abstract
Cited 123 times since 2003 (5.6 per year)
source: EuropePMC
Circulation,
Volume 108, Issue 11, 25 4 2003, Pages 1368-1374
Rosuvastatin reduces atherosclerosis development beyond and independent of its plasma cholesterol-lowering effect in APOE*3-Leiden transgenic mice: evidence for antiinflammatory effects of rosuvastatin.
Kleemann R, Princen HM, Emeis JJ, Jukema JW, Fontijn RD, Horrevoets AJ, Kooistra T, Havekes LM
Background: Statins can exert anti-inflammatory antiatherosclerotic effects through an anti-inflammatory action, independent of lowering cholesterol. We addressed the question whether the anti-inflammatory activities of statins can reduce atherosclerosis beyond the reduction achieved by cholesterol lowering per se. Methods and results: Two groups of 20 female APOE*3-Leiden mice received either a high-cholesterol diet (HC) or a high-cholesterol diet supplemented with 0.005% (wt/wt) rosuvastatin (...
Abstract
Cited 250 times since 2003 (11.3 per year)
source: EuropePMC
Genome research,
Volume 13, Issue 9, 12 2 2003, Pages 1998-2004
The human transcriptome map reveals extremes in gene density, intron length, GC content, and repeat pattern for domains of highly and weakly expressed genes.
Versteeg R, van Schaik BD, van Batenburg MF, Roos M, Monajemi R, Caron H, Bussemaker HJ, van Kampen AH
The chromosomal gene expression profiles established by the Human Transcriptome Map (HTM) revealed a clustering of highly expressed genes in about 30 domains, called ridges. To physically characterize ridges, we constructed a new HTM based on the draft human genome sequence (HTMseq). Expression of 25,003 genes can be analyzed online in a multitude of tissues (http://bioinfo.amc.uva.nl/HTMseq). Ridges are found to be very gene-dense domains with a high GC content, a high SINE repeat density, and...
Abstract
